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| 1 | Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma显示文摘AIM: To assess the clinical features and prognosis of 151 patients with extrahepatic metastases from primary hepatocellular carcinoma (HCC), and describe the treatment strategy for such patients. METHODS: After the diagnosis of HCC, all 995 consecutive HCC patients were followed up at regular intervals and 151 (15.2%) patients were found to have extrahepatic metastases at the initial diagnosis of primary HCC or developed such tumors during the follow-up period. We assessed their clinical features, prognosis, and treatment strategies. RESULTS: The most frequent site of extrahepatic metastases was the lungs (47%), followed by lymph nodes (45%), bones (37%), and adrenal glands (12%). The cumulative survival rates after the initial diagnosis of extrahepatic metastases at 6, 12, 24, and 36 mo were 44.1%, 21.7%, 14.2%, 7.1%, respectively. The median survival time was 4.9 mo (range, 0-37 mo). Fourteen patients (11%) died of extrahepatic HCC, others died of primary HCC or liver failure. CONCLUSION: The prognosis of HCC patients with extrahepatic metastases is poor. With regard to the cause of death, many patients would die of intrahepatic HCC and few of extrahepatic metastases. Although most of HCC patients with extrahepatic metastases should undergo treatment for the primary HCC mainly, treatment of extrahepatic metastases in selected HCC patients who have good hepatic reserve, intrahepatictumor stage (T0-T2), and are free of portal venous invasion may improve survival. | Kiminori Uka Hiroshi Aikata Shintaro Takaki Hiroo Shirakawa Soo Cheol Jeong Keitaro Yamashina Akira Hiramatsu Hideaki Kodama Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，3： | 44 |
| 2 | Maintenance for healed erosive esophagitis:PhaseⅢcomparison of vonoprazan with lansoprazole显示文摘AIM To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis(EE).METHODS A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg(n = 201), vonoprazan 10 mg(n = 202), or vonoprazan 20 mg(n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period. The secondary endpoint was the EE recurrence rate at Week 12 during maintenance treatment. Additional efficacy endpoints included the incidence of heartburn and acid reflux, and the EE healing rate 4 wk after the initiation of maintenance treatment. Safety endpoints comprised adverse events(AEs), vital signs, electrocardiogram findings, clinical laboratory results, serum gastrin and pepsinogen Ⅰ/Ⅱ levels, and gastric mucosa histopathology results.RESULTS Rates of EE recurrence during the 24-wk maintenance period were 16.8%, 5.1%, and 2.0% with lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg, respectively. Vonoprazan was shown to be non-inferior to lansoprazole 15 mg(P < 0.0001 for both doses). In a post-hoc analysis, EE recurrence at Week 24 was significantly reduced with vonoprazan at both the 10 mg and the 20 mg dose vs lansoprazole 15 mg(5.1% vs 16.8%, P = 0.0002, and 2.0% vs 16.8%, P < 0.0001, respectively); by contrast, the EE recurrence rate did not differ significantly between the two doses of vonoprazan(P = 0.1090). The safety profiles of vonoprazan 10 and 20 mg were similar to that of lansoprazole 15 mg in patients with healed EE. Treatment-related AEs were reported in 11.4%, 10.4%, and 10.3% of patients in the lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg arms, respectively.CONCLUSION Our findings confirm the non-inferiority of vonoprazan 10 and 20 mg to lansoprazole 15 mg as maintenance therapy for patients with healed EE. | Kiyoshi Ashida Katsuhiko Iwakiri Naoki Hiramatsu Yuuichi Sakurai Tetsuharu Hori Kentarou Kudou Akira Nishimura Eiji Umegaki | 2018 | World Journal of Gastroenterology2018，24，14： | 18 |
| 3 | Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis显示文摘AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic criteria.On 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for EUS-FNA.RESULTS:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent EUSFNA.EUS-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic body-tail.Nine of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of LPSP.No one met level 1 findings of IDCP,but 3 patients met level 2 findings of IDCP.Of 10 seronegative cases,2 cases were diagnosed with 'definitive type 1 AIP',and 3 cases were diagnosed with 'probable type 2 AIP' when considering both the level 2 histological findings and response to steroids.CONCLUSION:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases. | Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hirosh Matsubara Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto Yoshiki Hirooka | 2012 | World Journal of Gastroenterology2012，18，29： | 8 |
| 4 | A pedunculated polyp-shaped small-bowel lymphangioma causing gastrointestinal bleeding and treated by double-balloon enteroscopy显示文摘We report a rare case of a small-bowel lymphangioma causing massive gastrointestinal (GI) bleeding that we successfully diagnosed and treated using double-balloon enteroscopy (DBE). An 81-year-old woman suffering from repeated GI bleeding of unknown origin underwent a capsule endoscopy at a previous hospital. She was suspected of having bleeding from the jejunum, and was referred to our department for diagnosis and treatment. An oral DBE revealed a 20 mm × 10 mm, regularly surfaced, white to yellowish, elongated, pedunculated jejunal polyp with small erosions at 10 cm distal to the ligament of Treiz. Since no other source of bleeding was identified by endoscopy in the deep jejunum, anendoscopic polypectomy (EP) was performed for this lesion. A subsequent histopathological examination of the resected polyp showed clusters of lymphatic vessels with marked cystic dilatation in the submucosa and the deep layer of the lamina propria mucosae. These characteristics are consistent with the typical features of small-bowel lymphangioma with erosions. Although clip-ping hemostasis was performed during EP, re-bleeding occurred. Finally, a complete hemostasis was achieved by performing an additional argon plasma coagulation. | Akihiko Kida Koichiro Matsuda Satoshi Hirai Akiyoshi Shimatani Yousuke Horita Katsushi Hiramatsu Mitsuru Matsuda Hidero Ogino Shin Ishizawa Yatsugi Noda | 2012 | World Journal of Gastroenterology2012，18，34： | 5 |
| 5 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 4 |
| 6 | ELECTROPLATED Zn-Ni-SiO_2 COMPOSITE COATINGS TREATED WITH A SILANE COUPLING AGENT TO REPLACE CHROMATING显示文摘The fixing of a silane coupling agent to Zn-Ni-silica (SiO2) composite coatings was studied for the purpose of developing a coating process as an alternative to chromating. The corrosion resistance of Zn-Ni-silica composite coatings was rem arkably improved by the silica nanoparticles in the composite, which were disper sed in the surface of this film. The silane coupling agent formed chemical bonds with the inorganic silica particles during the silane coupling treatment on the se composite coatings. The treatment suppressed the formation of white corrosion products to the same extent as chromating, as measured in salt spray tests. It is concluded that treating Zn-Ni-silica composite coatings with silane coupling agents is a viable alternative technique to chromating. | M. Hino M. Hiramatsu K. Murakami A. Saijo T. Kanadani | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，3： | 4 |
| 7 | Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection 1 1 No competing interests declared.显示文摘 | Jacques Belghiti Kazuhiro Hiramatsu Stéphane Benoist Pierre Philippe Massault Alain Sauvanet Olivier Farges | 2000 | Journal of the American College of Surgeons2000，，1： | 3 |
| 8 | Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection 1 1 No competing interests declared.显示文摘 | Jacques Belghiti Kazuhiro Hiramatsu Stéphane Benoist Pierre Philippe Massault Alain Sauvanet Olivier Farges | 2000 | Journal of the American College of Surgeons2000，，1： | 3 |
| 9 | ENVIRONMENTAL FRIENDLY ANODIZING ON AZ91D MAGNESIUM ALLOYS AND COATING CHARACTERISTICS显示文摘An environmental friendly anodizing treatment (Anomag) from a phosphate-based so lution without heavy metals on AZ91D magnesium alloy was studied. The characteri stics of the coatings, such as structure, composition and corrosion resistance w ere investigated. The effects of this anodizing treatment on the mechanical prop erties were examined. X-ray diffraction (XRD) analysis revealed that the structu re of the coatings is amorphous or glassy. In salt spray tests coatings with an average thickness of 10μm had an anticorrosive performance of over 1000 hours. Fatigue tests revealed that anodizing onto AZ91D magnesium alloy does not affect the fatigue strength. These results demonstrate the utility of this anodizing t reatment on magnesium alloy for application as a structural material, such as in the automotive field. | A. Saijo M. Hino M. Hiramatsu T. Kanadani | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，3： | 3 |
| 10 | Rapid nondestructive screening for melamine in dried milk by Raman spectroscopy显示文摘 | Shigetoshi Okazaki Mitsuo Hiramatsu Kunio Gonmori Osamu Suzuki Anthony T. Tu | 2009 | Forensic Toxicology2009，，2： | 2 |
| 11 | Contrast-enhanced endoscopic ultrasonography in digestive diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Hiroyuki Sugimoto Hajime Sumi Daijiro Hayashi Naoki Ohmiya Ryoji Miyahara Masanao Nakamura Kohei Funasaka Masatoshi Ishigami Yoshiaki Katano Hidemi Got | 2012 | Journal of Gastroenterology2012，，10： | 2 |
| 12 | Contrast-enhanced endoscopic ultrasonography in digestive diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Hiroyuki Sugimoto Hajime Sumi Daijiro Hayashi Naoki Ohmiya Ryoji Miyahara Masanao Nakamura Kohei Funasaka Masatoshi Ishigami Yoshiaki Katano Hidemi Got | 2012 | Journal of Gastroenterology2012，，10： | 2 |
| 13 | Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis显示文摘 | Yoshio Katamura Hiroshi Aikata Shintaro Takaki Takahiro Azakami Tomokazu Kawaoka Koji Waki Akira Hiramatsu Yoshiiku Kawakami Shoichi Takahashi Masahiro Kenjo Naoyuki Toyota Katsuhide Ito Kazuaki Chayama | 2009 | Journal of Gastroenterology2009，，5： | 2 |
| 14 | Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma显示文摘 | Yohji Honda Tomoki Kimura Hiroshi Aikata Tomoki Kobayashi Takayuki Fukuhara Keiichi Masaki Takashi Nakahara Noriaki Naeshiro Atsushi Ono Daisuke Miyaki Yuko Nagaoki Tomokazu Kawaoka Shintaro Takaki Akira Hiramatsu Masaki Ishikawa Hideaki Kakizawa Masahiro | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
| 15 | U-50488H,a selective kappa-opioid receptor agonist,improves carbon monoxide-induced delayed amnesia in mice显示文摘 | Hyodo T Kameyama T | 1996 | Eur J Pharmacol1996，315，2： | 1 |
| 16 | NOD/SCID/γcnullmouse:an excellent recipient mousemodel for engraftment of human cells显示文摘 | Ito M Hiramatsu H Kobayashi K | 2002 | Blood2002，100，9： | 1 |
| 17 | Ahemative expression of achitosanase gene produces two different proteins in cells infected withchlorella virus CVK2显示文摘 | YAMADA T HIRAMATSU S SONGSRI P | 1997 | Virology1997，230，2： | 1 |
| 18 | Effects of size and shape (aspect ratio) on the hemodynemics of saccular aneurysms:a possible index for surgical treatment of intracranial aneurysms显示文摘 | Ujiie H Tachibana H Hiramatsu O | 1999 | J Neurosurg1999，45，1： | 1 |
| 19 | Urinary and plasma epidermal growth factor levels are decreased in neonates with intrauterine growth retardation and in their mother显示文摘 | Shigeta K Hiramatsu Y Eguchi K | 1992 | Biol-Nconate1992，62，23： | 1 |
| 20 | Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo 显示文摘 | Yada T Shimokawa H Hiramatsu O | 2005 | J Am Coll Cardiol2005，45，4： | 1 |
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