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| 1 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Primary prevention of colorectal cancer:Myth or reality?显示文摘Colorectal cancer incidence has been rising strongly in parallel with economic development.In the past few decades,much has been learned about the lifestyle,dietary and medication risk factors for this malignancy.With respect to lifestyle,compelling evidence indicates that prevention of weight gain and maintenance of a reasonable level of physical activity can positively influence in lowering the risk.Although there is controversy about the role of specific nutritional factors,consideration of dietary pattern as a whole appears useful for formulating recommendations.Though quite often recommended,the role for many supplements,including omega-3,vitamin D,folate,and vitamin B6,remains unsettled.Only calcium and vitamin D supplementation appear to add a modest benefit,particularly in those with a low daily intake.With regard to chemoprevention,medications such as aspirin and nonsteroidal antiinflammatory drugs,and postmenopausal hormonal replacement for women might be associated with substantial reductions in colorectal cancer risk,though their utility is affected by their side effect profile.However,the role of agents such as statins,bisphosphonates and antioxidants have yet to be determined.Ultimately,primary prevention strategies focusing on modifying environmental,lifestyle risk factors,and chemopreventive drugs are options that have already been tested,and may impact on colon cancer incidence. | Marcela Crosara Teixeira Maria Ignez Braghiroli Jorge Sabbaga Paulo M Hoff | 2014 | World Journal of Gastroenterology2014，20，41： | 5 |
| 4 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 5 | Intima media thickness of the carotid arteries:early pointer to arteriosclerosis and therapeutic endpoint显示文摘 | LUDWIG M VON PETZINGER-KRUT HOFF A VON BUQUOY M | 2003 | Ultraschall Med2003，24，3： | 1 |
| 6 | Evalution of CHAMP radio occultation refractivity using data assinzilation office analysis and radiosondes显示文摘 | Poli P Joiner J Hoff R M | 2003 | J Geophys Res Lett2003，30，15： | 1 |
| 7 | Analysis of chromosome 22markers in nine schizophrenia pedigrees 显示文摘 | Coon H Holik J Hoff M | 1994 | Am J Med Genet1994，54，1： | 1 |
| 8 | Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells 显示文摘 | Del Poeta M Chen SF Von Hoff D | 1999 | Antimicrob Agents Chemother1999，43，12： | 1 |
| 9 | The use of mutants and transgenic plants to study nitrate assimilation 显示文摘 | HOFF T TRUONG H N CABOCHE M | 1994 | Plant Cell Environ1994，17，5： | 1 |
| 10 | Radiation therapy for rectal cancer: current status and future directions显示文摘 | Hoffe S E Shridhar R Biagioli M C | 2010 | Cancer Control2010，17，1： | 1 |
| 11 | Quantifying factors affecting sidewall air inlet performance 显示文摘 | Oberreuter M E Hoff S J | 2000 | Transactions of the ASAE2000，43，3： | 1 |
| 12 | Longitudinal neuropsycho- logical follow-up study of patients with first-episode schizophrenia 显示文摘 | Hoff L Sakuma M Wieneke M | 1999 | Am J Psychiatry1999，156，9： | 1 |
| 13 | Role of bone morphogenetic proteins in cardiac differentiation显示文摘 | Wijk B Moorman A Hoff M | | 0，，02： | 1 |
| 14 | Osteopoikilosis aml multiple exostoses caused by novel mutations in LEMD3 and EXTI genes respectively--coinci- dence within one family显示文摘 | Baadanjav S Jamsheer A Kolanczyk M Horn D Latos T Hoff mann K | 2010 | BMC Med Genet2010，11，： | 1 |
| 15 | STUDY OF PT-PROMOTED COBALT CO HYDROGENATION CATALYSTS显示文摘 | Schanke D Vada S Blekkan E A Hilmen A M Hoff A Holmen A | | 0，，： | 1 |
| 16 | Molecular cloning and immunological characterization of potential allergens from the mould Fusarium culmorum显示文摘 | HOFF M BALLMER-WEBER B K NIGGEMANN B | 2003 | Mol Immunol2003，39，15： | 1 |
| 17 | Use of mutants and transgenic plants to study nitrate assimilation显示文摘 | Hoff T Truong H-N Caboche M | 1994 | Plant1994，1994，17： | 1 |
| 18 | Linkage analysis between schizophrenia and index simple-sequence repeat loci for chromosome 21显示文摘 | Byerley W Hoff M Holik J | 1995 | Hum Genet1995，45，1： | 1 |
| 19 | Changes in the Periodontal ligament after experimental tooth movementusing hi^i and low continuous forces in beagle dogs显示文摘 | Van Bt^il M Maltha J Van den Hoff H KuijPers - Jagtman AM | 2004 | AngleOrthod2004，74，1： | 1 |
| 20 | Hot Stamping Steel 22MnB5显示文摘 | Geiger M Merklein M Hoff C | | 0，，6： | 1 |
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