|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data显示文摘The rapid development of high-throughput sequencing techniques has led biology into the big-data era.Data analyses using various bioinformatics tools rely on programming and command-line environments,which are challenging and time-consuming for most wet-lab biologists.Here,we present TBtools(a Toolkit for Biologists integrating various biological data-handling tools),a stand-alone software with a userfriendly interface.The toolkit incorporates over 130 functions,which are designed to meet the increasing demand for big-data analyses,ranging from bulk sequence processing to interactive data visualization.A wide variety of graphs can be prepared in TBtools using a new plotting engine('JIGplot')developed to maximize their interactive ability;this engine allows quick point-and-click modification of almost every graphic feature.TBtools is platform-independent software that can be run under all operating systems with Java Runtime Environment 1.6 or newer.It is freely available to non-commercial users at http://gffzz188fe103f8f1460asku55o5cvkb0q6cfx.ffgz.tsg.suse.edu.cn/CJ-Chen/TBtools/releases. | Chengjie Chen Hao Chen Yi Zhang Hannah R.Thomas Margaret H.Frank Yehua He Rui Xia | 2020 | Molecular Plant2020，13，8： | 805 |
| 2 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 3 | Positioning accuracy assessment for the 4GEO/5IGSO/2MEO constellation of COMPASS显示文摘Determined to become a new member of the well-established GNSS family,COMPASS(or BeiDou-2) is developing its capabilities to provide high accuracy positioning services.Two positioning modes are investigated in this study to assess the positioning accuracy of COMPASS' 4GEO/5IGSO/2MEO constellation.Precise Point Positioning(PPP) for geodetic users and real-time positioning for common navigation users are utilized.To evaluate PPP accuracy,coordinate time series repeatability and discrepancies with GPS' precise positioning are computed.Experiments show that COMPASS PPP repeatability for the east,north and up components of a receiver within China's Mainland is better than 2 cm,2 cm and 5 cm,respectively.Apparent systematic offsets of several centimeters exist between COMPASS precise positioning and GPS precise positioning,indicating errors remaining in the treatments of COMPASS measurement and dynamic models and reference frame differences existing between two systems.For common positioning users,COMPASS provides both open and authorized services with rapid differential corrections and integrity information available to authorized users.Our assessment shows that in open service positioning accuracy of dual-frequency and single-frequency users is about 5 m and 6 m(RMS),respectively,which may be improved to about 3 m and 4 m(RMS) with the addition of differential corrections.Less accurate Signal In Space User Ranging Error(SIS URE) and Geometric Dilution of Precision(GDOP) contribute to the relatively inferior accuracy of COMPASS as compared to GPS.Since the deployment of the remaining 1 GEO and 2 MEO is not able to significantly improve GDOP,the performance gap could only be overcome either by the use of differential corrections or improvement of the SIS URE,or both. | ZHOU ShanShi CAO YueLing ZHOU JianHua HU XiaoGong TANG ChengPan LIU Li GUO Rui HE Feng CHEN JunPing WU Bin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 31 |
| 4 | Changes of net primary productivity in China during recent 11 years detected using an ecological model driven by MODIS data显示文摘网主要生产率(NPP ) 是陆上的碳周期的一个重要部件。精确地在中国印射 NPP 的空间时间的变化为全球碳骑车是关键的学习。在这研究,基于过程的北方的生态系统生产率模拟器(BEPS ) 被采用从 2000 ~ 2010 为时期在中国的生态系统学习 NPP 的变化。BEPS 模型首先用在在不同区域测量的典型流动地点和森林 NPP 测量的粗野主要生产率(GPP ) 被验证。然后,它与叶区域索引( LAI )被驾驶从中等分辨率成像分光辐射函数( MODIS )反射和陆地盖子产品和气象学的数据的 inversed 在 753 个国家基本气象学的车站从观察插入内推从1月1日在每日的时间步和 500 m 的空间分辨率模仿 NPP , 2000 到2010年12月31日。确认证明 BEPS 能在中国的不同区域捕获基于塔的 GPP 的季节的变化和森林 NPP 的空间可变性。年度 NPP 的估计的国家总数从 2.63 变化了到 2.84Pg C 獥吗? | Yibo LIU Weimin JU Honglin HE Shaoqiang WANG Rui SUN Yuandong ZHANG | 2013 | Frontiers of Earth Science2013，7，1： | 30 |
| 5 | Geophysical survey and geodynamic study of crust and upper mantle in the Qinghai-Tibet Plateau显示文摘 | Rui Gao Zhanwu Lu Qiusheng Li Ye Guan Jisheng Zhang Rizheng He Liyan Huang | 2005 | Episodes2005，28，4： | 26 |
| 6 | Three-dimensional hydrodynamic and water quality model for TMDL development of Lake Fuxian,China显示文摘Lake Fuxian is the largest deep freshwater lake in China.Although its average water quality meets Class I of the China National Water Quality Standard(CNWQS),i.e.,GB3838-2002,monitoring data indicate that the water quality approaches the Class II threshold in some areas.Thus it is urgent to reduce the watershed load through the total maximum daily load(TMDL) program.A three-dimensional hydrodynamic and water quality model was developed for Lake Fuxian,simulating flow circulation and pollutant fate and transport.The model development process consists of several steps,including grid generation,initial and boundary condition configurations,and model calibration processes.The model accurately reproduced the observed water surface elevation,spatiotemporal variations in temperature,and total nitrogen(TN),total phosphorus(TP),and chemical oxygen demand(COD) concentrations,suggesting a reasonable numerical representation of the prototype system for further TMDL analyses.The TMDL was calculated using two interpretations of the water quality standards for Class I of the CNWQS based on the maximum instantaneous surface and annual average surface water concentrations.Analysis of the first scenario indicated that the TN,TP and COD loads should be reduced by 66%,68% and 57%,respectively.Water quality was the highest priority;however,local economic development and cost feasibility for load reduction can pose significant issues.In the second interpretation,the model results showed that,under the existing conditions,the average water quality meets the Class I standard and therefore load reduction is unnecessary.Future studies are needed to conduct risk and cost assessments for realistic decision-making. | Lei Zhao Xiaoling Zhang Yong Liu Bin He Xiang Zhu Rui Zou Yuanguan Zhu | 2012 | Journal of Environmental Sciences2012，24，8： | 25 |
| 7 | Acute inflammation stimulates a regenerative response in the neonatal mouse heart显示文摘 | Chunyong Han Yu Nie Hong Lian Rui Liu Feng He Huihui Huang Shengshou Hu | 2015 | Cell Research2015，25，10： | 26 |
| 8 | Precise orbit determination for geostationary satellites with multiple tracking techniques显示文摘A new precise orbit determination (POD) strategy based on the combination of satellite laser ranging (SLR) and C-band transfer ranging for geostationary satellites (GEO) is presented.Two approaches to calibrate ranging biases of the C-band ranging system are proposed,namely the two tracking system co-location comparison and the combined POD method,with calibration accuracies estimated to be 0.5 ns and 1 ns respectively.Using data from a C-band tracking network in China,POD experiments indicate that meter-level POD accuracy is achievable for GEO.Root-mean-square (RMS) of the post-fit C-band ranging data is about 0.205 m.The radial component errors of POD are evaluated with SLR data from a station in Beijing,with residual RMS of 0.133 m.Orbital overlapping experiments show the total orbit error is a few meters.Computations of SLR residuals also suggest that for 2-hour prediction,the predicted radial error is about 0.373 m. | GUO Rui HU XiaoGong TANG Bo HUANG Yong LIU Li CHENG LiuCheng HE Feng | 2010 | Chinese Science Bulletin2010，55，8： | 24 |
| 9 | Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca^2+ oscillations on hippocampal neurons显示文摘目的: 在有教养的海马趾的 network.Methods 由 astragaloside IV (AGS-IV ) 导致了在自发的神经元易兴奋性调查变化: 在为 9-11 d 的文化的海马趾的神经原被用于这研究。这些海马趾的神经原的自发的接合的活动被 Ca^(2+) 成像和整个房间的斑夹钳技术检验。总共,当实验正在拿 place.Results 时,在 DMSO 和 2 mL/L DMSO 溶解的 40 mg/L AGS-IV 在一台显微镜下面被用于神经原: AGS-IV 禁止了同步自发的Ca^(2+)摆动的频率到59.39% ±3 .25%( mean+SEM ),自发的 postsynaptic 水流到43.78% ±7 .72%( mean+SEM ),和到控制时期的那些的49.25%+7.06%(吝啬的 ±S 他们)的自发的有刺激性的 postsynaptic 水流,分别地在 AGS-IV applications.AGS-IV 也减少了以后,在 16 min ,山峰在那时间 point.Conclusion 电压门K^+和Na^+隧道水流珍视:这些结果显示 AGS-IV 有效地压制自发的神经元易兴奋性。神经元活动的如此的调整能作为 neuroprotector 为 AGS-IV 代表新证据。 | Shao-qing ZHU Lei QI Yan-fang RUI Ru-xin LI Xiang-ping HE Zuo-ping XIE | 2008 | Acta Pharmacologica Sinica2008，29，1： | 23 |
| 10 | Development of mechatronic driving system for seed meters equipped on conventional precision corn planter显示文摘Precision planters are more and more widely used for planting corn in China.Seed meters of conventional precision corn planters are usually driven by ground wheel and chain and sprocket system at present.Because of the slippage of ground wheels and vibration of chains,planting accuracy cannot be ensured,especially at higher forward speed.To improve the planting performance of precision planters,a mechatronic driving system was designed and its field working performance was evaluated in this research.A two-row pneumatic precision planter was modified to allow simultaneously using two different driving systems,i.e,with one row unit equipped with the newly designed mechatronic driving system and the other row unit equipped with conventional mechanical driving system,and used for planting at three forward speeds(9,11 and 12 km/h)on no-tillage and rotary-tillage lands.The distances between adjacent seeds in each plot were measured and the indices of uniformity in seed spacing,quality of feeding index(QFI),missing-seeding index and precision index were analyzed.With the average 4.70%increase of QFI and 3.54%decrease of missing-seeding index,the mechatronic driving system performed better than the mechanical driving system both on no-tillage and rotary-tillage lands at each forward speed.The values of QFI,missing-seeding index and precision index of the mechatronic driving system on rotary-tillage land are comparable to those on no-tillage land,by contrast,these indices of the mechanical driving system on rotary-tillage land are significantly worse than those on no-tillage land.The result indicates that the mechatronic driving system can eliminate the effect of ground wheel slippage on planting quality and maintain the uniformity of seed distribution.Although the QFI,missing-seeding index and precision index become worse with the increase of forward speed,with the worst values of QFI of 89.93%,missing-seeding index of 5.08%and precision index of 18.92%at the highest forward speed of 12 km/h,the mechatronic driving system can reduce the effect of forward speed on planting accuracy effectively.The result indicates that planters equipped with the mechatronic driving system are suitable for high speed planting.As compared to the mechanical driving system,the advantage of the mechatronic driving system is more noticeable especially when the forward speed is more than 11 km/h. | Yang Li He Xiantao Cui Tao Zhang Dongxing Shi Song Zhang Rui Wang Mantao | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 22 |
| 11 | Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization显示文摘 | Yuli Lin Xuguang Yang Wenjie Yue Xiaofei Xu Bingji Li Linlin Zou Rui He | 2014 | Cellular & Molecular Immunology2014，11，4： | 21 |
| 12 | Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation显示文摘OBJECTIVE Psoriasis is an immune system meditated disease,especially T cells.It disturbed many people around the world and hard to therapy.Paeonia lactiflora Pall has been used as a medicine in china for thousands of years.Recent studies has found that the main component of Paeonia lactiflora Pall can alleviates the immune response in many diseases.In this study,we researched the effects and possible mechanisms of total glucosides of paeony(TGP)on animal psoriasis in order to study the therapeutic effects and mechanisms of TGP in 5%propranolol creaminduced psoriasis in guinea pigs and Imiquimod(IMQ)cream-induced psoriasis in mice.METHODS The effect of TGP was evaluated using a psoriasis-like model of guinea pigs and mice.Ear thickness was accessed,and pathology injury was observed by HE staining.The levels of serum IL-1β,IL-6,IL-12,IL-17,IL-23,TNF-α,and IFN-γ,skin IL-17A,IL-22 and orphan nuclear receptor(RORγt)mRNA expression,proliferating cell nuclear antigen(PCNA),total or phosphorylated signal transducers and activators of transcription(STAT1 and STAT3)were determined by ELISA,real time PCR,immu⁃nohistochemical staining,and Western blotting,respectively.RESULTS Compared with model group,TGP treatment decreased the ear thickness,improved pathology of psoriasis,alleviated IMQ-induced keratinocyte proliferation,reduced the inflammatory cytokine,and downregulated IL-17A,IL-22,and RORγt mRNA in mice.Further study indicated that TGP inhibited STAT1 and STAT3 phosphorylation in lesion skins of psoriasis-like mice.CONCLUSION TGP alleviates the symptoms of psoriasis-like guinea pigs and mice,and the possible mechanism may relate to inhibit T helper 17(TH17)cell differentiation and keratinocytes proliferation by inhibiting STAT1 and STAT3 phosphorylation. | LI Bin-bin HE Shu-cheng LIU Rui HUANG Liang-liang LIU Ge WANG Rui-xuan YANG Zhuo-yue LIU Xin-yi LENG Ye LIU Dan YE Cheng-yu LI Yun-man CHEN Yong-jian IN Hong FANG Wei-rong | 2019 | 中国药理学与毒理学杂志2019，33，9： | 21 |
| 13 | Effects of Tongxinluo-facilitated cellular cardiomyoplasty with autologous bone marrow-mesenchymal stem cells on postinfarct swine hearts显示文摘<正> Background Treatment of ischemic heart disease remains an important challenge,though there have been enormousprogresses in cardiovascular therapeutics.This study was conducted to evaluate whether Tongxinluo(TXL)treatmentaround the transplantation of mesenchymal stem cells(MSCs)can improve survival and subsequent activities ofimplanted cells in swine hearts with acute myocardial infarction(AMI)and reperfusion.Methods Twenty-eight Chinese mini-pigs were divided into four groups including a control group(n=7);group 2,administration of low-dose TXL alone from the 3rd day prior to AMI to the 4th day post transplantation(n=7);group 3,MSCs alone(n=7)and group 4,TXL+MSCs(n=7).AMI models were made by occlusion of the left anterior descendingcoronary artery for 90 minutes.Autologous bone marrow-MSCs(3×10~7 cells/animal)were then injected into thepost-infarct myocardium immediately after AMI and reperfusion.The survival and differentiation of implanted cells in vivowere detected by immunofluorescent analysis.The data of cardiac function were obtained at baseline(1 week aftertransplantation)and endpoint(6 weeks after transplantation)by single photon emission computed tomography(SPECT)and magnetic resonance imaging(MRI).Apoptosis was detected by TUNEL assay and the oxidative stress level wasinvestigated in the post-infarct myocardium at endpoint.Results At endpoint,there was less fibrosis and inflammatory cell infiltration with more surviving myocardium in group 4than in the control group.In group 4 the survival and differentiation of implanted MSCs were significantly improved morethan that seen in group 3 alone(P<0.0001);the capillary density was also significantly greater than in the control group,group 2 or 3 both in the infarcted zone(P<0.0001)and the peri-infarct zone(P<0.0001).MRI showed that parameters atbaseline were not significantly different between the 4 groups.At endpoint,regional wall thickening and the left ventricularejection fraction were increased while the left ventricular mass index,dyskinetic segments and infarcted size weredecreased only in group 4 compared with control group(P<0.0001).SPECT showed that the area of perfusion defectwas significantly decreased at endpoint only in group 4 compared with control group(P<0.0001).TUNEL assay indicatedthat TXL administration significantly decreased cell apoptosis in peri-infarct myocardium in groups 2 and 4.Furthermore,superoxide dismutase(SOD)significantly increased and malondialdehyde(MDA)decreased in groups 2 and 4 by theadministration of TXL.Conclusions Our study demonstrates the following:(1)immediate intramyocardial injection of MSCs after AMI andreperfusion resulted in limited survival and differentiation potential of implanted cells in vivo,thus being incapable ofbeneficially affecting post-hearts;(2)TXL-facilitation resulted in a significant survival and differentiation potential ofimplanted cells in vivo via inhibition of apoptosis and oxidative stress,accompanied by significant benefits in cardiacfunction.Chin Med J 2007;120(16) | QIAN Hai-yan YANG Yue-jin HUANG Ji GAO Run-lin DOU Ke-fei YANG Guo-sheng LI Jian-jun SHEN Rui HE Zuo-xiang LU Min-jie ZHAO Shi-hua | 2007 | Chinese Medical Journal2007，，16： | 19 |
| 14 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 15 | Diurnal variation of number concentration and size distribution of ultrafine particles in the urban atmosphere of Beijing in winter显示文摘在尺寸的在空中的粒子的数字集中和分发变化 5.6 ~ 560 nm 直径在冬季 2005 为一个 15-d 时期在北京被测量。成核模式(5.6 20 nm ) 的每天平均的数字集中,艾特肯模式(20 100 nm ) ,和累积模式(100 560 nm ) 粒子,和全部的粒子是 17500, 32000, 4000,和 53500 厘米(? 3 ) 分别地。平均颗粒大小分发是单音的与在夜里和与大约 10 和大约 40 nm 的模式直径形式的双性人的大约 40 nm 的一条模式直径形式在白天期间。新粒子形成事件,它被连接到日报成核模式粒子的变化,被观察在多于观察天的一半。事件经常在 10:00 11:00 汉语标准时间(CST ) 附近开始了并且在 3 4 h 以后结束了。艾特肯和累积模式粒子的集中从午夜增加了并且在大约 10:00 CST 到达了他们的最大值,然后减少并且在下午变得最低。分析日报在交通体积和气象学的参数的周期表明在艾特肯的粒子和在早上的累积模式的累积被在车辆排放的倒置和增加的形成影响,并且在下午的如此的粒子的分散与更有效的垂直混合和更高的风速度被联系。 | SHI Zong-bo HE Ke-bin YU Xue-chun YAO Zhi-liang YANG Fu-mo MA Yong-liang MA Rui JIA Ying-tao ZHANG Jie | 2007 | Journal of Environmental Sciences2007，19，8： | 16 |
| 16 | Symbiosis of Marshes and Permafrost in Da and Xiao Hinggan Mountains in Northeastern China显示文摘Recently,the degradation of permafrost and marsh environments in the Da and Xiao Hinggan Mountains has become a great concern as more human activities and pronounced climate warming were observed during the past 30 years and projected for the near future.The distribution patterns and development mechanisms of the permafrost and marshes have been examined both in theories and in field observations,in order to better understand the symbiosis of permafrost and marshes.The permafrost and marshes in the Da and Xiao Hinggan Mountains display discernible zonations in latitude and elevation.The marsh vegetation canopy,litter and peat soil have good thermal insulation properties for the underlying permafrost,resulting in a thermal offset of 3℃ to 4℃ and subsequently suppressing soil temperature.In addition,the much higher thermal conductivity of frozen and ice-rich peat in the active layer is condu-cive to the development or in favor of the protection of permafrost due to the semi-conductor properties of the soils overlying the permafrost.On the other hand,because permafrost is almost impervious,the osmosis of water in marsh soils can be effectively reduced,timely providing water supplies for helophytes growth or germination in spring.In the Da and Xiao Hinggan Mountains,the permafrost degradation has been accelerating due to the marked climate warming,ever increasing human activities,and the resultant eco-environmental changes.Since the permafrost and marsh envi-ronments are symbiotic and interdependent,they need to be managed or protected in a well-coordinated and integrated way. | JIN Huijun SUN Guangyou YU Shaopeng JIN Rui HE Ruixia | 2008 | Chinese Geographical Science2008，18，1： | 13 |
| 17 | Dietary L-theanine alleviated lipopolysaccharide-induced immunological stress in yellow-feathered broilers显示文摘L-theanine, a natural nonprotein amino acid with a high biological activity, is reported to exert anti-stress properties. An experiment with a 3 ? 2 factorial arrangement was conducted to investigate the effects of dietary L-theanine on growth performance and immune function in lipopolysaccharide(LPS)-challenged broilers. A total of 432 one-day-old male yellow-feathered broilers were randomly assigned to 3 dietary treatments(control, antibiotic and L-theanine diets) with 2 subgroups of each(6 replicate cages;12 birds/cage). Birds from each subgroup of the 3 dietary treatments were intra-abdominally injected with the same amount of LPS or saline at 24, 25, 26 d of age. Both dietary L-theanine and antibiotic improved(P < 0.05) the growth performance of birds before LPS injection(d 1 to 21). The effect of dietary L-theanine was better(P < 0.05) than that of antibiotic. Lipopolysaccharide decreased feed intake(FI) and body weight gain(BWG) from d 22 to 28(P < 0.05), BWG and feed to gain ratio(F:G) from d 29 to 56(P < 0.05), increased mortality in different growth periods(P < 0.05), elevated the levels of serum cortisol, a1-acid glycoprotein(a1-AGP), interleukin-6(IL-6) on d 24 and 25(P < 0.05), reduced immune organ indexes and contents of jejunal mucosal secretory immunoglobulin A(s Ig A) on d 28(P < 0.05). The decreased FI and BWG, as well as increased F:G and mortality in LPS-challenged birds, were alleviated by dietary L-theanine or antibiotic from d 29 to 56 and from d 1 to 56. Dietary L-theanine mitigated the elevated serum a1-AGP level on d 25, serum IL-6 concentration on d 24 and 26, and the decreased jejunal mucosal s Ig A content on d 28 of the LPS-challenged birds. The results indicated that L-theanine had potential to alleviate LPS-induced immune stress in broilers. | Rui Li Zehe Song Jianfei Zhao Dongxiao Huo Zhiyong Fan De-Xing Hou Xi He | 2018 | Animal Nutrition2018，，3： | 13 |
| 18 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 19 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 20 | DNMT3A/3B overexpression might be correlated with poor patient survival, hypermethylation and low expression of ESR1/PGR in endometrioid carcinoma: an analysis of The Cancer Genome Atlas显示文摘Background:DNA methylation is involved in numerous biologic events and associates with transcriptional gene silencing, playing an important role in the pathogenesis of endometrial cancer.ESR1/PGR frequently undergoes de novo methylation and loss expression in a wide variety of tumors, including breast, colon, lung, and brain tumors.However, the mechanisms underlying estrogen and progesterone receptors (ER/PR) loss in endometrial cancer have not been studied extensively.The aims of this study were to determine the expression of DNA (cytosine-5)-methyltransferase 3A/3B (DNMT3A/3B) in endometrial cancer to investigate whether the methylation catalyzed by DNMT3A/3B contributes to low ER/PR expression.Methods:The clinicopathologic information and RNA-Seq expression data of DNMT3A/3B of 544 endometrial cancers were derived from The Cancer Genome Atlas (TCGA) uterine cancer cohort in May 2018.RNA-Seq level of DNMT3A/3B was compared between these clinicopathologic factors with t-test or one-way analysis of variance.Results:DNMT3A/3B was overexpressed in endometrioid carcinoma (EEC) and was even higher in non-endometrioid carcinoma (NEEC) (DNMT3A, EEC vs.NEEC:37.6% vs.69.9%, t=-7.440, P<0.001;DNMT3B, EEC vs.NEEC:42.4% vs.72.8 %, t=-6.897, P<0.001).In EEC, DNMT3A overexpression was significantly correlated with the hypermethylation and low expression of the ESR1 and PGR (P<0.05).The same trend was observed in the DNMT3B overexpression subgroup.In the ESR1/PGR low-expression subgroups, as much as 83.1% of ESR1 and 59.5% of PGR were hypermethylated, which was significantly greater than the ESR1/PGR high-expression subgroups (31.3% and 11.9%, respectively).However, the above phenomena were absent in NEEC, while DNMT3A/3B overexpression, ESR1/PGR hypermethylation, and low ER/PR expression occurred much more often.In univariate analysis, DNMT3A/3B overexpressions were significantly correlated with worse prognosis.In multivariate analysis, only DNMT3A was an independent predictor of disease-free survival (P<0.05).Conclusions:DNMT3A/3B expression increases progressively from EEC to NEEC and is correlated with poor survival.The mechanisms underlying low ER/PR expression might be distinct in EEC vs.NEEC.In EEC, methylation related to DNMT3A/3B overexpression might play a major role in ER/PR downregulation. | Dan He Xiao Wang Yan Zhang Jian Zhao Rui Han Ying Dong | 2019 | Chinese Medical Journal2019，，2： | 12 |
您所在的机构暂未开通此部分的功能，请联系管理员