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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Application of a microseismic monitoring system in deep mining显示文摘A microseismic monitoring system was used in the Donggua Shan underground copper mine, and its application was intro- duced. The spacial distribution of the seismic event was monitored effectively during mining with this system. The distribution of the seismic intensity in different time periods and in the different mining districts was obtained via the clustering analysis of the monitored results, and the different intensity concentration districts of seismicity were compartmentalized. The various characteristics and wave- forms of different vibrations in the underground mine were revealed with the help of the micro-seismic monitoring system. It was proved that the construction and application of the micro-seismic monitoring system in the mine not only realized the continuous monitoring of seismicity in the deep mine, but also settled an important foundation for further studies on hazard prediction, based on this system. | Chengxiang Yang Zhouquan Luo Guobin Hu Xiaoming Liu | 2007 | Journal of University of Science and Technology Beijing2007，14，1： | 14 |
| 3 | Recent Changes in Precipitation Extremes in the Heihe River Basin,Northwest China显示文摘Changes in rainfall extremes pose a serious and additional threat to water resources planning and management,natural and artificial oasis stability,and sustainable development in the fragile ecosystems of arid inland river basins. In this study,the trend and temporal variation of extreme precipitation are analyzed using daily precipitation datasets at 11 stations over the arid inland Heihe River basin in Northwest China from 1960 to 2011. Eight indices of extreme precipitation are studied.The results show statistically significant and large-magnitude increasing and decreasing trends for most indices,primarily in the Qilian Mountains and eastern Hexi Corridor. More frequent and intense rainfall extremes have occurred in the southern part of the desert area than in the northern portion. In general,the temporal variation in precipitation extremes has changed throughout the basin. Wet day precipitation and heavy precipitation days show statistically significant linear increasing trends and step changes in the Qilian Mountains and Hexi Corridor. Consecutive dry days have decreased obviously in the region in most years after approximately the late 1980 s,but meanwhile very long dry spells have increased,especially in the Hexi Corridor. The probability density function indicates that very long wet spells have increased in the Qilian Mountains. The East Asian summer monsoon index and western Pacific subtropical high intensity index possess strong and significant negative and positive correlations with rainfall extremes,respectively. Changes in land surface characteristics and the increase in water vapor in the wet season have also contributed to the changes in precipitation extremes over the river basin. | CHENG Aifang FENG Qi Guobin FU ZHANG Jiankai LI Zongxing HU Meng WANG Gang | 2015 | Advances in Atmospheric Sciences2015，32，10： | 5 |
| 4 | Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importinα7 is counteracted by TBK1-p62 axis-mediated autophagy显示文摘As a major component of the viral ribonucleoprotein(vRNP)complex in influenza A virus(IAV),nucleoprotein(NP)interacts with isoforms of importinαfamily members,leading to the import of itself and vRNP complex into the nucleus,a process pivotal in the replication cycle of IAV.In this study,we found that BinCARD1,an isoform of Bcl10-interacting protein with CARD(BinCARD),was leveraged by IAV for efficient viral replication.BinCARD1 promoted the nuclear import of the vRNP complex and newly synthesized NP and thus enhanced vRNP complex activity.Moreover,we found that BinCARD1 interacted with NP to promote NP binding to importinα7,an adaptor in the host nuclear import pathway.However,we also found that BinCARD1 promoted RIG-I-mediated innate immune signaling by mediating Lys63-linked polyubiquitination of TRAF3,and that TBK1 appeared to degrade BinCARD1.We showed that BinCARD1 was polyubiquitinated at residue K103 through a Lys63 linkage,which was recognized by the TBK1-p62 axis for autophagic degradation.Overall,our data demonstrate that IAV leverages BinCARD1 as an important host factor that promotes viral replication,and two mechanisms in the host defense system are triggered—innate immune signaling and autophagic degradation—to mitigate the promoting effect of BinCARD1 on the life cycle of IAV. | Xuyuan Wang Li Jiang Guangwen Wang Wenjun Shi Yuzhen Hu Bo Wang Xianying Zeng Guobin Tian Guohua Deng Jianzhong Shi Liling Liu Chengjun Li Hualan Chen | 2022 | Cellular & Molecular Immunology2022，19，10： | 3 |
| 5 | Bone marrow and the control of immunity显示文摘Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination. | Ende Zhao Huanbin Xu Lin Wang Ilona Kryczek Ke Wu Yu Hu Guobin Wang Weiping Zou | 2012 | Cellular & Molecular Immunology2012，9，1： | 3 |
| 6 | TRIM28 protects CARM1 from proteasome-mediated degradation to prevent colorectal cancer metastasis显示文摘TRIM28 (Tripartite motif-containing protein 28), a member of TRIM family, is aberrantly expressed and reportedly has different functions in many types of human cancer. However, the biological roles of TRIM28 and related mechanism in colorectal cancer (CRC) remain unclear. Here, we showed that TRIM28 was downregulated in colorectal cancer compared with normal mucosa, especially at advanced stages, and acted as an independent prognostic factor of favorable outcome. Functional studies demonstrated that TRIM28 restrained CRC migration and invasion in vitro and in vivo. Mechanistically, we reported that CARM1 (co-activator-associated arginine methyltransferase1) was a critical player downstream of TRIM28. TRIM28 interacted with CARM1, and protected CARM1 from proteasome-mediated degradation through physical protein-protein interaction to suppress CRC metastasis. Further, TRIM28 suppressed the migration and invasion of CRC cells through inhibiting WNT/β-catenin signaling in a CARM1-dependent manner, but independent of CARM1′s methyltransferase activity. The protein expression of CARM1 was positively correlated with TRIM28 in CRC tissues. Patients with high levels of TRIM28 and CARM1 had improved prognosis, whereas patients with low TRIM28 and CARM1 expression had the poor outcomes. Thus, our study reveals an inhibitory role of TRIM28 in CRC metastasis, which was achieved through a TRIM28-CARM1-WNT/β-catenin axis. This work provides potential prognostic and therapeutic targets for CRC treatment. | Jinyuan Cui Jia Hu Zhilan Ye Yongli Fan Yuqin Li Guobin Wang Lin Wang Zheng Wang | 2019 | Science Bulletin2019，64，14： | 1 |
| 7 | On the Security of an Efficient and Non-interactive Hierarchical Key Agreement Protocol显示文摘 | Guobin Zhu Hu Xiong Zhiguang Qin | 2014 | Wireless Personal Communications2014，，2： | 1 |
| 8 | Marginal-ized Iterated Unscented Kalman Filter 显示文摘 | Chang Lubin Hu Baiqing Chang Guobin and Li An | 2012 | IET Control Theory &Applications2012，6，6： | 1 |
| 9 | Huber -based Novel Robust Unscented Kalman Filter 显示文摘 | Chang Lubin Hu Baiqing Chang Guobin and Li An | 2012 | IET Science Measurement and Technology2012，6，6： | 1 |
| 10 | An IRF-3 homolog that is up-regulated by DNA virus and poly Ⅰ:C in turbot,Scophthalnus maximus显示文摘 | Guobin Hu Jun Xia Huimin Lou | 2011 | Fish Shellfish Immunology2011，31，6： | 1 |
| 11 | Spatial Heterogeneity of Marine Environment Changes:A Case Study in Laizhou Bay and Its Adjacent Waters,China显示文摘Temporal and spatial heterogeneity identifications of marine environment and its changes have great significances in marine spatial planning and offshore pollution control.In this study,considering the integration of marine ecological environment and sea-land interaction,we built a spatialized evaluation model named Marine Environment Change Spatial Assessment(MECSA)to quantify the marine environment status and changes.In MECSA,we applied the geospatial model and the pressure-state-response(PSR)model for processing and integrating evaluation indicators.A case study in the Laizhou Bay showed that the marine environment quality was generally in a declining state from 2009 to 2015.In 2015,the Marine Environment Index(MEI)had decreased by 0.1 compared with 2009,although the two years all reached a‘Good'level.The spatial MEI layers of the two years showed a same distribution:the southwestern part was in poorer status,with a fan ring shape gradually getting better to the northeast.The Marine Organisms Response Index(MORI)contributed the most to the MEI.Therefore,future marine environmental assessment and spatial planning should focus on the identification the marine environment with its changes from the perspective of spatial heterogeneity and systemicity.Based on single indicators and comprehensive evaluation results,we can propose spatially targeted policies and recommendations scientifically. | WANG Youxiao YU Ge HU Guobin LIU Dahai | 2021 | Journal of Ocean University of China2021，20，1： | 0 |
| 12 | 2-7 Charge and Frequency Resolved Isochronous Mass Spectrometry in Storage Rings: First Direct Mass Measurement of the Short-lived Neutron-de cient 51Co Nuclide显示文摘Isochronous mass spectrometry in storage rings is a successful technique for the precision mass measurements ofthe nuclides with half-lives down to tens of microseconds[1]. Since the isochronous condition =t greatly reducesthe influence of the velocity difference on the ion revolution periods, the revolution period difference ΔT =T ??TRof a stored ion with respect to a reference time TR is directly related to its mass-to-charge ratio difference Δ(m=q),written in the first order as: | Shuai Peng Xu Hushan Tu Xiaolin Zhang Yuhu Sun Baohua Yu.A.Litvinov Yan Xinliang K.Blaum Wang Meng Zhou Xiaohong He Jianjun Sun Yang K.Kaneko Yuan Youjin Xia Jiawen Yang Jiancheng G.Audi Chen Xiangcheng Jia Guobin Hu Zhengguo Ma Xinwen Mao Ruishi Mei Bo Sun Zhiyu Wang Shitao Xiao Guoqing Xu Xing T.Yamaguchi Y.Yamaguchi Zang Yongdong Zhao Hongwei Zhao Tiecheng Zhang Wei Zhan Wenlong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 13 | Transcriptome analysis reveals immune-related genes in tissues of Vibrio anguillarum-infected turbot Scophthalmus maximus显示文摘Turbot Scophthalmus maximus is an important mariculture fish species with high economic value.However,the bacterial diseases caused by Vibrio anguillarum infection bring huge economic losses to the turbot aquaculture industry.To understand the immune response of the turbot against V.anguillarum infection and to explore novel immune-related genes,the transcriptome analysis of turbot spleen and gills were conducted after V.anguillarum infection.Differentially expressed genes(DEGs)were identified in spleen and gill of the turbot amounted to 17261 and 16436,respectively.A large number of immunerelated DEGs were enriched in cytokine-cytokine receptor interaction signaling pathway,and the others by the kyoto encyclopedia of genes and genomes(KEGG)enrichment.The gene ontology(GO)classification analysis revealed that V.anguillarum infection had the greatest effect on biological processes and cellular components.Twelve immune-related DEGs were identified in the spleen(cstl.1,egfl6,lamb21,v2rx4,calcr,and gpr78a)and gills(ghra,sh3gl2a,cst12,inhbaa,cxcl8,and il-1b)by heat map.The proteinprotein interaction(PPI)networks were constructed to analyze the immune mechanism.The results demonstrate that the maturation and antigen processing of major histocompatibility complex(MHC)class II molecule,and calcitonin-or adrenomedullin-regulated physiological activity were important events in the immunity of turbot against V.anguillarum infection.In the gills,the protein interactions in TGF-βsignaling pathway,production of inflammatory factors,and endocytosis regulation were most significant.Our research laid a foundation for discovering novel immune-related genes and enriching the knowledge of immune mechanisms of turbot against V.anguillarum infection. | Yuting SONG Maqsood Ahmed SOOMRO Xianzhi DONG Guobin HU | 2024 | Journal of Oceanology and Limnology2024，42，1： | 0 |
| 14 | M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes显示文摘Influenza A virus(IAV) commandeers numerous host cellular factors for successful replication. However, very few host factors have been revealed to be involved in the fusion of viral envelope and late endosomal membranes. In this study, we identified cation-dependent mannose-6-phosphate receptor(M6PR) as a crucial host factor for the replication of IAV. We found that siRNA knockdown of M6PR expression significantly reduced the growth titers of different subtypes of IAV, and that the inhibitory effect of M6PR siRNA treatment on IAV growth was overcome by the complement of exogenously expressed M6PR. When A549 cells were treated with siRNA targeting M6PR,the nuclear accumulation of viral nucleoprotein(NP) was dramatically inhibited at early timepoints post-infection, indicating that M6PR engages in the early stage of the IAV replication cycle. By investigating the role of M6PR in the individual entry and post-entry steps of IAV replication, we found that the downregulation of M6PR expression had no effect on attachment, internalization, early endosome trafficking,or late endosome acidification. However, we found that M6PR expression was critical for the fusion of viral envelope and late endosomal membranes. Of note, M6PR interacted with the hemagglutinin(HA) protein of IAV, and further studies showed that the lumenal domain of M6PR and the ectodomain of HA2 mediated the interaction and directly promoted the fusion of the viral and late endosomal membranes,thereby facilitating IAV replication. Together, our findings highlight the importance of the M6PR–HA interaction in the fusion of viral and late endosomal membranes during IAV replication. | Yuzhen Hu Li Jiang Guangwen Wang Yangming Song Zhibo Shan Xuyuan Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng Liling Liu Hualan Chen Chengjun Li | 2024 | Science China(Life Sciences)2024，67，3： | 0 |
| 15 | Supramolecular Polymerization Powered by Escherichia coli:Fabricating a Near-Infrared Photothermal Antibacterial Agent in Situ显示文摘An Escherichia coli reduction-powered supramolecular polymerization is reported,leading to the fabrication of a near-infrared(NIR)photothermal antibacterial agent in situ.To this end,a bifunctional monomer containing two viologen moieties was designed.WhenincubatingE.coli with thebifunctional monomer and cucurbit[8]uril,viologen moieties were reduced to viologen cation radicals by E.coli,and a supramolecular polymer with supramolecular dimers of viologen cation radicals integrated into the main chain was fabricated on the surface of E.coli. | Zihe Yin Yuchong Yang Jinpeng Yang Guobin Song Hao Hu Peng Zheng Jiang-Fei Xu | 2022 | CCS Chemistry2022，4，10： | 0 |
| 16 | Inducing Fe 3d Electron Delocalization and Spin‑State Transition of FeN_(4) Species Boosts Oxygen Reduction Reaction for Wearable Zinc–Air Battery显示文摘Transition metal-nitrogen-carbon materials(M-N-Cs),particularly Fe-N-Cs,have been found to be electroactive for accelerating oxygen reduction reaction(ORR)kinetics.Although substantial efforts have been devoted to design Fe-N-Cs with increased active species content,surface area,and electronic conductivity,their performance is still far from satisfactory.Hitherto,there is limited research about regulation on the electronic spin states of Fe centers for Fe-N-Cs electrocatalysts to improve their catalytic performance.Here,we introduce Ti_(3)C_(2) MXene with sulfur terminals to regulate the electronic configuration of FeN_(4) species and dramatically enhance catalytic activity toward ORR.The MXene with sulfur terminals induce the spin-state transition of FeN_(4) species and Fe 3d electron delocalization with d band center upshift,enabling the Fe(II)ions to bind oxygen in the end-on adsorption mode favorable to initiate the reduction of oxygen and boosting oxygen-containing groups adsorption on FeN_(4) species and ORR kinetics.The resulting FeN_(4)-Ti_(3)C_(2)Sx exhibits comparable catalytic performance to those of commercial Pt-C.The developed wearable ZABs using FeN_(4)-Ti_(3)C_(2)Sx also exhibit fast kinetics and excellent stability.This study confirms that regulation of the electronic structure of active species via coupling with their support can be a major contributor to enhance their catalytic activity. | Shengmei Chen Xiongyi Liang Sixia Hu Xinliang Li Guobin Zhang Shuyun Wang Longtao Ma Chi‑Man Lawrence Wu Chunyi Zhi Juan Antonio Zapien | 2023 | Nano-Micro Letters2023，15，4： | 0 |
| 17 | Liver Tumor Segmentation Based on Multi-Scale and Self-Attention Mechanism显示文摘Liver cancer has the second highest incidence rate among all types of malignant tumors,and currently,its diagnosis heavily depends on doctors’manual labeling of CT scan images,a process that is time-consuming and susceptible to subjective errors.To address the aforementioned issues,we propose an automatic segmentation model for liver and tumors called Res2Swin Unet,which is based on the Unet architecture.The model combines Attention-Res2 and Swin Transformer modules for liver and tumor segmentation,respectively.Attention-Res2 merges multiple feature map parts with an Attention gate via skip connections,while Swin Transformer captures long-range dependencies and models the input globally.And the model uses deep supervision and a hybrid loss function for faster convergence.On the LiTS2017 dataset,it achieves better segmentation performance than other models,with an average Dice coefficient of 97.0%for liver segmentation and 81.2%for tumor segmentation. | Fufang Li Manlin Luo Ming Hu Guobin Wang Yan Chen | 2023 | Computer Systems Science & Engineering2023，47，12： | 0 |
| 18 | Analysis and improvement of a provable secure fuzzy identity-based signature scheme显示文摘To enjoy the property of error tolerance in the biometric identities extraction,the fuzzy identitybased signature has been initialized to issue a signature on behalf of a descriptive attributes setωinstead of a single string.Any attributes setω′can be used to verify the validity of the signature in case the distance betweenωandω′is less than a pre-defined threshold.Recently,Wang re-formalized the notion of fuzzy identitybased signature and proposed a concrete pairing-based construction along with the efficiency analysis and formal security proof.Unfortunately,by giving concrete attack,we indicate that Wang’s scheme is not secure against forgery attack.We also present an improved scheme to prevent this attack. | XIONG Hu CHEN YaNan ZHU GuoBin QIN ZhiGuang | 2014 | Science China(Information Sciences)2014，57，9： | 0 |
| 19 | How to Integrate Abstract Algebra and Number Theory in the Teaching of Public Key Cryptography Elegantly显示文摘Different from traditional symmetric cryptography, public key cryptography allows each user to own a pair of public/private key pair. Given the public key of one user and the data to be encrypted, a ciphertext can be generated such that only the intended user is able to recover the data using his/her private key associated with public key involved in the encryption process. To really understand the philosophy behind the public key cryptography is not an easy task and sometimes it seems somewhat difficult, if not impossible, for the beginners without the knowledge of the abstract algebra and number theory. In this paper, we introduce briefly the basic definition of public key cryptography as well as the corresponding mathematical hard problems. Besides, we explain why the mathematical backgrounds, especially abstract algebra and number theory, matter in the study of public key cryptography. | Hu Xiong Ting Zhong Guobin Zhu Zhiguang Qin | 2018 | 计算机教育2018，，12： | 0 |
| 20 | Presence of a long nuclear-localization signal sequence in homeodomain transcription factor Nkx 1.2显示文摘Homeodomains,a 60-amino acid sequence encoded by 180 nucleotides,are highly conserved DNA-binding motifs that are present in a variety of transcription factors in species ranging from yeast to humans.The NKX proteins belong to the homeodomain(HD)-containing transcription factor family.They play vital roles in the regulation of morphogenesis.NKX1-2 is one member of the NKX subfamily.At present,information about its nuclear localization signal(NLS)sequence is limited.We studied the NLS sequence of zebrafish Nkx1.2 by introducing sequence changes such as deletion,mutation,and truncation,and identified an NLS motif(QNRRTKWKKQ)that is localized at the C-terminus of the homeodomain.Moreover,the deletion of two amino acid residues(RR)in this NLS motif prevents Nkx1.2 from entering the nucleus,indicating that the two amino acids are essential for Nkx1.2 nuclear localization.However,the NLS motif alone is unable to target cytoplasmic protein glutathione S-transferase(GST)to the nucleus.An intact homeodomain is necessary for mediating the complete nuclear transport of cytoplasmic protein.Unlike most nuclear import proteins with short NLS sequences,a long NLS is present in zebrafish Nkx1.2.We also demonstrated that the sequences of homeodomain of NKX1.2 are well conserved among different species.This study is informative to verify the function of the NKX1.2 protein. | Xinyi LI Lihui CHEN Xinyuan WANG Chen SUN Guangdong JI Guobin HU Zhenhui LIU | 2024 | Journal of Oceanology and Limnology2024，42，2： | 0 |
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