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| 1 | Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization显示文摘 | Yuli Lin Xuguang Yang Wenjie Yue Xiaofei Xu Bingji Li Linlin Zou Rui He | 2014 | Cellular & Molecular Immunology2014，11，4： | 21 |
| 2 | CAS FGOALS-f3-L Model Datasets for CMIP6 Historical Atmospheric Model Intercomparison Project Simulation显示文摘The outputs of the Chinese Academy of Sciences(CAS) Flexible Global Ocean–Atmosphere–Land System(FGOALS-f3-L) model for the baseline experiment of the Atmospheric Model Intercomparison Project simulation in the Diagnostic,Evaluation and Characterization of Klima common experiments of phase 6 of the Coupled Model Intercomparison Project(CMIP6) are described in this paper. The CAS FGOALS-f3-L model, experiment settings, and outputs are all given. In total,there are three ensemble experiments over the period 1979–2014, which are performed with different initial states. The model outputs contain a total of 37 variables and include the required three-hourly mean, six-hourly transient, daily and monthly mean datasets. The baseline performances of the model are validated at different time scales. The preliminary evaluation suggests that the CAS FGOALS-f3-L model can capture the basic patterns of atmospheric circulation and precipitation well, including the propagation of the Madden–Julian Oscillation, activities of tropical cyclones, and the characterization of extreme precipitation. These datasets contribute to the benchmark of current model behaviors for the desired continuity of CMIP. | Bian HE Qing BAO Xiaocong WANG Linjiong ZHOU Xiaofei WU Yimin LIU Guoxiong WU Kangjun CHEN Sicheng HE Wenting HU Jiandong LI Jinxiao LI Guokui NIAN Lei WANG Jing YANG Minghua ZHANG Xiaoqi ZHANG | 2019 | Advances in Atmospheric Sciences2019，36，8： | 12 |
| 3 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 4 | Single event upset rate modeling for ultra-deep submicron complementary metal-oxide-semiconductor devices显示文摘Based on the integral method of single event upset(SEU) rate and an improved charge collection model for ultra-deep submicron complementary metal-oxide-semiconductor(CMOS) devices, three methods of SEU rate calculation are verified and compared. The results show that the integral method and the figure of merit(FOM) methods are basically consistent at the ultra-deep submicron level. By proving the validity of the carrier collection model considering charge sharing, the applicability of two FOM methods is verified, and the trends of single-bit and multiple-bit upset rates for ultra-deep submicron CMOS are analyzed. | Liang HE Hua CHEN Peng SUN Xiaofei JIA Chongguang DAI Jing LIU Long SHAO Zhaoqing LIU | 2016 | Science China(Information Sciences)2016，59，4： | 5 |
| 5 | CAS FGOALS-f3-L Model Datasets for CMIP6 GMMIP Tier-1 and Tier-3 Experiments显示文摘The Chinese Academy of Sciences(CAS)Flexible Global Ocean Atmosphere Land System(FGOALS-f3-L)model datasets prepared for the sixth phase of the Coupled Model Intercomparison Project(CMIP6)Global Monsoons Model Intercomparison Project(GMMIP)Tier-1 and Tier-3 experiments are introduced in this paper,and the model descriptions,experimental design and model outputs are demonstrated.There are three simulations in Tier-1,with different initial states,and five simulations in Tier-3,with different topographies or surface thermal status.Specifically,Tier-3 contains four orographic perturbation experiments that remove the Tibetan Iranian Plateau,East African and Arabian Peninsula highlands,Sierra Madre,and Andes,and one thermal perturbation experiment that removes the surface sensible heating over the Tibetan Iranian Plateau and surrounding regions at altitudes above 500 m.These datasets will contribute to CMIP6’s value as a benchmark to evaluate the importance of long-term and short-term trends of the sea surface temperature in monsoon circulations and precipitation,and to a better understanding of the orographic impact on the global monsoon system over highlands. | Bian HE Yimin LIU Guoxiong WU Qing BAO Tianjun ZHOU Xiaofei WU Lei WANG Jiandong LI Xiaocong WANG Jinxiao LI Wenting HU Xiaoqi ZHANG Chen SHENG and Yiqiong TANG | 2020 | Advances in Atmospheric Sciences2020，37，1： | 4 |
| 6 | Adaptive Cascaded High-Resolution Source Localization Based on Collaboration of Multi-UAVs显示文摘Effective information fusion is very important in hybrid source localization. In this paper, the performance analysis of conventional joint direction of arrival(DOA) and time difference of arrival(TDOA) system is derived and it is shown that this hybrid system may inferior to the single system when the ratio of angular measurements error to distance measurements error exceeds a threshold. To avoid this problem, an effective DOA/TDOA adaptive cascaded(DTAC) technique is presented. The rotation feature of UAVs and spatial filtering technique are applied to gain the signal-to-noise ratio(SNR), which leads to more accurate estimation of time delay by using DOAs. Nevertheless, the time delay estimation precision is still limited by the sampling frequency, which is constrained by the finite load of UAV. To break through the limitation, an enhanced self-delay-compensation(SDC) method is proposed, which aims at detecting the overlooked time delay within the sampling interval by adding a tiny time delay. Finally, the position of the source is estimated by the Chan algorithm. Compared to DOA-only algorithm, TDOA-only algorithm and joint DOA/TDOA(JDT) algorithm, the proposed method shows better localization accuracy regardless of different SNRs and sampling frequencies. Numerical simulations are presented to validate the effectiveness and robustness of the proposed algorithm. | Yi He Jianfeng Li Xiaofei Zhang | 2020 | China Communications2020，17，4： | 4 |
| 7 | Robust non-negative matrix factorization显示文摘Non-negative matrix factorization(NMF)is a recently popularized technique for learning partsbased,linear representations of non-negative data.The traditional NMF is optimized under the Gaussian noise or Poisson noise assumption,and hence not suitable if the data are grossly corrupted.To improve the robustness of NMF,a novel algorithm named robust nonnegative matrix factorization(RNMF)is proposed in this paper.We assume that some entries of the data matrix may be arbitrarily corrupted,but the corruption is sparse.RNMF decomposes the non-negative data matrix as the summation of one sparse error matrix and the product of two non-negative matrices.An efficient iterative approach is developed to solve the optimization problem of RNMF.We present experimental results on two face databases to verify the effectiveness of the proposed method. | Lijun ZHANG Zhengguang CHEN Miao ZHENG Xiaofei HE | 2011 | Frontiers of Electrical and Electronic Engineering in China2011，6，2： | 4 |
| 8 | VMStore: Distributed storage system for multiple virtual machines显示文摘Desktop virtualization is a very hot concept in both industry and academic communities. Since virtualized desktop system is based on multiple virtual machines (VM), it is necessary to design a distributed storage system to manage the VM images. In this paper, we design a distributed storage system, VMStore, by taking into account three important characteristics: high performance VM snapshot, booting optimization from multiple images and redundancy removal of images data. We adopt a direct index structure of blocks for VM snapshots to speed up VM booting performance significantly; provide a distribute storage structure with good bandwidth scalability by dynamically changing the number of storage nodes; and propose a data preprocessing strategy with intelligent object partitioning techniques, which would eliminate duplication more effectively. Performance analysis for VMStore focuses on two metrics: the speedup of VM booting and the overhead of de-duplication. Experimental results show the efficiency and effectiveness of VMStore. | LIAO XiaoFei LI He JIN Hai HOU HaiXiang JIANG Yue & LIU HaiKun | 2011 | Science China(Information Sciences)2011，54，6： | 3 |
| 9 | Carbonaceous matter in glacier at the headwaters of the Yangtze River:Concentration,sources and fractionation during the melting process显示文摘Carbonaceous matter has an important impact on glacial retreat in the Tibetan Plateau,further affecting the water resource supply.However,the related studies on carbonaceous matter are still scarce in Geladaindong(GLDD)region,the source of the Yangtze River.Therefore,the concentration,source and variations of carbonaceous matter at Ganglongjiama(GLJM)glacier in GLDD region were investigated during the melting period in 2017,which could deepen our understanding on carbonaceous matter contribution to glacier melting.The results showed that dissolved organic carbon(DOC)concentration of snowpit samples(283±200μg/L)was much lower than that of precipitation samples(624±361μg/L),indicating that large parts of DOC could be rapidly leached from the snowpit during the melting process.In contrast,refractory black carbon(rBC)concentration measured by Single Particle Soot Photometer of snowpit samples(4.27±3.15μg/L)was much higher than that of precipitation samples(0.97±0.49μg/L).Similarly,DOC with high mass absorption cross-section measured at 365 nm value was also likely to enrich in snowpit during the melting process.In addition,it was found that both r BC and DOC with high light-absorbing ability began to leach from the snowpit when melting process became stronger.Therefore,rBC and DOC with high light-absorbing ability exhibited similar behavior during the melting process.Based on relationship among DOC,rBC and K^+ in precipitation,the main source of carbonaceous matter in GLJM glacier was biomass burning during the study period. | Zhaofu Hu Shichang Kang Xiaobo He Fangping Yan Yulan Zhang Pengfei Chen Xiaofei Li Shaopeng Gao Chaoliu Li | 2020 | Journal of Environmental Sciences2020，32，1： | 3 |
| 10 | H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of lung alveolar epithelial cells显示文摘The H7N9 influenza virus emerged in China in 2013,causing more than 1560 human infections,39% of which were fatal.A ‘cytokine storm’ in the lungs of H7N9 patients has been linked to a poor prognosis and death;however,the underlying mechanism that triggers the cytokine storm is unknown.Here,we found that efficient replication of the H7N9 virus in mouse lungs activates gasdermin E(GSDME)-mediated pyroptosis in alveolar epithelial cells,and that the released cytosolic contents then trigger a cytokine storm.Knockout of Gsdme switched the manner of death of A549 and human primary alveolar epithelial cells from pyroptosis to apoptosis upon H7N9 virus infection,and Gsdme knockout mice survived H7N9 virus lethal infection.Our findings reveal that GSDME activation is a key and unique mechanism for the pulmonary cytokine storm and lethal outcome of H7N9 virus infection and thus opens a new door for the development of antivirals against the H7N9 virus. | Xiaopeng Wan Jiqing Li Yupeng Wang Xiaofei Yu Xijun He Jianzhong Shi Guohua Deng Xianying Zeng Guobin Tian Yanbing Li Yongping Jiang Yuntao Guan Chengjun Li Feng Shao Hualan Chen | 2022 | National Science Review2022，9，1： | 3 |
| 11 | Multiple Emitters Localization by UAV with Nested Linear Array:System Scheme and 2D-DOA Estimation Algorithm显示文摘Unmanned Aerial Vehicle(UAV)equipped with uniform linear array has been applied to multiple emitters localization.Meanwhile,nested linear array enables to enhance localization resolution and achieve under-determined Direction of Arrival(DOA)estimation.In this paper,we propose a new system structure for emitters localization that combines the UAV with nested linear array,which is capable of significantly increasing the positioning accuracy of interested targets.Specifically,a localization scheme is designed to obtain the paired two-dimensional DOA(2D-DOA,i.e.azimuth and elevation angles)estimates of emitters by nested linear array with UAV.Furthermore,we propose an improved DOA estimation algorithm for emitters localization that utilizes Discrete Fourier Transform(DFT)method to obtain coarse DOA estimates,subsequently,achieve the fine DOA estimates by sparse representation.The proposed algorithm has lower computational complexity because the coarse DOA estimates enable to shrink the range of over-complete dictionary of sparse representation.In addition,compared to traditional uniform linear array,improved 2D-DOA estimation performance of emitters can be obtained with a nested linear array.Extensive simulation results testify the effectiveness of the proposed method. | Xinping Lin Xiaofei Zhang Lang He Wang Zheng | 2020 | China Communications2020，17，3： | 2 |
| 12 | A Breeding Method for New Lodging Resistant Rice Varieties Based on Phenotype显示文摘The concept of lodging resistance core traits and their screening principles were first proposed on the basis of previous research.Afterwards,a lodging resistance breeding method based on phenotypic trait index was proposed based on a case study of screening lodging resistant aromatic rice by Yuehesimiao and Xiangyaxiangzhan.In other words,the materials that meet the breeding goals could be selected quickly by constructing breeding population and referring to lodging resistance core traits in each generation.Eventually,the advantages and disadvantages of the method were analyzed in combination with the actual situation,in order to provide the reference for rice breeding researchers. | Wang Xiaofei He Xiuying Lu Zhanhua Liu Wei Lu Dongbai Wang Shiguang Xue Jiao | 2020 | Plant Diseases and Pests2020，11，4： | 2 |
| 13 | Aggregation-enhanced emission and efficient electroluminescence of conjugated polymers containing tetraphenylethene units显示文摘Tetraphenylethene (TPE) is a popular luminogen characterized by aggregation-induced emission and has been widely used to construct solid-state emissive materials. In this work, two thermally stable polymers (P1 and P2) consisting of TPE conjugated to the 2,7-positions of fluorene and carbazole, respectively, are synthesized and characterized. Both polymers are weakly fluorescent in solutions but show greatly enhanced emission as the aggregate formation, presenting an aggregation-enhanced emission feature. Two kinds of polymer light-emitting diodes are fabricated utilizing P1 and P2 as emitters (EML) (device I: ITO/PEDOT:PSS (45 nm)/PVK:EML (1:1 wt%, 55 nm)/TPBI (38 nm)/Ca:Ag; device II: ITO/PEDOT:PSS (45 nm)/ PVK:OXD-7:EML (3:1:3 wt%, 55 nm)/TPBI (38 nm)/Ca:Ag). The device II of P2 shows the best performances, affording a maximum luminance of 6500 cd/m 2 and a high peak efficiency of 2.11 cd/A. | HE BaiRong YE ShangHui GUO YanJu CHEN Bin XU XiaoFei QIU HuaYu ZHAO ZuJin | 2013 | Science China Chemistry2013，56，9： | 2 |
| 14 | Research Progress of Bactrocera(Zeugodacus) scutellata(Hendel)(Diptera: Tephritidae)显示文摘The stripped fruit fly,Bactrocera( Zeugodacus) scutellata( Hendel),is one of the most dangerous quarantine insect pests in China. Due to its wide distribution and heavy damage,it has caused serious economic losses in fruit and vegetable production in China. This paper assembles research progresses in morphological characteristics,classification status,host ranges,geographical distribution,population dynamics,molecular ecology and biology of B. scutellata,and put forward the following research prospects as well. | Jin Yan Liu Xiaofei He Xingcai Ye Hui | 2015 | Plant Diseases and Pests2015，6，3： | 2 |
| 15 | Challenges and opportunities for managing pediatric central nervous system tumors in China显示文摘Central nervous system(CNS)tumors represent the most deadly cancer in pediatric age group.In China,thousands of children are diagnosed with CNS tumors every year.Despite the improving socioeconomic status and availability of medical expertise within the country,unique challenges remain for the delivery of pediatric neuro-oncology service.In this review,we discuss the existing hurdles for improving the outcome of children with CNS tumors in China.Need for precise disease burden estimation,lack of intra-and inter-hospital collaborative networks,high probability of treatment abandonment,along with financial toxicities from treatment represent the key challenges that Chinese healthcare providers encounter.The tremendous opportunities for advancing the status of pediatric neuro-oncology care in and beyond the country are explored. | Anthony Pak-Yin Liu Daniel CMoreira Chenchen Sun Lisa Krull Yijin Gao Bo Yang Chenran Zhang Kejun He Xiaojun Yuan Godfrey Chi-Fung Chan Xiaofei Sun Xiaoli Ma Ibrahim AQaddoumi | 2020 | Pediatric Investigation2020，4，3： | 2 |
| 16 | Structures of a P4-ATPase lipid flippase in lipid bilayers显示文摘Dear Editor,Phospholipid molecules are unevenly distributed in membrane bilayers of eukaryotic cells.Phosphatidylethanolamine(PE)and phosphatidylserine(PS)are concentrated in the cytoplasmic leaflet,whereas phosphatidylcholine(PC)is enriched in the exoplasmic leaflet(lumenal or extracellular leaflet)(van Meer et al.2008).Type 4 P-type ATPases(P4-ATPases)are the phospholipid flippases which move specific lipids from the exoplasmic leaflet to the cytoplasmic leaflet.P4-ATPases belong to the P-type ATPase family.P4-ATPases are conserved in eukaryotes. | Yilin He Jinkun Xu Xiaofei Wu Long Li | 2020 | Protein & Cell2020，11，6： | 2 |
| 17 | Controllable synthesis of grain boundary-enriched Pt nanoworms decorated on graphitic carbon nanosheets for ultrahigh methanol oxidation catalytic activity显示文摘Although one-dimensional Pt nanocrystals have long been regarded as ideal electrode catalysts for fuel cells,the synthetic techniques commonly involve the use of various complicated templates or surfactants,which have largely hampered their large-scale industrial application.Herein,we present a convenient and cost-effective approach to the stereoassembly of quasi-one-dimensional grain boundary-enriched Pt nanoworms on nitrogen-doped low-defect graphitic carbon nanosheets(Pt NWs/NL-CNS).Benefiting from its numerous catalytically active grain boundaries as well as optimized electronic structure,the as-derived Pt NWs/NL-CNS catalyst possesses exceptionally good electrocatalytic properties for methanol oxidation,including an ultrahigh mass activity of 1949.5 mA mg^(-1), reliable long-term durability,and strong poison tolerance,affording one of the most active Pt-based electrocatalysts for methanol oxidation reaction.Density functional theory calculation further reveals that the formation of worm-shape Pt morphology is attributed to the modified electronic structure as well as controllable defect density of the carbon matrix,which could also weaken the adsorption ability of Pt towards CO molecule and meanwhile synergistically promotes the catalytic reaction kinetics. | Huajie Huang Yujie Wei Ying Yang Minmin Yan Haiyan He Quanguo Jiang Xiaofei Yang Jixin Zhu | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 18 | Face recognition using laplacianfaces显示文摘 | He Xiaofei Yan Shuicheng Hu Yuxiao | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence2005，27，3： | 1 |
| 19 | Document Clustering Using Locality Preserving Indexing显示文摘 | Cai Deng He Xiaofei Han Jiawei | 2005 | Knowledge and Data Engineering2005，17，12： | 1 |
| 20 | Squeezer: an efficient algorithm for clustering categorical data显示文摘 | HE Zengyou XU Xiaofei DENG Shengchun | 2002 | Jounranl of Computer Science and Technology2002，17，5： | 1 |
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