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| 1 | Impact of dietary L-arginine supply during early gestation on myofiber development in newborn pigs exposed to intra-uterine crowding显示文摘Background: Intra-uterine crowding(IUC) observed in hyperprolific sows impairs myofiber hyperplasia and overall fetal growth. Arginine supplementation(ARG) in gestation diets has been shown to positively affect litter and muscle development. The study objective was to assess whether the effect of ARG on offspring characteristics, with special emphasis on myofiber hyperplasia, differs under IUC conditions from these responses,because in that situation growth retardation is particularly prevalent due to reduced fetal nutrient supply.Unilateral oviduct ligation(OL) was used as a model for an uncrowded and hyperprolificacy(IN) as a model for a crowded intra-uterine environment.Methods: Five OL and five IN sows were fed a diet supplemented daily with either 43 g L-alanine(Ctrl) or 25 g L-arginine from d 14 to 28 of gestation in a cross-over design(two periods: 5^( th) and 6^( th) parity). At farrowing, two male and two female offspring, respectively, with a low and intermediate birth weight(BtW) were selected. After euthanization, the Semitendinosus muscle(STM) was removed and weighed, and the light and dark portions(STM_d and STM_l) were prepared for myofiber histochemistry using ATPase staining and the entire STM for gene expression analysis of myogenesis-related genes using RT-qPCR. In addition, various organs were removed and weighed. Data were analyzed using the MIXED model in SYSTAT.Results: No effect of either IUC or dietary treatment was found in litter characteristics. Offspring of ARG sows displayed a greater muscle area in STM(P < 0.01) as a result of the greater myofiber hyperplasia(P < 0.01). The increase was more distinct in the STM_l(P < 0.05) than in the STM_d(P = 0.131). Offspring of OL sows were heavier at birth(P < 0.01), had a heavier STM(P < 0.05), liver(P < 0.01) and kidney(P < 0.05), but when expressed relative to birth weight, these differences were absent. In addition, IUC had an effect(P < 0.05) on the expression of one of the myogenesis-related genes investigated.Conclusions: Independent from the extent of IUC, ARG improved Bt W, muscle and organ weights and myofiber hyperplasia in offspring. | Johannes Gulmann Madsen Camilo Pardo Michael Kreuzer Giuseppe Bee | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 3 |
| 2 | Quantitative cell signalling analysis reveals downregulation of MAPK pathway activation in colorectal cancer显示文摘 | Gulmann C Sheehan KM Conroy RM | | 0，，04： | 1 |
| 3 | CD44V6:a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays显示文摘 | Grace A Leader M | 2003 | Eur J Gastroenterol Hepatol2003，15，9： | 1 |
| 4 | Adenomatous polyposis coli gene, beta-catenin, and E-cadherin expression in proximal and distal gastric cancers and precursor lesions: an immunohistochemical study using tissue microarrays 显示文摘 | Gulmann C Grace A Leader M | 2003 | Appl Immunohistochem Mol Morphol2003，11，3： | 1 |
| 5 | Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract 显示文摘 | GULMANN C PANER GP PARAKH RS | 2013 | Hum Pathol2013，44，2： | 1 |
| 6 | CD44v6:a potential marker of malignant trans-formation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays显示文摘 | Gulmann C Grace A Leader M | 2003 | European Journal of Gastroenterology and Hepatology2003，15，9： | 1 |
| 7 | Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder 显示文摘 | PANER GP ANNAIAH C GULMANN C | 2014 | Hum Pathol2014，45，7： | 1 |
| 8 | Telomerase activity in proximal and distal gastric neoplastic and preneoplastic lesions using immunohistochemical detection of hTERT显示文摘 | Gulmann C Lantuejoul S GraceA | 2005 | Dig Liver Dis2005，37，6： | 1 |
| 9 | Determinants for the use of psychotropics among nursing home residents显示文摘 | Sorensen L Foldspang A Gulmann NC | 2001 | Int J Geriatr Psychiatry2001，16，2： | 1 |
| 10 | Determinants for the use of psychotropics among nursing home residents显示文摘 | SorensenL Foldspang A Gulmann NC | 2001 | Int J Geriatr Psychiatry2001，16，2： | 1 |
| 11 | Anti-depressive treatment in Parkinson' s disease:A controlled trial of the effect of nortriptyline in patients with Parkinson' s disease treated with L-DOPA显示文摘 | Andersen J Aabro E Gulmann N | 1980 | Acta Neurol Scand1980，62，： | 1 |
| 12 | lm- munohistochemieal profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract显示文摘 | Gulmann C Paner GP Parakh RS | 2013 | Human Pathol2013，44，2： | 1 |
| 13 | Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder 显示文摘 | Paner GP Annaiah C Gulmann C | 2014 | Hum Pathol2014，45，： | 1 |
| 14 | CD44v6:a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays 显示文摘 | Gulmann C Grace A Leader M | 2003 | Eur J Gastroenterol Hepatol2003，15，9： | 1 |
| 15 | Gytokeratin 7/20 and MUC 1, 2, 5AC and 6 expression patterns in Barrett' s esophagus and intestinal metaplsia of the stomach: intestinal metaplsia of the cardia is related to Barrett's esophagus显示文摘 | Gulmann C Shaqaq O A Grace A | 2004 | Appl Immunohistochem Mol Morphol2004，12，2： | 1 |
| 16 | Tissue microarrays: an overview显示文摘 | Gulmann C O'Grady A | | 0，，： | 1 |
| 17 | CD44v6:a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays 显示文摘 | Gulmann C Grace A Leader M | 2003 | Eur J Gastroenterol Hepatol2003，15，9： | 1 |
| 18 | Biopsy of a biopsy : validation of immunoprofiling in gastric cancer biopsy tissue microarrays显示文摘 | Gulmann C Butler D Kay E | 2003 | Histopathology2003，42，1： | 1 |
| 19 | Telomerase activity in proximal and distal gastric neoplastic and preneoplastic lesions using immunohistochemical detection of hTERT 显示文摘 | Gulmann C Lantuejoul S Grace A | 2005 | Dig Liver Dis2005，37，6： | 1 |
| 20 | Cytokeratin 7/ 20 and MUC1, 2, 5AC, and 6 expression patterns in Bar- rett's esophagus and intestinal metaplasia of the stomach: intestinal metaplasia of the cardia is related to Barrett' s esophagus 显示文摘 | Gulmann C Shaqaqi O A Grace A | 2004 | Appl Immunohistochem Mol Morphol2004，12，2： | 1 |
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