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| 1 | 一种鉴定结核分枝杆菌“北京家族”菌株的新方法显示文摘目的研究结核分枝杆菌“北京家族”菌株鉴定的新方法——RD105缺失检测的可行性。方法分别应用间隙寡核苷酸分型(Spoligotyping)和RD105缺失检测两种方法对结核分枝杆菌进行“北京家族”的鉴定,比较分析两种方法进行菌株鉴定结果的差异。结果共对来自北京、福建、新疆和吉林的342株结核分枝杆菌临床分离菌株进行了鉴定,“北京家族”菌株261株,占76.32%。非“北京家族”菌株81株,占23.68%。两种方法鉴定结果的符合度达100%。结论简单、快速的新方法——RD105缺失检测可替代原始经典方法Spoligotyping用于结核分枝杆菌“北京家族”菌株的鉴定。 | 刘敬华 Christine Pourel Yolande Hauck 赵秀芹 刘志广 万康林 | 2008 | 中华微生物学和免疫学杂志2008，28，2： | 21 |
| 2 | New multi protein patterns differentiate liver fibrosis stages and hepatocellular carcinoma in chronic hepatitis C serum samples显示文摘瞄准:识别一多象用为肝纤维变性(F1-F2 ) 的察觉和区别的提高表面的激光 desorption/ionisation time-of-flight 团 spectrometry (SELDI-TOF-MS ) 的单个蛋白质标记一样的浆液蛋白质模式,在有长期的丙肝病毒(HCV ) 的病人的肝肝硬化(F4 ) andhepatocellular 癌(HCC ) 。方法:有 F1/F2 纤维变性的 39 个病人,的 Serumsamples 有 F4 纤维变性的 44 个病人,有我们重新申请到 CM10 数组并且分析了使用 SELDI-TOF ProteinChip 系统的 HCC 的 34 个病人(PBS-IIc;CiphergenBiosystems ) 在阴离子交换分别以后。所有病人 andhistologically 有长期的丙肝证实的纤维变性 stage/HCC。数据被 multivariatestatistical 技术和人工的神经网络为蛋白质模式分析。结果:4 肽 / 蛋白质 multimarkerpanel (7486, 12843, 44293 和 53598 Da ) 正确地在训练样品(AUROC0.943 ) 的 HCV 肝硬化对 HCV-HCC 的二方法比较与 100% 的敏感和 85% 的特性识别了 HCC。为 HCC 的鉴定的敏感和特性为随机的测试样品是 68% 和 80% 。肝脏硬化症的病人能被歧视有多使用 5peptide/protein 的 F1 或 F2 纤维变性的病人标记模式( 2873 , 6646 , 7775 , 10525 和 67867 Da )与100%和在训练样品( AUROC 0.976 )的85%的敏感和敏感和特性of80%的特性并且67%为随机的测试样品。有 APRI 分数 andalfa-fetopotein (法新社) 的简历标记分类器的联合改进了诊断表演。为肝纤维变性的 6646 Da 标记蛋白质作为 apolipoprotein C-I 被识别。结论:与蛋白质模式分析相结合的 SELDI-TOF-MS 技术与长期的丙肝在病人为肝肝硬化 andhepatocellular 癌的鉴定似乎是一条珍贵途径。最可能,不同浆液标记的联合将帮助以后识别肝肝硬化和早阶段的 hepatocellularcarcinomas。 | Thomas Gbel Sonja Vorderwülbecke Katarzyna Hauck Holger Fey Dieter Hussinger Andreas Erhardt | 2006 | World Journal of Gastroenterology2006，12，47： | 21 |
| 3 | Genetic dissection of maize seedling root system architecture traits using an ultra-high density bin-map and a recombinant inbred line population显示文摘Maize(Zea mays) root system architecture(RSA)mediates the key functions of plant anchorage and acquisition of nutrients and water. In this study,a set of 204 recombinant inbred lines(RILs) was derived from the widely adapted Chinese hybrid ZD958(Zheng58 Chang7-2),genotyped by sequencing(GBS) and evaluated as seedlings for 24 RSA related traits divided into primary,seminal and total root classes. Signi ficant differences between the means of the parental phenotypes were detected for 18 traits,and extensive transgressive segregation in the RIL population was observed for all traits. Moderate to strong relationships among the traits were discovered. A total of 62 quantitative trait loci(QTL) were identi fied that individually explained from1.6% to 11.6%(total root dry weight/total seedling shoot dry weight) of the phenotypic variation. Eighteen,24 and 20 QTL were identi fied for primary,seminal and total root classes of traits,respectively. We found hotspots of 5,3,4 and 12 QTL in maize chromosome bins 2.06,3.02-03,9.02-04,and 9.05-06,respectively,implicating the presence of root gene clusters or pleiotropic effects. These results characterized the phenotypic variation and genetic architecture of seedling RSA in a population derived from a successful maize hybrid. | Weibin Song Baobao Wang Andrew L Hauck Xiaomei Dong Jieping Li Jinsheng Lai | 2016 | Journal of Integrative Plant Biology2016，58，3： | 13 |
| 4 | Equations for estimating the above-ground biomass of Larix sibirica in the forest-steppe of Mongolia显示文摘Biomass functions were established to estimate above-ground biomass of Siberian larch (Larix sibirica) in the Altai Mountains of Mongolia. The functions are based on biomass sampling of trees from 18 different sites, which represent the driest locations within the natural range of L. sibirica. The best performing regression model was found for the equations y = (D2 H)/(a+bD) for stem biomass, y = aDb for branch biomass, and y=aDb Hc for needle biomass, where D is the stem diameter at breast height and H is the tree height. The robustness of the biomass functions is assessed by comparison with equations which had been previously published from a plantation in Iceland. There, y=aDb H c was found to be the most significant model for stem and total above-ground biomasses. Applying the equations from Iceland for estimating the above-ground biomass of trees from Mongolia resulted in the underestimation of the biomass in large-diameter trees and the overestimation of the biomass in thin trees. The underestimation of thick-stemmed trees is probably attributable to the higher wood density, which has to be expected under the ultracontinental climate of Mongolia compared to the euoceanic climate of Iceland. The overestimation of the biomass in trees with low stem diameter is probably due to the high density of young growth in the not systematically managed forests of the Mongolian Altai Mountains, which inhibits branching, whereas the plantations in Iceland are likely to have been planted in lower densities. | Purevragchaa Battulga Jamsran Tsogtbaatar Choimaa Dulamsuren Markus Hauck | 2013 | Journal of Forestry Research2013，24，3： | 10 |
| 5 | Associations between Mycobacterium tuberculosis Beijing geno- type and drug resistance to four first-line drugs: a survey in China显示文摘在中国的 Mycobacterium 肺结核的基因差异上的调查证明了北京遗传型紧张起一个主导的作用。学习在 M. 之间的协会 ? 肺结核北京遗传型和药抵抗显型, 1286 M。肺结核临床和病人的流行病学、临床的信息孤立从肺结核(TB ) 的中心被收集在在中国的北京自治市和九个省或自治区域的预防和控制或 TB 医院。测试的药抵抗在所有 isolates 上被进行到四首要的 anti-TB 药(异菸肼, rifampicin,链球菌,和 ethambutol ) 。585 紧张的一个总数被发现对四 anti-TB 药中的至少一个抵抗。北京家庭紧张由 499 组成了(53.20%) 药敏感的紧张并且 439 (46.80%) 药抵抗的紧张,而非北京家庭紧张包括了 202 (58.05%) 药敏感的紧张并且 146 (41.95%) 药抵抗的紧张。没有重要差别在流行被观察(c 2=2.41, P > 0.05 ) 在在北京家庭紧张之中的药抵抗、药敏感的紧张之间。药抵抗的 monoresistance, multidrug 抵抗的 TB,和地理分发的分析没发现在 M. 之间的任何关系 ? 在中国的肺结核北京遗传型和药抵抗显型。结果证实了北京遗传型,占优势的 M。在中国的肺结核遗传型,没与药抵抗被联系。 | Haican Liu Yuanyuan Zhang Zhiguang Liu Jinghua Liu Yolande Hauck Jiao Liu Haiyan Dong Jie Liu Xiuqin Zhao Bing Lu Yi Jiang Gilles Vergnaud Christine Pource Kanglin Wan | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 6 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 7 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 8 | Response of tree-ring width to climate warming and selective logging in larch forests of the Mongolian Altai显示文摘Aims The Mongolian Altai is an old settlement area,which is populated by pastoral nomads since 2000–3000 years.Forests in this region(at ca.2300 m a.s.l.)are highly fragmented and border on steppe and alpine grasslands,which are used for mobile livestock husbandry.The climate in Central Asia is warming to levels clearly above the global average,which affects the vegetation.Furthermore,the transition from planned to market economy and the decollectivization of livestock 20 years ago has strongly changed land use practices in Mongolia,especially resulting in an increase in recent logging activities.We were interested in the question how climate warming and selective logging influence the annual stem growth and the stand structure.Methods The impact of climate and land use by the pastoral nomads on the annual stem increment of more than 1800 trees of Siberian larch(Larix sibirica)was analyzed.Different groups of trees with divergent growth trends depending on the social position and stand history were identified by non-metric multidimensional scaling and analysis of similarities.Long-term trends in the annual stem increment were analyzed by establishing separate regional growth curves for trees of different age classes.Important Findings Instrumental climate data substantiate an increase of temperature by 2.1°C since 1940 at constant precipitation.Trees benefit from the increased temperatures.Climate–response analysis revealed that radial stem increment was promoted by the temperature in early summer,but also high precipitation in spring and in the year before tree-ring formation.Forest dynamics is also strongly influenced by anthropogenic activities.In addition to the natural forest dynamics,logging resulted in divergent growth trends within given age classes and habitats(forest interior and forest edge);overall,22 groups of trees with different characteristics in the annual radial stem increment were identified.A tree-ring series-based reconstruction of logging intensity since 1935 suggests that moderate selective logging occurred throughout the study period.However,selective logging was strongly intensified after 1990 as the result of the breakdown of the Communist regime in Mongolia and the transition from centrally planned to market economy.Because tree stump densities showed that the ratio of felled to live trees was 2:1 in the interior or even 0.9:1 at the edges of the forests and most logging occurred during the past 20 years,it must be concluded that the forests of the Mongolian Altai are presently exploited far beyond the level of sustainability.A close correlation of the ratio of felled to live trees with the density of summer camps of pastoral nomads in the vicinity suggests that trees are primarily felled by the local population. | Choimaa Dulamsuren Mookhor Khishigjargal Christoph Leuschner Markus Hauck | 2014 | Journal of Plant Ecology2014，7，1： | 5 |
| 9 | Mapping and genome organization of microsatellite sequences in rice (Oryza sativa L.)显示文摘 | S. Temnykh William D. Park Nicola Ayres Sam Cartinhour N. Hauck L. Lipovich Y. G. Cho T. Ishii S. R. McCouch | 2000 | TAG Theoretical and Applied Genetics2000，，5： | 3 |
| 10 | STRUCTURE-BORNE SOUND AND VIBRATION FROM RAIL TRAFFIC显示文摘 | M. Heckl G. Hauck R. Wettschureck | 1996 | Journal of Sound and Vibration1996，，1： | 2 |
| 11 | Liver Environment and HCV Replication Affect Human T-Cell Phenotype and Expression of Inhibitory Receptors显示文摘 | Daniela C. Kroy Donatella Ciuffreda Jennifer H. Cooperrider Michelle Tomlinson Garrett D. Hauck Jasneet Aneja Christoph Berger David Wolski Mary Carrington E. John Wherry Raymond T. Chung Kenneth K. Tanabe Nahel Elias Gordon J. Freeman Rosemarie H. de Kru | 2014 | Gastroenterology2014，，2： | 2 |
| 12 | Novel directions of precision oncology:circulating microbial DNA emerging in cancer-microbiome areas显示文摘Microbiome research has extended into the cancer area in the past decades.Microbes can affect oncogenesis,progression,and treatment response through various mechanisms,including direct regulation and indirect impacts.Microbiota-associated detectionmethods and agents have been developed to facilitate cancer diagnosis and therapy.Additionally,the cancermicrobiome has recently been redefined.The identification of intra-tumoral microbes and cancer-related circulating microbial DNA(cmDNA)has promoted novel research in the cancer–microbiome area.In this review,we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid biopsy.We outline all existing studies on the relationship between cmDNA and cancer and the outlook for potential preclinical and clinical applications of cmDNA in cancer precision medicine,as well as critical problems to be overcome in this burgeoning field. | Liting You Juan Zhou Zhaodan Xin J.Spencer Hauck Feifei Na Jie Tang Xiaohan Zhou Zichen Lei Binwu Ying | 2022 | Precision Clinical Medicine2022，5，1： | 2 |
| 13 | Non-contact left ventricular endocardial mapping in cardiac resynchronization therapy显示文摘 | Lambiase PD Rinaldi A Hauck J | 2004 | Heart2004，90，1： | 1 |
| 14 | Can anatomical left Ventricularmass be estimatedrelialy by Mmod echocardiography Aclincopathological study of 93 patients显示文摘 | Bacenberg TG Hauck AJ | 1991 | Eckocardio-graphy1991，8，： | 1 |
| 15 | An in vitro-differenti- ated human cell line as a model system to study the interaction of Neisseria gonorrhoeae with phagocytic cells 显示文摘 | Hauck CR Lorenzen D Saas J Meyer TF | 1997 | Infect Immun1997，65，5： | 1 |
| 16 | Size ratio correlates withintracranial aneurysm rupture status:a prospective study显示文摘 | Rahman M Smietana J Hauck E | 2010 | Stroke2010，41，5： | 1 |
| 17 | Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease显示文摘 | Emery CF Schein RL Hauck ER | | 0，，： | 1 |
| 18 | Translocation of two glucose transporters in heart: effects of rotenone, uncouplers,workload, palmitate, insulin and anoxia显示文摘 | WHEELER T J FELL R D HAUCK M A | 1994 | Biochim Biophys Acta1994，1196，2： | 1 |
| 19 | Implantation of Accuflex and Strecker stents in malignant bronchial stenoses by flexible bronchoscopy显示文摘 | Lembeck RM Enslander HP | 1997 | Chest1997，112，： | 1 |
| 20 | Prostaglandin E1 long-term self injection programme for treatment of erectile dysfunction--a follow-up of at least 5 year显示文摘 | Alfinkilic BM Schroeder-Printzen I | 1999 | Andrologia1999，31，1： | 1 |
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