|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of Gubenfangxiao decoction on respiratory syncytial virus-induced asthma and expression of asthma susceptibility gene orosomucoid 1-like protein 3 in mice显示文摘OBJECTIVE: To investigate the effect of Gubenfangxiao decoction(GBFXD) on respiratory-syncytial-virus(RSV)-induced asthma and the expression of asthma susceptibility gene, orosomucoid 1-like protein 3(ORMDL3) in mice.METHODS: Seventy-two female BALB/c mice were randomly assigned to normal, model, GBFXD high dose, GBFXD moderate dose, GBFXD low dose and montelukast groups. An asthma model was induced via intraperitoneal injection and aerosol inhalation of ovalbumin(OVA) and repeated intranasal instillation of RSV in all mice, except those in the normal group. All treatments were administered at the first onset of asthma(within 8 weeks of model establishment) and the mice were euthanized after 28 days of treatment. The levels of transforming growth factor-β(TGF-β) and interleukin-6(IL-6) in bronchoalveolar lavage fluid(BALF) of the mice were measured and the expression of asthma susceptibility gene ORMDL3 in lung tissue was determined using real-time polymerase chain reaction(RT-PCR) and western blotting.RESULTS: Expression of ORMDL3 and levels of TGF-β and IL-6 were significantly higher in the model group(P < 0.05, P < 0.01) compared with the normal mice. Levels of ORMDL3, TGF-β and IL-6 were significantly lower in all three GBFXD treated groups(P < 0.05) compared with the model group.However, the levels in the GBFXD treatment groups did not differ significantly from the montelukast group.CONCLUSION: GBFXD had a therapeutic effect in this experimental model. The functional mechanism of GBFXD may involve multiple factors, including alleviation of airway inflammation, down-regulation of asthma susceptibility gene ORMDL3 and inhibition of airway remodeling. | Huang Zhengguang Gao Lijuan Zhao Xia Ling Hao Chen Wenjun | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 7 |
| 2 | TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-αpathway显示文摘Background:Inflammation is a complex physiological and pathological process.Although many types of inflammation are well characterized,their physiological func-tions are largely unknown.tRNA aspartic acid methyltransferase 1(TRDMT1)has been implicated as a stress-related protein,but its intrinsic biological role is unclear.Methods:We constructed a Trdmt1 knockout rat and adopted the LPS-induced sepsis model.Survival curve,histopathological examination,expression of inflammatory fac-tors,and protein level of TLR4 pathway were analyzed.Results:Trdmt1 deletion had no obvious impact on development and growth.Trdmt1 de-letion slightly increased the mortality during aging.Our data showed that Trdmt1 strongly responded in LPS-treated rats,and Trdmt1 knockout rats were vulnerable to LPS treat-ment with declined survival rate.We also observed more aggravated tissue damage and more cumulative functional cell degeneration in LPS-treated knockout rats compared with control rats.Further studies showed upregulated TNF-αlevel in liver,spleen,lung,and serum tissues,which may be explained by enhanced p65 and p38 phosphorylation.Conclusions:Our data demonstrated that Trdmt1 plays a protective role in inflamma-tion by regulating the TLR4-NF-κB/MAPK-TNF-αpathway.This work provides useful information to understand the TRDMT1 function in inflammation. | Zhengguang Li Xiaolong Qi Xu Zhang Lei Yu Lijuan Gao Weining Kong Wei Chen Wei Dong Lijun Luo Dan Lu Lianfeng Zhang Yuanwu Ma | 2022 | Animal Models and Experimental Medicine2022，5，2： | 5 |
| 3 | Research on Testing Technology of Relay Protection for Intelligent Substations显示文摘Intelligent substations adopt various kinds of new technologies, including information sharing technology based on IEC61850, digital sampling technology, synchronization technology, and network transmission technology. Relay protection equipment faces all the challenges brought by the application of these new technologies. After analyzing the demand for test, the authors propose testing methods and technical requirements targeting the test items in great need, including ICD model file test, digital interface performance test, coordination performance test with merging unit and smart terminal, network pressure test. And the problems occurring during the tests are summarized. | Zhan Rongrong Li Yanjun Zhang Xiaoli Zhan Zhihua Yu Yue Chen Zhengguang | 2014 | Electricity2014，25，5： | 5 |
| 4 | Robust non-negative matrix factorization显示文摘Non-negative matrix factorization(NMF)is a recently popularized technique for learning partsbased,linear representations of non-negative data.The traditional NMF is optimized under the Gaussian noise or Poisson noise assumption,and hence not suitable if the data are grossly corrupted.To improve the robustness of NMF,a novel algorithm named robust nonnegative matrix factorization(RNMF)is proposed in this paper.We assume that some entries of the data matrix may be arbitrarily corrupted,but the corruption is sparse.RNMF decomposes the non-negative data matrix as the summation of one sparse error matrix and the product of two non-negative matrices.An efficient iterative approach is developed to solve the optimization problem of RNMF.We present experimental results on two face databases to verify the effectiveness of the proposed method. | Lijun ZHANG Zhengguang CHEN Miao ZHENG Xiaofei HE | 2011 | Frontiers of Electrical and Electronic Engineering in China2011，6，2： | 4 |
| 5 | Correlation analysis between characteristics under gastroscope and image information of tongue in patients with chronic gastritis显示文摘OBJECTIVE:To explore the correlation between diagnostic information of tongue and gastroscopy results of patients with chronic gastritis.METHODS:Frequent pattern growth(FP-Growth),SPSS Modeler was used to analyze the correlation rules between the image information of tongue parameters and the characteristics of the stomach and duodenum seen under gastroscopy.RESULTS:Ranking in order of confidence:cyanotic tongue,slippery fur,yellow fur and spotted tongue were sequently associated with both gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.L,one value of tongue coating color,which counted among(30,60),tooth-marked tongue and b,one value of tongue coating color,which counted in the range of(5,20)were sequently associated with gastric antrum mucosal erythema/macula.A,one value of tongue body color,which counted in the range of(0,20),was related to both gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.a,one value of tongue coating color,which counted in the range of(15,35),was associated with gastric antrum mucosal erythema/macula.There are a total of 9 strong correlation rules.CONCLUSIONS:Cyanotic tongue,slippery fur,yellow fur,the CIE Lab value of tongue coating,a,the value of tongue body color,spotted tongue,and tooth-marked tongue are all related to the gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.The conditions of gastric mucosa could be predicted by the examination of the above related image information of tongue. | SHANG Zimeng DU Zhengguang GUAN Bei JI Xingyu CHEN Longchang WANG Yongji MA Yun | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 2 |
| 6 | Characterization of mesoporous activated carbons prepared by pyrolysis of sewage sludge with pyrolusite 显示文摘 | CHEN LIU ZHENGGUANG TANG YAO CHEN | 2010 | Bioresource Technology2010，101，3： | 1 |
| 7 | Characterization of mesoporous activated carbons prepared by pyrolysis of sewage sludge with pyrolusite显示文摘 | Chen Liu Zhengguang Tang Yao Chen Shijun Su Wenju Jiang | 2009 | Bioresource Technology2009，，3： | 1 |
| 8 | Mechanism,properities and microstructure of titanium carbide-iron metal-ceramic from ilmenite by in-situ carbothermic reduction显示文摘 | Zou Zhengguang Chen Hanyuan | 2003 | Materials Science Forum2003，，423425： | 1 |
| 9 | Mechanism,properities and microstructure of titanium carbide-iron metal-ceramic from ilmenite by in-situ carbothermic reduction显示文摘 | Zou Zhengguang Chen Hanyuan | 2003 | Mater Sci Forum2003，，： | 1 |
| 10 | The beneficial effect of Rheum tanguticum polysaccharide on protecting against diarrhea, colonic inflammation and ulceration in rats with TNBS-induced colitis: The role of macrophage mannose receptor in inflammation and immune response显示文摘 | Li Liu Zhenjun Guo Zhengguang Lv Yang Sun Wei Cao Rong Zhang Zhenguo Liu Chen Li Shousong Cao Qibing Mei | 2008 | International Immunopharmacology2008，，11： | 1 |
| 11 | Optimization methods of production layer combination for coalbed methane development in multi-coal seams显示文摘Based on the productivity equation of coalbed methane(CBM) wells, three indexes, main production layer optimization index, main production layer expansion index and capacity contribution index are proposed, with which the three-step optimization method of production-layer combination is established. In selecting main production layer, the coal seam thickness, CBM content, coal seam permeability, coal seam reservoir pressure and coal structure are considered comprehensively to evaluate the potential of the production layer. In selecting expansion of the main production layer combination, on the premise of ensuring full and slow desorption of the main production layer and non-exposure of the main production layer out of liquid surface, the degree of mutual interference between the main and non-main production layers is comprehensively evaluated by coupling the critical desorption pressure, layer spacing and reservoir pressure gradient difference. In optimizing production layer combination, the main concern is the economic efficiency of the combined layers. Only when the contribution coefficient of the main production layer is greater than 30% and the contribution index of the other production layers is more than 10%, the economic benefit of a CBM well after being put into production can be ensured. Based on the comparative analysis of the development effect of the development test wells in Songhe of Guizhou province, it is proved that the 'three-step method' for the optimization of production-layer combination is scientific and practical, and can be used to design the multi-layer commingling scheme of coalbed methane. | YANG Zhaobiao ZHANG Zhengguang QIN Yong WU Congcong YI Tongsheng LI Yangyang TANG Jun CHEN Jie | 2018 | Petroleum Exploration and Development2018，45，2： | 1 |
| 12 | Differential diagnosis between malignant and benign hepatic tumors using apparent diffusion coefficient on 1.5-T MR imaging: A meta analysis显示文摘 | Youwei Li Zhengguang Chen Jichen Wang | 2011 | European Journal of Radiology2011，，3： | 1 |
| 13 | Mechanism, properties and microstructure of titanium carbide - iron metal - ceramic from ilmenite by in-situ carbothermic reduction显示文摘 | ZOU Zhengguang CHEN Hanyuan | 2003 | Mater Sci Forum2003，，： | 1 |
| 14 | Characterization of mesoporous activated carbons prepared by pyrolysis of sewage sludge with pyrolusite显示文摘 | Chen Liu Zhengguang Tang Yao Chen | 2010 | Bioresource Technology2010，101，3： | 1 |
| 15 | Characterization of mesoporous activated carbons prepared by pyrolysis of sewage sludge with pyrolusite 显示文摘 | Chen Liu Zhengguang Tang Yao Chert | 2010 | Bioresouree Technology2010，101，3： | 1 |
| 16 | Crystallization behavior and roughing mechanism of poly(ethylene oxide) in polyoxymethylene / poly(ethylene oxide) crystalline / crystalline blends显示文摘 | Liu Yongcheng Zhou Tao Chen Zhengguang | 2014 | Polymers Advanced Technologies2014，25，76： | 1 |
| 17 | Co-evolved plant and blast fungus ascorbate oxidases orchestrate the redox state of host apoplast to modulate rice immunity显示文摘Apoplastic ascorbate oxidases(AOs)play a critical role in reactive oxygen species(RoS)-mediated innate host immunity by regulating the apoplast redox state.To date,little is known about how apoplastic effectors of the riceblast fungus Magnaportheoryzaemodulate the apoplast redox state of rice to subvert plant immunity.In this study,we demonstrated that M.oryzae MoAo1 is an Ao that plays a role in virulence by modulating the apoplast redox status of rice cells.We showed that MoAo1 inhibits the activity of rice OsAO3and OsAO4,which also regulate the apoplast redox status and plant immunity.In addition,we found that MoAo1,OsAO3,andOsAO4 allexhibit polymorphic variations whosevaried interactions orchestrate pathogen virulence and rice immunity.Taken together,our results reveal a critical role for extracellular redox enzymes during rice blast infection and shed light on the importance of the apoplast redox state anditsregulation inplant-pathogeninteractions. | Jiexiong Hu Muxing Liu Ao Zhang Ying Dai Weizhong Chen Fang Chen Wenya Wang Danyu Shen Mary Jeanie Telebanco-Yanoria Bin Ren Haifeng Zhang Huanbin Zhou Bo Zhou Ping Wang Zhengguang Zhang | 2022 | Molecular Plant2022，15，8： | 0 |
| 18 | Tunable oxygen defect density and location for enhancement of energy storage显示文摘Defect engineering is in the limelight for the fabrication of electrochemical energy storage devices.However,determining the influence of the defect density and location on the electrochemical behavior remains challenging.Herein,self-organized TiO_(2)nanotube arrays(TNTAs)are synthesized by anodization,and their oxygen defect location and density are tuned by a controllable post-annealing process.TNTAs annealed at 600℃ in N2 exhibit the highest capacity(289.2 m Ah g^(-1)at 0.8 C)for lithium-ion storage,while those annealed at 900℃ in N2 show a specific capacitance of 35.6 m F cm^(-2)and stability above96%after 10,000 cycles for supercapacitor.Ex situ electron paramagnetic resonance spectra show that the surface-exposed oxygen defects increase,but the bulk embedded oxygen defects decrease with increasing annealing temperature.Density functional theory simulations reveal that a higher density of bulk oxygen defects corresponds to higher localized electrons states,which upshift the Fermi level and facilitate the lithium intercalation kinetic process.Meanwhile,differential charge density calculation indicates that the increase of surface oxygen defects in the anatase(101)plane leads to higher density excess electrons,which act as negative charge centers to enhance the surface potential for ion adsorption.This oxygen-deficient location and density tunable strategy introduce new opportunities for high-energy and high-power-density energy storage systems. | Jun Chen Jiangao Li Ling Sun Zhong Lin Zhengguang Hu Hongtao Zhang Xiaoling Wu Dongbo Zhang Guoan Cheng Ruiting Zheng | 2021 | Journal of Energy Chemistry2021，30，8： | 0 |
| 19 | Development unit division and favorable area evaluation for joint mining coalbed methane显示文摘Based on the productivity equation of coalbed methane (CBM) well, considering the impact of coal reservoir reformability on gas well productivity, the main production layer optimization index in the “three-step method” of optimal combination of production layers is corrected, and then the CBM production layer potential index is introduced to evaluate favorable areas for commingled multi-coal seam production. Through analysis of the key parameters of coal reservoirs affecting the CBM productivity index, a development unit division method for areas with multi-coal seams is established, and a quantitative grading index system is proposed. On this basis, the evaluation process of CBM development favorable area is developed: the mature 3-D modeling technology is used to characterize the reservoir physical properties of multi-coal seams in full-scale;the production layer potential index of each grid is calculated, and the production layer potential index contour under single-layer or commingled multi-layer production are plotted;according to the distribution of the contour of production layer potential index, the quantitative index of CBM development unit is adopted to outline the grade I, II, III coal reservoir distribution areas, and thus to pick out the favorable development areas. The practical application in the Yuwang block of Laochang in Yunnan proved that the favorable area evaluation process proposed can effectively overcome the defects of selecting favorable development areas only relying on evaluation results of a major coal seam pay, and enhance the accuracy of the evaluation results, meeting the requirements of selecting favorable areas for multi-coal seam commingled CBM production. | YANG Zhaobiao LI Yangyang QIN Yong SUN Hansen ZHANG Ping ZHANG Zhengguang WU Congcong LI Cunlei CHEN Changxiao | 2019 | Petroleum Exploration and Development2019，46，3： | 0 |
| 20 | Monitoring model for predicting maize grain moisture at the filling stage using NIRS and a small sample size显示文摘The change in the maize moisture content during different growth stages is an important indicator to evaluate the growth status of maize.In particular,the moisture content during the grain-filling stage reflects the grain quality and maturity and it can also be used as an important indicator for breeding and seed selection.At present,the drying method is usually used to calculate the moisture content and the dehydration rate at the grain-filling stage,however,it requires large sample size and long test time.In order to monitor the change in the moisture content at the maize grain-filling stage using small sample set,the Bootstrap re-sampling strategy-sample set partitioning based on joint x-y distances-partial least squares(Bootstrap-SPXY-PLS)moisture content monitoring model and near-infrared spectroscopy for small sample sizes of 10,20,and 50 were used.To improve the prediction accuracy of the model,the optimal number of factors of the model was determined and the comprehensive evaluation thresholds RVP(coefficient of determination(R^(2)),the root mean square error of cross-validation(RMSECV)and the root mean square error of prediction(RMSEP))was proposed for sub-model screening.The model exhibited a good performance for predicting the moisture content of the maize grain at the filling stage for small sample set.For the sample sizes of 20 and 50,the R^(2) values were greater than 0.99.The average deviations of the predicted and reference values of the model were 0.1078%,0.057%,and 0.0918%,respectively.Therefore,the model was effective for monitoring the moisture content at the grain-filling stage for a small sample size.The method is also suitable for the quantitative analysis of different concentrations using near-infrared spectroscopy and small sample size. | Xue Wang Tiemin Ma Tao Yang Ping Song Zhengguang Chen Huan Xie | 2019 | International Journal of Agricultural and Biological Engineering2019，12，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员