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| 1 | Incidence and mortality of acute and chronic pancreatitis in the Netherlands:A nationwide record-linked cohort study for the years 1995-2005显示文摘AIM:To analyze trends in incidence and mortality of acute pancreatitis(AP) and chronic pancreatitis(CP) in the Netherlands and for international standard populations.METHODS:A nationwide cohort is identified through record linkage of hospital data for AP and CP,accumulated from three nationwide Dutch registries:the hospital discharge register,the population register,and the death certificate register.Sex-and age-group specific incidence rates of AP and CP are defined for the period 2000-2005 and mortality rates of AP and CP for the period 1995-2005.Additionally,incidence and mortality rates over time are reported for Dutch and international(European and World Health Organization) standard populations.RESULTS:Incidence of AP per 100000 persons per year increased between 2000 and 2005 from 13.2(95%CI:12.6-13.8) to 14.7(95%CI:14.1-15.3).Incidence of AP for males increased from 13.8(95%CI:12.9-14.7) to 15.2(95%CI:14.3-16.1),for females from 12.7(95%CI:11.9-13.5) to 14.2(95%CI:13.4-15.1).Irregular patterns over time emerged for CP.Overall mean incidence per 100000 persons per year was 1.77,for males 2.16,and for females 1.4.Mortality for AP fluctuated during 1995-2005 between 6.9 and 11.7 per million persons per year and was almost similar for males and females.Concerning CP,mortality for males fluctuated between 1.1(95%CI:0.6-2.3) and 4.0(95%CI:2.8-5.8),for females between 0.7(95%CI:0.3-1.6) and 2.0(95%CI:1.2-3.2).Incidence and mortality of AP and CP increased markedly with age.Standardized rates were lowest for World Health Organization standard population.CONCLUSION:Incidence of AP steadily increased while incidence of CP fluctuated.Mortality for both AP and CP remained fairly stable.Patient burden and health care costs probably will increase because of an ageing Dutch population. | BW Marcel Spanier Marco J Bruno Marcel GW Dijkgraaf | 2013 | World Journal of Gastroenterology2013，19，20： | 20 |
| 2 | Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Thl cells within immune organ of mouse IgA nephropathy显示文摘 | Jia, LW Wang, C Kong, HW Yang, J Li, FL Lv, S Xu, GW | 2007 | 中国生物学文摘2007，21，11： | 19 |
| 3 | 反流性食管炎中埃索美拉唑比奥美拉唑更能促进病变愈合和症状缓解显示文摘 | Kahrilas PJ Falk GW Johnson DA Schmitt C Collins DW Whipple J D’Amino D Hamelin B Joelsson B 钟捷 | 2002 | 中华消化杂志2002，22，11： | 19 |
| 4 | Age of the Shahewan rapakivi granite in the Qinling Orogen, China, and its constraints on the end time of the main erogenic stage of this orogen显示文摘the Qinling Mountains in central China are a joint orogenic zone between the Sino-Korean (or North China) and the Yangtze (or South China) craton blocks, the two major tectonic units of eastern Asia. On the end time of the main orogenic stage in this orogenic | Zhang, ZQ Zhang, GW Tang, SH Lu, XX | 1999 | Chinese Science Bulletin1999，44，21： | 15 |
| 5 | 荧光原位杂交法快速鉴定金黄色葡萄球菌和凝固酶阴性葡萄球菌显示文摘目的 建立一种新的荧光原位杂交法,快速鉴定血培养中的金黄色葡萄球菌(金葡菌)和凝固酶阴性葡萄球菌。方法 将荧光同位素标记的针对金葡菌和凝固酶阴性葡萄球菌的核糖体16SrRNA序列的互补的DNA寡核苷酸探针,在同一张玻片上50℃杂交1 h,用杂交缓冲液50℃洗涤10min,干燥后置荧光显微镜下观察,全过程大约2 h。结果 探针的特异性经标准菌株和临床分离菌株证实。将259份临床标本测试与培养法比较,金葡菌的特异性和敏感性均为100%,CoNs的特异性和敏感性分别为100%和95.5%,荧光原位杂交法的最低检出限为103CFU/ml。结论 本方法适用于血培养中的金葡菌和凝固酶阴性葡萄球菌的快速鉴定。 | 王沛 Welling GW Meessen N Raangs GC | 2004 | 中华检验医学杂志2004，27，7： | 12 |
| 6 | 口服抗栓药物预防非瓣膜性房颤患者的卒中:美国心脏协会/美国卒中协会的科学建议显示文摘成年房颤患者的卒中发生率,依据合并症和既往脑血管事件史,为每年1%~20%不等(平均每年为4.5%)。对卒中风险的分层非常重要,因为用抗栓药降低房颤导致卒中的主要风险是出血。如华法令在减少缺血性事件风险的同时,每年有1%~12% | 戴若莲 糜建华 华驾略 董荃 苏爱萍 李焰生 Furie KL Goldstein LB Albers GW Khatri P Neyens R Turakhia MP Turan TN Wood KA | 2012 | 神经病学与神经康复学杂志2012，9，3： | 12 |
| 7 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 8 | 野生种花生叶片内超氧物歧化酶及其抗paraquat特性显示文摘对几种野生花生和栽培花生叶内的超氧物歧化酶(SOD)特性作了比较研究,发现野生种有较高的SOD木平。当用除莠剂paraquat处理两类花生的叶片时,野生种也表现出较强的耐受力。Paraquat处理导致两类花生叶内SOD水平的下降,但野生种内下降的幅度要比栽培种中小得多。用等电聚焦凝胶电泳分析叶中的SOD同工酶后发现,paraquat主要破坏叶绿体SOD(栽培花生叶内SOD活性的主要成分),而对野生花生叶细胞内所含的细胞质SOD及线粒体SOD却没有明显影响,因而野生种花生的抗paraquat特性不仅由于其SOD水平较高,而且也取决于SOD同工酶亚细胞分布的特点。 | 武宝玕 Mitchell ED Jobnson BL Todd GW | 1990 | 植物生理学报(0257-4829)1990，16，2： | 7 |
| 9 | 12-Deoxyphorbol Esters from Euphorbia Fischeriana显示文摘12-DeoxyphorbolEstersfromEuphorbiaFischerianaWenZiLIU;XiaoYunWU;GenJinYANG;QingGaoMA;TianXiZHOU;XiCanTANGandGuoWeiQIN(Departm... | Liu, WZ Wu, XY Yang, GJ Ma, QG Zhou, TX Tang, XC Qin, GW | 1996 | Chinese Chemical Letters1996，7，10： | 7 |
| 10 | 水力压裂监测新方法显示文摘深入了解水力压裂裂缝的几何形态和延伸情况有助于改善低渗油气藏压裂增产作业效果,改善油气井产能并提高油气采收率。应用地震方法对水力压裂裂缝进行监测和描述已经有多年了,而新的地震硬件和处理技术的出现使得这类监测更加有效、可靠。 | Les Bennett Joeol Le Calvez David R. ( Rich ) Sarver Kevin Tanner W.S.(Scott)Birk George Waters Julian Drew Gw e nola Michaud Paolo Primiero Leo Eisner Rob Jones David Leslie Michael John Williams Jim Govenlock Richard C. ( Rick ) Klein Kazuhiko Tezuka | 2007 | 国外测井技术2007，22，4： | 7 |
| 11 | New Bibenzyl and Phenanthrenedione from Dendrobium densiflorum显示文摘A new bibenzyl 1 and a new phenanthrenedione 2 were identified from the stems of Dendrobium densiflorum (Orchidaceae). | Fan, CQ Zhao, WM Qin, GW | 2000 | Chinese Chemical Letters2000，11，8： | 6 |
| 12 | Numerical Simulation for Refraction-Diffraction of Waves in Water of Slowly Varying Current and Topography显示文摘A new numerical finite difference iteration method for refraction-diffraction of waves in waterof slowly varying current and topography is developed in this paper.And corresponding theoretical modelincluding the dissipation term is briefly described,together with some analysis and comparison ofcomputational results of the model with measurements in a hydraulic scale model(Berkhoff et al.,1982).An example of practical use of the method is given,showing that the present model is useful to engineeringpractice. | Hong, GW Feng, WB Xia, QY Pan, SH | 1997 | China Ocean Engineering1997，12，4： | 5 |
| 13 | 荧光原位杂交法快速鉴定血培养阳性葡萄球菌的临床应用显示文摘目的快速鉴定血培养中的金黄色葡萄球菌和凝固酶阴性葡萄球菌(CoNS),结合临床快速判定是否为污染菌。方法采用荧光原位杂交法鉴定血培养中的金黄色葡萄球菌和CoNS,杂交结果若为CoNS,根据临床资料进行判断,并与文献推荐的污染判断法进行结果比较。结果探针的特异性经由标准菌株和临床分离菌株证实。金黄色葡萄球菌探针的特异性和敏感性均为100%,GoNS探针的特异性和敏感性分别为100%和95.5%。179株CoNS中117株判断为污染菌,污染率为68%,与文献推荐的污染判断方法一致。结论荧光原位杂交法适用于血培养中的金黄色葡萄球菌和CoNS的快速鉴定,以排除CoNS污染。 | 何永贵 王沛 邬家平 Welling GW Meessen N | 2005 | 检验医学2005，20，4： | 4 |
| 14 | Grayanane Diterpenoids from Pieris formosa显示文摘Three grayanane diterpenoids 1-3 were isolated from Pierisfonnosa. 1 was identifiedas a new natural product and 2 and 3 as known grayanoside C and grayanotoxin XVIII on the basisof spectral analysis. | Wang, LQ Ding, BY Zhao, WM Qin, GW | 1998 | Chinese Chemical Letters1998，9，5： | 3 |
| 15 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 16 | Small bowel capsule endoscopy for management of Crohn’s disease: A retrospective tertiary care centre experience显示文摘 | Catherine Dussault Corinne Gower-Rousseau Julia Salleron Gwénola Vernier-Massouille Julien Branche Jean-Frédéric Colombel Vincent Maunoury | 2013 | Digestive and Liver Disease2013，，7： | 3 |
| 17 | Segmentation of a wrap-around model using an active contour显示文摘 | MJ Milroy C Bradley GW Vickers | 1997 | Computer-Aided Design1997，，4： | 3 |
| 18 | Surgical management of persistent,symptomatic nonvenereal Sclerosing lymphangitis of the Penis显示文摘 | Broaddus SB Leadbtter GW | 1982 | J Urol1982，127，5： | 2 |
| 19 | Review of arterial vascular ultrasound显示文摘 | Phillips GW | 2000 | World J Surg2000，24，2： | 2 |
| 20 | 荧光原位杂交技术快速鉴定深部组织的病原菌感染显示文摘 | 王沛 邬家平 何永贵 Welling GW | 2004 | 中国人兽共患病杂志2004，20，10： | 2 |
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