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| 1 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 2 | Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery显示文摘AIM: To investigate the effect of compound Danshen injection on lipopolysaccharide (LPS)-induced rat mesenteric microcirculatory dysfunctions and the underlying possible mechanism by an inverted intravital microscope and high-speed video camera system. METHODS: LPS was continuously infused through the jugular artery of male Wistar rats at the dose of 2 mg/kg per hour. Changes in mesenteric microcirculation,such as diameters of arterioles and venules,velocity of RBCs in venules,leukocyte rolling,adhesion and emigration,free radicals released from post-capillary venules,FITC- albumin leakage and mast cell degranulation,were observed through an inverted intravital microscope assisted with CCD camera and SIT camera. Meanwhile,the expression of adhesion molecules CD11b/CD18 and the production of free radical in neutrophils,and the expression of intercellular adhesion molecule 1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) were quantified by flow cytometry (FACS) in vitro. RESULTS: The continuous infusion with LPS resulted in a number of responses in microcirculation,including a significant increase in the positive region of venulestained with Monastral blue B,rolling and adhesion of leukocytes,production of oxygen radical in venular wall,albumin efflux and enhanced mast cell degranulation in vivo,all of which,except for the leukocyte rolling,were attenuated by the treatment with compound Danshen injection. Experiments performed in vitro further revealed that the expression of CD11b/CD18 and the production of oxygen free radical in neutrophils,and the expression of ICAM-1 in HUVECs were increased by exposure to LPS,and they were attenuated by compound Danshen injection. CONCLUSION: These results suggest that compound Danshen injection is an efficient drug with multi-targeting potential for improving the microcirculatory disturbance. | Jing-Yan Han Yoshinori Horie Soichiro Miura, Yasutada Akiba Jun Guo Dan Li Jing-Yu Fan Yu-Ying Liu Bai-He Hu Li-Hua An Xin Chang Man Xu De-An Guo Kai Sun Ji-Ying Yang Shu-Ping Fang Ming-Ji Xian Masahiro Kizaki Hiroshi Nagata Toshifumi Hibi | 2007 | World Journal of Gastroenterology2007，13，26： | 26 |
| 3 | Incidence of Pleural Effusion in Patients with Pulmonary Embolism显示文摘 | Min Liu Ai Cui Zhen-Guo Zhai Xiao-Juan Guo Man Li Lei-Lei Teng Li-Li Xu Xiao-Juan Wang Zhen Wang Huan-Zhong Shi | 2015 | Chinese Medical Journal2015，，8： | 25 |
| 4 | Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges显示文摘BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, as to date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main current therapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation. | Jia Xiao Rui Guo Man Lung Fung Emily C Liong George L Tipoe | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 14 |
| 5 | Effects of warming and clipping on plant and soil properties of an alpine meadow in the Qinghai-Tibetan Plateau, China显示文摘Climate warming and livestock grazing are known to have great influences on alpine ecosystems like those of the Qinghai-Tibetan Plateau(QTP) in China. However, it is lacking of studies on the effects of warming and grazing on plant and soil properties in these alpine ecosystems. In this study, we reported the related research from manipulative experiment in 2010–2012 in the QTP. The aim of this study was to investigate the individual and combined effects of warming and clipping on plant and soil properties in the alpine meadow ecosystem. Infrared radiators were used to simulate climate warming starting in July 2010, while clipping was performed once in October 2011 to simulate the local livestock grazing. The experiment was designed as a randomized block consisting of five replications and four treatments: control(CK), warming(W), clipping(C) and warming+clipping combination(WC). The plant and soil properties were investigated in the growing season of the alpine meadow in 2012. The results showed that W and WC treatments significantly decreased relative humidity at 20-cm height above ground as well as significantly increases air temperature at the same height, surface temperature, and soil temperature at the depth of 0–30 cm. However, the C treatment did not significantly decrease soil moisture and soil temperature at the depth of 0–60 cm. Relative to CK, vegetation height and species number increased significantly in W and WC treatment, respectively, while vegetation aboveground biomass decreased significantly in C treatment in the early growing season. However, vegetation cover, species diversity, belowground biomass and soil properties at the depth of 0–30 cm did not differ significantly in W, C and WC treatments. Soil moisture increased at the depth of 40–100 cm in W and WC treatments, while belowground biomass, soil activated carbon, organic carbon and total nitrogen increased in the 30–50 cm soil layer in W, C and WC treatments. Although the initial responses of plant and soil properties to experimental warming and clipping were slow and weak, the drought induced by the downward shift of soil moisture in the upper soil layers may induce plant belowground biomass to transfer to the deeper soil layers. This movement would modify the distributions of soil activated carbon, organic carbon and total nitrogen. However, long-term data collection is needed to further explain this interesting phenomenon. | Man Hou XU Fei PENG Quan Gang YOU Jian GUO Xia Fei TIAN Min LIU Xian XUE | 2015 | Journal of Arid Land2015，7，2： | 14 |
| 6 | Ginsenoside Rd inhibits apoptosis following spinal cord ischemia/reperfusion injury显示文摘Ginsenoside Rd has a clear neuroprotective effect against ischemic stroke. We aimed to verify the neuroprotective effect of ginsenoside Rd in spinal cord ischemia/reperfusion injury and explore its anti-apoptotic mechanisms. We established a spinal cord ischemia/reperfusion injury model in rats through the occlusion of the abdominal aorta below the level of the renal artery for 1 hour. Successfully established models were injected intraperitoneally with 6.25, 12.5, 25 or 50 mg/kg per day ginsenoside Rd. Spinal cord morphology was observed at 1, 3, 5 and 7 days after spinal cord ischemia/reperfusion injury. Intraperitoneal injection of ginsenoside Rd in ischemia/reperfusion injury rats not only improved hindlimb motor function and the morphology of motor neurons in the anterior horn of the spinal cord, but it also reduced neuronal apoptosis. The optimal dose of ginsenoside Rd was 25 mg/kg per day and the optimal time point was 5 days after ischemia/reperfusion. Immunohistochemistry and western blot analysis showed ginsenoside Rd dose-dependently inhibited expression of pro-apoptotic Caspase 3 and down-regulated the expression of the apoptotic proteins ASK1 and JNK in the spinal cord of rats with spinal cord ischemia/reperfusion injury. These findings indicate that ginsenoside Rd exerts neuroprotective effects against spinal cord ischemia/reperfusion injury and the underlying mechanisms are achieved through the inhibition of ASK1-JNK pathway and the down-regulation of Caspase 3 expression. | Baogang Wang Qingsan Zhu Xiaxia Man Li Guo Liming Hao | 2014 | Neural Regeneration Research2014，9，18： | 13 |
| 7 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 8 | Temperature distribution and dynamic control of secondary cooling in slab continuous casting显示文摘To predict and optimize the temperature distribution of slab continuous casting in steady operational state, a three-dimensional model (named 'offline model') based on the heat transfer and solidification theories was developed. Both heat transfer and flux distribution characteristics of the nozzle sprays on the slab were considered, and the complicated boundary condi-tions, such as spray cooling, natural convection, thermal radiation as well as contact cooling of individual rolls were involved in the model. By using the calibrated caster dependent model factors, the calculated temperature and shell thickness accorded well with the measured. Furthermore, a dynamic secondary water cooling control system was also developed on the basis of a two-dimensional transient heat transfer model (named 'online model') and incremental PID control algorithm to reduce slab surface temperature fluctuation in unsteady state. Compared with the traditional spray table control method, the present online model and dynamic PID con-trol demonstrate a higher capability and flexibility to adjust cooling water flowrate and reduce slab surface temperature fluctuation when the casting speed is changed. | Liang-hang Guo Yong Tian Man Yao Hou-fa Shen | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，6： | 9 |
| 9 | Efficient and rapid generation of induced pluripotent stem :ells using an alternative culture medium显示文摘 | Xiao-yang Zhao Wei Li Zhuo Lv Lei Liu Man Tong Tang Hai Jie Hao Chang-long Guo Xia ng Wang Liu Wang Fanyi Zeng Qi Zhou | 2010 | Cell Research2010，20，3： | 9 |
| 10 | Effects of di-n-butyl phthalate on male rat reproduction following pubertal exposure显示文摘Di-n-butyl phthalate (DBP ) 是有潜力影响男复制的内分泌破坏的化学药品。然而,低剂量的 DBP 的繁殖效果仍然不是众所周知的,特别在分子的水平。在现在的学习, pubertal 男性 Sprague-Dawley 老鼠是在大量剂量的口头上地管理的 DBP (0.1, 1.0, 10, 100 和 500 为 30 天的 mg kg −1 天 −1) 。选择结束点包括了繁殖机关重量,阴囊的组织病理学说和浆液神经质的层次。另外, proteomic 分析被执行识别是在低剂量由于暴露表示到 DBP 的差别的蛋白质(0.1, 1.0 和 10 mg kg −1 天 −1) 。有毒的效果在高剂量的组被观察,包括睾丸和 epididymides 的异常开发,生精的小管,精子发生的损失和浆液荷尔蒙的反常层次的严重萎缩。有 DBP 的低剂量的处理似乎施加 ‘浆液荷尔蒙上的刺激 effect' 。老鼠睾丸的 Proteomics 分析证明 20 差别表示了蛋白质。(SOD1 ) 在这些蛋白质,在 HnRNPA2/B1 的表示的改变, vimentin 和 superoxide dismutase 之中, 1 被西方的污点和 immunohistochemistry 进一步证实。一起拿,我们断定 DBP 的高剂量导致了阴囊的毒性,并且 DBP 的低剂量在在 Sertoli 和 Leydig 房间的数字和功能象变化一样涉及精子发生的蛋白质的表示导致了变化,尽管没有明显的词法变化出现了。这些差别的鉴定表示了蛋白质关于在雄的老鼠复制上位于 DBP 的效果下面的机制提供重要信息。 | Ai-Mei Bao Xiao-Ming Man Xue-Jiang Guo Hui-Bin Dong Fu-Qiang Wang Hong Sun Yu-Bang Wang Zuo-Min Zhou Jia-Hao Sha | 2011 | Asian Journal of Andrology2011，13，5： | 8 |
| 11 | Soil erosion of unpaved loess roads subjected to an extreme rainstorm event: a case study of the Jiuyuangou watershed on the Loess Plateau, China显示文摘Rainfall can cause serious soil loss in the Loess Plateau hilly and gully region, but little focus has been placed on the extreme rainstorm effects on unpaved loess road soil erosion. A field survey method was used to investigate the erosional effects of the '7·26' heavy rainfall event on unpaved loess roads in the Jiuyuangou watershed of the Loess Plateau, China. The results showed that the average and maximum widths of the eroded gullies that formed on the unpaved roads were 0.65-1.48 m and 1.00-3.60 m, respectively. The average and maximum depths of theeroded gullies were 0.42-1.13 m and 0.75-4.30 m, respectively. The average width-to-depth ratio was 1.31, indicating that the widening effect was greater than the downcutting effect in the eroded gullies. In addition, the gully density ranged from 0.07 to 0.29 m m-2, and the road surface dissection degree ranged from 0.03 to 0.41 km2 km-2. Eroded gullies generally developed at the slope toe of the cut bank side. The average eroded gully width and depth at turns in the road were 1.47-2.64 times and 1.30-3.47 times greater, respectively, than those in other road sections. The road erosion modulus increased from the upper section to the lower section of the roads. The average road erosion modulus of the study catchment was 235,000 t km-2. Turns in the road were associated with collapses, sinkholes and other gravitational erosion phenomena. The amount of road erosion under extreme rainfall conditions is mainly related to the interactions among road length, width, slope and soil bulk density. Our results provide a useful reference for developing further measures for preventing road erosion on the Loess Plateau. | YANG Bo WANG Wen-long GUO Ming-ming GUO Wen-zhao WANG Wen-xin KANG Hong-liang ZHAO Man CHEN Zhuo-xin | 2019 | Journal of Mountain Science2019，16，6： | 8 |
| 12 | Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer显示文摘Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin(DOX) and Toll-like receptor 7 agonist imiquimod(IMQ) in low molecular weight heparin(LMWH)-D-α-tocopheryl succinate(TOS) micelles(LT). In this process, LMWH and TOS were conjugated by ester bond and they were not only served as the hydrophilic and hydrophobic segments of the carrier, but also exhibited strong anti-metastasis effect. The direct killing of tumor cells mediated by DOX-loaded micelles(LT-DOX)generated tumor-associated antigens, initiating tumor-specific immune responses in combination with IMQ-loaded micelles(LT-IMQ). Furthermore, the blockade of immune checkpoint with programmed cell death ligand 1(PD-L1) antibody further elevated the immune responses by up-regulating the maturation of DCs as well as the ratios of CD8+ CTLs/Treg and CD4+ Teff/Treg. Therefore, such a multifunctional strategy exhibited great potential for inhibiting the growth of orthotopic and metastatic breast cancer. | Jiaojie Wei Yang Long Rong Guo Xinlei Liu Xian Tang Jingdong Rao Sheng Yin Zhirong Zhang Man Li Qin He | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 13 | Seasonal variation of nitrogen and phosphorus in Xiaojiang River-A tributary of the Three Gorges Reservoir显示文摘A yearlong monitoring program in the backwater area of Xiaojiang River(XBA)was launched in order to investigate the eutrophication of backwater areas in tributaries of the Yangtze River in the Three Gorges Reservoir(TGR)in China,starting after the impoundment water level of the TGR reached 156 m.From March 2007 to March 2008,the average concentration of total nitrogen(TN)and total phosphorus(TP)were(1553484)μg·L^(–1)and(6231)μg·L^(–1),respectively.The mean value of chlorophyll was(9.070.91)μg·L^(–1).The trophic level of XBA was meso-eutrophic,while the general nutrient limitation was phosphorus.The results indicated that XBA has a strong ability to purify itself and has non-point source pollution from terrestrial runoff.The variation of TN/TP ratio was caused by a variation in TN rather than in TP when TN/TP<22.N-fixation from cyanobacteria occurred and became an important process in overcoming the nitrogen deficit under a low TN/TP ratio.When TN/TP≥22,the variation of TP affected the TN/TP ratio more significantly than TN.The increase of TP in XBA was caused mainly by particulate phosphorus,which could originate from a non-point source as adsorptive inorganic forms after heavy rainfall and surface runoff.An increase in the river’s flow could also contribute to an unstable environment for the growth of phytoplankton. | Zhe LI Jinsong GUO Man LONG Fang FANG Jinping SHENG Hong ZHOU | 2009 | Frontiers of Environmental Science & Engineering2009，3，3： | 8 |
| 14 | Cucurbitacin I inhibits STAT3, but enhances STAT1 signaling in human cancer cells in vitro through disrupting actin filaments显示文摘STAT1 和 STAT3 是 STAT (抄写的信号变换器和使活跃之物) 的二个重要成员在调整癌症房间生长反对角色的蛋白质家庭和玩。压制 STAT3 或提高 STAT1 发信号被认为是吸引人的 anticancer 策略。Cucurbitacin (CuI ) 我从 cucurbitacin 家庭孤立被报导是 STAT3 发信号和肌动朊细胞骨架的 disruptor 的一个禁止者。在这研究,我们在调整在 vitro 在人的癌症房间发信号的 STAT 调查了 CuI 的功能和机制。CuI (0.1-10 mmol/L ) dose-dependently 禁止了 STAT3 的 phosphorylation,并且通过破坏肌动朊细丝可能在肺腺癌 A549 房间提高了 STAT1 的 phosphorylation。我们进一步证明肌动朊细丝身体上在 A549 房间与 JAK2 和 STAT3 联系了并且通过二调整了他们的 phosphorylation 表明建筑群, IL-6 受体建筑群和焦点的粘附建筑群。肌动朊细丝也在 A549 房间与 STAT1 交往了并且调整了它的 dephosphorylation。一起拿,这研究在 STAT 发信号的规定并且在人的癌症细胞生长的可能的抑制揭示 CuI 的分子的机制。更重要地,这研究揭开在调整 STAT 发信号的肌动朊和联系肌动朊的发信号建筑群的一个新奇角色。 | Hui GUO Shan KUANG Qiao-ling SONG Man LIU Xiao-xiao SUN Qiang YU | 2018 | Acta Pharmacologica Sinica2018，39，3： | 8 |
| 15 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 16 | Clinical significance of PCR in Helicobacter pylori DNA detection in human gastric disorders显示文摘ClinicalsignificanceofPCRinHelicobacterpyloriDNAdetectioninhumangastricdisordersXUGuoMing,JIXuHuai,LIZhaoShen,MANXiaoHua... | XU Guo Ming, JI Xu Huai, LI Zhao Shen, MAN Xiao Hua and ZHANG Hong Fu | 1997 | World Journal of Gastroenterology1997，3，2： | 6 |
| 17 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 18 | Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling显示文摘Numerous circular RNAs(circ RNAs) have been identified as vital regulators in various cancers. The newly reported circular RNA ubiquitin-associated protein 2(circ UBAP2) is a critical player in cell growth and metastasis in various types of cancers, although its role in colorectal cancer(CRC) has yet to be fully elucidated. We find that circ UBAP2 is upregulated in CRC tissues and cell lines to induce autophagy both in vitro and in vivo. The effects of circ UBAP2 on migration, invasion, and proliferation may be partially related to autophagy. Mechanistically, we uncover that circ UBAP2 can directly interact with mi R-582-5 p and subsequently act as a micro RNA sponge to regulate the expression of the mi R-582-5 p target gene forkhead box protein O1(FOXO1) and downstream signaling molecules, which collectively advance the progression and metastasis of CRC. These results suggest that circ UBAP2 acts as an oncogene via a novel circ UBAP2/mi R-582-5 p/FOXO1 axis, providing a potential biomarker and therapeutic target for CRC management. | Feifei Chen Lei Guo Jiehui Di Man Li Dong Dong Dongsheng Pei | 2021 | Journal of Genetics and Genomics2021，48，12： | 5 |
| 19 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 20 | High N-doped hierarchical porous carbon networks with expanded interlayers for efficient sodium storage显示文摘Sodium-ion batteries (SIBs) have been attracting considerable attention as a promising candidate for large-scale energy storage because of the abundance and low-cost of sodium resources. However, lack of appropriate anode materials impedes further applications. Herein, a novel self-template strategy is designed to synthesize uniform flowerlike N-doped hierarchical porous carbon networks (NHPCN) with high content of N (15.31 at.%) assembled by ultrathin nanosheets via a self-synthesized single precursor and subsequent thermal annealing. Relying on the synergetic coordination of benzimidazole and 2-methylimidazole with metal ions to produce a flowerlike network, a self-formed single precursor can be harvested. Due to the structural and compositional advantages, including the high N doping, the expanded interlayer spacing, the ultrathin two-dimensional nano-sized subunits, and the three-dimensional porous network structure, these unique NHPCN flowers deliver ultrahigh reversible capacities of 453.7 mAh·g^−1 at 0.1 A·g^−1 and 242.5 mAh·g^−1 at 1 A·g^−1 for 2,500 cycles with exceptional rate capability of 5 A·g^−1 with reversible capacities of 201.2 mAh·g^−1. The greatly improved sodium storage performance of NHPCN confirms the importance of reasonable engineering and synthesis of hierarchical carbon with unique structures. | Dongqin Su Man Huang Junhao Zhang Xingmei Guo Jiale Chen Yanchun Xue Aihua Yuan Qinghong Kong | 2020 | Nano Research2020，13，10： | 5 |
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