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| 1 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 2 | Expression of nerve growth factor precursor, mature nerve growth factor and their receptors during cerebral ischemia-reperfusion injury显示文摘We investigated nerve growth factor precursor (proNGF) and mature NGF expression in ischemic and non-ischemic cortices after cerebral ischemia-reperfusion injury. In both ischemic and non-ischemic cortices, proNGF was found to be present in the extracellular space and cytoplasm. In addition, mature NGF was expressed in extracellular space, but with a very low signal. In ischemic cortex only, proNGF was significantly decreased, reaching a minimal level at 1 day. Mature NGF was increased at 4 hours, then reached a minimal level at 3 days. The p75 neurotrophin receptor (p75NTR) was significantly decreased after ischemia, and increased at 3 days after ischemia. These results confirmed that proNGF was the predominant form of NGF during the pathological process of cerebral ischemia-reperfusion injury. In addition, our findings suggest that ischemic injury may influence the conversion of proNGF to mature NGF, and that proNGF/p75NTR may be involved in reperfusion injury. | Guoqian He Jian Guo Jiachuan Duan Wenming Xu Ning Chen Hongxia Li Li He | 2011 | Neural Regeneration Research2011，6，22： | 3 |
| 3 | Establishment of a rhesus monkey model of middle cerebral artery ischemia and reperfusion using a microcatheter embolization method显示文摘Nonhuman primates are closest to humans in terms of lineage,and middle cerebral artery ischemia/reperfusion responses of nonhuman primates are most similar to ischemic stroke in humans.Therefore,nonhuman primates could be utilized to simulate the process of ischemic stroke in the human.Few studies,however,have reported the use of endovascular technology to establish a rhesus monkey stroke model.In the present study,seven adult,male,rhesus monkeys were selected and,following anesthesia,a microcatheter was inserted into one side of the middle cerebral artery via the femoral artery to block blood flow,thereby resulting in middle cerebral artery occlusion.After 2 hours,the microcatheter was withdrawn to restore the middle cerebral artery blood flow and to establish ischemia/reperfusion.Results from angiography and magnetic resonance angiography confirmed occlusion and reopening of the middle cerebral artery.Magnetic resonance imaging revealed the existence of ischemic brain lesions,and neurological examination showed sustained functional deficits following surgery.The rhesus monkey middle cerebral artery ischemia/reperfusion models established by microcatheter embolization had the advantage of non-craniotomy invasion and reproducibility.The scope and degree of ischemic damage using this model was controllable.Therefore,this nonhuman primate model is an ideal model for cerebral ischemia and reperfusion. | Jie Yang Jian Guo Hongbo Zheng Muke Zhou Li He Wenying Cao Li Xiao Jiachuan Duan Qiyong Gong Xiaoqi Huang Hongxia Li Li Wang Jingqiu Cheng | 2010 | Neural Regeneration Research2010，5，15： | 2 |
| 4 | Heavy ion micro-beam study of single-event transient(SET) in Si Ge heterjunction bipolar transistor显示文摘Silicon-germainum heterojunction bipolar transistor(Si Ge HBT)has been demonstrated to be suitable in extreme environment because of its superior temperature characteristics which can operate from 43 K to 400 K[1].In addition,outstanding hardness to both total ionizing dose(TID)radiation and displacement damage make Si Ge HBT technology particularly attractive for | Jinxin ZHANG Hongxia GUO Fengqi ZHANG Chaohui HE Pei LI Yunyi YAN Hui WANG Linxia ZHANG | 2017 | Science China(Information Sciences)2017，60，12： | 2 |
| 5 | Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis显示文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis. | Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen | 2022 | International Journal of Oral Science2022，14，2： | 2 |
| 6 | Observed features of temperature, salinity and current in central Chukchi Sea during the summer of 2012显示文摘During the summer of 2012, the fifth CHINARE Arctic Expedition was carried out, and a submersible mooring system was deployed in M5 station located at(69°30.155'N,169°00.654'W) and recovered 50 d later. A set of temperature, salinity and current profile records was acquired. The characteristics of these observations are analyzed in this paper. Some main results are achieved as below.(1) Temperature generally decreases while salinity generally increases with increasing depth. The average values of all records are 2.98°C and 32.21 psu.(2)Salinity and temperature are well negatively correlated, and the correlation coefficient between them is –0.84.However, they did not always vary synchronously. Their co-variation featured different characters during different significant periods.(3) The average velocity for the whole water column is 141 mm/s with directional angle of347.1°. The statistical distribution curve of velocity record number gets narrower with increasing depth. More than85% of the recorded velocities are northward, and the mean magnitudes of dominated northward velocities are100–150 mm/s.(4) Rotary spectrum analysis shows that motions with low frequency take a majority of energy in all layers. The most significant energy peaks for all layers are around 0.012 cph(about 3.5 d period), while the tidal motion in mooring area is nonsignificant.(5) Velocities in all layers feature similar and synchronous temporal variations, except for the slight decrease in magnitude and leftward twist from top to bottom. The directions of velocity correspond well to those of surface wind. The average northward volume transport per square meter is0.1–0.2 m3/s under southerly wind, but about –0.2 m3/s during northerly wind burst. | HE Yan LIU Na CHEN Hongxia TENG Fei LIN Lina WANG Huiwu | 2015 | Acta Oceanologica Sinica2015，34，5： | 2 |
| 7 | Synthesis and Application of a Zeolite-containing Composite Material Made from Spent FCC Catalyst显示文摘Novel composite material with a wide pore distribution was synthesized by an in situ technique using spent FCC catalyst as raw material. The characterization results indicated that the composite material contained 56.7% of zeolite Y and exhibited a much larger specific surface area and pore volume as well as strong hydrothermal stability. Fluid catalytic cracking(FCC) catalyst was prepared based on the composite material. The results indicated that the as-prepared catalyst possessed a unique pore structure that was advantageous to the diffusion-controlled reactions. In addition, the attrition resistance, activity and hydrothermal stability of the studied catalyst were superior to those of the reference catalyst. The catalyst also exhibited excellent nickel and vanadium passivation performance, strong bottoms upgrading selectivity, and better gasoline and coke selectivity. In comparison to the reference catalyst, the yields of the gasoline and light oil increased by 1.61 and 1.31 percentage points, respectively, and the coke yield decreased by 0.22 percentage points, and the olefin content in the produced gasoline reduced by 2.51 percentage points, with the research octane number increased by 0.7 unit. | Zheng Shuqin He Lijun Yao Hua Ren Shao Yu Hongxia Zhang Jiance | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，4： | 2 |
| 8 | Investigation on propagation properties of terahertz waveguide hollow plastic fiber显示文摘 | HE Xiaoyong LU Hongxia | | 0，，02： | 1 |
| 9 | Thermal and mechanical evaluation of cyanate ester resin modified with bismaleimide and diallyl phthalate显示文摘 | He Shaobo Liang Guozheng Yan Hongxia | | 0，，9： | 1 |
| 10 | miR‐106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS显示文摘 | Zaozao Wang Mei Liu Hongxia Zhu Wei Zhang Shun He Chenfei Hu Lanping Quan Jinfeng Bai Ningzhi Xu | 2013 | Carcinog2013，，8： | 1 |
| 11 | microRNA regulation of fruit development,quality formation and stress response显示文摘Fruits,as the reproductive organs of many higher plants,are an integral part of a balanced diet,providing rich nutrients and bioactive substances for our health.Over the years,the research on fruit development,quality formation and stress response has deepened,which sheds light on the regulatory mechanism and application of fruit quality improvement.Among the many regulatory factors,microRNAs(miRNAs)are a class of short non-coding RNAs,ranging from 20 to 24-nt,which post-transcriptionally regulate target gene expression.miRNAs and their functions have been extensively examined in plants especially in model species,and they play critical roles in the regulation of diverse biological processes in response to endogenous developmental signals and external environmental cues,respectively.In fruit crops,the function of miRNAs and their regulation have also been under intensive study.In particular,the novel roles of miRNAs that have not been revealed in the model annual species have been unraveling,which reflect the genetic,physiological,and developmental complexity of gene regulation in fruit crops.Here we review the current research progress achieved,specifically in fruit crops,with a focus on the function of miRNAs in the control of fruit development and quality as well as response to various stresses.The future prospects of miRNAs for quality-targeted fruit breeding are also discussed. | Xiangjin Kong Meiying He Zhihong Guo Yijie Zhou Zhongsuzhi Chen Hongxia Qu Hong Zhu | 2021 | Fruit Research2021，1，1： | 1 |
| 12 | Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population显示文摘 | Yong Gao Yisha He Jing Xu Lin Xu Jiangbo Du Chen Zhu Haiyong Gu Hongxia Ma Zhibin Hu Guangfu Jin Xiaofei Chen Hongbing Shen | 2013 | Human Genetics2013，，6： | 1 |
| 13 | Biodegradation of 2,4,6-trinitrophenol (picric acid) in a biological aerated filter (BAF)显示文摘 | Shen Jinyou He Rui Yu Hongxia Wang Lianjun Zhang Jianfa Sun Xiuyun Li Jiansheng Han Weiqing Xu Lu | 2009 | Bioresource Technology2009，，100： | 1 |
| 14 | Wavelet-based semi-fragile watermarking with tamper detection显示文摘 | DING Ke HE Chen JIANG Lingge WANG Hongxia | 2005 | IEICE Trans Fundamentals2005，88，3： | 1 |
| 15 | The distribution and inter-annual variation of water masses on the Bering Sea shelf in summer显示文摘On the basis of the CTD data obtained within the Bering Sea shelf by the Second to Sixth Chinese National Arctic Research Expedition in the summers of 2003, 2008, 2010, 2012 and 2014, the classification and interannual variation of water masses on the central Bering Sea shelf and the northern Bering Sea shelf are analyzed. The results indicate that there are both connection and difference between two regions in hydrological features. On the central Bering Sea shelf, there are mainly four types of water masses distribute orderly from the slope to the coast of Alaska: Bering Slope Current Water(BSCW), MW(Mixed Water), Bering Shelf Water(BSW) and Alaska Coastal Water(ACW). In summer, BSW can be divided into Bering Shelf Surface Water(BSW_S) and Bering Shelf Cold Water(BSW_C). On the northern Bering Sea shelf near the Bering Strait,it contains Anadyr Water(AW), BSW and ACW from west to east. But the spatial-temporal features are also remarkable in each region. On the central shelf, the BSCW is saltiest and occupies the west of 177°W, which has the highest salinity in 2014. The BSW_C is the coldest water mass and warmest in 2014; the ACW is freshest and mainly occupies the east of 170°W, which has the highest temperature and salinity in 2012. On the northern Bering Sea shelf near the Bering Strait, the AW is saltiest with temperature decreasing sharply compared with BSCW on the central shelf. In the process of moving northward to the Bering Strait, the AW demonstrates a trend of eastward expansion. The ACW is freshest but saltier than the ACW on the central shelf,which is usually located above the BSW and is saltiest in 2014. The BSW distributes between the AW and the ACW and coldest in 2012, but the cold water of the BSW_C on the central shelf, whose temperature less than 0°C, does not exist on the northern shelf. Although there are so many changes, the respond to a climate change is synchronized in the both regions, which can be divided into the warm years(2003 and 2014) and cold years(2008, 2010 and 2012). The year of 2014 may be a new beginning of warm period. | LIU Na LIN Lina WANG Yingjie CHEN Hongxia HE Yan | 2016 | Acta Oceanologica Sinica2016，35，11： | 1 |
| 16 | Efficiency of a pilot-scale integrated sludge thickening and digestion reactor in treating low- organic excess sludge 显示文摘 | HE Qiang LI Jiang LIU Hongxia | 2012 | Environmental Technology2012，33，12： | 1 |
| 17 | Estimation of Postmortem Interval by Postmortem Myocardial Computed Tomography Value显示文摘Background:The estimation of postmortem interval(PMI)is one of the most important topics in forensic medicine research.We speculate that with an increased PMI,the computed tomography(CT)values of different tissues may show regular changes.Purpose:To use postmortem computed tomography(PMCT)to measure the myocardial CT value(unit:Hounsfield Unit,HU)of the heart to explore its pattern in postmortem change,and to discuss whether it can serve as a new parameter for PMI estimation.Methods:A total of 10 healthy adult New Zealand rabbits were selected and then put into a 20℃ incubator after being sacrificed.Within 0-156 h after death,CT scans were performed every 12 h to detect changes in the myocardial CT value of the heart over time.Regression analysis was used to determine the relationship between the myocardial CT value of the heart and PMI.At the same time,HE and Masson were used to stain the cardiac tissue sections detected by PMCT at Oh,48h and 156h,respectively.Results:During 0-156 h,the overall myocardial CT value showed a trend of first rising and then decreasing with the increase of PMI.The fitting regression equation was y=-2873.193+143.866x-1.728x2(x:myocardial CT value,unit:Hu;y:PMI,unit:h,R2=0.466,P<0.05).During 48-156 h,the overall myocardial CT value decreased gradually with the increase of PMI.The fitting regression equation was y=-93.038+18.700x-0.321x2(x:myocardial CT value,unit:Hu;y:PMI,unit:h,R2=0.963,P<0.001).The results of the morphological changes of the myocardial tissue structure after death showed that the myocardial cell structure was relatively complete at 0-48 hours after death;and the myocardial cell structure disappeared at 156 hours after death.Conclusions:Our results revealed evident postmortem changes in the myocardial CT value of the heart.Accordingly,measuring the myocardial CT value through PMCT shows promise for being used as a parameter for PMI estimation in forensic medicine and is worthy of further studies.The morphological changes of the myocardial tissue structure after death provide morphological basis for postmortem changes of tissue density,and further prove the reasons for the changes of CT value. | Zhiyuan An Hongxia He Qing Niu Haibiao Zhu Yucong Wang Ran Liu Weiliang Hou Peng Tang Tiantong Yang Dong Zhao | 2021 | Journal of Forensic Science and Medicine2021，7，3： | 1 |
| 18 | Genomes of 12 fig wasps provide insights into the adaptation of pollinators to fig syconia显示文摘Figs and fig pollinators are one of the few classic textbook examples of obligate pollination mutualism.The specific dependence of fig pollinators on the relatively safe living environment with sufficient food sources in the enclosed fig syconia implies that they are vulnerable to habitat changes.However,there is still no extensive genomic evidence to reveal the evolutionary footprint of this long-term mutually beneficial symbiosis in fig pollinators.In fig syconia,there are also non-pollinator species.The non-pollinator species differ in their evolutionary and life histories from pollinators.We conducted comparative analyses on 11 newly sequenced fig wasp genomes and one previously published genome.The pollinators colonized the figs approximately 66.9 million years ago,consistent with the origin of host figs.Compared with nonpollinators,many more genes in pollinators were subject to relaxed selection.Seven genes were absent in pollinators in response to environmental stress and immune activation.Pollinators had more streamlined gene repertoires in the innate immune system,chemosensory toolbox,and detoxification system.Our results provide genomic evidence for the differentiation between pollinators and nonpollinators.The data suggest that owing to the long-term adaptation to the fig,some genes related to functions no longer required are absent in pollinators. | Jinhua Xiao Xianqin Wei Yi Zhou Zhaozhe Xin Yunheng Miao Hongxia Hou Jiaxing Li Dan Zhao Jing Liu Rui Chen Liming Niu Guangchang Ma Wenquan Zhen Shunmin He Jianxia Wang Xunfan Wei Weihao Dou Zhuoxiao Sui Haikuan Zhang Shilai Xing Miao Shi Dawei Huang | 2021 | Journal of Genetics and Genomics2021，48，3： | 1 |
| 19 | A procedure of parameter inversion for a nonlinear constitutive model of soils with shield tunneling 显示文摘 | He Yu Li Shouju Duan Hongxia | 2011 | Computers & Mathematics with Applications2011，61，8： | 1 |
| 20 | Production of very-high-amylose cassava by post-transcriptional silencing of branching enzyme genes显示文摘High amylose starch can be produced by plants deficient in the function of branching enzymes(BEs).Here we report the production of transgenic cassava(Manihot esculenta Crantz)with starches containing up to 50%amylose due to the constitutive expression of hair-pin ds RNAs targeting the BE1 or BE2 genes.All BE1-RNAi plant lines(BE1i)and BE2-RNAi plant lines(BE2i)were grown up in the field,but with reduced total biomass production.Considerably high amylose content in the storage roots of BE2i plant lines was achieved.Storage starch granules of BE1i and BE2i plants had similar morphology as wild type(WT),however,the size of BE1i starch granules were bigger than that of WT.Comparisons of amylograms and thermograms of all three sources of storage starches revealed dramatic changes to the pasting properties and a higher melting temperature for BE2i starches.Glucan chain length distribution analysis showed a slight increase in chains of DP>36 in BE1i lines and a dramatic increase in glucan chains between DP 10-20 and DP>40 in BE2i lines.Furthermore,BE2i starches displayed a B-type X-ray diffraction pattern instead of the A-type pattern found in BE1i and WT starches.Therefore,cassava BE1 and BE2 function differently in storage root starch biosynthesis. | Wenzhi Zhou Shanshan Zhao Shutao He Qiuxiang Ma Xinlu Lu Xiaomeng Hao Hongxia Wang Jun Yang Peng Zhang | 2020 | Journal of Integrative Plant Biology2020，62，6： | 1 |
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