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	题名	作者	年代	出处	被引量
1	Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice.	Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip	2014	World Journal of Gastroenterology2014，20，24：	2
2	Nitrification of municipal wastewater in moving bed biofilm reactors显示文摘	HEM J ODEGAARD H	1995	Wat Environ Res1995，67，1：	1
3	Nitrogen removal from dilute wastewater in cold climate using moving bed reactors 显示文摘	Rusten B Hem L Φdegard H	1995	Water Environ Res1995，67，1：	1
4	Provenance associations as core values of place umbrella brands:A framework of characteristics显示文摘	IVERSEN N HEM L	2008	European Journal of Marketing2008，42，56：	1
5	Antimicrobial activity of polysaccharide films containing essential oils显示文摘	Sanchez-González L Cháler M Hemández M		0，，08：	1
6	Prognostic marker of colorectal cancer:an evaluation of DNA content,epidermal growth factor receptor,and ki-67显示文摘	Hemming A W Davis N L Kluftinger A		0，，03：	1
7	Thyroid cancer in children: the Royal Marsden Hospital experience 显示文摘	Landau D Vini L A'Hem - R	1998	Head Neck1998，20，：	1
8	Medullary thyroid cancer: multivariate analysis of prognostic factors influencing survival 显示文摘	Hyer SL Vini L A'Hem R	2000	Eur J Surg Oneol2000，26，7：	1
9	Investigating the role of the brain-derived neurotrophic factor (BDNF) va166met variant in obsessive-compulsive disorder (OCD) 显示文摘	HEMMINGS S M KINNEAR C J van der MERWE L et al	2008	World J Biol Psychiatry2008，9，2：	1
10	Clinical performance of university nursing graduates显示文摘	BATTERSBY D HEMMINGS L	1991	The Australian Journal of Advanced Nursing1991，9，1：	1
11	Glucoamylase overexpression and secretion in Aspergillus niger: analysis of glycosylation显示文摘	Wallis G L Swift R J Hemming F W	1999	Biochimica et Biophysica Acta1999，1472，3：	1
12	Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。	Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís	2015	Journal of Geriatric Cardiology2015，12，4：	1
13	The speciWcity of polygalacturonaseinhibiting protein (PGIP) : a single amino acid substitution in the solvent-exposed β-strand/13-turn region of the leucine-rich repeats (LRRs) conferconfers a new recognition capability 显示文摘	Leckie F Mattei B Capodicasa C Hemmings A Nuss L Aracri B DeLorenzo G Cervone F		The EMBO J0，18，：	1
14	Nitrification in a moving bed biofilm reactor显示文摘	Hem L Rusten B φdegaard H	1994	Water Research1994，28，6：	1
15	The future is now: Model‐based clinical trial design for Alzheimer’s disease显示文摘	K Romero K Ito JA Rogers D Polhamus R Qiu D Stephenson R Mohs R Lalonde V Sinha Y Wang D Brown M Isaac S Vamvakas R Hemmings L Pani LJ Bain B Corrigan	2015	Clin. Pharmacol. Ther2015，，3：	1
16	Oscillating glacial northern and southern deep water formation from combined neodymium and carbon isotopes显示文摘	Piotrowski A W Goldstein S L Hemming S R	2008	Earth and Planetary Science Letters2008，272，：	1
17	Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase显示文摘	Filippa N Sable C L Filloux C Hemmings B Obberghen E V	1999	Mol Cell Biol1999，19，：	1
18	The diagnostic value and molecular characterization of an Echinococcous multilocularis antigen gene clone 显示文摘	McManus DP	1991	Mol Biochem Parasitol1991，44，1：	1
19	BDNF Val66Met andDRD2 TaqlA polymorphisms interact to influence PTSD symptom se-verity :a preliminary investigation in a South African population显示文摘	Hemmings S Martin L Klopper M	2013	Prog Neuropsychopharmacol Biol Psychiatry2013，40，：	1
20	High-performance liquid chromatographic determination of chitin in the snow crab, chionoecetes opilio 显示文摘	Pun' m Crespo M O Vilasoa Mart' mez M L' opez Hem' andez J	2006	Journal of Chromatography A2006，1116，：	1

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