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| 1 | Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI显示文摘 | Wang L Zang Y He Y Liang M Zhang X Tian L Wu T Jiang T Li K | 2006 | 中国生物学文摘2006，20，10： | 84 |
| 2 | Isolation and initial characterization of GW5, a major QTL associated with rice grain width and weight显示文摘谷物重量是庄稼谷物产量的一个主要决定因素并且被自然地发生的量的特点 loci (QTL ) 控制。我们更早识别了控制米饭谷物宽度和重量的主要 QTL, GW5,它在米饭染色体 5 上被印射到一个再结合热点。获得 GW5 怎么控制米饭谷物宽度的更好的理解,我们进行了这个地点的好印射并且揭开在米饭栽培变种 Asominori 与增加的谷物宽度联系的 1 212-bp 删除,与苗条谷物米饭 IR24 比较。另外, 46 米饭栽培变种的 genotyping 分析表明这删除高度与谷物宽度显型被相关,建议 GW5 删除可能在米饭驯服期间被选择了。GW5 编码对原子核局部性的 144 氨基酸的新奇原子蛋白质。而且,我们证明 GW5 身体上在酵母与 polyubiquitin 交往二混血儿的试金。一起,我们的结果建议 GW5 代表主要 QTL 内在的米饭宽度和重量,并且它多半在 ubiquitin-proteasome 小径行动在种子开发期间调整房间分割。这研究提供新奇卓见进控制米饭谷物开发的分子的机制并且建议 GW5 能为庄稼的产量很高的繁殖用作一个潜在的工具。 | Jianfeng Weng Suhai Gu Xiangyuan Wan He Gao Tao Guo Ning Su Cailin Lei Xin Zhang Zhijun Cheng Xiuping Guo Jiulin Wang Ling Jiang Huqu Zhai Jianmin Wan | 2008 | Cell Research2008，18，12： | 248 |
| 3 | Research progress of heavy metal pollution in China:Sources,analytical methods,status,and toxicity显示文摘Heavy metal pollution is one of the most serious environmental problems in China and a large number of people are threatened by heavy metal pollution.Extensive damage to human organs,such as liver,kidney,digestion system,and nervous system can be caused by uptake of excess heavy metals.Heavy metals in the environment can originate from both natural and anthropogenic sources.Although contamination of heavy metals has been known to be a severe environmental problem for decades,it is still getting worse in recent years and there are few feasible approaches to resolve this problem.Due to their high toxicity,prevalent existence and persistence in the environment,lead(Pb),mercury(Hg),cadmium(Cd),chromium(Cr) and arsenic(As) are commonly considered as the priority heavy metals which should be concerned and their emission should be controlled in China.This paper reviewed the pollution of heavy metals in China,focusing on the following four aspects:current status of heavy metal pollution in China,sources of heavy metals in China,toxicity and potential risk,and possible reduction strategies. | HE Bin YUN ZhaoJun SHI JianBo JIANG GuiBin | 2013 | Chinese Science Bulletin2013，58，2： | 114 |
| 4 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 5 | 中国成年人高血压患病率、知晓率、治疗和控制状况显示文摘目的 评估中国成年人高血压的患病率、高血压知晓率、治疗和控制状况。方法 亚洲国际心血管病合作研究 (InterASIA)于 2 0 0 0~ 2 0 0 1年进行 ,应用多阶段抽样方法选择有代表性的样本。共调查了 35~ 74岁的成年人 15 838人。测量血压时 ,先让调查对象休息 5min ,由经过培训合格的调查人员应用标准水银柱血压计测量 3次血压。应用标准问卷询问高血压病史及高血压的治疗情况。高血压定义为收缩压≥ 140mmHg、舒张压≥ 90mmHg或正在服用降压药。结果 35~ 74岁的中国成年人的高血压患病率为 2 7 2 %,即全国约有 1 3亿高血压患者。 35~ 44、45~ 5 4、5 5~ 6 4和 6 5~ 74岁年龄组的高血压患病专率分别为男性 17 4%、 2 8 2 %、 40 7%和 47 3 %;女性为 10 7%、2 6 8%、38 9%和 5 0 2 %。在高血压病人中 ,44 7%知道自己患有高血压 ,2 8 2 %正在服用降压药 ,8 1%的人血压得到了控制 ( <140 / 90mmHg)。在过去 10年中 ,高血压知晓、治疗和控制率的增长百分率分别为 86 2 %、92 6 %和 145 4%。结论 在过去的 10年中 ,高血压知晓、治疗和控制率有显著的提高。中国成年人高血压的患病率比较高 ,而高血压的知晓率偏低 ,治疗率和控制率又非常低。在我国迫切需要改善高血压的预防、检测和治疗状况? | 顾东风 Jiang He 吴锡桂 Kristi Reynolds 甘文奇 刘东海 宿少勇 段秀芳 黄广勇 Paul K.Whelton | 2003 | 中华预防医学杂志2003，37，2： | 553 |
| 6 | 中国成年人主要死亡原因及其危险因素显示文摘目的调查我国成人的主要死亡原因及其可改变的主要危险因素。方法前瞻性队列研究。该队列包括169871名≥40岁男女性有代表性样本,基线调查于1991年,于1999和2000年进行随访,随访率为93.4%。结果我国40~64岁人群中,恶性肿瘤、脑血管疾病和心脏病死亡率分别为265.9/10万人.年、171.5/10万人.年和159.1/10万人.年,高于美国同年龄人群。高血压的全死因相对危险性和人群归因危险度(PAR)分别为1.48%(95%CI1.44~1.53),11.7%;与未患高血压的人群相比,高血压患者总死亡率高48%,若高血压得到有效控制,预计全人群的全死因死亡将下降11.7%。吸烟、缺乏体力活动分别为第2、3位主要死亡原因,吸烟、缺乏体力活动PAR分别是7.9%和6.8%。男性的前5位死因为恶性肿瘤、心脏病、脑血管疾病、意外伤害和传染病;女性前5位死因为心脏病、脑血管疾病、恶性肿瘤、肺炎、流感和传染性疾病。结论血管疾病和癌症是中国成年人死亡的主要原因。控制血压、戒烟、增加体力活动和改善营养等方法是降低中国成年人早死负担的重要策略。 | 顾东风 Jiang He 吴锡桂 段秀芳 姚崇华 王家良 Kristi Reynolds Chung-Shiuan Chen Michael J.Klag Paul K.Whelton | 2006 | 中国慢性病预防与控制2006，14，3： | 74 |
| 7 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 8 | 米索前列醇和PG05配伍米非司酮终止早孕的临床多中心随机比较试验显示文摘本研究为一项由十个单位参加的多中心临床试验,随机比较了三种用药方案:1.米非司酮25mgQ12h×5+PG051mg阴道塞药(组Ⅰ),2.米非司酮,同前十米索600μg(组Ⅱ),3.米非司酮200mg+米索600μg(组Ⅲ)终止早孕的安全性、有效性和可接受性。结果显示完全流产率为94.22%(913/969),其中组Ⅲ为91.50%,明显低于组Ⅰ(95.22%)和组Ⅰ(96.12%)(P=0.025);失败率为1.65%(16/969),其中组Ⅲ为3.52%,显著高于组Ⅰ(1.37%)、组Ⅱ(0%)(P=0.001);不完全流产率为2.89%(28/969),失访(结局不明)率为1.24%(12/969),三组间均无明显差异(P>0.05);自应用PG至孕囊排出时间,三组分别为3.06±1.65,2.81±2.75,3.21±1.61h(X±SD),组Ⅱ稍短于其他两组,其差异有统计学意义(P<0.05);阴道出血持续时间和转经时间无明显组间差异(P>0.05)。90%以上的对象均对药物流产方法表示满意。结果提示米索配伍米非司酮的安全性、有效性和可接受性令人满意;米非司酮低剂量多次给药与米索有较好的协同作用。 | He Chang-hai Gao Er-sheng Chen Jun-hang Gu Jiang Gui You-lnn and Cao Feng-zhen et al.(Collabrating Grou) for Clinical Study on Misoprostol to induce Abortion, Shanghai, 200032) | 1994 | 生殖与避孕1994，14，1： | 47 |
| 9 | A Novel QTL qTGW3 Encodes the GSK3/ SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate Grain Size and Weight in Rice显示文摘谷物尺寸和形状在米饭是谷物重量和产量的重要决定因素。这里,我们报导一个新主要量的特点在米饭的地点(QTL ) , qTGW3,那种控制谷物尺寸和重量。这个地点, qTGW3,编码 OsSK41 (也作为 OsGSK5 知道) , GLYCOGEN SYNTHASE KINASE 3/SHAGGY-like 家庭的一个成员。带 OsSK41 的 loss-of-function 等位基因的瑞斯 near-isogenic 线增加了谷物长度和重量。我们证明那 OsSK41 交往与并且 phosphorylates 植物生长素反应因素 4 (OsARF4 ) 。有 OsARF4 的 OsSK41 的合作表示在米饭原物增加 OsARF4 的累积。OsARF4 的功能的损失导致更大的米饭谷物。定序 RNA 分析建议 OsARF4 和 OsSK41 镇压下游的基因的一个普通集合的表示, ? 包括一些植物生长素应答的基因,在米饭谷物开发期间。在 qTGW3 的 OsSK41 的 loss-of-function 形式代表没被指向的基因编辑或 QTL 节节上升广泛地在 OsSK41 功能的米饭 breeding.?Suppression 利用了的稀罕等位基因提高米饭谷物尺寸和重量。因此,我们的学习在米饭谷物开发揭示 OsSK41 的重要角色 ?? 并且在另外的谷物庄稼在米饭并且也许为谷物产量的基因改进提供新候选人基因。 | Zejun Hu Sun-Jie Lu Mei-Jing Wang Haohua He Le Sun Hongru Wang Xue-Huan Liu Ling Jiang Jing-Liang sun Xiaoyun Xin Wei Kong Chengcai Chu Hong-Wei Xue Jinshui Yang Xiaojin Luo Jian-Xiang Liu | 2018 | Molecular Plant2018，11，5： | 47 |
| 10 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 11 | Inhibition on the production of collagen type Ⅰ, Ⅲ of activated hepatic stellate cells by antisense TIMP-1 recombinant plasmid显示文摘AIM: To investigate the inhibition effects on the productionof collagen type I, Ⅲ secreted by activated rat hepatic stellatecells (rHSCs) by antisense tissue inhibitors of metalloproteinase1 (TIMP-1) recombinant plasmid through elevating interstitialcollagenase activity.METHODS: rHSCs were extracted from normal rat liverby pronase and collagenase digestion and purified bycentrifugal elutriation, and were cultured on plastic dishesuntil they were activated to a myofibroblastic phenotypeafter 7-10 days. RT-Nest-PCR and gene recombinanttechniques were used to construct the rat antisense TIMP-1 recombinant plasmids which can express in eucaryoticcells. The recombinant plasmid and the pcDNA3 emptyplasmid were transfected in rHSCs by Effectene (QIAGEN)separately. Cells were selected after growing in DMEMcontaining 400 μg/ml G418 for 2-3 weeks. Expression ofexogenous gene was assessed by Northern blot, andexpression oflIMP-1 in rHSCs was determined by Northernblot and Western blot. We tested the interstitial collagenaseactivity with FITC-labled type I collagen as substrate.Ultimately, we quantified the type Ⅰ, Ⅲ collagen byWestern blot.RESULTS: The exogenous antisense TIMP-1 recombinantplasmid could be expressed in rHSCs well, which couldblock the expression of TIMP-1 greatly, the ratio of TIMP-1/GAPDH was 0.67, 2.41, and 2.97 separately at mRNAlevel (P<0.05); the ratio of TIMP-1/β-actin was 0.31, 0.98and 1.32 separately at protein level (P<0.05); It mightelevate active and latent interstitial collagenase activity,the collagenase activity was 0.3049, 0.1411 and 0.1196respectively. (P<0.05), which led to promotion thedegradation of type Ⅰ, Ⅲ collagen, the ratio of collagen I/β-actin was 0.63, 1.78 and 1.92 separately (P<0.05); andthe ratio of collagen Ⅲ/β-actin was 0.59, 1.81 and 1.98separately (P<0.05).CONCLUSION: These data shows that the antisense TIMP-1 recombinant plasmid has the inhibitory effects on theproduction of type Ⅰ, Ⅲ collagens secreted by activatedrHSCs in vitro. It could be a novel method to reverse hepaticfibrosis in the future. | Wen-Bin Liu Chang-Qing Yang Wei Jiang Yi-Qing Wang Jing-Sheng Guo Bo-Ming He Ji-Yao Wang Division of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | 2003 | World Journal of Gastroenterology2003，9，2： | 42 |
| 12 | Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation显示文摘ABSTRACTHuman placenta-derived mononuclear cells (MNC) were isolated by a Percoll density gradient and cultured in mesen-chymal stem cell (MSC) maintenance medium. The homogenous layer of adherent cells exhibited a typical fibroblast-like morphology, a large expansive potential, and cell cycle characteristics including a subset of quiescent cells. In vitrodifferentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic, osteogenic andchondrogenic lineages. Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was ahomogeneous cell population devoid of hematopoietic cells, which uniformly expressed CD29, CD44, CD73, CD105,CD166, laminin, fibronectin and vimentin while being negative for expression of CD31, CD34, CD45 and α-smoothmuscle actin. Most importantly, immuno-phenotypic analyses demonstrated that these cells expressed class I majorhistocompatibility complex (MHC-I), but they did not express MHC-II molecules. Additionally these cells could sup-press umbilical cord blood (UCB) lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli. Thisstrongly implies that they may have potential application in allograft transplantation. Since placenta and UCB arehomogeneous, the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells(HSC) from UCB to reduce the potential graft -versus-host disease (GVHD) in recipients. | Chang Dong LI Wei Yuan ZHANG He Lian LI Xiao Xia JIANG Yi ZHANG Pei Hsien TANG Ning MAO | 2005 | Cell Research2005，15，7： | 36 |
| 13 | Uptake, Subcellular Distribution, and Chemical Forms of Cadmium in Wild-Type and Mutant Rice显示文摘Wild-type(Zhonghua 11) and mutant rice(Oryza sativa L.) plants were used to investigate the effect of cadmium(Cd) application on biomass production,to characterize the inffux of Cd from roots to shoots,and to determine the form,content,and subcellular distribution of Cd in the roots,leaf sheaths,and leaves of the rice plants.Seedlings were cultivated in a nutrient solution and were treated with 0.5 mmol L-1 of Cd2+ for 14 d.The sensitivity of rice plants to Cd toxicity was tested by studying the changes in biomass production and by observing the onset of toxicity symptoms in the plants.Both the wild-type and mutant rice plants developed symptoms of Cd stress.In addition,Cd application significantly(P ≤ 0.01) decreased dry matter production of roots,leaf sheaths,and leaves of both types,especially the mutant.The Cd content in roots of the mutant was significantly(P ≤ 0.05) higher than that of the wild-type rice.However,there was no significant di?erence in the Cd content of roots,leaf sheaths,and leaves between the wild-type and mutant rice.Most of the Cd was bound to the cell wall of the roots,leaf sheaths,and leaves,and the mutant had greater Cd content in cell organelles than the wild type.The uneven subcellular distribution could be responsible for the Cd sensitivity of the mutant rice.Furthermore,different chemical forms of Cd were found to occur in the roots,leaf sheaths,and leaves of both types of rice plants.Ethanol-,water-,and NaCl-extractable Cd had greater toxicity than the other forms of Cd and induced stunted growth and chlorosis in the plants.The high Cd content of the toxic forms of Cd in the cell organelles could seriously damage the cells and the metabolic processes in mutant rice plants. | HE Jun-Yu ZHU Cheng REN Yan-Fang YAN Yu-Ping CHENG Chang JIANG De-An SUN Zong-Xiu | 2008 | Pedosphere2008，18，3： | 37 |
| 14 | Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study显示文摘 | WEN Ying JIANG Li XU Yuan QIAN Chuan-yun LI Shu-sheng QIN Tie-he CHEN Er-zhen LIN Jian-dong AI Yu- hang WU Da-wei WANG Yu-shan SUN Ren-hua HU Zhen-jie CAO Xiang-yuan ZHOU Fa-chun HE Zhen-yang ZHOU Li-hua AN You-zhong KANG Yan MA Xiao-chun YU Xiang-you ZHAO Ming-yan XI Xiu-ming DU Bin | 2013 | Chinese Medical Journal2013，，23： | 40 |
| 15 | One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces显示文摘编辑技术 CRISPR 的指导 RNA 的 DNA 定期聚类 interspaced 短 palindromic repeats/Cas9 被用来介绍双 stranded 闯入染色体并且在细菌指导随后的地点特定的插入 / 删除或基因材料的代替例如 Escherichia coli,链球菌肺病,和乳杆菌 reuteri。在这研究,我们建立了在 Streptomyces 基因操作为使用编辑 plasmid pKCcas9dO 的一个高效率的 CRISPR/Cas9 染色体,它包括目标特定的指南 RNA,优化 codon 的 cas9,和二个指导相同的修理模板。由交付编辑 plasmids 进模型紧张 Streptomyces coelicolor M145 的 pKCcas9dO 系列,通过一步舞 intergeneric 转移,我们完成了与60%100%的高效率在不同层次编辑的染色体,包括单个基因删除,例如 actII-orf4 ,整顿,和 glnR ,并且单个大尺寸的基因簇删除,扮演 21.3 kb , undecylprodigiosin 红 31.6 kb ,和 Ca 2+-dependent 抗菌素例如 actinorhodin 的抗菌素 biosynthetic 簇 82.8 kb 。而且,我们也分别地与 54% 和 45% 的高效率认识到 actII-orf4 和整顿,并且 ACT 和红 biosynthetic 基因簇的同时的删除。最后,我们使用了这个系统介绍核苷酸点变化进 rpsL 基因,它与抵抗授与异种到链球菌。用这个系统,显著地,为一个轮染色体修正要求的时间被三分之一个减少或为常规方法的那些的一个一半。这些结果清楚地显示实质地编辑系统的确定的 CRISPR/Cas9 染色体改进与当前存在的方法相比编辑效率在的染色体 Streptomyces,和它在另外的放线菌种类为申请有诺言到染色体修正。 | He Huang Guosong Zheng Weihong Jiang Haifeng Hu Yinhua Lu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 37 |
| 16 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 17 | Initial detections and spread of invasive Spodoptera frugiperda in China and comparisons with other noctuid larvae in cornfields using molecular techniques显示文摘The fall armyworm,Spodoptera frugiperda,is a species native to the Americas and has spread to many countries in Africa and Asia in recent years.Proactive actions for potential invasion of S.frugiperda to China coordinated by government agencies and agricultural extension systems resulted in timely detection in January 2019 in Yunnan province neighboring onto Myanmar.The extensive monitoring in southern provinces of China since February 2019 resulted in dynamic tracking of S.frugiperda spreading to 13 provincial regions in China within 4 months by May 10,2019,which is crucial for timely management actions in the fields.The first detections of S.frugiperda(corn strain)in China were confirmed using cytochrome oxidase subunit 1(COl)and triosephosphate isomerase(Tpi)genes molecular marker method.In addition to S.frugiperda,larvae of three other noctuid species with similar morphological appearance(S.litura,S.exigna and Mythimna separata)can occur simultaneously and cause similar damage in cornfields in southern China.Thus,we can use both morphological and molecular marker methods to compare larval stages of four noctuid species.Further,we discuss the risk of potential spread of invasive S.frugiperda to other regions and impact on corn production in China. | Da-Peng Jing Jing-Fei Guo Yu-Ying Jiang Jian-Zhou Zhao Amit Sethi Kang-Lai He Zhen-Ying Wang | 2020 | Insect Science2020，27，4： | 35 |
| 18 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 19 | Coordinated regulation of apical hook development by gibberellins and ethylene in etiolated Arabidopsis seedlings显示文摘当在土壤发芽时,当通过土壤耸出时,黑暗成年的 Arabidopsis 幼苗开发一个顶端的钩,它保护子叶和顶端的 meristematic 纸巾。几荷尔蒙被报导清楚地调制这个过程。以前的研究证明了乙烯和赤霉素(气体) 并列地调整钩发展,尽管内在的分子的机制大部分是未知的。当 paclobutrazol 镇压了时,这里,我们显示出提高的那 GA 3 ethylene-overexpression 和 EIN3-overexpression (EIN3ox ) 导致了钩弯曲,并且 della 异种展出了夸大的钩弯曲,它要求了发信号的未经触动的乙烯小径。基因学习表明那提高 GA 的钩开发依赖于无钩 1 (HLS1 ) ,调停的一个中央管理者多重发信号小径的输入在顶端的钩开发期间。我们进一步发现那 GA 3 导致(并且 DELLA 蛋白质镇压了) 在乙烯感觉迟钝的 3/EIN3-LIKE 的 HLS1 表示 1 (EIN3/EIL1 ) 依赖举止, EIN3/EIL1 由此激活 HLS1 抄写由对它的倡导者直接有约束力。另外, DELLA 蛋白质被发现与 EIN3/EIL1 的 DNA 有约束力的领域交往并且镇压 EIN3/EIL1-regulated HLS1 表示。有 naphthylphthalamic 酸的处理,一个极的植物生长素运输禁止者,镇压 EIN3ox 线的组成地夸大的钩弯曲和 della 异种,支持那植物生长素在钩开发乙烯和 GA 小径下游地工作。一起拿,我们的结果作为联系 DELLA 的抄写因素的一个新类识别 EIN3/EIL1 并且证明 GA 由经由 EIN3/EIL1 函数的 derepression 导致 HLS1 的表达式部分与乙烯在合作支持顶端的钩形成。 | Fengying An Xing Zhang Ziqiang Zhu Yusi Ji Wenrong He Zhiqiang Jiang Mingzhe Li Hongwei Guo | 2012 | Cell Research2012，22，5： | 34 |
| 20 | Broadband diffusion of terahertz waves by multi-bit coding metasurfaces显示文摘The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light waves.In the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional devices.Here,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding elements.We propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric scales.We show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding sequences.As an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and experiments.The presented method opens a new route to reducing the scattering of terahertz waves. | Li-Hua Gao Qiang Cheng Jing Yang Shao-Jie Ma Jie Zhao Shuo Liu Hai-Bing Chen Qiong He Wei-Xiang Jiang Hui-Feng Ma Qi-Ye Wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun Cui | 2015 | Light(Science & Applications)2015，4，1： | 31 |
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