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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 3 | 抑郁治疗和急性心肌梗死后1年死亡率的相关性:TRIUMPH注册研究显示文摘在急性心肌梗死(acute myocardial infarction,AMI)患者中,抑郁症是很普遍的,并且与不良的生活质量和预后相关。尽管一些国家组织提出了筛选抑郁症的建议,但尚不清楚AMI患者的抗抑郁治疗是否与更好的预后相关。该研究的目的是确定接受抗抑郁治疗是否对患者的预后有影响。方法: | 刘莉 叶鹏 Smolderen KG Buchanan DM Gosch K Whooley MA Chan PS Vaccarino V Parashar S Shah AJ Ho PM Spertus JA | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Podocytes contribute to the formation of glomerular crescents 显示文摘 | Thorner PS Ho M Eremina V | 2008 | J Am Soc Nephrol2008，19，3： | 1 |
| 5 | A qualitative and quanti- tative review of antecedents of counterproductive behav- ior in organizations 显示文摘 | Lau V S Au W T & Ho J C | 2003 | Journal of Business and Psy- chology2003，18，1： | 1 |
| 6 | The apparent contact dimension and covariates among orthodontically treated and nontreated subjects显示文摘 | Raj V Heymann HO Hershey HG | 2009 | J Esthet Restor Dent2009，21，2： | 1 |
| 7 | Abatement of nitrogen oxides in a catalytic reactor enhanced by nonther- mal plasma discharge 显示文摘 | Mok Young Sun Ravi V Kang Ho Chul | 2003 | IEEE Transactions on Plasma Science2003，31，1： | 1 |
| 8 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 9 | Micro-Doppler Effect in Radar-Phenomenon,Model and Simulation Study显示文摘 | Chen V C Li F Y Ho S S | 2006 | IEEE Trans on Aerospace and Electronic Systems2006，42，1： | 1 |
| 10 | Visualization and spectroscopy of a Metal-Molecule-Metal bridge显示文摘 | Nazin G V Qiu X H Ho W | 2003 | Science2003，302，： | 1 |
| 11 | Hepatic veno-occlusive disease:pathogenesis,diagnosis and treatment显示文摘 | Wadleigh M Ho V Momtaz P | 2003 | Curr Opin Hematol2003，10，6： | 1 |
| 12 | ANN Based Estima- tor for Distillation-inferential Control显示文摘 | SINGH V GUPTA I GUPTA Ho | 2005 | Chemical En- gineering and Processing2005，44，7： | 1 |
| 13 | Ahernative fuel reburning 显示文摘 | Maly P M Zamansky V M Ho L | | Fuel0，78，3： | 1 |
| 14 | Transport of ironbased nanoparticles: role of magnetic properties 显示文摘 | Yongsuk Ho Ryan J H Nosang V | 2009 | Environmental Science & Technology2009，43，23： | 1 |
| 15 | Micro-doppler effect in radar:phenomenon,model,and simulation study显示文摘 | Chen V C Li F Y Ho S | 2006 | IEEE Transactionson Aerospace and Electronic Systems2006，42，1： | 1 |
| 16 | Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enbanced expression of FasL 显示文摘 | Syed V Ho SM | 2003 | Oncogene2003，22，： | 1 |
| 17 | The elemental composi- tion of some marine phytoplankton显示文摘 | Ho T Y Quigg A Finkel Z V | 2003 | J Phycol2003，39，6： | 1 |
| 18 | p53-dependent DNA repair and apoptosis respond differently to high-and low-dose ultraviolet radiation显示文摘 | Li G Ho V C | 1998 | Br J Dermatol1998，139，1： | 1 |
| 19 | The effects of compression and gas diffusion layers on the performance of a PEM fuel cell 显示文摘 | Lee Wk Ho C H Zee J W V | 1999 | Journal of Power Sources1999，84，： | 1 |
| 20 | Effect of magnetite nanoparticle agglomerates on ultrasound induced inertial cavitation显示文摘 | Smith M J Ho V H B Darton N J | | 0，，06： | 1 |
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