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| 1 | Preface显示文摘This special issue of Acta Mathematica Scientia is dedicated to the celebration of the 70th birthday of Constantine M. Dafermos. Costas is the Alumni-Alumnae University Professor of Brown University, a Fellow of the American Academy of Arts and Sciences, | Chen, Gui-Qiang G. Hsiao, Ling Huang, Feimin Tzavaras, Athanasios Wang, Zhen | 2012 | Acta Mathematica Scientia2012，32，1： | 72 |
| 2 | Tetramethylpyrazine suppresses HIF-1α,TNF-α,and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats显示文摘瞄准:检验详细机制位于禁止的效果 oftetramethylpyrazine (TMPZ ) 下面在煽动性并且 apoptotic 回答在 rats.Methods 由中间的服的 arteryocclusion (MCAO ) 导致了:在老鼠的导致 MCAO 的焦点的服的局部缺血在 thisstudy.The 被使用组织缺氧可诱导的 factor-1alpha (HIF-1alpha ) , caspase-3 的激活,和在 ischemic 区域的 TNF-alpha mRNAtranscription 被 immunoblotting andRT-PCR 检测, respectively.Anti 氧化的活动用 thiobarbituric acid-reactivesubstance (TBARS ) 被调查老鼠大脑 homogenate preparations.Results 的测试:我们显示出溶剂的梗塞区域的 statisticalresults --并且 TMPZ ( 20 mg/kg )在在在有 TMPZ ( 20 mg/kg )的 rats.Treatment 的 导致MCAO 的焦点的服的局部缺血的正面的杆显著地减少了的各种各样的 distancesfrom 对待组在所有区域的梗塞区域,在特别,第三显著地与 ischemic regions.These expressionswere 的 caspase-3 ,以及 TNF-alpha 抄写的 HIF-1alpha 和 theactivation 的增加被联系到 导致fifthsections.MCAO 的焦点的服的局部缺血我 neuroprotective effectof TMPZ 可以至少被 EOF-1alpha 和 TNF-alphaactivations 的抑制的部分调停,由 apoptosis 形成(活跃 caspase-3 )的抑制列在后面,在 ischemia-reperfusion 大脑 injury.Thus 在梗塞体积导致 areduction , TMPZ 处理 mayrepresent 在 ischemia-reperfusionbrain 降低风险或改善功能的一条理想的途径损害相关的混乱。 | Yi CHANG George HSIAO Seu-hwa CHEN Yi-cheng CHEN Jiing-han LIN Kuang-hung LIN Duen-suey CHOU Joen-rong SHEU | 2007 | Acta Pharmacologica Sinica2007，28，3： | 30 |
| 3 | 确立RBRVS为目的的医生劳动的估算显示文摘本文研制出按资源投入为基准的相对价值费用率(RBRVS),藉以替代基于医生服务收费的支付制度。医生资源投入包括:1.每项服务中医生的劳动投入总量;2.医疗成本(含治疗失当保险费);3.专科训练成本。综合这三种因素,制定出非货币单位的相对价值费用率。在此,我们对定义、估算医生劳动的过程进行了描述。本项研究提出两个问题:何为每项服务中的医生劳动?能否可靠、有效地对医生劳动进行估算?结论是:医生劳动包含四个部分,即时间、脑力劳动和判断、专业技能和体力劳动、以及心理压力。通过对四个部分加以全面考虑,医生在其专科范围内可直接估算其服务的相对劳动量,而且此种估算值具有高度的再现性、一致性,并因此可能具备有效性。 | Hsiao WC 施荣根 | 1992 | 国外医学(卫生经济分册)1992，9，2： | 16 |
| 4 | Efficacy and safety of transnasal butorphanol for pain relief after anal surgery显示文摘AIM:To compare the analgesic properties and efficacy of transnasal butorphanol with intramuscular meperidine after anal surgery.METHODS: Sixty patients who underwent fistulectomy were enrolled in the study from January 2006 to December 2007. They were randomly divided into transnasal butorphanol (n=30) or intramuscular meperidine (n=30) treatment groups. Assessment of postoperative pain was made using a visual analogue scale (VAS). The VAS score was recorded 6 h after the completion of surgery, before receiving the first dose of analgesic, 60 min after analgesia and the next morning. Any adverse clinical effects such as somnolence, dizziness, nausea or vomiting were recorded. Satisfaction with narcotic efficacy, desire to use the particular analgesic in the future and any complaints were recorded by patients using questionnaires before being discharged.RESULTS: Forty-two men and eighteen women were included in the study. There were no significant differences in VAS scores between the groups within 24 h. Length of hospital stay and the incidence of adverse effects between the groups were similar. In addition, most patients were satisfied with butorphanol nasal spray and wished to receive this analgesic in the future, if needed.CONCLUSION: Butorphanol nasal spray is effective for the relief of pain after fistulectomy. However, it offered patients more convenient usage and would be suitable for outpatients. | Chen-Ming Mai Liang-Tsai Wan Yu-Ching Chou Hsiang-Yu Yang Chang-Chieh Wu Shu-Wen Jao Cheng-Wen Hsiao | 2009 | World Journal of Gastroenterology2009，15，38： | 13 |
| 5 | 多方共赢的政策设计案例:宁夏盐池县县级医院包干制显示文摘2009年以来,我国多个地区都开展了各具特色的卫生改革尝试。总结这些改革的经验对于深化我国医药卫生体制有着积极意义。文章以宁夏回族自治区盐池县县级医院支付制度改革为核心,系统阐述了这次改革的政策安排并对政策效果进行了初步的评价。通过剖析这些安排对医疗服务提供者的激励作用,着重分析了这次改革如何实现'医、患、保多方共赢'的政策目标。 | 简伟研 Winnie Yip William Hsiao 陈文 胡敏 | 2014 | 中国卫生经济2014，33，11： | 11 |
| 6 | THREE-DIMENSIONAL NUMERICAL SIMULATION OF INTAKE MODEL WITH CROSS FLOW显示文摘The hydrodynamics of a pump sump consisting of a main channel,pump sump,and intake pipe is examined using Truchas,a three-dimensional Navier-Stokes solver,with a Large Eddy Simulation(LES) turbulence model.The numerical results of streamwise velocity profiles and flow patterns are discussed and compared with experimental data of Ansar and Nakato.Fairly good agreement is obtained.Furthermore,unlike Ansar et al.'s inviscid solution,the proposed numerical model includes the effect of fluid viscosity and considers more realistic simulation conditions.Simulation results show that viscosity affects the prediction of flow patterns and that the streamwise velocity can be better captured by including cross flow.The effects of the submergence Froude number on the free surface and streamwise velocity are also examined.The free surface significantly fluctuates at high submergence Froude number flows and the corresponding distribution of streamwise velocity profiles exhibits a trend different from that obtained for low submergence Froude number flows. | HSIAO Shih-Chun | 2011 | Journal of Hydrodynamics2011，23，3： | 9 |
| 7 | Sonographic fatty liver and hepatitis B virus carrier status: Synergistic effect on liver damage in Taiwan Residents adults显示文摘AIM: To examine the epidemiology of hepatitis B virus carrier status (HBVC) and sonographic fatty liver (SFL) in Taiwan Residents adults, and to evaluate their possible interaction in inducing liver damage (LD). From an epidemiological viewpoint, we analyzed previous studies which indicated that fatty liver sensitizes host immune response to HBV infection and enhances liver damage.METHODS: A cross-sectional retrospective analysis of health records including medical history, physical examination, abdominal sonogram, blood biochemistry and hepatic virological tests. We utilized the Student's t-test, chi-square, multivariate logistic regression and synergy index to assess risks for LD.RESULTS: Among a total of 5406 Taiwan Residents adults (mean age 46.2 years, 51.5% males), the prevalence of LD, HBVC and SFL were 12.3%, 15.1% and 33.4%, respectively; 5.1% of participants had SFL plus HBVC. Multivariate logistic regression analysis demonstrated that male gender (odds ratio (OR) = 2.8, 95% confidence interval (CI): 2.3-3.5), overweight state (OR = 1.6, 95% CI: 1.3-2.0), HBVC (OR = 2.5, 95% CI: 2.0-3.1) and SFL (OR = 4.2, 95% CI: 2.2-5.3) were independently associated with LD. Synergism analysis showed that the adjusted OR for LD in adults with HBVC-alone was 3.3 (95% CI: 2.4-4.6), SFL-alone, 4.7 (95% CI: 3.7-6.1) and combined HBVC and SFL, 9.5 (95% CI: 6.8-13.3); the synergy index was 1.4 (95% CI: 1.001-2.0).CONCLUSION: In Taiwan Residents adults, SFL plus HBVC have a significant synergistic association with LD. | Yu-Cheng Lin Shu-Tin Hsiao Jong-Dar Chen | 2007 | World Journal of Gastroenterology2007，13，12： | 9 |
| 8 | NYD-SP27,a novel intrinsic decapacitation factor in sperm显示文摘Prior to fertilization sperm has to undergo an activation process known as capaciation,leading to the acrosome reaction.Till now,little is known about the mechanism for preventing premature capacitation in sperm although decapacitation factors from various sources have been thought to be involved.In this study,we report that NYD-SP27,an isoform of phospholipase C Zeta 1(PLCZ1),is localized to the sperm acrosome in mouse and human spermatozoa by immunofluorescence using a specific antibody.Western blot and double staining analyses show NYD-SP27 becomes detached from sperm,as they undergo capacitation and acrosome reaction.The absence of HCO_(3)^(-),a key factor in activating capacitation,from the capacitation-inducing medium prevents the loss of NYD-SP27 from sperm.The anti-NYD-SP27 antibody also prevents the loss of NYD-SP27 from sperm,reduced the number of capacitated sperm,inhibited the acrosome reaction induced by ATP and progesterone,and inhibited agonist-induced PLC-coupled Ca^(2+)mobilization in sperm,which can be mimicked by the PLC inhibitor,U73122.These data strongly suggest that NYD-SP27 is a physiological inhibitor of PLC that acts as an intrinsic decapacitation factor in sperm to prevent premature capacitation and acrosome reaction. | Ye Bi Wen-Ming Xu Hau Yan Wong Hui Zhu Zuo-Min Zhou Hsiao Chang Chan Jia-Hao Sha | 2009 | Asian Journal of Andrology2009，11，2： | 8 |
| 9 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 10 | Awareness of and attitudes towards infertility and its treatment: a cross-sectional survey of men in a United States primary care population显示文摘以前的研究在不孕的治疗描述了种族、社会经济的不同。象态度和了解那样的耐心的因素可能正在贡献因素。因为主要照顾经常是用作一个条目进药的另外的区域的背景,我们寻求了在主要照顾背景评估人男不孕的态度和了解。做这,我们从在亚特兰大等待房间的二个主要照顾诊所在 210 个人执行了人对人的健康问题的态度的代表性的调查,乔治娅。调查与 closed-ended 问题项目是自我管理的并且是在长度的约 20 min。走近的 310 个人, 210 同意参与并且归还了完成的调查。总的来说, 52% 人说他们是 “ very”或 “ somewhat”熟悉不孕并且 25% 为不孕熟悉了治疗。一些人为男不孕作为治疗听说了外科(21%) 和药(35%) 。有条件的了解和熟悉在高社会经济的地位人是更大的(即有收入 > 的学院毕业生或那些; $100 k 每年) 但是没在 multivariate 分析上由种族不同。对不孕的态度与是更可能的显示不孕是一个严重条件,并且相信它减少的非白种人人一起由种族变化了,到担心不孕一个人的 quality-of-life。因此,了解的缺乏,然而并非否定态度,可以在不孕的治疗贡献以前描述的不同。 | Robert S Gerhard Chad WM Ritenour Michael Goodman Dipak Vashi Wayland Hsiao | 2014 | Asian Journal of Andrology2014，16，6： | 7 |
| 11 | Prospective randomized comparison of oral sodium phosphate and polyethylene glycol lavage for colonoscopy preparation显示文摘AIM: To compare the effectiveness, patient acceptability, and physical tolerability of two oral lavage solutions prior to colonoscopy in a Taiwan Residents population. METHODS: Eighty consecutive patients were randomized to receive either standard 4 L of polyethylene glycol (PEG) or 90 mL of sodium phosphate (NaP) in a split regimen of two 45 mL doses separated by 12 h, prior to colonoscopic evaluation. The primary endpoint was the percent of subjects who had completed the preparation. Secondary endpoints included colonic cleansing evaluated with an overall assessment and segmental evaluation, the tolerance and acceptability assessed by a selfadministered structured questionnaire, and a safety profile such as any unexpected adverse events, electrolyte tests, physical exams, vital signs, and body weights. RESULTS: A significantly higher completion rate was found in the NaP group compared to the PEG group(84.2% vs 27.5%, P<0.001). The amount of fluid suctioned was significantly less in patients taking NaP vs PEG (50.13±54.8 cc vs 121.13±115.4 cc, P<0.001),even after controlling for completion of the oral solution(P = 0.031). The two groups showed a comparable overall assessment of bowel preparation with a rate of 'good' or 'excellent' in 78.9% of patients in the NaPgroup and 82.5% in PEG group (P = 0.778). Patients taking NaP tended to have significantly better colonic segmental cleansing relative to stool amount observedin the descending (94.7% vs 70%, P = 0.007) andtransverse (94.6% vs 74.4%, P = 0.025) colon. Slightly more patients graded the taste of NaP as 'good' or 'very good' compared to the PEG patients (32.5% vs 12.5%;P = 0.059). Patients' willingness to take the same preparation in the future was 68.4% in the NaP compared to 75% in the PEG group (P = 0.617). There was a significant increase in serum sodium and a significant decrease in phosphate and chloride levels in NaP group on the day following the colonoscopy without any clinical sequelae. Prolonged (>24 h) hemodynamic changes were also observed in 20-35% subjects of either group.CONCLUSION: Both bowel cleansing agents proved to be similar in safety and effectiveness, while NaP appeared to be more cost-effective. After identifying and excluding patients with potential risk factors, sodium phosphate should become an alternative preparation for patients undergoing elective colonoscopy in the Taiwan Residents population. | Kai-Lin Hwang William Tzu-Liang Chen Koung-Hong Hsiao Hong-Chang Chen Ting-Ming Huang Chien-Ming Chiu Ger-Haur Hsu | 2005 | World Journal of Gastroenterology2005，11，47： | 7 |
| 12 | EFFECT OF A PROPELLER AND GAS DIFFUSION ON BUBBLE NUCLEI DISTRIBUTION IN A LIQUID显示文摘A multi-bubble dynamics code accounting for gas diffusion in the liquid and through the bubble wall was developed and used to study the modification of a bubble nuclei population dynamics by a propeller.The propeller flow field was obtained using a Reynolds-Averaged Navier-Stokes(RANS) solver and bubble nuclei populations were propagated in this field.The numerical pro-cedure enabled establishment of the possibility of production behind the propeller of relatively large visible bubbles starting from typical ocean nuclei size distributions.The resulting larger bubbles are seen to cluster in the blade wakes and tip vortices.Parametric investigations of the initial nuclei size distribution,the dissolved gas concentration,and the cavitation number were conducted to ide-ntify their effects on bubble entrainment and the resultant void fractions and bubble distribution modifications downstream from the propeller.Imposed synthetic turbulence-like fluctuations unto the average RANS flow field were also used to study the effect avera-ging in the RANS procedure has on the results. | HSIAO Chao-Tsung CHAHINE Georges L. | 2012 | Journal of Hydrodynamics2012，24，6： | 7 |
| 13 | AN EXPERIMENTAL OBSERVATION OF A SOLITARY WAVE IMPINGE-MENT,RUN-UP AND OVERTOPPING ON A SEAWALL显示文摘A sequence of laboratory experiments using solitary waves was performed to model the effect of leading form of three types of tsunamis(a bore,an impinging wave and an overtopping wave)on a seawall on a sloping beach.The wave evolution process,impinging pressure along the seawall surface,total overtopping discharge behind the seawall and the maximum run-up height on the rear slope were measured and compared.Laboratory data were employed to re-examine relevant empirical formulae in the literature.The effect of the presence of the seawall in reducing maximum run-up height using the present setup was briefly discussed.The present data can be used for calibrating numerical and mathematical models. | LIN Ting-Chieh HWANG Kao-Shu HSIAO Shih-Chun YANG Ray-Yeng | 2012 | Journal of Hydrodynamics2012，24，1： | 7 |
| 14 | Hybrid metal-insulator-metal structures on Si nanowires array for surface enhanced Raman scattering显示文摘Surface enhanced Raman scattering(SERS)is an efficient technique to detect low concentration molecules.In this work,periodical silicon nanowires(Si NWs)integrated with metal-insulator-metal(MIM)layers are employed as SERS substrates.Laser interference lithography(LIL)combined with reactive ion etching(RIE)is used to fabricate large-area periodic nanostructures,followed by decorating the MIM layers.Compared to MIM disks array on Si surface,the SERS enhancement factor(EF)of the MIM structures on the Si NWs array can be increased up to 5 times,which is attributed to the enhanced electric field at the boundary of the MIM disks.Furthermore,high density of nanoparticles and nanogaps serving as hot spots on sidewall surfaces also contribute to the enhanced SERS signals.Via changing the thickness of the insulator layer,the plasmonic resonance can be tuned,which provides a new localized surface plasmon resonance(LSPR)characteristic for SERS applications. | Kaichen Xu Chentao Zhang Tzu Hsiao Lu Puqun Wang Rui Zhou Rong Ji Minghui Hong | 2017 | 光电工程2017，44，2： | 6 |
| 15 | Randomized Controlled Trial of Entecavir Prophylaxis for Rituximab-Associated Hepatitis B Virus Reactivation in Patients With Lymphoma and Resolved Hepatitis B显示文摘 | Yi-Hsiang Huang Liang-Tsai Hsiao Ying-Chung Hong Tzeon-Jye Chiou Yuan-Bin Yu Jyh-Pyng Gau Chun-Yu Liu Muh-Hwa Yang Cheng-Hwai Tzeng Pui-Ching Lee Han-Chieh Lin Shou-Dong Lee | 2013 | Journal of Clinical Oncology2013，，22： | 6 |
| 16 | 脉冲染料激光联合外用咪喹莫特与单纯激光治疗鲜红斑痣的初步对比研究显示文摘研究目的评估脉冲染料激光(pulsed dye laser PDL)联合外用咪喹莫特治疗与单纯激光治疗鲜红斑痣的疗效。研究设计对20名亚裔鲜红斑痣受试者的结果进行评估。鲜红斑痣皮损内设置三个治疗测试区:A区用PDL+外用咪喹莫特治疗;B区单纯PDL治疗;C区单纯外用咪喹莫特软膏治疗。治疗后1、3、6和12个月进行随访,利用皮肤光谱检测仪测量血红蛋白指数。 | 苑凯华 Chang CJ Hsiao YC Mihm MC | 2011 | 中国激光医学杂志2011，20，1： | 6 |
| 17 | Preservation of superior rectal artery in laparoscopically assisted subtotal colectomy with ileorectal anastomosis for slow transit constipation显示文摘BACKGROUND Slow transit constipation(STC)has traditionally been considered as a functional disorder.However,evidence is accumulating that suggests that most of the motility alterations in STC might be of a neuropathic etiology.If the patient does not meet the diagnosis of pelvic outlet obstruction and poorly response to conservative treatment,surgical intervention with subtotal colectomy may be effective.The most unwanted complication of the procedure is anastomotic leakage,however,preservation of the superior rectal artery(SRA)may reduce its incidence.AIM To evaluate the preservation of the SRA in laparoscopically assisted subtotal colectomy with ileorectal anastomosis in STC patients.METHODS This was a single-center retrospective observational study.STC was diagnosed after a series of examinations which included a colonic transit test,anal manometry,a balloon expulsion test,and a barium enema.Eligible patients underwent laparoscopically assisted total colectomy with ileorectal anastomosis and were examined between January 2016 and January 2018.The operation time,blood loss,time to first flatus,length of hospital days,and incidence of minor or major complications were recorded.RESULTS A total of 32 patients(mean age,42.6 years)who had received laparoscopic assisted subtotal colectomy with ileorectal artery anastomosis and preservation of the SRA.All patients were diagnosed with STC after a series of examinations.The mean operative time was 151 min and the mean blood loss was 119 mL.The mean day of first time to flatus was 3.0 d,and the mean hospital stay was 10.6 d.There were no any patients conversions to laparotomy.Post-operative minor complications including 1 wound infection and 1 case of ileus.There was no surgical mortality.No anastomosis leakage was noted in any of the patients.CONCLUSION Laparoscopically assisted subtotal colectomy with ileorectal anastomosis and preservation of the SRA can significantly improve bowel function with careful patient selection.Sparing the SRA may protect against anastomosis leakage. | Chien-Wei Wu Ta-Wei Pu Jung-Cheng Kang Cheng-Wen Hsiao Chao-Yang Chen Je-Ming Hu Kuan-Hsun Lin Tzu-Chiao Lin | 2021 | World Journal of Gastroenterology2021，27，22： | 6 |
| 18 | Anticancer Activities and the Drug Targets of Botanical Saponins from a Medicinal Herb,Gynostemma Pentaphyllum显示文摘Triterpenoid saponins are metabolites produced in most plant species through complex biosynthetic pathways.They play important roles to humansowing to their diverse medicinal | W.L.Wendy HSIAO William Chi Shing TAI Ziyao MO Pui Kei WU | 2008 | Journal of Acupuncture and Tuina Science2008，6，5： | 6 |
| 19 | Two-stage resection for malignant colonic obstructions:The timing of early resection and possible predictive factors显示文摘AIM:To study potential predictive factors for early radical resection in two-stage resection for left malignant colonic obstruction.METHODS:Thirty-eight cases of left-sided obstructive colon cancer undergoing two-stage operations were reviewed between January 1998 and August 2008.Patients were classified into two groups(n = 19 each):early radical resection(interval ≤ 10 d) and late radical resection(interval > 10 d).Baseline demographics,post-diversion outcome,perioperative data,tumor characteristics,outcome and complications were analyzed.RESULTS:The baseline demographics revealed no differences except for less pre-diversion sepsis in the early group(P < 0.001) and more obstruction days in the late group(P = 0.009).The mean intervals of early and late radical resections were 7.9 ± 1.3 d and 17.8 ± 5.5 d,respectively(P < 0.001).After diversion,the presence of bowel sounds,flatus,removal of the nasogastric tube and the resumption of oral feeding occurred earlier in the early group.The operation time and duration of hospital stay were both significant reduced in the early group.Complication rates did not differ between groups.CONCLUSION:The earlier recovery of bowel function seems to be predictive of early radical resection.In contrast,pre-diversion sepsis and more obstruction days were predictive of delayed radical resection. | Hsiang-Yu Yang Chang-Chieh Wu KuoFeng Hsu Kevin Cheng-Wen Hsiao | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 20 | Gastric juice acidity in upper gastrointestinal diseases显示文摘AIM: To search the independent factors determining gastric juice acidity and to investigate the acidity of gastric juices in various benign and malignant upper gastrointestinal diseases. METHODS: Fasting gastric juice acidity of 165 healthysubjects and 346 patients with esophageal ulcer (n = 21), gastric ulcer (n = 136), duodenal ulcer (n = 100) or gastric cancer (n = 89) were measured and compared. Additionally, gastric specimens were taken from the antrum and body for rapid urease test and histological examination. RESULTS: Multivariate analysis revealed that bile stain of gastric juice, high acute inflammatory score of the corpus, and atrophy of the corpus were independent risk factors for the development of gastric hypoacidity with odds ratios of 3.1 (95% CI: 1.3-7.3), 3.1 (95% CI: 1.2-7.9) and 3.5 (95% CI: 1.3-9.2). Esophageal ulcer and duodenal ulcer patients had a lower pH level (1.9 and 2.1 vs 2.9, both P < 0.05) of gastric juices than healthy subjects. In contrast, gastric ulcer and gastric cancer patients had a higher pH level (3.4 and 6.6 vs 2.9, both P < 0.001) than healthy controls. Hypoacidity existed in 22%, 5%, 29%, 5% and 88% of healthy subjects, esophageal ulcer, gastric ulcer, duodenal ulcer and gastric cancer patients, respectively. CONCLUSION: Bile reflux, atrophy and dense neutrophil infiltrate of the corpus are three independent factors determining the acidity of gastric juice. | Pei-Jung Lu Ping-I Hsu Chung-Hsuan Chen Michael Hsiao Hui-Hwa Tseng Kung-Hung Lin Seng-Kee Chuah | 2010 | World Journal of Gastroenterology2010，16，43： | 5 |
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