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| 1 | Improved outcomes from transradial over transfemoral access in primary percutaneous coronary intervention for patients with acute ST-segment elevation myocardial infarction and upstream use of tirofiban显示文摘 | ZHANG Qi QIU Jian-ping ZHANG Rui-yan HU Jian YANG Zhen-kun DING Feng-hua DU Run ZHU Tian-qi ZHANG Jian-sheng SHEN Wei-feng | 2013 | Chinese Medical Journal2013，，6： | 14 |
| 2 | Electropharmacological properties of telmisartan in blocking hKvl.5 and HERG potassium channels expressed on Xenopus laevis oocytes^1显示文摘瞄准:这研究的目的是调查 telmisartan 的禁止的行动,一种选择血管收缩素 II 类型 1 个受体对手,在 hKv1.5 和人的 ether-a-go-go-related 上,基因(HERG ) 隧道在 Xenopus laevis 卵母细胞上表示了。方法:hKv1.5 和 HERG 隧道在 Xenopus laevis 卵母细胞上被表示并且用 2-microelectrode 电压学习了夹钳技术。结果:在 hKv1.5 隧道, telmisartan 生产了电压依赖者和集中依赖者抑制;封锁的功效在山峰和 1.5 s 结束脉搏电流是不同的,它是 7.75%± 2 .39%( 一半最大的抑制集中[IC 50]=2.25 ± 0.97 μmol/L ) 并且在 1 μmol/L telmisartan 的 52.64%± 3 .77%(IC 50=0.82 ± 0.39 μmol/L ) 分别地。同时, telmisartan 加速了在里面隧道的激活。然而, telmisartan 为 HERG 隧道(IC 50=24.35 ± 5.06 μmol/L ) 展出了一种低亲密关系;封锁是电压依赖者和集中依赖者。Telmisartan 优先地堵住了开状态的 HERG 隧道。释放的慢时间常数被加速(n=6, P<0.05 ) ,它与“ foot-in-the-door ”不一致效果。结论:Telmisartan 堵住在治疗学的剂量的血浆集中层次包含开、使 \O 失去活性的状态的 hKv1.5 钾隧道;而 HERG 隧道的封锁仅仅在在上发生,血浆集中在开、靠近状态的隧道治疗学的剂量并且优先地铺平。 | Dan-na TU Yu-hua LIAO An-ruo ZOU Yi-mei DU Qi RUN Xian-pei WANG Lu LI | 2008 | Acta Pharmacologica Sinica2008，29，8： | 10 |
| 3 | Impact of angina prior to acute ST-elevation myocardial infarction on short-term outcomes after primary percutaneous coronary intervention: results from the Shanghai Registry of Acute Coronary Syndrome (SRACE)显示文摘 | ZHANG Qi ZHANG Rui-yan ZHU Tian-qi HU Jian YANG Zhen-kun DING Feng-hua DU Run ZHU Zheng-bin SHEN Wei-feng | 2012 | Chinese Medical Journal2012，，6： | 7 |
| 4 | Acute coronary syndrome is an independent risk factor for late incomplete stent apposition after sirolimus-eluting stent implantation显示文摘背景晚不完全的 stent 并置(ISA ) 可以发生在 drug-eluting stent 培植以后,影响长期的临床的结果。在有借助于三维的容量的 intravascular 超声(IVUS ) 的 sirolimus-eluting stents (SES ) 的经皮的冠的干预(一种总线标准) 分析以后,这研究试图在迟了的 ISA 上评估冠的动脉疾病的临床的演讲的影响。有冠的动脉疾病的 137 个病人在一种总线标准期间收到了 SES 培植并且与 IVUS 检查有重复 angiography 的方法。所有病人在过程以后在一年上面被跟随。在外套 219 的结果对待损害(137 个病人) ,迟了的 ISA 在 25 损害(16 个病人) 被识别。急性冠的症候群(交流) 和长 stents 的使用的临床的诊断在病人与是更普通的比在那些没有迟了的 ISA。有迟了的 ISA 的病人有更大的外部有弹性的膜( EEM )在 stented 片断的区域(( 15.34+5.44 )对(13.83=, -4.51 ) mm2 , P=0.026 ), stented-to-reference 片断 EEM 区域比率( 1.13he 瘤是穿正常白人衣服的 evaluated.With creatinine 山峰选择为内部的物质标准,细胞回复较原始状、不正常、良性的 meningiomas 的 lipid/creatinine 比率是 0.844 ?琠獥楴汣獥?湉猠浯?獡数瑣?猠'?獡瀠敲敳癲湩?慲'M瑩?栠慥瑲?爠瑡?椠瑮獥楴慮?畭潣慳愠摮瀠湡牣慥敳?琠敨攠晦'?景???潳畬楴湯眠獡猠灵牥潩?潴唠? | ZHANG Rui-yan DU Run ZHU Zheng-bin ZHANG Qi HU Jian LU An-kang ZHANG Jian-sheng SHEN Wei-feng | 2008 | Chinese Medical Journal2008，，24： | 4 |
| 5 | Microneedle-array patch with pH-sensitive formulation for glucoseresponsive insulin delivery显示文摘Glucose-responsive insulin delivery systems show great promise to improve therapeutic outcomes and quality of life for people with diabetes.Herein,a new microneedle-array patch containing pH-sensitive insulin-loaded nanoparticles(NPs)(SNP(I))together with glucose oxidase(GOx)-and catalase(CAT)-loaded pH-insensitive NPs(iSNP(G+C))is constructed for transcutaneous glucose-responsive insulin delivery.SNP(I)are prepared via double emulsion from a pH-sensitive amphiphilic block copolymer,and undergo rapid dissociation to promote insulin release at a mild acidic environment induced by GOx in iSNP(G+C)under hyperglycemic conditions.CAT in iSNP(G+C)can further consume excess H_(2)O_(2) generated during GOx oxidation,and thus reduce the risk of inflammation toward the normal skin.The in vivo study on type 1 diabetic mice demonstrates that the platform can effectively regulate blood glucose levels within normal ranges for a prolonged period. | Feng-Qin Luo Guojun Chen Wei Xu Daojia Zhou Jia-Xian Li Yong-Cong Huang Run Lin Zhen Gu Jin-Zhi Du | 2021 | Nano Research2021，14，8： | 4 |
| 6 | p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular smooth muscle cells显示文摘冠的动脉粥样硬化是长期的肾疾病的主要复杂并发症。这个条件在分离病人贡献增加的死亡。p-Cresyl 硫酸盐(PCS ) 是蛋白质界限的一个原型不能高效地通过平淡的分离过程被移开的尿毒症的毒素。在现在的学习,也就是,经历了 5/6 肾切除术的 ApoE -/- 老鼠随机被划分成二个组对待车辆的组(n = 20 ) 并且对待 PCS 的组(n = 20 ) 。老鼠被牺牲为在在高脂肪的饮食的 8 或 24 个星期以后的脸和 immunohistological 分析。老鼠大动脉的脉管的光滑的肌肉房间(VSMC ) 与的磷酸盐缓冲区答案或 500 mol/L PCS 被对待在 vitro 评估。对待 PCS 的老鼠被观察在八星期 PCS 管理以后承受增加的动脉粥样硬化患者损害。而且, 24 星期 PCS 管理显著地也增加了大动脉的匾的危险索引。PCS 也被观察在疾病的前进期间便于 VSMC 的迁居和增长。而且, PCS 在匾以内扰乱了在矩阵 metalloproteinases 和 metalloproteinases 的织物禁止者之间的平衡。因此, PCS 在支持 atherogenesis 并且由指向 VSMC 可能扰乱形成的匾的稳定性起了一个重要作用。 | Hui Han Yanjia Chen Zhengbin Zhu Xiuxiu Su Jingwei Ni Run Du Ruiyan Zhang Wei Jin | 2016 | Frontiers of Medicine2016，10，3： | 3 |
| 7 | Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging显示文摘Mesial temporal lobe epilepsy(mTLE),the most common type of focal epilepsy,is associated with functional and structural brain alterations.Machine learning(ML)techniques have been successfully used in discriminating mTLE from healthy controls.However,either functional or structural neuroimaging data are mostly used separately as input,and the opportunity to combine both has not been exploited yet.We conducted a multimodal ML study based on functional and structural neuroimaging measures.We enrolled 37 patients with left mTLE,37 patients with right mTLE,and 74 healthy controls and trained a support vector ML model to distinguish them by using each measure and the combinations of the measures.For each single measure,we obtained a mean accuracy of 74%and 69%for discriminating left mTLE and right mTLE from controls,respectively,and 64%when all patients were combined.We achieved an accuracy of 78%by integrating functional data and 79%by integrating structural data for left mTLE,and the highest accuracy of 84%was obtained when all functional and structural measures were combined.These findings suggest that combining multimodal measures within a single model is a promising direction for improving the classification of individual patients with mTLE. | Baiwan Zhou Dongmei An Fenglai Xiao Running Niu Wenbin Li Wei Li Xin Tong Graham J Kemp Dong Zhou Qiyong Gong Du Lei | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 8 | SARS Patients-derived Human Recombinant Antibodies to S and M Proteins Efficiently Neutralize SARS-Coronavirus Infectivity显示文摘Objective To develop a specific SARS virus-targeted antibody preparation for emergent prophylaxis and treatment of SARS virus infection. Methods By using phage display technology, we constructed a naive antibody library from convalescent SARS patient lymphocytes. To obtain the neutralizing antibody to SARS virus surface proteins, the library panning procedure was performed on purified SARS virions and the specific Fab antibody clones were enriched by four rounds of repeated panning procedure and screened by highthroughput selection. The selected Fab antibodies expressed in the periplasma of E. Coli were soluble and further purified and tested for their binding properties and antiviral function to SARS virus. The functional Fab antibodies were converted to full human IgG antibodies with recombinant baculovirus/insect cell systems and their neutralizing activities were further determined. Results After four rounds of the panning, a number of SARS-CoV virus-targeted human recombinant Fab antibodies were isolated from the SARS patient antibody library. Most of these were identified to recognize both natural and recombinant SARS spike (S) proteins, two Fab antibodies were specific for the virus membrane (M) protein, only one bound to SARS-CoV nucleocapsid protein. The SARS-CoV S and M protein-targeted Fab or IgG antibodies showed significant neutralizing activities in cytopathic effect (CPE) inhibition neutralization test, these antibodies were able to completely neutralize the SARS virus and protect the Vero cells from CPE after virus infection. However, the N protein-targeted Fab or IgG antibodies failed to neutralize the virus. In addition, the SARS N protein-targeted human Fab antibody reacted with the denatured N proteins, whereas none of the S and M protein specific neutralizing antibodies did. These results suggested that the S and M protein-specific neutralizing antibodies could recognize conformational epitopes which might be involved in the binding of virions to cellular receptors and the fusion activity of the virus.Conclusion The SARS-CoV spike protein and membrane proteins are able to elicite efficient neutralizing antibodies in SARS patients. The neutralizing antibodies we generated in this study may be more promising candidates for prophylaxis and treatment of SARS infection. | MI-FANG LIANG RUN -LEI DU JING-ZHI LIU CHUAN LI QUAN-FU ZHANG LU-LU HAN JIAN-SHI YU SHU-MIN DUAN XIAO-FANG WANG KONG-XING WU ZHAO-HUI XION QI JIN DE-XIN LI | 2005 | Biomedical and Environmental Sciences2005，18，6： | 1 |
| 9 | Increased serum vWF and sVCAM-1 levels are associated with late or very late angiographic stent thrombosis after sirolimus-eluting stent implantation显示文摘 | Cao Jin Lin Lu Zheng Bin Zhu Rui Yan Zhang Qi Zhang Run Du Feng Hua Ding Qiu Jing Chen Wei Feng Shen | 2010 | Coronary Artery Disease2010，，5： | 1 |
| 10 | Nitric oxide-mediated immunosuppressive effect of Human amniotic membrane-derived mesenchymal stem cells on the viability and migration of microglia显示文摘 | Ke Yan Run Zhang Lei Chen Fanfan Chen Yi Liu Lingmei Peng Haitao Sun Weiyi Huang Chengmei Sun Bingke Lv Feng Li Yingqian Cai Yanping Tang Yuxi Zou Mouxuan Du Lingsha Qin Hengzhu Zhang Xiaodan Jiang | 2014 | Brain Research2014，，： | 1 |
| 11 | Progress and Prospect of Photothermal Catalysis显示文摘Recently,solar-driven synthesis due to its energy-saving and environmentally friendly advantages has attracted more and more attention,whereas the low solar-to-chemical conversion efficiency significantly hindered its development.New effective options that fully utilize full-band sunlight are urgently needed.Novel photothermal catalysis combined with the advantages of photocatalysis and thermalcatalysis can improve the utilization efficiency of solar energy and lower the reaction temperature,thus becoming a promising technology.This review divides photothermal catalysis into photo-assisted thermalcatalysis,thermal-assisted photocatalysis,and photothermal synergistic catalysis.Furthermore,the catalytic mechanical understanding of how photothermal affects the catalytic property of different applications(e.g.,water splitting,CO_(2)/N_(2) reduction,and environmental treatment)was also summed up and discussed in detail.The discussion ends with unsolved challenges in photothermal catalysis,particularly emphasizing the effect of temperature or sunlight on catalytic performance. | DU Shihao BIAN Xuanang ZHAO Yunxuan SHI Run ZHANG Tierui | 2022 | Chemical Research in Chinese Universities2022，38，3： | 1 |
| 12 | An injectable self-adaptive polymer as a drug carrier for the treatment of nontraumatic early-stage osteonecrosis of the femoral head显示文摘Core decompression(CD)with the elimination of osteonecrotic bone is the most common strategy for treating early-stage nontraumatic osteonecrosis of the femoral head(ONFH).Adjuvant treatments are widely used in combination with CD as suitable methods of therapy.Existing augmentations have to be fabricated in advance.Here,we report a novel injectable glycerin-modified polycaprolactone(GPCL)that can adapt to the shape of the CD cavity.GPCL shows great flowability at 52.6℃.After solidification,its compressive modulus was 120 kPa at body temperature(37℃).This excellent characteristic enables the polymer to provide mechanical support in vivo.In addition,GPCL acts as a carrier of the therapeutic agent zoledronic acid(ZA),demonstrating sustained release into the CD region.ZA-loaded GPCL was injected into ONFH lesions to treat early-stage nontraumatic cases.Compared to that in the CD group,CD+ZA-loaded GPCL injection preserved bone density and increased the collagen level in the femoral head.At the interface between the GPCL and CD tunnel wall,osteogenesis was significantly promoted.In addition,morphological evaluations revealed that the femoral heads in the CD+ZA-GPCL group exhibited improved pressure resistance.These results suggest a strategy effective to preserve the bone density of the femoral head,thus decreasing the possibility of femoral head collapse.This novel injectable polymer has,therefore,considerable potential in clinical applications. | Ning Kong Hang Yang Run Tian Guanzhi Liu Yiyang Li Huanshuai Guan Qilu Wei Xueshan Du Yutian Lei Zhe Li Ruomu Cao Yiwei Zhao Xiaohui Wang Kunzheng Wang Pei Yang | 2022 | Bone Research2022，10，3： | 1 |
| 13 | Study of micro-trichome (mict) reveals novel connections between transcriptional regulation of multicellular trichome development and specific metabolism in cucumber显示文摘Trichomes that cover the epidermis of aerial plant organs play multiple roles in plant protection.Compared with a unicellular trichome in model plants,the development mechanism of the multicellular trichome is largely unclear.Notably,variations in trichome development are often accompanied by defects in the biosynthesis of cuticle and secondary metabolites;however,major questions about the interactions between developmental differences in trichomes and defects in metabolic pathways remain unanswered.Here,we characterized the glabrous mutant mict/csgl1/cstbh via combined metabolomic and transcriptomic analyses to extend our limited knowledge regarding multicellular trichome development and metabolism in cucumber.Mict was found to be explicitly expressed within trichome cells.Transcriptomic analysis indicated that genes involved in flavonoid and cuticle metabolism are significantly downregulated in mict mutants.Further metabolomic analysis confirmed that flavonoids,lipids,and cuticle compositions are dramatically altered in mict mutants.Additional studies revealed that Mict regulates flavonoid,lipid,and cuticle biosynthesis by likely directly binding to downstream functional genes,such as CsTT4,CsFLS1,CsCER26,and CsMYB36.These findings suggest that specific metabolic pathways(e.g.,flavonoids and cuticle components)are co-regulated by Mict and provide insights into transcriptional regulation mechanisms of multicellular trichome development and its specific metabolism in cucumber. | Jian Pan Leyu Zhang Guanqun Chen Haifan Wen Yue Chen Hui Du Junlong Zhao Huanle He Hongli Lian Huiming Chen Jianxin Shi Run Cai Gang Wang Junsong Pan | 2021 | Horticulture Research2021，8，1： | 1 |
| 14 | Multi-class SVM promotion per- formance analysis 显示文摘 | Run Zhigang Du Peijun | 2009 | Data Acquisition and Processing2009，24，4： | 1 |
| 15 | Efficient Transposition of the Retrotransposon Tnt1 in Cucumber(Cucumis sativus L.)显示文摘Tnt1 is an active retrotransposon originally identified in tobacco(Nicotiana tabacum L.)(Grandbastien et al.,1989),but its transposition activity could be activated through tissue culture in other plant species.The insertions are stable and inheritable in the progeny,which has made it a valuable and versatile tool for developing insertional mutagenesis libraries in several plant species.Here,we explored its utility for mutagenesis in cucumber(Cucumis sativus L.).T_3 Tnt1 transgenic cucumber plants were subjected to tissue culture to regenerate self-pollinated progeny.With PCR and analyses and Southern hybridization,we found regenerated plants maintained the original Tnt1 insertion and created new insertions suggesting characteristic re-transposition activity of Tnt1 during this process.Using genome walking,some flanking sequences of Tnt1 insertions were recovered in regenerated plants.The results demonstrated that Tnt1 could be stably inherited and re-transposable during tissue culture in cucumber and that it is feasible to use for developing an insertional mutagenesis library for cucumber. | ZHANG Qi DU Hui LV Duo XIAO Tingting PAN Jian HE Huanle WANG Gang CAI Run WENG Yiqun PAN Junsong | 2018 | Horticultural Plant Journal2018，4，3： | 0 |
| 16 | Adsorption of emerging sodium p-perfluorous nonenoxybenzene sulfonate(OBS) onto soils: Kinetics, isotherms and mechanisms显示文摘The widespread use of sodium p-perfluorous nonenoxybenzene sulfonate(OBS), a typical alternative to perfluorooctane sulfonate, has resulted in potential threats to the environment, but the adsorption behavior of OBS in soils has not yet been reported. In this study, the adsorption behaviors of OBS on five soils with different physicochemical properties were investigated. The rate of OBS adsorption was fast, and most of the OBS uptake was completed within 12 h. The good model fit of OBS adsorption to the pseudo-second-order and Elovich models indicated the occurrence of chemical adsorption. The adsorption isotherms of OBS on the soils were better described by the Freundlich model than by the Langmuir model, suggesting that the OBS adsorption sites on the soils were heterogeneous. This is possibly associated with various adsorption mechanisms including hydrophobic, π-π, hydrogen bonding, and electrostatic interactions,further confirmed by the good model fit to the D-R isotherm. Adsorption of OBS occurred on the soils, and the adsorption process was spontaneous and endothermic. In addition, the soils were more suitable for OBS adsorption at lower pH values due to the stronger electrostatic adsorption. The OBS adsorption on the soils decreased with the increase of soil depth from 0 to 30 cm. Moreover, the presence of organic matter and ammonia nitrogen in the soils was favorable for OBS adsorption, and these parameters decreased with increasing soil depth, making OBS adsorption less prominent in the deeper soil. This study indicates that OBS is easily enriched in surface soils, and that soil organic matter and ammonia nitrogen significantly affect OBS migration in soil. | Wei WANG Xue ZHANG Yuhui ZHANG Xin MI Run WANG Huilan SHI Chunli LI Ziwen DU Youming QIAO | 2021 | Pedosphere2021，31，4： | 0 |
| 17 | Triple antiplatelet therapy for clopidogrel resistance with stent malapposition: a case report显示文摘 | DING Feng-hua ZHANG Qi ZHANG Rui-yan HU Jian SHEN Jie ZHAO Liang-ping DU Run ZHANG Xian SHEN Wei-feng | 2009 | Chinese Medical Journal2009，，18： | 0 |
| 18 | Sparse flight spotlight mode 3-D imaging of spaceborne SAR based on sparse spectrum and principal component analysis显示文摘The spaceborne synthetic aperture radar(SAR)sparse flight 3-D imaging technology through multiple observations of the cross-track direction is designed to form the cross-track equivalent aperture,and achieve the third dimensionality recognition.In this paper,combined with the actual triple star orbits,a sparse flight spaceborne SAR 3-D imaging method based on the sparse spectrum of interferometry and the principal component analysis(PCA)is presented.Firstly,interferometric processing is utilized to reach an effective sparse representation of radar images in the frequency domain.Secondly,as a method with simple principle and fast calculation,the PCA is introduced to extract the main features of the image spectrum according to its principal characteristics.Finally,the 3-D image can be obtained by inverse transformation of the reconstructed spectrum by the PCA.The simulation results of 4.84 km equivalent cross-track aperture and corresponding 1.78 m cross-track resolution verify the effective suppression of this method on high-frequency sidelobe noise introduced by sparse flight with a sparsity of 49%and random noise introduced by the receiver.Meanwhile,due to the influence of orbit distribution of the actual triple star orbits,the simulation results of the sparse flight with the 7-bit Barker code orbits are given as a comparison and reference to illuminate the significance of orbit distribution for this reconstruction results.This method has prospects for sparse flight 3-D imaging in high latitude areas for its short revisit period. | ZHOU Kai LI Daojing CUI Anjing HAN Dong TIAN He YU Haifeng DU Jianbo LIU Lei ZHU Yu ZHANG Running | 2021 | Journal of Systems Engineering and Electronics2021，32，5： | 0 |
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