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| 1 | Early Serum HBsAg Kinetics as Predictor of HBsAg Loss in Patients with HBeAg-Negative Chronic Hepatitis B after Treatment with Pegylated Interferonα-2a显示文摘Hepatitis B surface antigen(HBsAg)loss is an ideal treatment endpoint for patients with chronic hepatitis B(CHB).We investigated the predictive value of on-treatment HBsAg levels for HBsAg loss in hepatitis B e antigen(HBe Ag)-negative CHB patients who received 120-week PEG-IFNα-2a treatment.Serum HBV DNA,HBsAg,and anti-HBs levels were assayed at baseline and every 3 months during the treatment.Of 81 patients,12 achieved HBsAg loss,20 achieved HBsAg\100 IU/mL,and 49 maintained HBs Ag C 100 IU/mL.HBsAg loss rate was only 3.7%at 48 weeks,while it reached to 11.1%and 14.8%after treatment of 96 weeks and 120 weeks.The cutoff HBs Ag levels at 12 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 400 IU/mL and 750 IU/mL,with AUC 0.725 and 0.722,positive predictive value(PPV)29.41%and 30.56%,and negative predictive value(NPV)93.75%and 97.78%,respectively.The cutoff HBsAg levels at 24 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 174 IU/m L and 236 IU/mL respectively,with AUC 0.925 and 0.922,PPV 40.0%and 46.15%,and both NPV 100%.The predictive ability of the cutoff HBsAg levels at 24 weeks was better than that at 12 weeks for HBs Ag loss at either 96 or 120 weeks(χ~2=3.880,P=0.049 andχ~2=4.412,P=0.036).These results indicate that extended therapy is critical to HBsAg loss in HBe Ag-negative CHB patients during PEG-IFN treatment,and the HBsAg level at 24 weeks can be used to predict HBsAg loss during tailoring PEG-IFN therapy. | Minghui Li Lu Zhang Yao Lu Qiqi Chen Huihui Lu Fangfang Sun Zhan Zeng Gang Wan Linqing Zhao Yao Xie | 2021 | Virologica Sinica2021，36，2： | 15 |
| 2 | Magnetic spin–orbit interaction of light显示文摘We study the directional excitation of optical surface waves controlled by the magnetic field of light.We theoretically predict that a spinning magnetic dipole develops a tunable unidirectional coupling of light to transverse electric(TE)polarized Bloch surface waves(BSWs).Experimentally,we show that the helicity of light projected onto a subwavelength groove milled into the top layer of a 1D photonic crystal(PC)controls the power distribution between two TE-polarized BSWs excited on both sides of the groove.Such a phenomenon is shown to be solely mediated by the helicity of the magnetic optical field,thus revealing a magnetic spin-orbit interaction of light.Remarkably,this magnetic optical effect is clearly observed via a near-field coupler governed by an electric dipole moment:it is of the same order of magnitude as the electric optical effects involved in the coupling.This opens up new degrees of freedom for the manipulation of light and offers desirable and novel opportunities for the development of integrated optical functionalities. | Mengjia Wang Hongyi Zhang Tatiana Kovalevich Roland Salut Myun-Sik Kim Miguel Angel Suarez Maria-Pilar Bernal Hans-Peter Herzig Huihui Lu Thierry Grosjean | 2018 | Light(Science & Applications)2018，7，1： | 15 |
| 3 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 4 | Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing. | HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO | 2018 | Photonics Research2018，6，6： | 8 |
| 5 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 6 | Preparation of monolayer-assembled fluorescent film and its sensing performances to hidden nitroaromatic explosives显示文摘Pyrene was chemically assembled on a glass plate surface in a monolayer manner via spacers con-taining triethylenetetramine (TETA) subunits. It has been demonstrated that the fluorescence emission of the film is sensitive to the presence of trace amount of nitroaromatic compound (NAC) vapors. As discovered in the present work, the response selectivity of the pyrene-functionalized film depends on the length of the spacer, the vapor pressure of a given NAC, and the quencher size. The film shows faster response to those quenchers which have higher vapor pressure and smaller size. Compared to the film with shorter spacers, the present film with longer flexible spacers shows a slower response to the NACs, but higher selectivity to the quencher size. Additionally, the detection limits to common ex-plosives in vapor phase, 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT), are 7.14×10-12 and 5.49×10-11 g·mL-1, respectively. Further examinations indicated that the sensing process is fully re-versible, and the vapors of those common interference such as benzene, toluene, ethanol, and perfume have little effect upon the sensing performances of the film. | LI HuiHui LU FengTing ZHANG ShuJuan HE Gang FANG Yu | 2008 | Chinese Science Bulletin2008，53，11： | 4 |
| 7 | Concise and efficient direct-view generation of arbitrary cylindrical vector beams by a vortex half-wave plate显示文摘A concise, efficient, and practical direct-view scheme is presented to generate arbitrary cylindrical vector(CV)beams, including CV beams, vortex beams, and cylindrical vector vortex(CVV) beams, by a vortex half-wave plate(VHP). Six kinds of first-order and other high-order CV beams, such as azimuthally polarized(AP) beams, antivortex radial polarization mode beams, and three-order AP beams, are formed by simply rotating a half-wave plate. The Stokes parameters and double-slit interference of multitype CV beams are investigated in detail.The polarization parameters, including degree of polarization, polarization azimuth, and ellipticity, are obtained,which demonstrates the efficient generation of CV beams. In addition, the double-slit interference experiment is introduced in the setup, and fringe misplacement and tilt appear for CVV beams, in which the misplacement number M is 2P+1 for P ≤ 2 and 2P-1 for P ≥ 3, where P is the polarization order number, and the fringe tilt offset is positively related to the topological charge number l of CVV beams. In addition, new types of VHPs can be formed by cascading two or more VHPs when the types of available VHPs are limited, assisting in more flexible generation of multitype CV beams. It is experimentally demonstrated that arbitrary CV beams with high quality are effectively achieved by the proposed setup, and the double-slit interference method can be utilized to determine and analyze CV beams rapidly and concisely by practical performance, which shows the potential to be implemented as a commercial device. | JUNLI QI WEIHUA WANG BO SHI HUI ZHANG YANAN SHEN HAIFEI DENG WENJING PU XIN LIU HUIHUI SHAN XIAOMIN MA LIANQIANG ZHANG WEI LU MEICHENG FU XIUJIAN LI | 2021 | Photonics Research2021，9，5： | 4 |
| 8 | Carbonaceous and nitrogenous disinfection byproduct precursor variation during the reversed anaerobic–anoxic–oxic process of a sewage treatment plant显示文摘Disinfection byproduct(DBP)precursors in wastewater during the reversed anaerobic–anoxic–oxic(A^2/O)process,as well as their molecular weight(MW)and polarity-based fractions,were characterized with UV scanning,fluorescence excitation emission matrix,Fourier transform infrared and nuclear magnetic resonance spectroscopy.Their DBP formation potentials(DBPFPs)after chlorination were further tested.Results indicated that the reversed A^2/O process could not only effectively remove the dissolved organic carbon(DOC)and dissolved total nitrogen in the wastewater,but also affect the MW distribution and hydrophilic–hydrophobic properties of dissolved organic matter(DOM).The accumulation of low MW and hydrophobic(HPO)DOM was possibly due to the formation of soluble microbial product-like(SMP-like)matters in the reversed A^2/O treatment,especially in the anoxic and aerobic processes.Moreover,DOM in the wastewater displayed a high carbonaceous disinfection byproduct formation potential(C-DBPFP)in the fractions of MW>100 k Da and MW<5 k Da,and revealed an increasing tendency of nitrogenous disinfection byproduct formation potential(N-DBPFP)with decrease of MW.For polarity-based fractions,the HPO fraction of wastewater showed significantly higher C-DBPFP and N-DBPFP than hydrophilic and transphilic fractions.Therefore,although the reversed A^2/O process could remove most DBP precursors by DOC reduction,it led to the enhancement of DBPFP with the formation and accumulation of low MW and HPO DOM.In addition,strong correlations between C-DBPFPs and SUVA,and between N-DBPFPs and DON/DOC,were observed in the wastewater,which might be helpful for DBPFP prediction in wastewater and reclaimed water chlorination. | Huihui Han Hengfeng Miao Yajing Zhang Minfeng Lu Zhenxing Huang Wenquan Ruan | 2018 | Journal of Environmental Sciences2018，30，3： | 3 |
| 9 | The Effects of Chronic Hypoxia on Thermoregulation and Metabolism in Phrynocephalus vlangalii显示文摘Phrynocephalus vlangalii are widely distributed on Tibetan plateau spanning diverse altitudes and habitats. In the present study, P.vlangalii were exposed to 8% oxygen concentration in a hypoxic chamber for 6 weeks. Then the body temperature(T_b), standard metabolic rate(SMR), heart rate and metabolic enzyme activities of the lizards were measured at 20℃ and 30℃. The results indicated that hypoxia exposure decreased T_b, SMR and heart rate. Lactate dehydrogenase(LDH) activity of 8% O_2 group became significant elevated in liver and skeletal muscle compared with control group at 20℃, but descended significantly in heart. Using electrophoresis we found that LDH contains five isozymes(LDH1, LDH2, LDH3, LDH4 and LDH5) and are expressed specifically in liver, skeletal muscle and heart. Citrate synthase(CS) activity in the liver also decreased at 20℃ and 30℃. No significant difference of CS activity was found between the two groups in skeletal muscle and heart. | Weixin LI Shiwei LIANG Huihui WANG Ying XIN Songsong LU Xiaolong TANG Qiang CHEN | 2016 | Asian Herpetological Research2016，7，2： | 3 |
| 10 | An effective rolling process of magnesium alloys for suppressing edge cracks: Width-limited rolling显示文摘To suppress the edge crack of the magnesium alloy sheet during the ordinary rolling process, a new rolling process named width-limited rolling was proposed in this paper. Width-limited rolling is a rolling method in which the width of the alloy sheet is limited by modifying the shape of the rollers, allowing a compressive stress field to form at the edge portion of the alloy sheet during rolling, resulting in the reduction of edge cracks. At present work, magnesium alloy sheets were separately subjected to ordinary rolling and width-limited rolling. The microstructure evolution and mechanical properties of the rolled sheets were investigated by EBSD, TEM, and XRD. The results exhibited that under the same rolling conditions, the sheet after ordinary rolling exhibited obvious edge cracks while no crack was found at the edge of the sheet after width-limited rolling. The edge crack suppressing effect was attributed to the reduction of the tensile stress along rolling direction during WLR, promoting the synchronous extension of the edge and center regions to suppress edge crack tendency. Microstructure observation showed that the compressive twins formed in the sheet after ordinary rolling usually exhibited as thin plates and cannot continue to fully develop due to the premature generation of the edge cracks. However, the compressive twins developed maturely in some of which double twins formed and various slip systems with different dislocation Burgers vectors occurred in the rolled sheet after WLR. More twin intersections and shear bands, providing more potential recrystallization nucleation sites, which are beneficial to weaken basal texture. With the cooperation of twinning and dislocation slip, the texture of the sheet after the width-limited rolling is weakened and the mechanical properties are improved. | Jing Tian Huihu Lu Wanggang Zhang Huihui Nie Quanxin Shi Jiafei Deng Wei Liang Lifei Wang | 2022 | Journal of Magnesium and Alloys2022，10，8： | 2 |
| 11 | Nitrogen-rich carbon spheres made by a continuous spraying process for high-performance supercapacitors显示文摘Supercapacitors 有高力量密度,高效率,和长骑车一生;然而,启用他们的更宽的使用,他们的精力密度必须显著地被改进。有更好的电容,率表演,和骑车的稳定性的改进的碳材料的设计和合成作为 supercapacitor 研究的主要主题出现了。此处,我们报导一个灵巧的合成方法基于一个连续喷洒喷雾器的过程准备充满氮的碳粒子。有高表面区域的方法收益粒子,一致多微孔的结构,并且是高度做 N 的,导致在水、商业的器官的电解质为使用与高精力和力量密度启用 supercapacitors 的构造的协同。而且,我们使用了密度证明改进性能由于提高的 wettability,在碳 / 电解质的离子吸附相互作用连接那的功能的理论计算源于氮做。这些调查结果提供新卓见进在碳材料的电容改进做的 heteroatom 的角色;另外,我们的方法为做的碳的大规模生产提供一条有效线路。 | Fei Sun Haobin Wu Xin Liu Fang Liu Huihui zhou Jihui Gao Yunfeng Lu | 2016 | Nano Research2016，9，11： | 2 |
| 12 | Deep white matter hyperintensity is spatially correlated to MRI-visible perivascular spaces in cerebral small vessel disease on 7 Tesla MRI显示文摘Background The association between perivascular space(PVS)and white matter hyperintensity(WMH)has been unclear.Normal-appearing white matter(NAWM)around WMH is also found correlated with the development of focal WMH.This study aims to investigate the topological connections among PVS,deep WMH(dWMH)and NAWM around WMH using 7 Tesla(7T)MRI.Methods Thirty-two patients with non-confluent WMHs and 16 subjects without WMHs were recruited from our department and clinic.We compared the PVS burden between patients with and without WMHs using a 5-point scale.Then,the dilatation and the number of PVS within a radius of 1 cm around each dWMH were compared with those of a reference site(without WMH)in the contralateral hemisphere.In this study,we define NAWM as an area within the radius of 1 cm around each dWMH.Furthermore,we assessed the spatial relationship between dWMH and PVS.Results Higher PVS scores in the centrum semiovale were found in patients with>5 dWMHs(median 3)than subjects without dWMH(median 2,p=0.014).We found there was a greater dilatation and a higher number of PVS in NAWM around dWMH than at the reference sites(p<0.001,p<0.001).In addition,79.59%of the dWMHs were spatially connected with PVS.Conclusion dWMH,NAWM surrounding WMH and MRI-visible PVS are spatially correlated in the early stage of cerebral small vessel disease.Future study of WMH and NAWM should not overlook MRI-visible PVS. | Yajing Huo Yilin Wang Cen Guo Qianyun Liu Lili Shan Mingyuan Liu Haibo Wu Guanwu Li Huihui Lv Lingdan Lu Yintin Zhou Jianfeng Feng Yan Han | 2023 | Stroke & Vascular Neurology2023，8，2： | 2 |
| 13 | Properties and structure of MWNTs/cellulose composite fibers prepared by Lyocell process显示文摘 | Lu Jiang Zhang Huihui Jian Yihui | 2012 | Journal of Applied Polymer Science2012，123，2： | 1 |
| 14 | Screening for testosterone, methyltestosterone, 19-nortestosterone residues and their metabolites in bovine urine with enzyme-linked immunosorbent assay (ELISA)显示文摘 | Huihui Lu Grainne Conneely Mark A. Crowe Margaret Aherne Miloslav Pravda George G. Guilbault | 2006 | Analytica Chimica Acta2006，，1： | 1 |
| 15 | Progress in aggregation-induced emission-active fluorescent polymeric hydrogels显示文摘Aggregation-induced emission(AIE)-active fluorescent polymeric hydrogels(FPHs)are the marriage of AIE-active materials and polymeric hydrogels.Different from the widely studied AIE-active materials that are primarily used in solution or dry solid state,they feature a three-dimensional crosslinked polymer network that can absorb water without dissolving.Consequently,they are known to bear many advantageous properties such as soft wet nature,tissue-like mechanical strength,biocompatibility,biomimetic self-healing feature,facilely tailored structure,as well as responsive fluorescence and volume/shape changes,thus representing a promising category of luminescent materials with many frontier uses.This Review is intended to give a systematic summary of the recent progress in this young but flourishing research area,with particular focus on their design and preparation.Current challenges and future outlooks in this field are also discussed in order to attract new interests and inspire more efforts. | Wei Lu Shuxin Wei Huihui Shi Xiaoxia Le Guangqiang Yin Tao Chen | 2021 | Aggregate2021，2，3： | 1 |
| 16 | Determination of formaldehyde in foodstuffs by flow injection spectrophotometry using phloroglucinol as chromogenic agent 显示文摘 | LI Ziwei MA Hongbing LU Huihui | 2008 | Talanta2008，74，4： | 1 |
| 17 | Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy显示文摘Chronic hepatitis B virus(HBV)infection is a global public health problem,which can cause chronic hepatitis,liver cirrhosis,hepatocellular carcinoma(HCC),and other diseases.Antiviral therapy is the most critical measure to slow down the progression of chronic hepatitis B,prevent or delay cirrhosis,HCC,and other kinds of liver decompensation events.At present,the anti-hepatitis B virus drugs are mainly nucleoside(acid)analogues(NAs)and interferon.Each kind of antiviral drug has different effects on the clinical outcome of hepatitis B patients(such as HCC).In this paper,we discussed the biological characteristics,natural course and prognosis of HBV infection,the mechanism of HBV-related HCC,the effect of different antiviral drugs on patients’outcome,predictive biomarkers and model for HBV clinical outcome,predictors of sustained response and recurrence after withdrawal of antiviral therapy,consideration of expanding therapeutic indications and antiviral therapy,hoping to give a hand to the clinical diagnosis and treatment of HBV. | Huihui Lu Wei Yi Fangfang Sun Zhan Zeng Lu Zhang Minghui Li Yao Xie | 2021 | Biosafety and Health2021，3，4： | 1 |
| 18 | Determination of formaldehyde in foodstuffs by flow injection spectrophotometry using phloroglucinol as chromogenic agent显示文摘 | LI Ziwei MA Hongbing LU Huihui | 2008 | Talanta2008，74，4： | 1 |
| 19 | Screening for testosterone,methyltestosterone,19-nortestosterone residues and their metabolites in bovine urine with enzyme-linked immunosorbent assay(ELISA)显示文摘 | Lu Huihui Conneely G Crowe M A | 2006 | Anal Chim Acta2006，570，1： | 1 |
| 20 | Analysis of Volatile Compounds in the Pericarp of Zanthoxylum bungeanum Maxim. by Ultrasonic Nebulization Extraction Coupled with Headspace Single-Drop Microextraction and GC–MS显示文摘 | Lu Wang Ziming Wang Xueyuan Li Huihui Zhang Xin Zhou Hanqi Zhang | 2010 | Chromatographia (-)2010，，5： | 1 |
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