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| 1 | Impact factors of soil wind erosion in the center of Taklimakan Desert显示文摘The development and progress of soil wind erosion are influenced by the factors of climate,terrain,soil and vegetation,etc. This paper,taking Tazhong region,a town in the centre of the Taklimakan Desert,as an example and using comparative and quantitative methods,discussed the effects of climate,surface roughness(including vegetation cover) and surface soil properties on soil wind erosion. The results showed that the climate factor index C of annual wind erosion is 28.3,while the maximum of C is 13.9 in summer and it is only 0.7 in winter. The value of C has a very good exponential relationship with the wind speed. In Tazhong region,the surface roughness height is relatively small with a mean of 6.32 × 10-5 m,which is in favor of soil wind erosion. The wind erosion is further enhanced by its sandy soil types,soil particle size,lacking of vegetation and low soil moisture content. The present situation of soil wind erosion is the result of concurrent effects of climate,vegetation and surface soil properties. | Qing HE XingHua YANG Ali Mamtimin ShiHao TANG | 2011 | Journal of Arid Land2011，3，1： | 8 |
| 2 | Sand flux estimation during a sand-dust storm at Tazhong area of Taklimakan Desert, China显示文摘In this paper, the sand transport during a sand-dust storm in the Tazhong area of the central Taklimakan Desert from 11:29 to 23:56 on July 19, 2008 was observed and measured in real time. The sand flux at Tazhong was estimated using sand transport empirical formulas. The critical friction velocity at Tazhong was 0.24 m/s and the functional relation between the wind speed and sediment discharge at the height of 2 m was established. It was also found that the calculated values by Lettau's sediment discharge formula were close to those of the instrument measurements. The horizontal sand flux and the vertical sand flux during this sand-dust storm at Tazhong were respectively 258.67×10-4 kg/(m·s) and 40.07×10-7 kg/(m2·s). | XingHua YANG XiaoLiang XU Qing HE Ali Mamtimin Bo YU ShiHao TANG | 2011 | Journal of Arid Land2011，3，3： | 6 |
| 3 | Bias-drift-free Mach–Zehnder modulators based on a heterogeneous silicon and lithium niobate platform显示文摘Optical modulators have been and will continue to be essential devices for energy-and cost-efficient optical communication networks.Heterogeneous silicon and lithium niobate modulators have demonstrated promising performances of low optical loss,low drive voltage,and large modulation bandwidth.However,DC bias drift is a major drawback of optical modulators using lithium niobate as the active electro-optic material.Here,we demonstrate high-speed and bias-drift-free Mach–Zehnder modulators based on the heterogeneous silicon and lithium niobate platform.The devices combine stable thermo-optic DC biases in silicon and ultra-fast electro-optic modulation in lithium niobate,and exhibit a low insertion loss of 1.8 d B,a low half-wave voltage of 3 V,an electro-optic modulation bandwidth of at least 70 GHz,and modulation data rates up to 128 Gb/s. | SHIHAO SUN MINGBO HE MENGYUE XU SHENGQIAN GAO ZIYAN CHEN XIAN ZHANG ZILIANG RUAN XIONG WU LIDAN ZHOU LIN LIU CHAO LU CHANGJIAN GUO LIU LIU SIYUAN YU XINLUN CAI | 2020 | Photonics Research2020，8，12： | 5 |
| 4 | Calibration procedures for the CHASE/HIS science data显示文摘The Hα line is an important optical line in solar observations containing the information from the photosphere to the chromosphere. To study the mechanisms of solar eruptions and the plasma dynamics in the lower atmosphere, the Chinese Hα Solar Explorer(CHASE) was launched into a Sun-synchronous orbit on October 14, 2021. The scientific payload of the CHASE satellite is the Hα Imaging Spectrograph(HIS). The CHASE/HIS acquires, for the first time, seeing-free Hα spectroscopic observations with high spectral and temporal resolutions. It consists of two observational modes. The raster scanning mode provides full-Sun or region-of-interest spectra at Hα(6559.7-6565.9 ?) and Fe I(6567.8-6570.6 ?) wavebands. The continuum imaging mode obtains full-Sun photospheric images at around 6689 ?. In this paper, we present detailed calibration procedures for the CHASE/HIS science data, including the dark-field and flat-field correction, slit image curvature correction, wavelength and intensity calibration, and coordinate transformation. The higher-level data products can be directly used for scientific research. | Ye Qiu ShiHao Rao Chuan Li Cheng Fang MingDe Ding Zhen Li YiWei Ni WenBo Wang Jie Hong Qi Hao Yu Dai PengFei Chen XiaoSheng Wan Zhi Xu Wei You Yuan Yuan HongJiang Tao XianSheng Li YuKun He Qiang Liu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 3 |
| 5 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 6 | Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol显示文摘 | Meifeng Yang Junye Miao Joshua Rizak Rongwei Zhai Zhengbo Wang Tanzeel Huma Ting Li Na Zheng Shihao Wu Yingwei Zheng Xiaona Fan Jianzhen Yang Jianhong Wang Shangchuan Yang Yuanye Ma Longbao Lü Rongqiao He Xintian Hu | 2014 | Journal of Alzheimer's Disease2014，，4： | 1 |
| 7 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 8 | Multi-Scale Superhydrophobic Anti-Icing Coating for Wind Turbine Blades显示文摘As a surface functional material,super-hydrophobic coating has great application potential in wind turbine blade anti-icing,self-cleaning and drag reduction.In this study,ZnO and SiO2 multi-scale superhydrophobic coatings with mechanical flexibility were prepared by embedding modified ZnO and SiO2 nanoparticles in PDMS.The prepared coating has a higher static water contact angle(CA is 153°)and a lower rolling angle(SA is 3.3°),showing excellent super-hydrophobicity.Because of its excellent superhydrophobic ability and micro-nano structure,the coating has good anti-icing ability.Under the conditions of−10C and 60%relative humidity,the coating can delay the freezing time by 1511S,which is 10.7 times slower than the normal freezing time.More importantly,due to the mechanical properties provided by SiO2 and the synergistic effect of micro-nano particles,the coating has excellent mechanical durability.After 10 wear tests,the contact angle of the coating is still as high as 141°and the rolling angle is 6.8°.This research provides a theoretical reference for the preparation of a mechanically stable coating with a simple preparation process,as well as a basic research on the anti-icing behavior of the coating. | Jiangyong Bao Jianjun He Biao Chen Kaijun Yang Jun Jie Ruifeng Wang Shihao Zhang | 2021 | Energy Engineering2021，118，4： | 1 |
| 9 | The impact of serum copper on the risk of epilepsy:a mendelian randomization study显示文摘Background The relationship between serum copper and epilepsy has been elucidated in observational studies.In this study,we aimed to explore the causal relationship between serum copper and epilepsy using Mendelian randomization(MR)analysis.Methods Single nucleotide polymorphisms(SNPs)associated with serum copper were used as instrumental variables for MR analysis to evaluate their causal effects on epilepsy.The main MR results were obtained by using the inverse variance weighting(IVW)method,supplemented by weighted median and MR-Egger regression.In addition,sensitivity analyses such as Cochran’s Q test and pleiotropy test were used to assess these SNPs on epilepsy in terms of horizontal pleiotropy and heterogeneity.Results The IVW method revealed that the serum copper was associated with an increased risk of generalized epilepsy(OR=1.07;95%CI 1.01-1.14;P=0.032),and the sensitivity analysis further supports the robustness of the results.Conclusions The current study reveals a possible causal role for serum copper in increasing the risk of generalized epilepsy,which provide guidance for identifying potential risk factors for epilepsy. | Shihao Chen Wenting Huang Qi Xu Tao He Mulan Zhang Huiqin Xu | 2023 | Acta Epileptologica2023，6，2： | 0 |
| 10 | Coupled modified Kd V equations, skew orthogonal polynomials, convergence acceleration algorithms and Laurent property显示文摘In this paper, we show that the coupled modified Kd V equations possess rich mathematical structures and some remarkable properties. The connections between the system and skew orthogonal polynomials,convergence acceleration algorithms and Laurent property are discussed in detail. | Xiangke Chang Yi He Xingbiao Hu Shihao Li Hon-wah Tam Yingnan Zhang | 2018 | Science China Mathematics2018，61，6： | 0 |
| 11 | GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis显示文摘Hyperplasia and migration of fibroblast-like synoviocytes(FLSs)are the key drivers in the pathogenesis of rheumatoid arthritis(RA)and joint destruction.Abundant Yes-associated protein(YAP),which is a powerful transcription co-activator for proliferative genes,was observed in the nucleus of inflammatory FLSs with unknown upstream mechanisms.Using Gene Expression Omnibus database analysis,it was found that Salvador homolog-1(SAV1),the pivotal negative regulator of the Hippo-YAP pathway,was slightly downregulated in RA synovium.However,SAV1 protein expression is extremely reduced.Subsequently,it was revealed that SAV1 is phosphorylated,ubiquitinated,and degraded by interacting with an important serine-threonine kinase,G protein-coupled receptor(GPCR)kinase 2(GRK2),which was predominately upregulated by GPCR activation induced by ligands such as prostaglandin E2(PGE2)in RA.This process further contributes to the decreased phosphorylation,nuclear translocation,and transcriptional potency of YAP,and leads to aberrant FLSs proliferation.Genetic depletion of GRK2 or inhibition of GRK2 by paroxetine rescued SAV1 expression and restored YAP phosphorylation and finally inhibited RA FLSs proliferation and migration.Similarly,paroxetine treatment effectively reduced the abnormal proliferation of FLSs in a rat model of collagen-induced arthritis which was accompanied by a significant improvement in clinical manifestations.Collectively,these results elucidate the significance of GRK2 regulation of Hippo-YAP signaling in FLSs proliferation and migration and the potential application of GRK2 inhibition in the treatment of FLSs-driven joint destruction in RA. | Paipai Guo Ji Jiang Rui Chu Feng He Mingli Ge Ruhong Fang Qiuyun Guan Huijuan Cheng Chunru Jiang Tiantian Su Zhenduo Zhu Hao Liu Wei Wei Shihao Zhang Qingtong Wang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 12 | Quantitative Trait Locus Mapping of High Photosynthetic Efficiency and Biomass in Oryza longistaminata显示文摘Photosynthetic efficiency,a key trait that determines yield potential in rice,is quantitatively regulated by multiple genes.Utilization of valuable genetic resources hidden in wild rice is an effective way to improve rice photosynthesis and yield potential.In this study,152 backcross inbred lines derived from wild rice Oryza longistaminata were explored for QTL mapping of photosynthetic rate(Pn)and biomass(BM)in natural fields.Five novel QTLs for Pn and seven QTLs for BM or daily biomass(DBM)derived from O.longistaminata were identified.One of these QTLs,qPn8.1,could significantly improve Pn and was located in a 68-kb region containing only 11 candidate genes.Meanwhile,qBM1.1 and qDBM1.1 for BM and DBM on chromosome 1 were overlapped with qPn1.1 for Pn from 9311,and could affect both Pn and BM in natural fields.These QTLs identified in O.longistaminata may provide a novel alternative to explore new genes and resources for yield potentiality,highlighting the important role of wild rice in rice breeding programs. | SI Fengfeng FAN Fengfeng WEI Xiao HE Shihao LI Xianlong PENG Xiaojue LI Shaoqing | 2022 | Rice science2022，29，6： | 0 |
| 13 | An injectable signal-amplifying device elicits a specific immune response against malignant glioblastoma显示文摘Despite exciting achievements with some malignancies,immunotherapy for hypoimmunogenic cancers,especially glioblastoma(GBM),remains a formidable clinical challenge.Poor immunogenicity and deficient immune infiltrates are two major limitations to an effective cancer-specific immune response.Herein,we propose that an injectable signal-amplifying nanocomposite/hydrogel system consisting of granulocyte-macrophage colony-stimulating factor and imiquimod-loaded antigen-capturing nanoparticles can simultaneously amplify the chemotactic signal of antigen-presenting cells and the'danger'signal of GBM.We demonstrated the feasibility of this strategy in two scenarios of GBM.In the first scenario,we showed that this simultaneous amplification system,in conjunction with local chemotherapy,enhanced both the immunogenicity and immune infiltrates in a recurrent GBM model;thus,ultimately making a cold GBM hot and suppressing postoperative relapse.Encouraged by excellent efficacy,we further exploited this signal-amplifying system to improve the efficiency of vaccine lysate in the treatment of refractory multiple GBM,a disease with limited clinical treatment options.In general,this biomaterial-based immune signal amplification system represents a unique approach to restore GBM-specific immunity and may provide a beneficial preliminary treatment for other clinically refractorymalignancies. | Qiujun Qiu Sunhui Chen Huining He Jixiang Chen Xinyi Ding Dongdong Wang Jiangang Yang Pengcheng Guo Yang Li Jisu Kim Jianyong Sheng Chao Gao Bo Yin Shihao Zheng Jianxin Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 14 | A member of the ALOG gene family has a novel role in regulating nodulation in Lotus japonicus显示文摘Legumes can control the number of symbiotic nodules that form on their roots, thus balancing nitrogen assimilation and energy consumption. Two major pathways participate in nodulation: the Nod factor(NF)signaling pathway which involves recognition of rhizobial bacteria by root cells and promotion of nodulation, and the autoregulation of nodulation(AON) pathway which involves long-distance negative feedback between roots and shoots. Although a handful of genes have a clear role in the maintenance of nodule number, additional unknown factors may also be involved in this process. Here, we identify a novel function for a Lotus japonicus ALOG(Arabidopsis LSH1 and Oryza G1) family member, LjALOG1,involved in positively regulating nodulation. LjALOG1 expression increased substantially after inoculation with rhizobia, with high levels of expression in whole nodule primordia and in the base of developing nodules. The ljalog1 mutants, which have an insertion of the LORE1 retroelement in LjALOG1, had significantly fewer nodules compared with wild type, along with increased expression of LjCLE-RS1(L. japonicus CLE Root Signal 1), which encodes a nodulation suppressor in the AON pathway. In summary,our findings identified a novel factor that participates in controlling nodulation, possibly by suppressing the AON pathway. | Yawen Lei Shihao Su Liang He Xiaohe Hu Da Luo | 2019 | Journal of Integrative Plant Biology2019，61，4： | 0 |
| 15 | Half space object classification via incident angle based fusion of radar and infrared sensors显示文摘In this paper,we introduce an incident angle based fusion method for radar and infrared sensors to improve the recognition rate of complex targets under half space scenarios,e.g.,vehicles on the ground in this paper.For radar sensors,convolutional operation is introduced into the autoencoder,a“winner-take-all(WTA)”convolutional autoencoder(CAE)is used to improve the recognition rate of the radar high resolution range profile(HRRP).Moreover,different from the free space,the HRRP in half space is more complex.In order to get closer to the real situation,the half space HRRP is simulated as the dataset.The recognition rate has a growth more than 7%com-pared with the traditional CAE or denoised sparse autoencoder(DSAE).For infrared sensor,a convolutional neural network(CNN)is used for infrared image recognition.Finally,we com-bine the two results with the Dempster-Shafer(D-S)evidence theory,and the discounting operation is introduced in the fusion to improve the recognition rate.The recognition rate after fusion has a growth more than 7%compared with a single sensor.After the discounting operation,the accuracy rate has been improved by 1.5%,which validates the effectiveness of the proposed method. | HE Zhenyu ZHUGE Xiaodong WANG Junxiang YU Shihao XIE Yongjun ZHAO Yuxiong | 2022 | Journal of Systems Engineering and Electronics2022，33，5： | 0 |
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