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| 1 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 2 | Improved outcomes from transradial over transfemoral access in primary percutaneous coronary intervention for patients with acute ST-segment elevation myocardial infarction and upstream use of tirofiban显示文摘 | ZHANG Qi QIU Jian-ping ZHANG Rui-yan HU Jian YANG Zhen-kun DING Feng-hua DU Run ZHU Tian-qi ZHANG Jian-sheng SHEN Wei-feng | 2013 | Chinese Medical Journal2013，，6： | 14 |
| 3 | Impact of angina prior to acute ST-elevation myocardial infarction on short-term outcomes after primary percutaneous coronary intervention: results from the Shanghai Registry of Acute Coronary Syndrome (SRACE)显示文摘 | ZHANG Qi ZHANG Rui-yan ZHU Tian-qi HU Jian YANG Zhen-kun DING Feng-hua DU Run ZHU Zheng-bin SHEN Wei-feng | 2012 | Chinese Medical Journal2012，，6： | 7 |
| 4 | Pre-operative radiochemotherapy of locally advanced rectal cancer显示文摘AIM: To evaluate results of pre-operative radiochemotherapy followed by surgery for 15 patients with locally advanced un-resectable rectal cancer.METHODS: 15 patients with advanced non-resectable rectal cancer were treated with pre-operative irriadiation of 40-46 Gy plus concomitant chemotherapy (5-FU+LV and 5′-DFuR) (RCS group). For comparison, 27 similar patients,treated by preoperative radiotherapy (40-50 Gy) plus surgery were served as control (RS group).RESULTS: No radiochemotherapy or radiotherapy was interrupted and then was delayed because of toxicities in both groups. The radical resectability rate was 73.3% in the RCS group and 37.0% (P=0.024) in RS group. Sphincter preservation rates were 26.6% and 3.7% respectively (P=0.028). Sphincter preservation rates of lower rectal cancer were 27.3 % and 0.0 % respectively (P=0.014). Response rates of RCS and RS groups were 46.7 % and 18.5 %(P=0.053). The tumor downstage rates were 8 (53.3%)and 9 (33.3%) in these groups (P=0.206). The 3-year overall survival rates were 66.7 % and 55.6% (P=0.485), and the disease free survival rates were 40.1% and 33.2%(P=0.663). The 3-year local recurrent rates were 26.7%and 48.1% (P=0.174). No obvious late effects were found in either groups.CONCLUSION: High resectability is possible following preoperative radiochemotherapy and can have more sphincters preserved. It is important to improve the quality of the patients′ life even without increasing the survival or local control rates. Preoperative radiotherapy with concomitant full course chemotherapy (5-Fu+LV and 5′-DFuR) is effective and safe. | Xiao-Nan Sun Qi-Chu Yang Jian-Bin Hu Department of Radiation Oncology,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,Zhejiang Province,China | 2003 | World Journal of Gastroenterology2003，9，4： | 6 |
| 5 | The genetics of tiger pelage color variations显示文摘 | Xiao XU Gui-Xin Dong Anne Schmidt-Kuntzel Xue-Li Zhang Yan Zhuang Run Fang Xin Sun Xue-Song Hu Tian-You Zhang Han-Dong Yang De-Lu Zhang Laurie Marker Zheng-Fan Jiang Ruiqiang Li Shu-Jin Luo | 2017 | Cell Research2017，27，7： | 5 |
| 6 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 7 | Relationship Between Coleoptile Length and Drought Resistance and Their QTL Mapping in Rice显示文摘By using a set of recombinant inbred line(RIL)population involving in 195 lines derived from a cross of Zhenshan 97B (lowland variety)and IRAT109(upland variety),the correlation analysis between coleoptile length(CL)and drought resistance index (DRI)and their QTL identification were conducted.There existed a significantly positive relationship between CL and DRI with the correlation coefficient of 0.2206**under water stress conditions.Under normal and water stress conditions,a total of eleven and four QTLs for CL and DRI,respectively,were detected on chromosomes 1,2,4,5,6,7,9,11 and 12 by using a linkage map including 213 SSR markers,which explained 4.84%to 22.65%of phenotypic variance.Chromosomes 1 and 9 possessing the QTLs for DRI harbored simultaneously QTLs for CL,and qCL9 shared the same chromosome location with qDRI9(RM160-RM215).Comparing the QTLs related to drought resistance in other studies,QTLs for CL and DRI were located in the same or adjacent marker interval as those related to root traits,such as number,dry weight,depth,and length of root.Moreover,sixteen and three pairs of epistatic loci for CL and DRI were found,which accounted for 56.17%and 11.93%of the total variation in CL and DRI,respectively. | HU Song-ping YANG Hua ZOU Gui-hua LIU Hong-yan LIU Guo-lan MEI Han-wei CAI Run LI Ming-shou LUO Li-jun | 2007 | Rice science2007，14，1： | 4 |
| 8 | Acute coronary syndrome is an independent risk factor for late incomplete stent apposition after sirolimus-eluting stent implantation显示文摘背景晚不完全的 stent 并置(ISA ) 可以发生在 drug-eluting stent 培植以后,影响长期的临床的结果。在有借助于三维的容量的 intravascular 超声(IVUS ) 的 sirolimus-eluting stents (SES ) 的经皮的冠的干预(一种总线标准) 分析以后,这研究试图在迟了的 ISA 上评估冠的动脉疾病的临床的演讲的影响。有冠的动脉疾病的 137 个病人在一种总线标准期间收到了 SES 培植并且与 IVUS 检查有重复 angiography 的方法。所有病人在过程以后在一年上面被跟随。在外套 219 的结果对待损害(137 个病人) ,迟了的 ISA 在 25 损害(16 个病人) 被识别。急性冠的症候群(交流) 和长 stents 的使用的临床的诊断在病人与是更普通的比在那些没有迟了的 ISA。有迟了的 ISA 的病人有更大的外部有弹性的膜( EEM )在 stented 片断的区域(( 15.34+5.44 )对(13.83=, -4.51 ) mm2 , P=0.026 ), stented-to-reference 片断 EEM 区域比率( 1.13he 瘤是穿正常白人衣服的 evaluated.With creatinine 山峰选择为内部的物质标准,细胞回复较原始状、不正常、良性的 meningiomas 的 lipid/creatinine 比率是 0.844 ?琠獥楴汣獥?湉猠浯?獡数瑣?猠'?獡瀠敲敳癲湩?慲'M瑩?栠慥瑲?爠瑡?椠瑮獥楴慮?畭潣慳愠摮瀠湡牣慥敳?琠敨攠晦'?景???潳畬楴湯眠獡猠灵牥潩?潴唠? | ZHANG Rui-yan DU Run ZHU Zheng-bin ZHANG Qi HU Jian LU An-kang ZHANG Jian-sheng SHEN Wei-feng | 2008 | Chinese Medical Journal2008，，24： | 4 |
| 9 | Establishment of a Sandwich ELISA Method for Detection of Vascular Endothelial Growth Factor in Serum Samples of Hepatocellular Carcinoma Patients显示文摘Objective To establish a sandwich ELISA method for detecting vascular endothelial growth factor (VEGF) in sera of population and the patients with hepatocellular carcinoma (HCC). Methods Full length and two truncated human VEGF cDNA sequences were amplified from a commercial plasmid pBLAST49-hVEGF by PCR and inserted into the prokaryotic-expression plasmid pET-32a or pGEX-2T. Various VEGF proteins were expressed and purified from E. coli in His-Trx or GST fusion forms. The specific VEGF antibodies were elicited in experimental rabbits and mice by immunization of the full length VEGF fusion protein His-Trx-VEGF1-165. After purification of antibodies with chromatograph of Protein G, a sandwich ELISA technique was established. Serum VEGF levels were evaluated in 229 adults and 291 HCC patients. Results SDS-PAGE displayed that the molecular weights of the expressed full length (His-Trx-VEGF1-165), N-terminal (His-Trx-VEGF1-100) and C-terminal (GST-VEGF100-165) human VEGF fusion proteins were about 38KD, 31KD, and 33KD, respectively. Western blots confirmed that the prepared antisera were able to recognize both prokaryoticly and eukaryoticly expressed recombinant VEGF proteins. Assays of serially diluted His-Trx-VEGF1-100 by the established sandwich ELISA method showed that the linear range of the standard curve was 0.625-320 ng/mL, with the squared correlation coefficient R2=0.991. Screening of a serum panel containing 291 serum samples of HCC patients and 229 health adults revealed that the average VEGF level in HCC patients was higher than that in healthy controls, with a statically significant difference. Conclusion The established sandwich ELISA reflects the level of serum VEGF and provide scientific basis for screening metastasis and recurrence of HCC using serum VEGF as an index. | BING SHAN CHEN GAO JIAN-MING CHEN XIN-Yu BI BAO-YUN ZHANG YAN GUO CHEN-FANG DONG RUN AN QI SHI JING-QUN HU PING ZHAO JUN HAN XIAO-PING DONG | 2008 | Biomedical and Environmental Sciences2008，21，1： | 4 |
| 10 | Black phosphorus-based van der Waals heterostructures for mid-infrared light-emission applications显示文摘Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR devices owing to their exotic optical properties,as well as the ultimate thickness limit.More importantly,van der Waals heterostructures-combining the best of various 2D materials at an artificial atomic level-provide many new possibilities for constructing MIR light-emitting devices of large tuneability and high integration.Here,we introduce a simple but novel van der Waals heterostructure for MIR light-emission applications built from thin-film BP and transition metal dichalcogenides(TMDCs),in which BP acts as an MIR light-emission layer.For BP–WSe_(2) heterostructures,an enhancement of~200% in the photoluminescence intensities in the MIR region is observed,demonstrating highly efficient energy transfer in this heterostructure with type-Ⅰ band alignment.For BP-MoS_(2) heterostructures,a room temperature MIR light-emitting diode(LED)is enabled through the formation of a vertical PN heterojunction at the interface.Our work reveals that the BP-TMDC heterostructure with efficient light emission in the MIR range,either optically or electrically activated,provides a promising platform for infrared light property studies and applications. | Xinrong Zong Huamin Hu Gang Ouyang Jingwei Wang Run Shi Le Zhang Qingsheng Zeng Chao Zhu Shouheng Chen Chun Cheng Bing Wang Han Zhang Zheng Liu Wei Huang Taihong Wang Lin Wang Xiaolong Chen | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 11 | Elevated-temperature tribological behavior of Ti–B–C–N coatings deposited by reactive magnetron sputtering显示文摘Quaternary Ti-B-C-N coatings with various carbon contents were deposited on high-speed steel(HSS)substrates by reactive magnetron sputtering(RMS) system.The elevated-temperature tribological behavior of Ti-BC-N coatings was explored using pin-on-disk tribometer,scanning electron microscopy(SEM),and energy-dispersive X-ray spectroscopy(EDX).The present results show that the steady-state friction coefficient value and the instantaneous friction coefficient fluctuation range of TiB-C-N coatings decrease as carbon content increases at100 and 300 ℃,while the steady-state friction coefficient value of all Ti-B-C-N coatings becomes higher than 0.4 at500 ℃.As ambient temperature increases,the running-in periods of all Ti-B-C-N coatings become shorter.Wear damage to Ti-B-C-N coatings during sliding at elevated temperature is mainly caused by adhesive wear,and adhesive-wear damage to Ti-B-C-N coatings increases as ambient temperature increases;however,higher carbon content is beneficial for decreasing the adhesive-wear damage to Ti-B-C-N coatings during sliding at elevated temperature. | Xiang-Yang Chen Shao-Fu Huang Sheng-Li Ma Run Huang Jin Zhang Hai-Xia Hu | 2015 | Rare Metals2015，34，12： | 2 |
| 12 | Meiotic nuclear divisions 1(MND1)fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma显示文摘Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of LUAD.Methods:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively acquired.Cell viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor growth.Aseries of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying mechanism.Results:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data analysis.In vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell cycle.The results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional repression.Luciferase reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback manner.Conclusions:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD.MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients. | Quanli Zhang Run Shi Yongkang Bai Lijuan Meng Jingwen Hu Hongyu Zhu Tongyan Liu Xiaomeng De Siwei Wang Jie Wang Lin Xu Guoren Zhou Rong Yin | 2021 | Cancer Communications2021，41，6： | 2 |
| 13 | Warhead power assessment based on double hierarchy hesitant fuzzy linguistic term sets theory and gained and lost dominance score method显示文摘Warhead power assessment of the anti-ship missile plays a vital role in determining the optimal design of missile, thus having important strategic research significance. However, in the assessment process, expert’s judgement will directly affect the assessment accuracy. In addition,there are many criteria involved in the missile design alternatives. Some criteria with poor performance may be compensated by other criteria with excellent performance, and then it is impossible to find the truly optimal alternative. Aimed at solving these problems, this paper proposes a synthetical assessment process based on fuzzy hesitant linguistic term set and the Gained and Lost Dominance Score(GLDS) method. In order to improve the assessment accuracy of experts and solve the problem that experts generate different opinions, combined with the advantages of fuzzy hesitant sets and linguistic term sets, the double hierarchy hesitant fuzzy linguistic term sets are used in this paper to improve the accuracy of expert’s judgement. In order to effectively combine expert’s experience with the data of criteria, the evidence theory and entropy weight method are used to transfer the expert’s judgement to the weight. In order to avoid selecting defective alternative of missile design, the GLDS is used to fuse expert information and criteria information. Sensitivity analysis shows that the assessment process has sensitivity to some extent. However, when the fluctuation of expert’s assessment makes the fluctuation of θ in the range of-5% to 5%, the impact on the results is not quite conspicuous. The analysis of calculation result and comparative analysis show that the assessment process proposed in this paper is accurate enough, has great advantage in selecting the current and potential optimal alternative of missile design, and avoids the alternatives with low criteria performance that cannot be compensated by other criteria being selected. | Tianle YAO Weili WANG Run MIAO Qiwei HU Jun DONG Xuefei YAN | 2022 | Chinese Journal of Aeronautics2022，35，4： | 2 |
| 14 | Kinetic Characteristics of Neutralizing Antibody Responses Vary among Patients with COVID-19显示文摘Objective The coronavirus disease 2019(COVID-19) pandemic continues to present a major challenge to public health. Vaccine development requires an understanding of the kinetics of neutralizing antibody(NAb) responses to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods In total, 605 serum samples from 125 COVID-19 patients(from January 1 to March 14, 2020)varying in age, sex, severity of symptoms, and presence of underlying diseases were collected, and antibody titers were measured using a micro-neutralization assay with wild-type SARS-CoV-2.Results NAbs were detectable approximately 10 days post-onset(dpo) of symptoms and peaked at approximately 20 dpo. The NAb levels were slightly higher in young males and severe cases, while no significant difference was observed for the other classifications. In follow-up cases, the NAb titer had increased or stabilized in 18 cases, whereas it had decreased in 26 cases, and in one case NAbs were undetectable at the end of our observation. Although a decreasing trend in NAb titer was observed in many cases, the NAb level was generally still protective.Conclusion We demonstrated that NAb levels vary among all categories of COVID-19 patients. Longterm studies are needed to determine the longevity and protective efficiency of NAbs induced by SARS-CoV-2. | LI Ling Hua TU Hong Wei LIANG Dan WEN Chun Yan LI An An LIN Wei Yin HU Ke Qi HONG Wen Shan LI Yue Ping SU Juan ZHAO San Tao LI Wei YUAN Run Yu ZHOU Ping Ping HU Feng Yu TANG Xiao Ping KE Chang Wen KE Bi Xia CAI Wei Ping | 2021 | Biomedical and Environmental Sciences2021，34，12： | 1 |
| 15 | Structure transition comparison between the amorphous nanosize particles and coarse - grained polycrystailine of cobalt显示文摘 | Changsheng Xie Junhui Hu Run Wu | | 0，，： | 1 |
| 16 | Accumulation of freshwater in the permanent ice zone of the Canada Basin during summer 2008显示文摘A combination of δ^(18)O and salinity data was employed to explore the freshwater balance in the Canada Basin in summer 2008.The Arctic river water and Pacific river water were quantitatively distinguished by using different saline end-members.The fractions of total river water,including the Arctic and Pacific river water,were high in the upper 50 m and decreased with depth as well as increasing latitude.In contrast,the fraction of Pacific river water increased gradually with depth but decreased toward north.The inventory of total river water in the Canada Basin was higher than other arctic seas,indicating that Canada Basin was a main storage region for river water in the Arctic Ocean.The fraction of Arctic river water was higher than Pacific river water in the upper 50 m while the opposite was true below 50 m.As a result,the inventories of Pacific river water were higher than those of Arctic river water,demonstrating that the Pacific inflow through the Bering Strait is the main source of freshwater in the Canada Basin.Both the river water and sea-ice melted water in the permanent ice zone were more abundant than those in the region with sea-ice just melted.The fractions of total river water,Arctic river water,Pacific river water increased northward to the north of 82°N,indicating an additional source of river water in the permanent ice zone of the northern Canada Basin.A possible reason for the extra river water in the permanent ice zone is the lateral advection of shelf waters by the Trans-Polar Drift.The penetration depth of sea-ice melted waters was less than 30 m in the southern Canada Basin,while it extended to 125 m in the northern Canada Basin.The inventory of seaice melted water suggested that sea-ice melted waters were also accumulated in the permanent ice zone,attributing to the trap of earlier melted waters in the permanent ice zone via the Beaufort Gyre. | TONG Jinlu CHEN Min1 YANG Weifeng ZHANG Run PAN Hong ZHENG Minfang QIU Yusheng HU Wangjiang ZENG Jian | 2017 | Acta Oceanologica Sinica2017，36，8： | 1 |
| 17 | The Brachypodium distachyon BdWRKY36 gene confers tolerance to drought stress in transgenic tobacco plants显示文摘 | Jiutong Sun Wei Hu Run Zhou Lianzhe Wang Xiatian Wang Qiong Wang Zhijuan Feng Yaping Li Ding Qiu Guangyuan He Guangxiao Yang | 2015 | Plant Cell Reports2015，，1： | 1 |
| 18 | Failure Modes and Effects Analysis on ITER DFLL-TBM system显示文摘 | Liqin Hu Run Yuan Hongli Chen Yunqing Bai | 2012 | Fusion Engineering and Design (-)2012，，78： | 1 |
| 19 | Near-/mid-field effect of color mixing for single phosphor-converted light-emitting diode package 显示文摘 | HU Run YU Shan ZOU Yong ZHENG Hai WANG Fei LIU Sheng LUO Xiao-bing | 2013 | IEEE Photonics Technology Letters2013，25，3： | 1 |
| 20 | Laser-melted surface layer of steel X165CrMoV12-1 and its tempering characteristics显示文摘 | Chang-sheng Xie Mulin Hu | 2000 | Materials Science and Engineering2000，278，： | 1 |
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