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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 3 | 基于定量宏基因组学评估肝硬化患者肠道菌群的变化与慢加急性肝衰竭及预后的关系显示文摘【据Gastroenterology 2020年9月报道】题:基于定量宏基因组学评估肝硬化患者肠道菌群的变化与慢加急性肝衰竭及预后的关系(作者SoléC等)肝硬化与肠道菌群组成的改变有关。慢加急性肝衰竭(ACLF)是肝硬化最严重的临床阶段,但目前仍缺乏使用定量宏基因组学研究ACLF中肠道菌群改变的信息。 | SOLéC GUILLY S Da SILVA K 邵玥明 温晓玉 | 2020 | 临床肝胆病杂志2020，36，11： | 4 |
| 4 | LABORATORY MEASUREMENTS IN SINE-GENERATED MEANDERING CHANNELS显示文摘The patterns (In flow plan) of rough turbulent steady flows in sine-generated meandering streams are investigated experimentally. The flow cross-section is rectangular, the flow width is uniform, the channel bed is flat; the plan shape is sine-generated. In contrast to previous works, where the computed flow patterns were of the same character, irrespective of the sinuosity of the channel, it is found, on the basis of present experiments, that every different Plan geometry of a meandering flow has its own flow picture. In the case of 'small' sinuosity, the flow convectively accelerates at the inner bank between the crossover-and apexsections; if, however, the sinuosity is 'large', the now convectively decelerates in the same region. The convergence-divergence areas (in flow Plan) of the present flows are in coincidence with the location of erosion-deposition zones in meandering streams, confirming that the convective behaviour of the vertically-averaged flow alone is sufficient to induce the bed and bank deformation. | A. M. Ferreira da SILVA and M. S YALIN (1 Research Hydraulic Engineer, Hydraulics Laboratory, Waterways Experiment Station, U. S. Army Corps of Engineers, Vicksburg, Mississippi. 2 Emeritus Professor, Department of Civil Engineering, Queen’s University, K | 1997 | International Journal of Sediment Research1997，12，1： | 2 |
| 5 | Cyclophotocoagulation: a report by the American Academy of Ophthalmology 显示文摘 | Paster SA Singh K Lee Da | 2001 | Ophthalmologica2001，108，11： | 2 |
| 6 | 冠状动脉钙化用于指导个性化阿司匹林治疗以预防心血管病:基于多民族动脉粥样硬化研究显示文摘最近美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)的一级预防指南建议,低剂量阿司匹林治疗仅适用于年龄40~70岁、患动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)风险较高,但出血风险不高的成年人。然而,尚不清楚如何更准确地识别出这些患者。根据2019年降低心血管病相对危险度和出血风险的阿司匹林荟萃分析研究数据,本研究旨在评估冠状动脉钙化(coronary artery calcium,CAC)在指导阿司匹林在一级预防中如何使用的价值。 | 周卫(译) 叶鹏(摘/审校) Achirica MC Miedema MD McEvoy JW Rifai MA Greenland P Dardari Z Budoff M Blumenthal RS Yeboah J Duprez DA Mortensen MB Dzaye O Hong J Nasir K Blaha MJ | 2020 | 中华高血压杂志2020，28，4： | 2 |
| 7 | Detection of epithelial cancer cells in peripheral blood by reverse transcriptase polymerase chain reaction显示文摘 | Bradbury MF Pittman K | 1995 | Brit J Cancer1995，71，： | 1 |
| 8 | Effects of race and family history of type 2 diabetes on metabolie status of women withpolycystie ovary syndrome显示文摘 | Ehrmann DA Kasza K Azziz R | 2005 | J Clin Endocrinol Metab2005，90，1： | 1 |
| 9 | Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells:the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways显示文摘 | Moerman EJ Teng K Lipschitz DA | 2004 | Aging Cell2004，3，6： | 1 |
| 10 | Neuroglobin:an endogenousneuroprotectant显示文摘 | Greenberg DA Jin K Khan AA | 2008 | Curr Opin Pharmacol2008，8，1： | 1 |
| 11 | Application of thermostable xylanases from Humicola sp for pulp improvement显示文摘 | Da Silva R Yim D K Park Y K | 1994 | J Ferment Bioeng1994，77，1： | 1 |
| 12 | Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis显示文摘 | Hashimoto S Takahashi K Richard DA | 1998 | Joint Reconstruction Res1998，41，7： | 1 |
| 13 | Association between blood pressure: the treatment of hypertension,and cardiovascular risk factors in women 显示文摘 | Nanchahal K Ashton WD Wood DA | 2000 | J Hypertens2000，18，： | 1 |
| 14 | Neurotrophin modulation of voltage-gated potassium channels in rat through TrKB receptors is time and sensory experience dependent显示文摘 | Tucker K Fadool DA | 2002 | J Physiol2002，542，2： | 1 |
| 15 | Near work, visual fatigue, and variations of oculomotor tonus显示文摘 | Owens DA Wolf-Kelly K | 1987 | Invest Ophthalmol Vis Sci1987，28，： | 1 |
| 16 | Three-dimensional structure of myosin subfragment-1 : a molecular motor显示文摘 | Rayment I Rypniewski WR Schmidt-Base K Smith R Tomchik DR Benning MM Winkelmann DA Wesenberg G Holden HM | 1993 | Science1993，261，： | 1 |
| 17 | Diagnostic value of the left atrial electrical potentials detected by body surface potential mapping in the prediction of coronary artery disease显示文摘 | Bauernfeind T Préda I Szakolczai K | 2011 | Int J Cardiol2011，150，3： | 1 |
| 18 | Cervical cancer: patterns of long-term survival 显示文摘 | Clemmens DA Knafl K Lev EL | 2008 | Oncology Nusing Forum2008，35，6： | 1 |
| 19 | The prevalence of dementia three months after stroke and its risk factors 显示文摘 | Narasimhalu K Ang S De Silva DA | 2011 | Stroke2011，42，4： | 1 |
| 20 | Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome显示文摘 | Ehrmann DA Liljenquist DR Kasza K | | 0，，： | 1 |
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