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| 1 | Progressive familial intrahepatic cholestasis显示文摘BACKGROUND:Three types of progressive familial intrahepatic cholestasis(PFIC)have been identified,but their etiologies include unknown mechanisms. DATA SOURCES:A PubMed search on'progressive familial intrahepatic cholestasis'and'PFIC'was performed on the topic,and the relevant articles were reviewed. RESULTS:The etiologies of the three PFIC types still include unknown mechanisms.Especially in PFIC type 1,enterohepatic circulation of bile acid should be considered.Ursodeoxycholic acid,partial external biliary diversion and liver transplantation have been used for the treatment of PFIC patients according to disease course. CONCLUSIONS:Since the etiologies and disease mechanisms of PFIC are still unclear,detailed studies are urgently required. Strategies for more advanced therapies are also needed.These developments in the future are indispensable,especially for PFIC type 1 patients. | Tomohide Hori Justin H.Nguyen Shinji Uemoto | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，6： | 9 |
| 2 | Stem cell-based therapy for human diseases显示文摘Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated.Stem cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative medicine.hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ layers.MsCs are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(AT),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular conditions.Moreover,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications.The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment. | Duc M.Hoang Phuong T.Pham Trung Q.Bach Anh T.L.Ngo Quyen T.Nguyen Trang T.K.Phan Giang H.Nguyen Phuong T.T.Le Van T.Hoang Nicholas R.Forsyth Michael Heke Liem Thanh Nguyen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 7 |
| 3 | Comparative mammalian cell cytotoxicity of wastewater with elevated bromide and iodide after chlorination,chloramination, or ozonation显示文摘Recycling wastewater is becoming more common as communities around the world try to better control their water resources against an increased frequency of either prolonged droughts or intense flooding. For communities in coastal areas, wastewaters may contain elevated levels of bromide(Br^-) and iodide(I^-) from seawater intrusion or high mineral content of source waters. Disinfection of such wastewater is mandatory to prevent the spread of pathogens, however little is known about the toxicity of wastewater after disinfection in the presence of Br^-and I^-. In this study we compared the induction of chronic cytotoxicity in mammalian cells in samples of municipal secondary wastewater effluent amended with elevated levels of Br^-/I^-after disinfection by chlorine, chloramines or ozone to identify which disinfection process generated wastewater with the lowest level of adverse biological response. Chlorination increased mammalian cell cytotoxicity by 5times as compared to non-disinfected controls. Chloramination produced disinfected wastewater that expressed 6.3 times more cytotoxicity than the non-disinfected controls and was 1.3 times more cytotoxic than the chlorinated samples. Ozonation produced wastewater with cytotoxicity comparable to the non-disinfected controls and was at least 4times less cytotoxic than the chlorine disinfected wastewaters. These results indicate that compared to chlorination and chloramination, ozonation of wastewater with high Br^-/Ilevels yielded the lowest mammalian cell cytotoxicity, suggesting its potential as a more favorable method to disinfect wastewater with minimizing the biological toxicity in mind. | Shengkun Dong Thanh H.Nguyen Michael J.Plewa | 2017 | Journal of Environmental Sciences2017，29，8： | 4 |
| 4 | Label-free SARS-CoV-2 detection and classification using phase imaging with computational specificity显示文摘Efforts to mitigate the COVID-19 crisis revealed that fast,accurate,and scalable testing is crucial for curbing the current impact and that of future pandemics.We propose an optical method for directly imaging unlabeled viral particles and using deep learning for detection and classification.An ultrasensitive interferometric method was used to image four virus types with nanoscale optical path-length sensitivity.Pairing these data with fluorescence images for ground truth,we trained semantic segmentation models based on U-Net,a particular type of convolutional neural network.The trained network was applied to classify the viruses from the interferometric images only,containing simultaneously SARS-CoV-2,H1N1(influenza-A virus),HAdV(adenovirus),and ZIKV(Zika virus).Remarkably,due to the nanoscale sensitivity in the input data,the neural network was able to identify SARS-CoV-2 vs.the other viruses with 96%accuracy.The inference time for each image is 60 ms,on a common graphic-processing unit.This approach of directly imaging unlabeled viral particles may provide an extremely fast test,of less than a minute per patient.As the imaging instrument operates on regular glass slides,we envision this method as potentially testing on patient breath condensates.The necessary high throughput can be achieved by translating concepts from digital pathology,where a microscope can scan hundreds of slides automatically. | Neha Goswami Yuchen R.He Yu-Heng Deng Chamteut Oh Nahil Sobh Enrique Valera Rashid Bashir Nahed Ismail Hyunjoon Kong Thanh H.Nguyen Catherine Best-Popescu Gabriel Popescu | 2021 | Light(Science & Applications)2021，10，9： | 3 |
| 5 | Response to pegylated interferon and ribavirin in Asian American patients with Chronic hepatitis C genotypes 1 vs 2/3 vs 6显示文摘 | N. H.Nguyen P.VuTien R. T.Garcia H.Trinh H.Nguyen K.Nguyen B.Levitt M. H.Nguyen | 2010 | Journal of Viral Hepatitis2010，，10： | 1 |
| 6 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 7 | Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic显示文摘Immunocompromised status and interrupted routine care may render patients with cirrhosis vulnerable to the coronavi-rus disease 2019(COVID-19)pandemic.A nationwide data-set that includes more than 99%of the decedents in the U.S.between April 2012 and September 2021 was used.Projected age-standardized mortality during the pandemic were esti-mated according to prepandemic mortality rates,stratified by season.Excess deaths were determined by estimating the difference between observed and projected mortality rates.A temporal trend analysis of observed mortality rates was also performed in 0.83 million decedents with cirrhosis between April 2012 and September 2021 was included.Following an increasing trend of cirrhosis-related mortality before the pandemic,with a semiannual percentage change(SAPC)of 0.54%[95%confidence interval(CI):(0.0-1.0%),p=0.036],a precipitous increase with seasonal variation occurred dur-ing the pandemic(SAPC 5.35,95%CI:1.9-8.9,p=0.005).Significantly increased mortality rates were observed in those with alcohol-associated liver disease(ALD),with a SAPC of 8.44(95%CI:4.3-12.8,p=0.001)during the pandemic.All-cause mortality of nonalcoholic fatty liver disease rose stead-ily across the entire study period with a SAPC of 6.79(95%CI:6.3-7.3,p<0.001).The decreasing trend of HCV-related mortality was reversed during the pandemic,while there was no significant change in HBV-related deaths.While there was significant increase in COVID-19-related deaths,more than 55%of the excess deaths were the indirect impact of the pandemic.We observed an alarming increase in cirrhosis-related deaths during the pandemic especially for ALD,with evidence in both direct and indirect impact.Our findings have implications on formulating policies for patients with cirrhosis. | Yee Hui Yeo Xinyuan He Fan Lv Yunyu Zhao Yi Liu Ju Dong Yang Jian Zu Fanpu Ji Mindie H.Nguyen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 8 | Spread spectrum indoor geolocation显示文摘 | B.B.Peterson C.Kmiecik R.Hartnett P.M.Thompson J.Mendoza and H.Nguyen | | 0，，02： | 1 |
| 9 | The Diagnostic Conundrum and Liver Transplantation Outcome for Combined Hepatocellular‐Cholangiocarcinoma显示文摘 | C.Panjala D. L.Senecal M. D.Bridges G. P.Kim R. E.Nakhleh J. H. H.Nguyen D. M.Harnois | 2010 | American Journal of Transplantation2010，，5： | 1 |
| 10 | 涡流监控复合材料固化显示文摘实时监控聚合物基体复合材料层板的固化过程,能够提高复合材料的质量,改善复合材料的性能。通常用几种传感技术,例如微电介质性能测量、荧光、纤维光学和超声波,提供实时信息,以保证固化过程的计算机分析。但每种方法都有一定的局限性。有一种新的力法,涡流接近传感方法。 | YOSEPH BAR COHEN KENNETH H.NGUYEN RON BOTSCO 林金赐 | 1991 | 洪都科技1991，，4： | 0 |
| 11 | Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow显示文摘Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions' efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation's efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading. | Jiang Wang Theresa H.Nguyen Nan Zheng | 2016 | Science China Chemistry2016，59，2： | 0 |
| 12 | Emotional Vietnamese Speech Synthesis Using Style-Transfer Learning显示文摘In recent years,speech synthesis systems have allowed for the produc-tion of very high-quality voices.Therefore,research in this domain is now turning to the problem of integrating emotions into speech.However,the method of con-structing a speech synthesizer for each emotion has some limitations.First,this method often requires an emotional-speech data set with many sentences.Such data sets are very time-intensive and labor-intensive to complete.Second,training each of these models requires computers with large computational capabilities and a lot of effort and time for model tuning.In addition,each model for each emotion failed to take advantage of data sets of other emotions.In this paper,we propose a new method to synthesize emotional speech in which the latent expressions of emotions are learned from a small data set of professional actors through a Flow-tron model.In addition,we provide a new method to build a speech corpus that is scalable and whose quality is easy to control.Next,to produce a high-quality speech synthesis model,we used this data set to train the Tacotron 2 model.We used it as a pre-trained model to train the Flowtron model.We applied this method to synthesize Vietnamese speech with sadness and happiness.Mean opi-nion score(MOS)assessment results show that MOS is 3.61 for sadness and 3.95 for happiness.In conclusion,the proposed method proves to be more effec-tive for a high degree of automation and fast emotional sentence generation,using a small emotional-speech data set. | Thanh X.Le An T.Le Quang H.Nguyen | 2023 | Computer Systems Science & Engineering2023，44，2： | 0 |
| 13 | Metabolic abnormalities play a crucial role in non-obese people suffering from non-alcoholic fatty liver disease(NAFLD)显示文摘We read the article entitled“The presence of NAFLD in nonobese subjects increased the risk of metabolic abnormalities than obese subjects without NAFLD:A population-based cross-sectional study”by Hu et al.(1),which was published in the latest issue of Hepatobiliary Surgery Nutrition,with great pleasure.As the authors described,due to rapid urbanization and sedentary lifestyles,the prevalence of non-alcoholic fatty liver disease(NAFLD)has increased.In this population-based,cross-sectional health survey study,in which the data were obtained from community health centers,the investigators reported that the prevalence of NAFLD in Shanghai,China grew from 15%in 2005 to 32.7%in 2017(1).To gain a better understanding of the prevalence of metabolic features in relation to NAFLD status,gender,and age,the authors quantified the risks of having different metabolic conditions between the following 4 groups:(I)the non-obese NAFLD group;(II)the non-obese non-NAFLD group;(III)the obese non-NAFLD group;and(IV)the obese NAFLD group(1). | Qing Ye Takanori Ito Linda Henry Mindie H.Nguyen | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 0 |
| 14 | 慢性乙型肝炎孕妇妊娠期及产后的管理(下)显示文摘本视频继续上期视频介绍慢性乙型肝炎孕妇孕前、妊娠期以及孕后的相关治疗,若女性患者诊断为慢性乙型肝炎肝硬化,则其怀孕可能性小(怀孕率约为1/5950),而自发性流产率、早产率、围产期病死率均较高,且胃肠道出血也是其最常见的并发症;相关治疗带来的效益可能大于胎儿承受的风险。分析产妇因素:许多非晚期慢性乙型肝炎患者处于丙氨酸氨基转移酶(alanine aminotransferase,ALT)水平分析正常的免疫耐受期则无需治疗,如果可接受疾病进展的风险,应考虑延缓治疗,在生育计划明确后再开始治疗。母婴传播因素:母婴传播率定义为血清HBV DNA>20 IU/ml(检测下限为20 IU/ml)或HBsAg阳性率在婴儿28周龄时的比例。疫苗接种/免疫预防仍然是婴幼儿最重要的预防策略。产后因素:母乳喂养需监测产妇产后肝炎突发情况:分娩后延长治疗不能预防肝炎突发,需要重新评估治疗是否停药或延用,且免疫预防后母乳喂养不会降低母婴传播风险。根据妊娠分级选择HBV抗病毒药物:妊娠分级B类:动物研究未见对胎儿有危险性,然而未进行妊娠女性对照研究;或动物研究显示药物对胎儿具有不良效应,但妊娠女性对照研究未能证明药物对胎儿具有危险性。妊娠分级C类:动物实验结果显示该药物具有致畸性和胚胎毒性效应,且未进行妊娠女性对照研究或无动物与妊娠妇女研究资料可供应用。 | Mindie H.Nguyen | 2020 | 中华实验和临床感染病杂志(电子版)2020，14，4： | 0 |
| 15 | Nanofibrillar collagen scaffolds for lymphedema treatment:current applications and future directions显示文摘Aim:Biosynthetic scaffolds represent cutting-edge therapeutic efforts for secondary lymphedema.In particular,nanofibrillar collagen scaffolds have shown efficacy in both preclinical and clinical contexts,and there has been growing interest in these scaffolds in recent years.This study systematically reviewed the current literature on nanofibrillar collagen scaffolds for lymphedema treatment to synthesize findings and highlight areas for further research.Methods:This was a systematic scoping review of the literature on nanofibrillar collagen scaffolds for lymphedema treatment.Results:Upon review of the literature,32 relevant articles were identified,of which seven articles specifically investigating nanofibrillar collagen scaffolds were selected for inclusion.Of these articles,three investigated scaffold placement in small or large animal models,while four were clinical investigations ranging from case reports to retrospective cohort studies.Across all studies,scaffold implantation was associated with significant improvement in lymphedema symptoms compared to untreated controls,especially when used in combination with physiologic microsurgical procedures such as vascularized lymph node transfer.However,even when used alone or in combination with lymph node fragments,subcutaneous placement of these scaffolds improved lymphedema symptoms.Additionally,in a rodent model of lymphedema,scaffold placement at the time of lymph node harvest forestalled the development of lymphedema,highlighting the preventative capacity of these scaffolds as well.Conclusion:Nanofibrillar collagen scaffolds have been demonstrated to effectively treat and/or prevent secondary lymphedema in both preclinical and clinical investigations.Ultimately,these scaffolds represent a promising intersection of tissue engineering and lymphedema therapy,and further clinical investigation is warranted. | Pooja S.Yesantharao Dung H.Nguyen | 2022 | Plastic and Aesthetic Research2022，9，1： | 0 |
| 16 | A Mixed-integer Linear Programming Model for Defining Customer Export Limit in PV-rich Low-voltage Distribution Networks显示文摘A photovoltaic(PV)-rich low-voltage(LV)distribution network poses a limit on the export power of PVs due to the voltage magnitude constraints.By defining a customer export limit,switching off the PV inverters can be avoided,and thus reducing power curtailment.Based on this,this paper proposes a mixed-integer nonlinear programming(MINLP)model to define such optimal customer export.The MINLP model aims to minimize the total PV power curtailment while considering the technical operation of the distribution network.First,a nonlinear mathematical formulation is presented.Then,a new set of linearizations approximating the Euclidean norm is introduced to turn the MINLP model into an MILP formulation that can be solved with reasonable computational effort.An extension to consider multiple stochastic scenarios is also presented.The proposed model has been tested in a real LV distribution network using smart meter measurements and irradiance profiles from a case study in the Netherlands.To assess the quality of the solution provided by the proposed MILP model,Monte Carlo simulations are executed in OpenDSS,while an error assessment between the original MINLP and the approximated MILP model has been conducted. | Pedro P.Vergara Juan S.Giraldo Mauricio Salazar Nanda K.Panda Phuong H.Nguyen | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，1： | 0 |
| 17 | A decade of research on patterns and architectures for IoT security显示文摘Security of the Internet of Things (IoT)-based Smart Systems involving sensors, actuators and distributed control loop is of paramount importance but very difficult to address. Security patterns consist of domain-independent time-proven security knowledge and expertise. How are they useful for developing secure IoT-based smart systems? Are there architectures that support IoT security? We aim to systematically review the research work published on patterns and architectures for IoT security (and privacy). Then, we want to provide an analysis on that research landscape to answer our research questions. We follow the well-known guidelines for conducting systematic literature reviews. From thousands of candidate papers initially found in our search process, we have systematically distinguished and analyzed thirty-six (36) papers that have been peer-reviewed and published around patterns and architectures for IoT security and privacy in the last decade (January 2010–December 2020). Our analysis shows that there is a rise in the number of publications tending to patterns and architectures for IoT security in the last three years. We have not seen any approach of applying systematically architectures and patterns together that can address security (and privacy) concerns not only at the architectural level, but also at the network or IoT devices level. We also explored how the research contributions in the primary studies handle the different issues from the OWASP Internet of Things (IoT) top ten vulnerabilities list. Finally, we discuss the current gaps in this research area and how to fill in the gaps for promoting the utilization of patterns for IoT security and privacy by design. | Tanusan Rajmohan Phu H.Nguyen Nicolas Ferry | 2022 | Cybersecurity2022，5，2： | 0 |
| 18 | Detection of Abnormal Network Traffic Using Bidirectional Long Short-Term Memory显示文摘Nowadays,web systems and servers are constantly at great risk from cyberattacks.This paper proposes a novel approach to detecting abnormal network traffic using a bidirectional long short-term memory(LSTM)network in combination with the ensemble learning technique.First,the binary classification module was used to detect the current abnormal flow.Then,the abnormal flows were fed into the multilayer classification module to identify the specific type of flow.In this research,a deep learning bidirectional LSTM model,in combination with the convolutional neural network and attention technique,was deployed to identify a specific attack.To solve the real-time intrusion-detecting problem,a stacking ensemble-learning model was deployed to detect abnormal intrusion before being transferred to the attack classification module.The class-weight technique was applied to overcome the data imbalance between the attack layers.The results showed that our approach gained good performance and the F1 accuracy on the CICIDS2017 data set reached 99.97%,which is higher than the results obtained in other research. | Nga Nguyen Thi Thanh Quang H.Nguyen | 2023 | Computer Systems Science & Engineering2023，46，7： | 0 |
| 19 | The future of COVID-19 vaccination rates for children显示文摘The COVID-19 pandemic has been ongoing for over two years since the first case was reported in the end of January 2020.Vietnam has successfully controlled the pandemic through its vaccination campaign,targeted messages and applications of various public health interventions including social distancing,quarantining,masking,and hand washing,which have made some significant achievements in reducing hospitalizations and deaths[1]. | Giao Huynh Kimberly H.Nguyen Han Thi Ngoc Nguyen Tuan Diep Tran Pham Le An | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，9： | 0 |
| 20 | Emotion Recognition with Capsule Neural Network显示文摘For human-machine communication to be as effective as human-tohuman communication, research on speech emotion recognition is essential.Among the models and the classifiers used to recognize emotions, neural networks appear to be promising due to the network’s ability to learn and the diversity in configuration. Following the convolutional neural network, a capsuleneural network (CapsNet) with inputs and outputs that are not scalar quantitiesbut vectors allows the network to determine the part-whole relationships thatare specific 6 for an object. This paper performs speech emotion recognition basedon CapsNet. The corpora for speech emotion recognition have been augmented byadding white noise and changing voices. The feature parameters of the recognition system input are mel spectrum images along with the characteristics of thesound source, vocal tract and prosody. For the German emotional corpus EMODB, the average accuracy score for 4 emotions, neutral, boredom, anger and happiness, is 99.69%. For Vietnamese emotional corpus BKEmo, this score is94.23% for 4 emotions, neutral, sadness, anger and happiness. The accuracy scoreis highest when combining all the above feature parameters, and this scoreincreases significantly when combining mel spectrum images with the featuresdirectly related to the fundamental frequency. | Loan Trinh Van Quang H.Nguyen Thuy Dao Thi Le | 2022 | Computer Systems Science & Engineering2022，41，6： | 0 |
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