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| 1 | Highly photostable nanogels for fluorescence-based theranostics显示文摘A novel photo-crosslinkable nanogel is prepared from a biodegradable polymer template with intrinsic photoluminescence and high photostability.The fluorescent nanogels display excellent biodegradability and cytocompatibility owed to the facile synthesis scheme involving a solvent-and surfactant-free onepot reaction,derived entirely from biocompatible monomers citric acid,maleic acid,L-cysteine,and poly(ethylene glycol).The resultant nanogels are less than 200 nm in diameter with a narrow size distribution and monodispersity,and demonstrate long-term structural stability in biological buffer for two weeks.To gauge potential in theranostic applications,the fluorescent nanogels were surface functionalized with biologically active RGD peptides and encapsulated with active anti-cancer drug Doxorubicin,resulting in a pH-responsive controlled drug release in acidic pH resembling tumor environments.The strong fluorescence of the nanogels enabled tracking of targeted drug delivery,showing that drug-loaded nanogels homed into the cytoplasmic regions of prostate cancer cells to significantly induce cell death.These photo-crosslinkable and biodegradable nanogels pose as a strong candidate for theranostic medicine,demonstrating versatile functionalization,high stability in biological buffers,and capacity for real-time fluorescence-based monitoring of targeted drug delivery. | Dipendra Gyawali Jimin P.Kim Jian Yang | 2018 | Bioactive Materials2018，3，1： | 1 |
| 2 | 二维范德瓦尔斯材料显示文摘1959年Richard Feynman在其著名的演讲中曾经提出一个问题:当选取最合适的单层来搭建层状结构时,我们可以实现什么?随着近年来对各种家族的单层材料的研究,我们正愈发接近问题的答案,并有望实现Feynman的梦想。层状材料以层内强共价键及层间弱范德瓦尔斯力结合在一起。每个单层都能通过打破范德瓦尔斯键分离出来,并相对容易地转移到其他衬底上。 | 陈伟 P.Ajayan P.Kim K.Banerjee | 2016 | 物理2016，45，9： | 1 |
| 3 | Construction of versatile multilayered composite nanoparticles from a customized nanogel template显示文摘We present a highly adaptable design platform for multi-responsive,multilayered composite nanoparticles(MC-NPs)with fine-tunable functional layers.A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method,enabling a high degree of control over each successive layer.From this template,we optimize“smart”biomaterials with biofunctional surfaces,tunable drug release kinetics,and magnetic or pH-responsive functionality,fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo.Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics. | Jian Zhang Jinpeng Jia Jimin P.Kim Fei Yang Xing Wang Hong Shen Sijia Xu Jian Yang Decheng Wu | 2018 | Bioactive Materials2018，3，1： | 1 |
| 4 | 查看详情显示文摘 | M.Y.Han B.(O)zyilmaz Y.Zhang P.Kim | | 0，，20： | 1 |
| 5 | The Diagnostic Conundrum and Liver Transplantation Outcome for Combined Hepatocellular‐Cholangiocarcinoma显示文摘 | C.Panjala D. L.Senecal M. D.Bridges G. P.Kim R. E.Nakhleh J. H. H.Nguyen D. M.Harnois | 2010 | American Journal of Transplantation2010，，5： | 1 |
| 6 | Use of prostate-specific antigen testing in Medicare beneficiaries:Association with previous evaluation显示文摘Objective:Determine uptake of prostate-specific antigen(PSA)testing in Medicare benefi-ciaries according to previous receipt of PSA testing.Methods:A 5%random sample of men aged 67 years or older without a previous diagnosis of prostate cancer was identified through 2009-2012 Medicare claims.We measured the annualized frequency of PSA screening among men due for PSA testing,stratified by PSA testing use in the previous 2 years,and clustered by ordering provider.Results:Throughout the study period,PSA testing use was consistently higher for men with previous screening than for men without previous screening.For men without previous screening,there was a decline in testing that was most pronounced in 2012.Compared with 2009,the cor-responding odds ratios were 0.98[95%confidence interval(CI)(0.96-1.00)]in 2010,0.94[95%CI(0.92-0.95)]in 2011,and 0.66[95%CI(0.65-0.68)]in 2012.In contrast,for men with previous screening,PSA testing frequency was stable from 2009 to 2011,and declined to a lesser extent in 2012[odds ratio 0.80,95%CI(0.79-0.81)].Conclusion:Receipt of PSA testing is highly dependent on whether an individual was tested in the recent past.In previously unscreened men,the largest decrease occurred in 2012,which may reflect in part the publication of US Preventive Services Task Force guidelines,but there was much less impact among men already being screened. | Gregory S.Cooper Tzuyung Doug Kou Mark D.Schluchter Avi Dor Siran M.Koroukian Simon P.Kim | 2017 | Family Medicine and Community Health2017，5，2： | 0 |
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