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| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Microscopic colitis: A retrospective study of clinical presentation in 53 patients显示文摘AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and diarrhea.METHODS: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively analyzed.RESULTS: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation subgroup.CONCLUSION: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups. | Zsolt Barta Gabriella Mekkel István Csíp(o|') László Tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher | 2005 | World Journal of Gastroenterology2005，11，9： | 3 |
| 3 | Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study显示文摘 | Christopher C Patterson Gisela G Dahlquist Eva Gyürüs Anders Green Gyula Soltész | 2009 | The Lancet2009，，9680： | 2 |
| 4 | Seroreactivity against Saccharomyces cerevisiae in patients with Crohn's disease and celiac disease显示文摘AIM:To explore whether there was anti-Saccharomyces cerevisiae antibodies (ASCA) positivity in our patients with biopsy-confirmed celiac disease.METHODS: A cohort of patients with inflammatory bowel diseases (42 patients with Crohn's disease and 10 patients with ulcerative colitis) and gluten sensitive enteropathy (16patients) from Debrecen, Hungary were enrolled in the study.The diagnosis was made using the formally accepted criteria.Perinuclear antineutrophil cytoplasmic antibodies (pANCA)and antiS-accharomyces cerevisiae antibodies (ASCA),antiendornysium antibodies (EMA), antigliadin antibodies (AGA) and anti human tissue transglutaminase antibodies (tTGA) were investigated.RESULTS: The results showed that ASCA positivity occurred not only in Crohn's disease but also in Celiac disease and in these cases both the IgG and IgA type antibodies were proved.CONCLUSION: It is conceivable that ASCA positivity correlates with the (auto-) immune inflammation of small intestines and it is a specific marker of Crohn's disease. | Zsolt Barta István Csíp■ Gábor G.Szabó Gyula Szegedi | 2003 | World Journal of Gastroenterology2003，9，10： | 2 |
| 5 | Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study显示文摘 | Christopher C Patterson Gisela G Dahlquist Eva Gyürüs Anders Green Gyula Soltész | 2009 | The Lancet2009，，9680： | 1 |
| 6 | Decrease in CD3-negative-CD8dim + and Vδ2/Vγ9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection显示文摘 | Gabriella Pár Daniel Rukavina Eckhard R Podack Margit Horányi Júlia Szekeres-Barthó Géza Hegedüs Mária Paál László Szereday Gyula Mózsik Alajos Pár | 2002 | Journal of Hepatology2002，，4： | 1 |
| 7 | A novel method for investigation of uptake and distribution of polluting microelements and nanoparticles in soil-inhabiting nematodes显示文摘 | Zoltán Sávoly Péter Nagy Gábor Varga Károly Havancsák Krisztina Hrács Gyula Záray | 2013 | Microchemical Journal2013，，： | 1 |
| 8 | Occurrence and determination of organic pollutants in aerosol, precipitation, and sediment samples collected at Lake Balaton 显示文摘 | Gyula K Andrds G Zoltdn K | 1997 | Journal of Chro matography A1997，774，12： | 1 |
| 9 | Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis显示文摘瞄准:与溃疡的 culitis (UC ) 并且与健康控制题目相比在成年病人决定血浆肉毒碱酉旨侧面。方法:用 ESI 三倍的四极双人脚踏车团分光术,肉毒碱酉旨侧面与 UC 和 44 匹配年龄、匹配性的健康控制在 44 个病人被测量。结果:在免费肉毒碱与 UC 和健康控制在病人之间铺平的 fasting 没有有效差量。禁食 propionyl-(0.331 +/- 0.019 对 0.392 +/- 0.017 micromol/L ) , butyryl-(0.219 +/- 0.014 对 0.265 +/- 0.012 ) ,并且 isovalerylcarnitine (0.111 +/- 0.008 对 0.134 +/- 0.008 ) 层次在 UC 病人被减少。由对比,octanoyl-的水平( 0.147 +/- 0.009 对 0.114 +/- 0.008 ),decanoyl-( 0.180 +/- 0.012 对 0.137 +/- 0.008 ),myristoyl-( 0.048 +/- 0.003 对 0.039 +/- 0.003 ),palmitoyl-( 0.128 +/- 0.006 对 0.109 +/- 0.004 ),palmitoleyl-( 0.042 +/- 0.003 对 0.031 +/- 0.002 )并且 oleylcarnitine ( 0.183 +/- 0.007 对 0.163 +/- 0.007 ;P <
0.05 在所有比较) 与 UC 在病人被增加。结论:我们的数据在 UC 病人建议肉毒碱酉旨的选择参与,可能由于他们的改变的新陈代谢。 | Judit Bene Katalin Komlósi Viktória Havasi Gábor Talián Beáta Gasztonyi Krisztina Horváth Gyula Mózsik Béla Hunyady Béla Melegh Mária Figler | 2006 | World Journal of Gastroenterology2006，12，1： | 1 |
| 10 | Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma显示文摘 | Márta Csire Gábor Mikala Mónika Pet? Judit Jánosi Attila Juhász Attila Tordai János Jákó Gyula Domján János Dolgos Gy?rgy Berencsi István Vályi‐Nagy | 2007 | FEMS Immunology & Medical Microbiology2007，，： | 1 |
| 11 | Slip-systems and dislocation densities in individual grains of polycrystalline aggregates of plastically deformed CoTi and CoZr alloys显示文摘 | Tamás Ungár Gábor Ribárik Gyula Zilahi Rupalee Mulay Ulrich Lienert Levente Balogh Sean Agnew | 2014 | Acta Materialia2014，，： | 1 |
| 12 | Effect of Lead,Nickel and Vanadium Contamination on Organic Acid Transport in Xylem sap of Cucumber显示文摘 | Enikoe Tatar Viktor G Mihucz Anita Varga Gyula Zaray and Edit Cseh | 1999 | Journal of Inorganic Biochemistry1999，75，3： | 1 |
| 13 | Pharmacokinetic and bioequivalence study of two gemfibrozil preparatio- ns显示文摘 | Sarolta B Sandor D Gyula G | 1997 | Arzneim Forsch Drug Res1997，47，2： | 1 |
| 14 | Distribution of polycyclic aromatic hydrocarbons on atmospheric aerosol particles of different sizes显示文摘 | Gyula K Zita Varga-Puchony G Rohrbacher | 1998 | Atmospheric Research1998，46，： | 1 |
| 15 | Revision of the genus Inouenola László,Ronkay & Witt,2010(Lepidoptera,Noctuoidea,Nolidae,Nolini) with description of 6 new species显示文摘This paper contains the revision of the genus Inouenola La′szlo′,Ronkay & Witt,2010 and presents the checklist of the known taxa and their distribution and the description of six new species(Inouenola brunneolineata,I.tertia,I.secunda,I.prima,I.micropuncta,and I.nigropunctata spp.n.) from South East Asia,with 24 colour photos and 18 genitalia figures. | Gyula M.László Gábor Ronkay László Ronkay | 2015 | Journal of Forestry Research2015，26，2： | 0 |
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