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| 1 | NK cell receptor imbalance and NK cell dysfunction in HBV nfection and hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 当前由于手术后的复发和转移是癌症死亡和普通差预后的恶意的第三个领先的原因。在长期的肝炎 B 之间有重要关联病毒(HBV ) 感染和 hepatocarcinogenesis。作为对病毒的感染和肿瘤的宿主防卫的第一根线,生来的杀手( NK )细胞表示很多有免疫力的识别受体( NK 受体( NKR ))在 hepatocytes ,肝正弦曲线 endothelial 细胞,星形的细胞和 Kupffer 细胞上认出 ligands ,它维持在有免疫力的反应和 NK 细胞的有免疫力的忍耐之间的平衡。不幸地,百分比和肝 NK 房间的绝对数字在 HCC 的发展和前进期间显著地减少。NK 房间受体和肝 NK 房间的机能障碍的反常表示贡献长期的 HBV 感染和 HCC 的前进并且显著地为肝癌症与差的预后被联系。在这评论,我们在 HCC 在反肿瘤免疫者回答集中于 NK 房间受体的角色,特别地 HBV 相关的 HCC。我们明确地讨论肿瘤房间怎么从 NK 房间躲避攻击并且 NKR 的新兴的理解怎么可以为 HCC 帮助新奇治疗的发展。小说单音 -- 并且指向 NK 房间 receptor-ligand 系统的治疗学的策略可以潜在地导致的联合在 HCC 的成功、有效的免疫疗法。 | Cheng Sun Haoyu Sun Cai Zhang Zhigang Tian | 2015 | Cellular & Molecular Immunology2015，12，3： | 55 |
| 2 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 3 | HAART预防艾滋病母婴传播的可行性和有效性显示文摘目的总结和分析在云南省边远的农村地区,对孕妇实施高效反转录病毒治疗(HAART)以预防艾滋病病毒(HIV)母婴传播(PMTCT)的有效性和可行性。方法梳理和定量分析2005-2012年,云南省与美国艾伦戴蒙德艾滋病研究中心开展的预防艾滋病母婴传播项目的效果。结果在1 861名HIV阳性孕妇中,1 353名孕妇(72.7%)采用了HAART阻断方案。在1 584名有HIV检测结果的婴儿中,阳性25人,阳性率为1.58%;其中1 168名采用HAART妇女所生的婴儿中,仅有9人阳性,阳性率为0.8%;在孕28周前开始HAART的妇女所生婴儿中,HIV阳性率为0.2%(2/899)。结论 HAART对于阻断HIV母婴传播效果非常显著,如果在孕28周前开始HAART,婴儿HIV感染率已经非常接近'零感染'的目标,可以推广和实施。 | 周曾全 劳云飞 陈庆玲 Kathrine Meyers 张燕 李慰 楼金成 杨一青 蒋成芹 郭云松 Haoyu Qian | 2014 | 中国艾滋病性病2014，20，2： | 20 |
| 4 | MR-DBSCAN: a scalable MapReduce-based DBSCAN algorithm for heavily skewed data显示文摘 | Yaobin HE Haoyu TAN Wuman LUO Shengzhong FENG Jianping FAN | 2014 | Frontiers of Computer Science2014，8，1： | 18 |
| 5 | NK cells in immunotolerant organs显示文摘象肝,子宫和肺那样的机关拥有特点 immunotolerant 特征,为支撑自我动态平衡使这些机关重要。这些机关包含一相对大量否定规章的有免疫力的房间,它被相信参加有免疫力的回答的规定。因为自然漂亮细胞在这些器官组成所有淋巴细胞的一个大比例,增加的注意被给了这些细胞在维持 immunotolerance 起的作用。这里,我们在这些 immunotolerant 机关考察分发,区别, phenotypic 特征和自然漂亮房间的功能的特征,除了这些房间上的本地微型环境的影响并且这些因素怎么贡献器官特定的疾病。 | Haoyu Sun Cheng Sun Zhigang Tian Weihua Xiao | 2013 | Cellular & Molecular Immunology2013，10，3： | 13 |
| 6 | Herbgenomics: A stepping stone for research into herbal medicine显示文摘From the prehistoric era until the publishing of the Compendium of Materia Medica and the first scientific Nobel Prize in the Chinese mainland for Tu's discovery on anti-malarial tablets,each milestone and stepping stone in the developmental history of herbal medicine involved intrepid exploration,bold hypothesis formulation,and cautious verification.After thousands of years of discovery and development,herbal research has entered a new era—the era of herbgenomics.Herbgenomics combines herbal and genomic research,bridging the gap between traditional herbal medicine and cutting-edge omics studies.Therefore,it provides a general picture of the genetic background of traditional herbs,enabling researchers to investigate the mechanisms underlying the prevention and treatment of human diseases from an omics perspective. | Haoyu Hu Xiaofeng Shen Baosheng Liao Lu Luo Jiang Xu Shilin Chen | 2019 | Science China(Life Sciences)2019，62，7： | 13 |
| 7 | High-accuracy primary and transfer standards for radiometric calibration显示文摘The first research and experimental results obtained in China of high-accuracy radiometric calibration based on cryogenic radiometer are reported. Uncertainties of cryogenic radiometer and trap detectors at 7 wavelengths in the visible spectrum (488-786 nm) were less than 0.023% and 0.035% respectively, which proved the reasonability and possibility of establishing and transferring high-accuracy radiometric standards based on detectors. | Xiaobing Zheng Haoyu Wu Junping Zhang Yucheng Liu Wei Zhou Leyi Wang Yanli Qiao | 2000 | Chinese Science Bulletin2000，45，21： | 12 |
| 8 | Field investigation on severely damaged aseismic buildings in 2014 Ludian earthquake显示文摘The 2014 magnitude 6.5 Ludian earthquake caused a death toll of 617, many landslides and tens of thousands of collapsed buildings. A field investigation to evaluate the damage to buildings was carried out immediately after the occurrence of the earthquake. Severely damaged aseismic buildings, which were basically observed in the downtown of Longtoushan Town, were carefully examined one by one with the aim to improve design codes. This paper summarizes the damage observed to the investigated aseismic buildings in both the structural and local levels. A common failure mode was observed that most of the aseismic buildings, such as RC frame structures and confined masonry structures, were similarly destroyed by severe damage or complete collapse of the first story. The related strong ground motion, which was recorded at the nearby station, had a short duration of less than 20 s but a very large PGA up to 1.0 g. The RC frames based on the new design codes still failed to achieve the design target for 'strong column, weak beam'. Typical local failure details, which were related to the interaction between RC columns and infill walls and between constructional columns and masonry walls, are summarized with preliminary analyses. | Lin Xuchuan Zhang Haoyu Chen Hongfu Chen Hao Lin Junqi | 2015 | Earthquake Engineering and Engineering Vibration2015，14，1： | 12 |
| 9 | Tissue-resident lymphocytes: from adaptive to innate immunity显示文摘Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems.For multiple decades,it has been believed that CD8+memory T cells and natural killer(NK)cells constantly and uniformly recirculate.Only recently was the existence of noncirculating memory T and NK cells that remain resident in the peripheral tissues,termed tissue-resident memory T(TRM)cells and tissue-resident NK(trNK)cells,observed in various organs owing to improved techniques.TRM cells populate a wide range of peripheral organs,including the skin,sensory ganglia,gut,lungs,brain,salivary glands,female reproductive tract,and others.Recent findings have demonstrated the existence of TRM in the secondary lymphoid organs(SLOs)as well,leading to revision of the classic theory that they exist only in peripheral organs.trNK cells have been identified in the uterus,skin,kidney,adipose tissue,and salivary glands.These tissue-resident lymphocytes do not recirculate in the blood or lymphatic system and often adopt a unique phenotype that is distinct from those of circulating immune cells.In this review,we will discuss the recent findings on the tissue residency of both innate and adaptive lymphocytes,with a particular focus on CD8+memory T cells,and describe some advances regarding unconventional T cells(invariant NKT cells,mucosal-associated invariant T cells(MAIT),andγδT cells)and the emerging family of trNK cells.Specifically,we will focus on the phenotypes and functions of these subsets and discuss their implications in anti-viral and anti-tumor immunity. | Haoyu Sun Cheng Sun Weihua Xiao Rui Sun | 2019 | Cellular & Molecular Immunology2019，16，3： | 12 |
| 10 | Preliminary Experimental Investigation on MHD Power Generation Using Seeded Supersonic Argon Flow as Working Fluid显示文摘这篇论文在 magnetohydrodynamic (MHD ) 上论述初步的试验性的调查把播种的超声的氩流动用作工作液体的发电。氦和氩被用作司机并且在一条吃惊隧道分别地驾驶气体。平衡接触表面操作模式被用来获得高温度气体,并且传导性被增加种子 K2CO3 粉末进驾驶的节获得。在嘴入口总数压力的条件下面是 0.32 MPa,全部的温度 6 504 K,磁场密度大约 0.5 T 和嘴插头速度 1 959 m/s,正式就职电压和分割 MHD 发电隧道的电线走火电流被测量,并且试验性的结果同意理论计算;平均传导性是从电压和电流的特征计算的大约 20 S/m。当负担因素是 0.5 时, MHD 发电隧道的最大的力量密度到达 4.797 1 MW/m3,和最大的热含量抽取率是 0.34% 。最后,为煤气的州的参数的间接测试的原则和方法被导出并且分析。 | LI Yiwen LI Yinghong LU Haoyu ZHU Tao ZHANG Bailing CHEN Feng ZHAO Xiaohu | 2011 | Chinese Journal of Aeronautics2011，24，6： | 11 |
| 11 | An Embedded Feature Selection Method for Imbalanced Data Classification显示文摘Imbalanced data is one type of datasets that are frequently found in real-world applications, e.g., fraud detection and cancer diagnosis. For this type of datasets, improving the accuracy to identify their minority class is a critically important issue.Feature selection is one method to address this issue. An effective feature selection method can choose a subset of features that favor in the accurate determination of the minority class. A decision tree is a classifier that can be built up by using different splitting criteria. Its advantage is the ease of detecting which feature is used as a splitting node. Thus, it is possible to use a decision tree splitting criterion as a feature selection method. In this paper, an embedded feature selection method using our proposed weighted Gini index(WGI) is proposed. Its comparison results with Chi2, F-statistic and Gini index feature selection methods show that F-statistic and Chi2 reach the best performance when only a few features are selected. As the number of selected features increases, our proposed method has the highest probability of achieving the best performance. The area under a receiver operating characteristic curve(ROC AUC) and F-measure are used as evaluation criteria. Experimental results with two datasets show that ROC AUC performance can be high, even if only a few features are selected and used, and only changes slightly as more and more features are selected. However, the performance of Fmeasure achieves excellent performance only if 20% or more of features are chosen. The results are helpful for practitioners to select a proper feature selection method when facing a practical problem. | Haoyue Liu MengChu Zhou Qing Liu | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，3： | 11 |
| 12 | Global Pharmacopoeia Genome Database is an integrated and mineable genomic database for traditional medicines derived from eight international pharmacopoeias显示文摘Genomic data have demonstrated considerable traction in accelerating contemporary studies in traditional medicine. However,the lack of a uniform format and dispersed storage limits the full potential of herb genomic data. In this study, we developed a Global Pharmacopoeia Genome Database(GPGD). The database contains 34,346 records for 903 herb species from eight global pharmacopoeias(Brazilian, Egyptian, European, Indian, Japanese, Korean, the Pharmacopoeia of the People’s Republic of China, and U.S. Pharmacopoeia’s Herbal Medicines Compendium). In particular, the GPGD contains 21,872 DNA barcodes from 867 species, 2,203 organelle genomes from 674 species, 55 whole genomes from 49 species, 534 genomic sequencing datasets from 366 species, and 9,682 transcriptome datasets from 350 species. Among the organelle genomes, 534 genomes from 366 species were newly generated in this study. Whole genomes, organelle genomes, genomic fragments, transcriptomes, and DNA barcodes were uniformly formatted and arranged by species. The GPGD is publicly accessible at http://gffzzf938e9d610ce4c4ah0b5bnfcvcvw06wbp.ffgz.tsg.suse.edu.cn and serves as an essential resource for species identification, decomposition of biosynthetic pathways, and molecular-assisted breeding analysis. Thus, the database is an invaluable resource for future studies on herbal medicine safety, drug discovery, and the protection and rational use of herbal resources. | Baosheng Liao Haoyu Hu Shuiming Xiao Guanru Zhou Wei Sun Yang Chu Xiangxiao Meng Jianhe Wei Han Zhang Jiang Xu Shilin Chen | 2022 | Science China(Life Sciences)2022，65，4： | 11 |
| 13 | Natural killer cells in liver diseases显示文摘 | Meijuan Zheng Haoyu Sun Zhigang Tian | 2018 | Frontiers of Medicine2018，12，3： | 11 |
| 14 | Hybrid finite-discrete element modelling of asperity degradation and gouge grinding during direct shearing of rough rock joints显示文摘 | H. Y. Liu Haoyu Han H. M. An J. J. Shi | 2016 | International Journal of Coal Science & Technology2016，3，3： | 10 |
| 15 | Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells显示文摘Multiple sclerosis(MS) is an autoimmune disease of the central nervous system(CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and there are currently no effective treatments. The development of neural stem cell(NSC) transplantation provides a promising strategy to treat neurodegenerative disease. However, the limited availability of NSCs prevents their application in neural disease therapy. In this study, we generated NSCs from induced pluripotent stem cells(iPSCs) and transplanted these cells into mice with experimental autoimmune encephalomyelitis(EAE), a model of MS. The results showed that transplantation of iPSC-derived NSCs dramatically reduced T cell infiltration and ameliorated white matter damage in the treated EAE mice. Correspondingly, the disease symptom score was greatly decreased, and motor ability was dramatically rescued in the iPSC-NSC-treated EAE mice, indicating the effectiveness of using iPSC-NSCs to treat MS. Our study provides pre-clinical evidence to support the feasibility of treating MS by transplantation of iPSC-derived NSCs. | Chao Zhang Jiani Cao Xiaoyan Li Haoyu Xu Weixu Wang Libin Wang Xiaoyang Zhao Wei Li Jianwei Jiao Baoyang Hu Qi Zhou Tongbiao Zhao | 2016 | Science China(Life Sciences)2016，59，9： | 9 |
| 16 | Partial Discharge Measurement and Analysis in High Voltage IGBT Modules Under DC Voltage显示文摘Insulation performance of high voltage IGBT modules is one of the key attributes in power system applications.However,the existing standards of IGBT devices and research on the evaluation of insulation performance of high voltage IGBT modules are insufficient;for example,partial discharge resistance under DC voltage blocking condition is not considered.In this paper,a new test was proposed to allow the measurement of partial discharges in all the components of IGBT modules under DC voltage.The topology of the measuring circuit is arranged in the polarity discrimination way to exclude the interference,and the voltage and discharge current waveforms during the partial discharge process are measured by the wideband time domain measurement technique.According to the proposed test,the discharge phenomenon of the IGBT modules below the rating voltage were detected.A comprehensive waveform analysis on the voltage and discharge current was performed,and the influence of the applied voltage on the waveform parameters was obtained.The waveform parameters are influenced by the applied voltage and insulation structure,which enables the discrimination of the causes of the observed partial discharge in the IGBT module under DC voltage by the waveform analysis technique.Based on the waveform analysis technique,the types and causes of the observed partial discharges were discussed and inferred,and the correctness of the inference was further verified by observation.The proposed test and waveform analysis technique provide the possibility to evaluate and distinguish partial discharges in the high voltage IGBT module under DC voltage,which may be helpful to insulation performance evaluation and insulation defect diagnosis in high voltage IGBT module. | Pengyu Fu Zhibin Zhao Xiang Cui Teng Wen Haoyu Wang Xuebao Li Peng Zhang | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 9 |
| 17 | Image Smearing Modeling and Verification for Strapdown Star Sensor显示文摘To further extend study on celestial attitude determination with strapdown star sensor from static into dynamic field, one prerequisite is to generate precise dynamic simulating star maps. First a neat analytical solution of the smearing trajectory caused by spacecraft attitude maneuver is deduced successfully, whose parameters cover the geometric size of optics, three-axis angular velocities and CCD integral time. Then for the first time the mathematical law and method are discovered about how to synthesize the two formulae of smearing trajectory and the static Gaussian distribution function (GDF) model, the key of which is a line integral with regard to the static GDF attenuated by a factor 1/ L s (L s is the arc length of the smearing trajectory) along the smearing trajectory. The dynamic smearing model is then obtained, also in an analytical form. After that, three sets of typical simulating maps and data are simulated from this dynamic model manifesting the expected smearing effects, also compatible with the linear model as its special case of no boresight rotation. Finally, model validity tests on a rate turntable are carried out, which results in a mean correlation coefficient 0.920 0 between the camera images and the corresponding model simulated ones with the same parameters. The sufficient similarity verifies the validity of the dynamic smearing model. This model, after parameter calibration, can serve as a front-end loop of the ground semi-physical simulation system for celestial attitude determination with strapdown star sensor. | WANG Haiyong ZHOU Wenrui CHENG Xuan LIN Haoyu | 2012 | Chinese Journal of Aeronautics2012，25，1： | 8 |
| 18 | Carbon Diffusion in Hot Strips of Low Carbon Steel Produced by CSP Line under Different Thermal Histories显示文摘Two experiments were carried out on the same compact strip production (CSP) line, which differs in that one of them experienced γ→α→γ* thermal history. The differences in microstructure, precipitation, misorientation etc between two experiments were investigated by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), electron back-scattered diffraction (EBSD) and positron annihilation technique (PAT). The carbon concentration in matrix is more inhomogeneous in the experiment than that with γ→α→γ* thermal history. The specific precipitation characteristic in the experiment without γ→α→γ* thermal history is discussed on the basis of different carbon diffusion behavior and interaction between dislocation and excess carbon. | HaoYU HaoREN YonglinKANG KeluWANG | 2005 | Journal of Materials Science & Technology2005，21，1： | 8 |
| 19 | Quantitative analysis on strengthening mechanism of ultra-thin hot strip of low carbon steel produced by CSP technique显示文摘Based on experimental data of positron annihilation technology, electrolytic dissolution technique, electron back-scattered pattern, etc. And by analysis the strengthening factors, the strengthening mechanism of ultra-thin hot strip of low carbon steel produced by CSP (Compact Strip Production) technique was investigated. The value of each strengthening mechanism and its contribution percentage to yield strength were achieved. The results show that refinement strengthening is the predominant strengthening mode; precipitation strengthening and dislocation strengthening are second to it, their contributions to yield strength are almost equal. | HaoYu YonglinKang XueyingXiong KeluWang JieFu GuijiangChen LiejunLi | 2004 | Journal of University of Science and Technology Beijing2004，11，5： | 8 |
| 20 | Channel Measurement and Path Loss Modeling from 220 GHz to 330 GHz for 6G Wireless Communications显示文摘Terahertz(THz)communication has been envisioned as a key enabling technology for sixthgeneration(6G).In this paper,we present an extensive THz channel measurement campaign for 6G wireless communications from 220 GHz to 330 GHz.Furthermore,the path loss is analyzed and modeled by using two single-frequency path loss models and a multiplefrequencies path loss model.It is found that at most frequency points,the measured path loss is larger than that in the free space.But at around 310 GHz,the propagation attenuation is relatively weaker compared to that in the free space.Also,the frequency dependence of path loss is observed and the frequency exponent of the multiple-frequencies path loss model is 2.1.Moreover,the cellular performance of THz communication systems is investigated by using the obtained path loss model.Simulation results indicate that the current inter-site distance(ISD)for the indoor scenario is too small for THz communications.Furthermore,the tremendous capacity gain can be obtained by using THz bands compared to using microwave bands and millimeter wave bands.Generally,this work can give an insight into the design and optimization of THz communication systems for 6G. | Pan Tang Jianhua Zhang Haoyu Tian Zhaowei Chang Jun Men Yuxiang Zhang Lei Tian Liang Xia Qixing Wang Jingsuo He | 2021 | China Communications2021，18，5： | 7 |
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