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| 1 | 聚乙二醇与磷酸钠在结肠镜检查前肠道准备的比较显示文摘目的对比聚乙二醇与磷酸钠在结肠镜检查前肠道准备的效果、依从性以及对血生化指标的影响。方法78例结肠镜检查者随机给予聚乙二醇电解质溶液或磷酸钠进行肠道准备,单盲法评价肠道清洁效果,问卷调查患者排便性状和次数以及对于药物的口感。另外,肠道准备前后检测各种血生化指标和体重,对比两种药物的差异。结果所有入选者都能饮完聚乙二醇电解质液或磷酸钠溶液,入选者似乎更容易接受磷酸钠。口感计分磷酸钠组为3.11±0.60,聚乙二醇组为2.85±0.74,两组无统计学显著性差异(P=0.09)。磷酸钠组肠道准备满意度计分2.32±0.66,聚乙二醇组为2.00±0.64(P=0.035),磷酸钠组肠道准备后血磷水平升高(由1.05±0.17升高至1.52±0.58,P<0.001),而血钙(P<0.001)降低,血钠(P=0.022)降低,但无明显临床症状。与聚乙二醇组相比,磷酸钠组有引起低血钾的趋势(P<0.096),而磷酸钠组肠道准备后与准备前相比,血钾下降有统计学差异(P=0.003)。结论从肠道准备效果上来看,磷酸钠优于聚乙二醇。在口感上二者相比虽无统计学差异,但入选者更倾向于接受磷酸钠。虽然没有临床症状,应警惕磷酸钠肠道准备后低钙、低钠、高磷血症,且血磷升高幅度非常明显,对于肾功能不全的患者,尤需谨慎。 | 李鹏 张澍田 吴咏冬 冀明 俞力 梁晓梅 牛应林 王拥军 于中麟 | 2009 | 临床消化病杂志2009，21，2： | 13 |
| 2 | 甘露醇和蓖麻油在儿童结肠镜肠道准备中的对比研究显示文摘目的探讨甘露醇和蓖麻油在儿童行肠镜检查前肠道准备中的应用效果。方法回顾2010年8月到2015年8月,76例在我院行结肠镜检查的6~13岁患儿,按肠道准备药物的不同分为口服甘露醇组和蓖麻油组,两组均同时予饮食控制,观察不同肠道准备药物的清洁程度和耐受程度的差异。结果甘露醇组肠道清洁满意率为88.5%,蓖麻油组肠道为92.5%,两组清洁程度相当(P=1.0)。而甘露醇组患儿对肠道准备的耐受程度达91.7%,蓖麻油组耐受程度为67.5%,两组患者的差异有统计学意义(P=0.01)。结论甘露醇和蓖麻油肠道准备的满意程度相当,但口服甘露醇的儿童耐受程度更好,因而甘露醇是患儿行肠镜检查有效、安全的肠道准备方法。 | 胡绍正 杜红宇 邹文书 | 2018 | 泰山医学院学报2018，39，2： | 10 |
| 3 | 2种清肠剂在胶囊内镜检查应用的对比研究显示文摘目的探讨聚乙二醇电解质散及磷酸钠盐口服液作为清肠剂在胶囊内镜检查时肠道准备的应用效果。方法60例胶囊内镜检查者随机分为聚乙二醇组与磷酸钠组,比较检查者口服清肠剂后的副反应发生率,并由2名内镜专家单盲对胶囊内镜图像的气泡量、肠液量及清洁度、观察效果进行定量分析,同时统计分析胶囊内镜通过胃及小肠的通过时间以及两者的不良反应。比较2种清肠剂对胶囊检查的影响。结果磷酸钠组的副反应发生率低于聚乙二醇组(P<0.05)。磷酸钠组与聚乙二醇组在胃内气泡量、消化液量、清洁度及观察效果上差异无显著性(P>0.05)。在小肠内磷酸钠组气泡量较聚乙二醇组多(P<0.05),消化液量聚乙二醇组明显多于磷酸钠组(P<0.05),磷酸钠组清洁度及观察效果较聚乙二醇组好(P<0.05)。两组在胃及小肠的通过时间差异无显著性(P>0.05)。结论作为胶囊内镜肠道清洁剂,磷酸钠盐口服液优于聚乙二醇电解质散。 | 杨晓强 赵亚刚 孙大勇 | 2009 | 中国内镜杂志2009，15，10： | 10 |
| 4 | 口服磷酸钠盐用于结肠癌术后老年患者结肠镜检查前肠道准备的效果观察显示文摘目的:评价口服磷酸钠盐用于结肠癌术后老年患者结肠镜检查前肠道准备的有效性、安全性及耐受性。方法:选取2011年9月1日至2011年12月31日间共116例行结肠镜检查的结肠癌术后老年患者,随机分组纳入试验组例和对照组,试验组口服磷酸钠盐进行肠道准备,对照组口服硫酸镁制剂。结肠镜检查术者单盲评价肠道准备的清洁度;患者在肠镜检查当日及检查结束1周后评价肠道准备的耐受度。并记录不良反应(安全性)。结果:试验组肠道准备的总满意率为82.1%(46/56),对照组为90.0%(54/60),两组之间无明显差异(P>0.05)。检查当10.7%的试验组患者和38.3%的对照组患者认为肠道准备过程难以耐受(P=0.001)。检查结束1周后7.1%的试验组患者和23.3%的对照组患者认为肠道准备过程难以耐受(P=0.003)。两组之间不良反应无显著性差异。结论:磷酸钠盐用于结肠癌术后老年患者的肠道准备,清洁效果和不良反应情况与硫酸镁制剂相似,但患者的耐受性却显著提高。 | 王鸣 陈玲 张钰 王志强 张子其 | 2012 | 现代生物医学进展2012，12，24： | 6 |
| 5 | Hyperphosphatemia after sodium phosphate laxatives in low risk patients:Prospective study显示文摘AIM:To establish the frequency of hyperphosphate-mia following the administration of sodium phosphate laxatives in low-risk patients. METHODS:One hundred consecutive ASAⅠ-Ⅱindividuals aged 35-74 years,who were undergoing colonic cleansing with oral sodium phosphate(OSP) before colonoscopy were recruited for this prospective study.Exclusion criteria:congestive heart failure, chronic kidney disease,diabetes,liver cirrhosis,intestinal obstruction,decreased bowel motility,increased bowel permeability,and hyperparathyroidism.The day before colonoscopy,all the participants entered a 24-h period of diet that consisted of 4 L of clear fluids with sugar or honey and 90 mL(60 g)of OSP in two 45-mL doses,5 h apart.Serum phosphate was measured before and after the administration of the laxative. RESULTS:The main demographic data(mean±SD) were:age,58.9±8.4 years;height,163.8±8.6 cm; weight,71±13 kg;body mass index,26±4;women, 66%.Serum phosphate increased from 3.74±0.56 to 5.58±1.1 mg/dL,which surpassed the normal value (2.5-4.5 mg/dL)in 87%of the patients.The highest serum phosphate was 9.6 mg/dL.Urea and creatinine remained within normal limits.Post-treatment OSP se-rum phosphate concentration correlated inversely with glomerular filtration rate(P<0.007,R 2=0.0755),total body water(P<0.001,R 2=0.156)and weight(P< 0.013,R 2=0.0635). CONCLUSION:In low-risk,well-hydrated patients, the standard dose of OSP-laxative-induced hyperphos-phatemia is related to body weight. | Marcela Noemi Casais Guillermo Rosa-Diez Susana Pérez Elina Noemi Mansilla Susana Bravo Francisco Carlos Bonofiglio | 2009 | World Journal of Gastroenterology2009，15，47： | 5 |
| 6 | 莫沙必利对聚乙二醇电解质散溶液用于结肠清洁的影响显示文摘目的评价莫沙必利是否能缓解口服聚乙二醇电解质散溶液(PEG)用于结肠清洁过程中的胃肠道不适症状,并了解它是否有助于改善PEG清洁肠道的质量。方法前瞻性随机对照研究,甲组(2000mL等渗PEG溶液+莫沙必利)92例、乙组(2000mL等渗PEG溶液)93例。主要观察恶心、呕吐、腹胀和腹痛等腹部不适症状的发生和严重程度,结肠清洁质量的分级和合格率,以及结肠镜是否插入盲肠和所用时间。结果甲组未出现恶心、呕吐和饱胀等不适症状的比例明显高于乙组,甲组发生中或重度恶心、呕吐和饱胀等腹部不适的比例明显低于乙组,差异有显著性(P<0.05)。两组间直乙状结肠的清洁质量分级比较差异无显著性(P=0.082);但甲组右半结肠清洁质量的分级效果优于乙组,差异有显著性(P=0.036)。甲组直乙状结肠或右半结肠清洁质量的合格率稍高于乙组,但差异均无显著性(P>0.05)。甲组插入盲肠的比例稍高于乙组,甲组插入盲肠所需时间稍短于乙组,但两组间比较差异均无显著性(P>0.05)。结论加用莫沙必利有助于减少和减轻口服2000mL等渗PEG溶液导致的消化道不适症状,可能会改善结肠清洁的质量。 | 丁祥武 莫慧琴 杨雨 周子琴 高山 | 2011 | 中国内镜杂志2011，17，10： | 5 |
| 7 | Comparative study of two bowel preparaton regimens for colonoscopy: Senna tablets vs sodium phosphate solution显示文摘AIM: To compare the efficacy and acceptance of senna tablet and sodium phosphate solution for bowel preparation before colonoscopy.METHODS: One hundred and thirty four patients, who needed elective colonoscopy, were randomly allocated to take 180 mg senna tablet or 95 mL sodium phosphate solution on the day before colonoscopy. The effi cacies of both laxatives were compared using the mean difference of colon-cleanliness score of the rectum, sigmoid segments, descending colon, transverse colon and cecum. The scores were rated by two observers who were blinded to the laxatives administered. The higher score means that the colon is cleaner. The efficacy of both laxatives were equivalent if the 95% confidence interval of the mean difference of the score of colon lie within -1 to +1. RESULTS: On intention-to-treat analysis, the mean cleanliness scores in the four segments of colon except the cecum were higher in the sodium phosphate group than those in senna group (7.9 ± 1.7 vs 8.3 ± 1.5, 8.0 ± 1.8 vs 8.5 ± 1.4, 7.9 ± 2.0 vs 8.5 ± 1.3, 7.9 ± 2.0 vs 8.2 ± 1.4 and 7.2 ± 1.7 vs 6.9 ± 1.4, respectively). The 95% conf idence intervals (95% CI) of mean difference in each segment of colon were not found to lie within 1 point which indicated that their effi cacies were not equivalent. The taste of senna was better than sodium phosphate solution. Also, senna had fewer side effects. CONCLUSION: The effi cacy of senna is not equivalentto sodium phosphate solution in bowel preparation for colonoscopy, but senna may be considered an alternative laxative. | Savit Kositchaiwat Weerapat Suwanthamma Ronnarat Suvikapakornkul Vaewvadee Tiewthanom Prisna Rerkpatanakit Chaowalitr Tinkornrusmee | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
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