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您的检索式：作者名="Nicolas Ferry"
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| 1 | HACD1,a regulator of membrane composition and fluidity,promotes myoblast fusion and skeletal muscle growth显示文摘The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies,yet the underlying cellular and molecular mechanisms remain elusive.In this study,we investigate the role of HACD1/PTPLA,which is involved in the elongation of the very long chain fatty acids,in muscle fibre formation.In humans and dogs,HACD1 deficiency leads to a congenital myopathy with fibre size disproportion associated with a generalized muscleweakness.Throughanalysis of HACD1-deficient Labradors,Hacd1-knockout mice,and Hacd1-deficient myoblasts,we provide evidence that HACD1 promotes myoblast fusion during muscle development and regeneration.We further demonstrate that in normal differentiating myoblasts,expression of the catalytically active HACD1 isoform,which is encoded by a muscle-enriched splice variant,yields decreased lysophosphatidylcholine content,a potent inhibitor of myoblast fusion,and increased concentrations of≥C18 and monounsaturated fatty acids of phospholipids.These lipid modifications correlate with a reduction in plasma membrane rigidity.In conclusion,we propose that fusion impairment constitutes a novel,non-exclusive pathological mechanism operating in congenital myopathies and reveal that HACD1 is a key regulator of a lipid-dependent muscle fibre growth mechanism. | Jordan Blondelle Yusuke Ohno Vincent Gache Stephane Guyot Sebastien Storck Nicolas Blanchard-Gutton Ines Barthelemy Gemma Walmsley Anaelle Rahier Stephanie Gadin Marie Maurer Laurent Guillaud Alexandre Prola Arnaud Ferry Genevieve Aubin-Houzelstein Jean Demarquoy Frederic Relaix Richard JPiercy Stephane Blot Akio Kihara Laurent Tiret Fanny Pilot-Storck | 2015 | Journal of Molecular Cell Biology2015，7，5： | 1 |
| 2 | Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats显示文摘 | Marie-Pierre Bralet Virginie Pichard Nicolas Ferry | 2002 | Hepatology2002，，： | 1 |
| 3 | Lowvoltage low-power novel CCII topologies and applications 显示文摘 | GIUSEPPE FERRI NICOLA CARLO GUERRINI | 2001 | IEEE2001，，： | 1 |
| 4 | Scintigraphic findings on 99m Tc-MDP, 99m Tc-sestamibi and 99m Tc-HMPAO images in Gaucher’s disease显示文摘 | Giuliano Mariani Nicola Molea Luca Civita Giovanni Porciello Elena Lazzeri Clodoveo Ferri | 1996 | European Journal of Nuclear Medicine1996，，4： | 1 |
| 5 | A decade of research on patterns and architectures for IoT security显示文摘Security of the Internet of Things (IoT)-based Smart Systems involving sensors, actuators and distributed control loop is of paramount importance but very difficult to address. Security patterns consist of domain-independent time-proven security knowledge and expertise. How are they useful for developing secure IoT-based smart systems? Are there architectures that support IoT security? We aim to systematically review the research work published on patterns and architectures for IoT security (and privacy). Then, we want to provide an analysis on that research landscape to answer our research questions. We follow the well-known guidelines for conducting systematic literature reviews. From thousands of candidate papers initially found in our search process, we have systematically distinguished and analyzed thirty-six (36) papers that have been peer-reviewed and published around patterns and architectures for IoT security and privacy in the last decade (January 2010–December 2020). Our analysis shows that there is a rise in the number of publications tending to patterns and architectures for IoT security in the last three years. We have not seen any approach of applying systematically architectures and patterns together that can address security (and privacy) concerns not only at the architectural level, but also at the network or IoT devices level. We also explored how the research contributions in the primary studies handle the different issues from the OWASP Internet of Things (IoT) top ten vulnerabilities list. Finally, we discuss the current gaps in this research area and how to fill in the gaps for promoting the utilization of patterns for IoT security and privacy by design. | Tanusan Rajmohan Phu H.Nguyen Nicolas Ferry | 2022 | Cybersecurity2022，5，2： | 0 |
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