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| 1 | Metabolic theory of septic shock显示文摘Septic shock is a life threatening condition that can develop subsequent to infection. Mortality can reach as high as 80% with over 150000 deaths yearly in the United States alone. Septic shock causes progressive failure of vital homeostatic mechanisms culminating in immunosuppression, coagulopathy and microvascular dysfunction which can lead to refractory hypotension, organ failure and death. The hypermetabolic response that accompanies a systemic inflammatory reaction places high demands upon stored nutritional resources. A crucial element that can become depleted early during the progression to septic shock is glutathione. Glutathione is chiefly responsible for supplying reducing equivalents to neutralize hydrogen peroxide, a toxic oxidizing agent that is produced during normal metabolism. Without glutathione, hydrogen peroxide can rise to toxic levels in tissues and blood where it can cause severe oxidative injury to organs and to the microvasculature. Continued exposure can result in microvascular dysfunction, capillary leakage and septic shock. It is the aim of this paper to present evidence that elevated systemic levels of hydrogen peroxide are present inseptic shock victims and that it significantly contributes to the development and progression of this frequently lethal condition. | Jay Pravda | 2014 | World Journal of Critical Care Medicine2014，3，2： | 16 |
| 2 | Radical induction theory of ulcerative colitis显示文摘To propose a new pathogenesis called Radical Induction to explain the genesis and progression of ulcerative colitis (UC). UC is an inflammatory bowel disease. Colonic inflammation in UC is mediated by a buildup of white blood cells (WBCs) within the colonic mucosal lining; however,to date there is no answer for why WBCs initially enter the colonic mucosa to begin with. A new pathogenesis termed 'Radical Induction Theory' is proposed to explain this and states that excess un-neutralized hydrogen peroxide, produced within colonic epithelial cells as a result of aberrant cellular metabolism, diffuses through cell membranes to the extracellular space where it is converted to the highly damaging hydroxyl radical resulting in oxidative damage to structures comprising the colonic epithelial barrier. Once damaged, the barrier is unable to exclude highly immunogenic fecal bacterial antigens from invading the normally sterile submucosa. This antigenic exposure provokes an initial immune response of WBC infiltration into the colonic mucosa. Once present in the mucosa,WBCs are stimulated to secrete toxins by direct exposure to fecal bacteria leading to mucosal ulceration and bloody diarrhea characteristic of this disease. | Jay Pravda | 2005 | World Journal of Gastroenterology2005，11，16： | 11 |
| 3 | Sepsis:Evidence-based pathogenesis and treatment显示文摘Sepsis can develop during the body’s response to a critical illness leading to multiple organ failure,irreversible shock,and death.Sepsis has been vexing health care providers for centuries due to its insidious onset,generalized metabolic dysfunction,and lack of specific therapy.A common factor underlying sepsis is the characteristic hypermetabolic response as the body ramps up every physiological system in its fight against the underlying critical illness.A hypermetabolic response requires supraphysiological amounts of energy,which is mostly supplied via oxidative phosphorylation generated ATP.A by-product of oxidative phosphorylation is hydrogen peroxide(H2O2),a toxic,membranepermeable oxidizing agent that is produced in far greater amounts during a hypermetabolic state.Continued production of mitochondrial H2O2 can overwhelm cellular reductive(antioxidant)capacity leading to a build-up within cells and eventual diffusion into the bloodstream.H2O2 is a metabolic poison that can inhibit enzyme systems leading to organ failure,microangiopathic dysfunction,and irreversible septic shock.The toxic effects of H2O2 mirror the clinical and laboratory abnormalities observed in sepsis,and toxic levels of blood H2O2 have been reported in patients with septic shock.This review provides evidence to support a causal role for H2O2 in the pathogenesis of sepsis,and an evidence-based therapeutic intervention to reduce H2O2 levels in the body and restore redox homeostasis,which is necessary for normal organ function and vascular responsiveness. | Jay Pravda | 2021 | World Journal of Critical Care Medicine2021，10，4： | 3 |
| 4 | Developmet of an amperometric L-ascorbic acid (Vitamin C)sensor based on electropolymerised aniline for pharmaceutical and food analysis显示文摘 | Philip J O' Connell Cicile Gormally Miloslav Pravda | 2001 | Analytica Chimica Acta2001，431，： | 2 |
| 5 | Recent applications of electrogenerated chemiluminescence in chemical analysis显示文摘 | Fahnrich K A Pravda M Guilbault G G | 2001 | Talanta2001，54，4： | 1 |
| 6 | Biosensors-42years and counting显示文摘 | Guilbault G G Pravda M Kreuzer M | 2004 | Anal Lett2004，37，14： | 1 |
| 7 | Recent applications of electrogenerated chemilumicesence in chemical analysis显示文摘 | Fahnrieh KA Pravda M Guilbault GG | | 0，，04： | 1 |
| 8 | Development of a disposable immunosensor for the detection of human heart fatty-acid binding protein in human whole blood using screen-printed carbon electrodes显示文摘 | Regan O Tina M Pravda Miloslav | 2002 | Talant2002，57，3： | 1 |
| 9 | Prussian blue bulk modified screen-printed eleetordes for H2O2 detection and for biosensors 显示文摘 | O'HALLORAN M P PRAVDA M GUILBAULT G G | 2001 | Talanta2001，55，3： | 1 |
| 10 | Recent applications of electrogenerated chemiluminescenee in chemical analysis显示文摘 | Karsten A Fahnrich Miloslav Pravda George G Guilbault | 2001 | Talanta2001，54，： | 1 |
| 11 | Screening for testosterone, methyltestosterone, 19-nortestosterone residues and their metabolites in bovine urine with enzyme-linked immunosorbent assay (ELISA)显示文摘 | Huihui Lu Grainne Conneely Mark A. Crowe Margaret Aherne Miloslav Pravda George G. Guilbault | 2006 | Analytica Chimica Acta2006，，1： | 1 |
| 12 | Recent Applications of Electrogenerated Chemiluminescence in Chemical Analysis显示文摘 | Fahnrich K A Pravda M Guilbault G G | 2001 | Talanta2001，54，： | 1 |
| 13 | Recent applications of electrogenerated chemiluminescence in chemical analysis显示文摘 | Faihnrich K A Pravda M Guilbault G G | 2001 | Talanta2001，54，： | 1 |
| 14 | Development of animmunosensor for the determination of allergy antibody ( IgE ) in blood samples显示文摘 | Kreuzer M P Sullivan C K Pravda M | 2001 | Anal Chim Acta2001，442，1： | 1 |
| 15 | 显示文摘 | FA HNRICH K A PRAVDA M GUILBAULT G G | 2001 | Talanta2001，54，： | 1 |
| 16 | Angiostatin reg- ulates the expression of antiangiogenic and proapop- totic pathways via targeted inhibition of mitochondrial proteins显示文摘 | Lee TY Musehal S Pravda EA | 2009 | Blood2009，114，9： | 1 |
| 17 | Recent applications of electrogenerated chemiluminescence in chemical analysis显示文摘 | FAHNRICH K A PRAVDA M GUILBAUIT G G | 2001 | Talanta2001，54，： | 1 |
| 18 | Recent applications of electrogenerated chemiluminescence in chemical analysis显示文摘 | Karsten A Fahnrich Miloslav Pravda George G Guilbault | 2001 | Talanta2001，54，： | 1 |
| 19 | Biosensors -42 years and counting显示文摘 | Guilbanh GC Pravda M Kreuzer M | 2004 | Anal Lett2004，37，14： | 1 |
| 20 | Development of animmunosensor for the determination of allergy antibody (IgE) in blood samples显示文摘 | Kreuzer M P Sullivan C K Pravda M | 2001 | Anal Chim Acta2001，442，1： | 1 |
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