|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Mechanisms of brain injury after intracerebral haemorrhage显示文摘 | Guohua Xi Richard F Keep Julian T Hoff | 2006 | Lancet Neurology2006，，1： | 4 |
| 4 | Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats显示文摘 | Keep RF Hoff J T | 1998 | J Neurosurg1998，89，： | 1 |
| 5 | Perfluorinated chemicals infiltrate ocean waters:link between exposure levels and stable isotope ratios in marine mammals显示文摘 | VIJVER K I HOFF P T DAS K | 2003 | Environmental Science and Technology2003，37，24： | 1 |
| 6 | Acute inflammatory reaction following experimental intracerebral hemorrhage in rat显示文摘 | Cong C Hoff J T Keep R F | 2000 | Brain Res2000，871，1： | 1 |
| 7 | Attentional Advice: Effects on Immediate, Delayed, and Transfer Task Performance显示文摘 | Foster J Hoff Macan T | 2002 | Human Performance2002，15，4： | 1 |
| 8 | Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine 显示文摘 | Von Hoff DD Ervin T Arena FP | 2013 | N Engl J Med2013，369，18： | 1 |
| 9 | The use of mutants and transgenic plants to study nitrate assimilation 显示文摘 | HOFF T TRUONG H N CABOCHE M | 1994 | Plant Cell Environ1994，17，5： | 1 |
| 10 | The importance of snow scavenging of polycyclic aromatic hydrocarbon vapors 显示文摘 | WANIA F MACKAY D HOFF J T | 1998 | Environmental Science and Technology1998，33，： | 1 |
| 11 | Pharmacokinetics of florfenicol and its metabolite florfenicol amine in Atlantic salmon显示文摘 | Horsberg T E Hoff K A Nordmo R | 1996 | Journal of Aquatic Animal Health1996，8，： | 1 |
| 12 | Tissue distribution of perfluorinated chemicals in habor seals (Phoca vitulina) from the Dutch Wadden Sea显示文摘 | VIJVER K I HOFF P T DAS K | 2005 | Environmental Science and Technology2005，39，18： | 1 |
| 13 | Sampling bias caused by materials used to monitor halocarbons in groundwater显示文摘 | Reynolds G W Hoff J T Gillham R W | 1990 | En- vironmental Science & Technology1990，24，1： | 1 |
| 14 | Osteopoikilosis aml multiple exostoses caused by novel mutations in LEMD3 and EXTI genes respectively--coinci- dence within one family显示文摘 | Baadanjav S Jamsheer A Kolanczyk M Horn D Latos T Hoff mann K | 2010 | BMC Med Genet2010，11，： | 1 |
| 15 | The enzyme 4- hydroxy- 2- oxoglutarate aldolase is deficient in primary hyperoxaluria type 3显示文摘 | Williams EL Bockenhauer D van't Hoff WG | 2012 | Nephrol Dial Transplant2012，27，： | 1 |
| 16 | The Arabidopsis downymildew resistance gene RPP8 is induced by pathogens andsalicylic acid and is regulated by W-box cis elements 显示文摘 | Mohr T J Mammarella N D Hoff T | 2010 | MolPlant-Micro Interac2010，23，10： | 1 |
| 17 | Enhancing career development through the career success club显示文摘 | Wessel R D Christian N T Hoff A K | 2003 | Journal of Career Development2003，，29： | 1 |
| 18 | Use of mutants and transgenic plants to study nitrate assimilation显示文摘 | Hoff T Truong H-N Caboche M | 1994 | Plant1994，1994，17： | 1 |
| 19 | Preoperative irradiation for the prevention of heterotopic ossification induces local in- flammation in humans显示文摘 | Hoff P Rakow A Gaber T | 2013 | Bone2013，55，1： | 1 |
| 20 | Increased surviv- al in pancreatic cancer with nab-paclitaxel plus gem- citabine显示文摘 | Von Hoff DD Ervin T Arena FP | 2013 | N Engl J Med2013，369，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员