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| 1 | Effects of a 24-week course of interferon-αtherapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma显示文摘AIM:To assess whether a 24-wk course of interferon (IFN)could prevent hepatocellular carcinoma(HCC) recurrence and worsening of liver function in patients with hepatitis C virus(HCV)-infected patients after receiving curative treatment for primary HCC. METHODS:Outcomes in 42 patients with HCV infection treated with IFN-α,after curative treatment for primary HCC(IFN group),were compared with 42 matched curatively treated historical controls not given IFN(non- IFN group). RESULTS:Although the rate of initial recurrence did not differ significantly between IFN group and non-IFN group (0%,44%,61%,and 67% vs 4.8%,53%,81%,and 87% at 1,3,5,and 7 years,P=0.153,respectively), IFN group showed a lower rate than the non-IFN group for second recurrence(0%,10.4%,28%,and 35% vs 0%,30%,59%,and 66% at 1,3,5 and 7 years, P=0.022,respectively).Among the IFN group,patients with sustained virologic response(SVR)were less likely to have a second HCC recurrence than IFN patients without an SVR,or non-IFN patients.Multivariate analysis identified the lack of SVR as the only independent risk factor for a second recurrence,while SVR and Child-Pugh class A independently favored overall survival. CONCLUSION:Most intrahepatic recurrences of HCV- related HCC occurred during persistent viral infection. Eradication of HCV is essential for the prevention of HCC recurrence and improvement of survival. | Soo Cheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro Takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，40： | 3 |
| 2 | Low-dose intermittent interferon-alpha therapy for HCV-related liver cirrhosis after curative treatment of hepatocellular carcinoma显示文摘AIM: To assess the efficacy of low-dose intermittent interferon (IFN) therapy in patients with hepatitis C virus (HCV)-related compensated cirrhosis who had received curative treatment for primary hepatocellular carcinoma (HCC). METHODS: We performed a prospective case controlled study. Sixteen patients received 3 MIU of natural IFN- alpha intramuscularly 3 times weekly for at least 48 wk (IFN group). They were compared with 16 matched historical controls (non-IFN group). RESULTS: The cumulative rate of first recurrence of HCC was not significantly different between the IFN group and the non-IFN group (0% vs 6.7% and 68.6% vs 80% at 1- and 3-year, P = 0.157, respectively). The cumulative rate of second recurrence was not also significantly different between the IFN group and the non-IFN group (0% vs 6.7% and 35.9% vs 67% at 1- and 3-year, P = 0.056, respectively). Although the difference in the Child-Pugh classification score between the groups at initial treatment of HCC was not signifi cant, the score was signifi cantly worse at the time of data analysis in the non-IFN group than IFN group (7.19 ± 1.42 vs 5.81 ± 0.75, P = 0.0008). The cumulative rate of deviation from objects of any treatment for recurrentHCC was also higher in the non-IFN group than IFN group (6.7% and 27% vs 0 and 0% at 1- and 3-year, P = 0.048, respectively). CONCLUSION: Low-dose intermittent IFN-alpha therapy for patients with HCV-related compensated cirrhosis after curative HCC treatment was effective by making patients tolerant to medical or surgical treatment for recurrent HCC in the later period of observation. | Soocheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro Takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，39： | 2 |
| 3 | Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis显示文摘 | Yoshio Katamura Hiroshi Aikata Shintaro Takaki Takahiro Azakami Tomokazu Kawaoka Koji Waki Akira Hiramatsu Yoshiiku Kawakami Shoichi Takahashi Masahiro Kenjo Naoyuki Toyota Katsuhide Ito Kazuaki Chayama | 2009 | Journal of Gastroenterology2009，，5： | 2 |
| 4 | E//ect of protease digestion and dephosphorylation on high emulsifying properties of hen egg yolk phosvitin显示文摘 | Khan M S Babiker E E Azakami H | 1998 | Journal of Agricultural and Food Chemistry1998，46，： | 1 |
| 5 | Effect of chemical andgenetic attachment of polysaccharides to proteins on the productionof IgG and IgE显示文摘 | Arita K Babiker E E Azakami H | 2001 | Journal of Agricultural and Food Chemistry2001，49，4： | 1 |
| 6 | In vivo glycosylation suppresses the aggregation of amyloidogenic hen egg white lysozymes expressed in yeast显示文摘 | Youtao Song Hiroyuki Azakami Mika Hamasu | 2001 | Federation of European Biochemical Societies2001，491，1： | 1 |
| 7 | Effects of Er: YAG la- ser irradiation on biofilm-forming bacteria associated with endo- dontic pathogens in vitro显示文摘 | Noiri Y Katsumoto T Azakami H | 2008 | J Endod2008，34，7： | 1 |
| 8 | Effect of chemical and genetic attachment of polysaccharides to proteins on the production of IgG and IgE 显示文摘 | ATITA K BABIKER E AZAKAMI H | 2001 | Journal of Agricultural and Food Chemistry2001，49，： | 1 |
| 9 | Purification, characteriza- tion, and crystallization of monoamine oxidase from Eschenchia coli K-12显示文摘 | ROH J H SUZUKI H AZAKAMI H | 1994 | Biosei Bioteehnol Bioehem1994，58，9： | 1 |
| 10 | Effect of protease digestion and dephosphorylation on high e- mulsifying properties of aen egg yolk phosvitin 显示文摘 | Khan M A S Babiker E E Azakami H | 1998 | J Agric Food Chem1998，46，12： | 1 |
| 11 | Effect of chenfical and genetic attachment of polysaccharides to proteins on the production of IgG and IgE显示文摘 | Arita K Babiker E E Azakami H | 2001 | J Agric Food Chem2001，49，20： | 1 |
| 12 | Effect of polysaccharide conjugation or transglutaminase treatment on the aller- genicity and fimctional properties of soy protein 显示文摘 | Babiker E E Azakami H Matsudomi N | 1998 | Journal of Agricultural and Food Chemistry1998，46，： | 1 |
| 13 | Effect of chemical and genetic attachment of polysaccharides to proteins on the production of Ig G and Ig E 显示文摘 | Arita K Babiker E E Azakami H | 2001 | Journal of Agricultural and Food Chemistry2001，49，： | 1 |
| 14 | Effects of Er: YAG laser irradiation on biofilm-forming bacteria associated with en- dodontic pathogens in vitro显示文摘 | Noiri Y Katsumoto T Azakami H | 2008 | JEndod2008，34，7： | 1 |
| 15 | Effects of Er:YAG Laser Irradiation on Bio film-forming Bacteria Associated with Endodontic Pathogens In Vitro显示文摘 | Noiri Y Katsumoto T Azakami H | | 0，，07： | 1 |
| 16 | Effect of protease digestion and dephosphorylation on high emulsifying properties of hen egg yolk phosvitin显示文摘 | Khan M A S Babiker E E Azakami H | 1998 | Journal of Agricultural and Food Chemistry1998，46，12： | 1 |
| 17 | Utilization of Alcohols for the Dehydration of Magnesium chloride显示文摘 | Zhang Duomo Azakami Takeshi Yazawa Akira | 1992 | Candian Metallurgical Quarterly1992，，6： | 1 |
| 18 | Beneficial effects of living-donor liver transplantation on esophageal varices显示文摘 | Tomokazu Kawaoka Shoichi Takahashi Hiroshi Aikata Takahiro Azakami Hiromi Saneto Shintaro Takaki Soo Cheol Jeong Toshimasa Asahara Katsuhide Ito Kazuaki Chayama | 2008 | Journal of Gastroenterology2008，，12： | 1 |
| 19 | Effect of protease digestion and dephosphorylation on high emul- sifying properties of hen egg yolk phosvitin 显示文摘 | Sattar Khan M A Babiker E E Azakami H | 1998 | Journal of Agricultural and Food Chemistry1998，46，： | 1 |
| 20 | A thermodynamic study of copper-iron and copper-cobalt liquid alloys by mass spectrometry 显示文摘 | TIMBERG L TOGURI J M AZAKAMI T | 1981 | Metall Trans B1981，12，： | 1 |
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