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| 1 | 粪菌移植应用于慢传输型便秘的临床疗效及疗效影响因素:一项前瞻性研究的长期随访结果显示文摘背景和目的肠道菌群参与结肠动力的调控,菌群失调是便秘是病因之一。粪菌移植被证实可以恢复肠道平衡。本研究旨在评估粪菌移植治疗慢传输型便秘(STC)的临床疗效和预后影响因素。方法:52例STC患者接受标准的粪菌移植入组研究,对其进行至少6个月的随访。记录入组患者的排便习惯、结肠传输时间、便秘相关的症状(PAC-SYM评分)、生活质量(PAC-QOL评分)、治疗满意度和不良反应。主要疗效指标是平均每周完全自主排便≥3次的患者比例。结果:治疗后34周、912周、2124周,每周完全自主排便≥3次患者的比例分别为50.0%、38.5%和32.7%,均较治疗前显著提高(均P<0.01)。其他排便情况、结肠传输时间、便秘相关症状和生活质量方面,治疗后亦有显著改善;但这些短期改善在治疗后12周和24周逐渐减小。治疗前排便不尽是唯一的疗效影响因素。治疗和随访期间未发现任何治疗相关的不良反应。结论:本研究显示粪菌移植治疗STC安全有效,但远期疗效有所降低。治疗前排便不尽感较少甚至没有的患者接受粪菌移植的治疗效果更佳。 | Chao Ding Wenting Fan Lili Gu Hongliang Tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li | 2018 | Gastroenterology Report2018，6，2： | 7 |
| 2 | H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway显示文摘 | Shenglan Gao Wenting Li Wei Zou Ping Zhang Ying Tian Fan Xiao Hongfeng Gu Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 6 |
| 3 | Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure显示文摘Background and Aims:Nonbiological artificial liver(NBAL)is frequently used as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF).This study aimed to compare the therapeutic efficacy and cost-effectiveness ratio(CER)of comprehensive medical treatment,plasma exchange(PE),and double plasma molecular adsorption system(DPMAS)plus half-dose PE(DPMAS+PE)in patients with HBV-ACLF.Methods:A total of 186 patients with HBV-ACLF randomly received comprehensive medical treatment,PE,or DPMAS+PE and were prospectively evaluated.Patients were divided into four subgroups based on the pretreatment prothrombin activity(PTA):Group I(PTA>40%),group II(PTA 30–40%),group III(PTA 20–30%),and group IV(PTA<20%).The main outcome measures were 28 day effectiveness;90 day liver transplantation-free survival;change of biochemical parameters;and CER.Results:DPMAS+PE treatment was associated with significantly higher 28 day effectiveness and 90 day liver transplantation-free survival compared with PE treatment in patients with group I liver failure.Clearance of serum total bilirubin(TBIL),AST,and creatinine(Cr)were significantly higher in the DPMAS+PE group than in the PE group.For subjects with group I liver failure,DPMAS+PE treatment had advantages of lower CER values and better cost-effectiveness.Conclusions:Compared with comprehensive medical treatment and PE alone,DPMAS with halfdose sequential PE treatment more effectively improved TBIL,AST,and Cr in HBV-ACLF patients,improved 28 day effectiveness and 90 day survival rates in patients with group I liver failure,and was more cost effective.DPMAS+PE is a viable NBAL approach for treatment of HBV-ACLF. | Cichun Wu Wenting Peng Da Cheng Huimin Gu Fei Liu Shifang Peng Lei Fu | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 5 |
| 4 | Effects of stability margin and thrust specific fuel consumption constrains on multi-disciplinary optimization for blended-wing-body design显示文摘Blended-Wing-Body(BWB) configuration, as an innovative transport concept, has become a worldwide research focus in the field of civil transports development. Relative to the conventional Tube-And-Wing(TAW) configuration, the BWB shows integrated benefits and serves as a most promising candidate for future ‘‘green aviation'. The objective of the present work is to figure out the effects of the stability margin and Thrust Specific Fuel Consumption(TSFC) on the BWB design in the framework of Multi-Disciplinary Optimization(MDO). A physically-based platform was promoted to study the effect static stability margin and engine technology level. Low-order physically based models are applied to the evaluation of the weight and the aerodynamic performance. The modules and methods are illustrated in detail, and the validation of the methods shows feasibility and confidence for the conceptual design of BWB aircrafts. In order to find out the relation between planform changes and the selection of stability and engine technology level, two sets of optimizations are conducted separately. The study proves that these two factors have dominant effects towards the optimized BWB designs in both aerodynamic shapes, weight distribution, which needs to be considered during the MDO design process. A balance diagram analysis is applied to find out a reasonable static stability margin range. It can be concluded that a recommended stability margin of a practical BWB commercial aircraft can be half of that of a conventional TAW design. | Minghui ZHANG Zhenli CHEN Zhaoguang TAN Wenting GU Dong LI Changsheng YUAN Binqian ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，8： | 3 |
| 5 | Ex vivo 3D osteocyte network construction with primary murine bone cells显示文摘Osteocytes reside as three-dimensionally(3D) networked cells in the lacunocanalicular structure of bones and regulate bone and mineral homeostasis. Despite of their important regulatory roles, in vitro studies of osteocytes have been challenging because:(1) current cell lines do not sufficiently represent the phenotypic features of mature osteocytes and(2) primary cells rapidly differentiate to osteoblasts upon isolation. In this study, we used a 3D perfusion culture approach to:(1) construct the 3D cellular network of primary murine osteocytes by biomimetic assembly with microbeads and(2) reproduce ex vivo the phenotype of primary murine osteocytes, for the first time to our best knowledge. In order to enable 3D construction with a sufficient number of viable cells, we used a proliferated osteoblastic population of healthy cells outgrown from digested bone chips. The diameter of microbeads was controlled to:(1) distribute and entrap cells within the interstitial spaces between the microbeads and(2) maintain average cell-to-cell distance to be about 19 mm. The entrapped cells formed a 3D cellular network by extending and connecting their processes through openings between the microbeads. Also, with increasing culture time, the entrapped cells exhibited the characteristic gene expressions(SOST and FGF23) and nonproliferative behavior of mature osteocytes. In contrast, 2D-cultured cells continued their osteoblastic differentiation and proliferation. This 3D biomimetic approach is expected to provide a new means of:(1) studying flow-induced shear stress on the mechanotransduction function of primary osteocytes,(2) studying physiological functions of 3D-networked osteocytes with in vitro convenience,and(3) developing clinically relevant human bone disease models. | Qiaoling Sun Yexin Gu Wenting Zhang Leah Dziopa Jenny Zilberberg Woo Lee | 2015 | Bone Research2015，3，3： | 2 |
| 6 | The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications显示文摘Magnesium alloys have gained great attention as biodegradable materials for stent applications.Cardiovascular stents are continuously exposed to different types of mechanical loadings simultaneously during service,including tensile,compressive and fluid shear stress.In this study,the in vitro degradation of WE43 wires was investigated under combined effect of tensile loading and fluid shear stress and compared with that experienced an individual loading condition.For the individual mechanical loading treatment,the degradation of magnesium wires was more severely affected by tensile loading than fluid shear stress.Under tensile loading,magnesium wires showed faster increment of corrosion rates,loss of mechanical properties and localized corrosion morphology with the increasing tensile loadings.With the combined stress,smaller variation of the corrosion rates as well as the slower strength degeneration was shown with increasing stress levels,in comparison with the individual treatment of tensile loading.This study could help to understand the effect of complex stress condition on the corrosion of magnesium for the optimization of biodegradable magnesium stents. | Xue-Nan Gu Yun Lu Fan Wang Wenting Lin Ping Li Yubo Fan | 2018 | Bioactive Materials2018，3，4： | 2 |
| 7 | Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population显示文摘 | Hongyan Chen Yuxiang Gu Wenting Wu Dan Chen Peiliang Li Weiwei Fan Daru Lu Fan Zhao Nidan Qiao Huijia Qiu Chaowei Fu Ying Mao Yao Zhao | 2010 | Journal of Clinical Neuroscience2010，，4： | 1 |
| 8 | S100 protein expression during induced Schwann cell-like cell differentiation of rat bone marrow mesenchymal cells in vitro显示文摘BACKGROUND: S100 protein can promote axonal growth. Therefore, transplantation of induced bone marrow-derived mesenchymal stem cells (MSCs) that can secrete S100 may provide a beneficial microenvironment for neural regeneration. OBJECTIVE: To explore the changes in S100 expression during rat MSCs differentiation into Schwann cells in vitro. DESIGN, TIME AND SETTING: This cytology experiment was performed at the Jiangsu Key Laboratory of Neuroregeneration, Nantong University in China, from January 2006 to May 2007. MATERIALS: The rabbit anti-S100 polyclonal antibody was purchased from Dako, Denmark; the mouse anti-rat S100 monoclonal antibody was purchased from Sigma, USA. METHODS: MSCs were cultured from adult Sprague-Dawley rat femur and tibia. Cell proliferation was determined by the MTT method and CD markers, and cell cycle was meas-ured by flow cytometry. MSCs were induced to differentiate into SC cells. SC cells were stained for S100 protein, glial fibrillary acidic protein, and low-affinity nerve growth factor receptor. S100 protein and mRNA levels were evaluated by flow cytometry, Western blot, and reverse transcription-polymerase chain reaction. MAIN OUTCOME MEASURES: S100 protein and mRNA expression. RESULTS: MSCs exhibited high amplification potential over eight passages. Prior to induction, the majority of MSCs were at the G0/G1 phase of the cell cycle. After induction, MSCs displayed morphology changes similar to Schwann cells. Moreover, induction increased S100 mRNA levels. Immunofluorescence showed that MSCs expressed S100 protein, glial fibrillary acidic protein, and low-affinity nerve growth factor receptor at 7 days of induction. Induction also increased S100 protein levels compared with untreated MSCs. CONCLUSION: MSCs are capable of differentiating into Schwann cells-like cells under conditional induction in vitro, with increasing S100 mRNA and protein expression. | Wenting Li Zenglu Xu Fei Ding Xiaosong Gu | 2010 | Neural Regeneration Research2010，5，3： | 1 |
| 9 | Numerical Study on the Impact of the Sewage Drainage on Wa- ter Quality of Shanghai Water Sources显示文摘 | Gu jie Li Wenting Huang Jing | 2012 | Advanced Materials Research2012，，： | 1 |
| 10 | 3-31 Sugar Accumlation in Stem of Sweet Sorghum Mutant Induced by Carbon Ion Irradiation显示文摘Sweet sorghum, the world's fifth most important cereal after rice, corn, wheat and barley, is a very attractivesource for biomass production. This raw material complements sugarcane production and is emerging as the idealfeed for animals and for the production of the first-generation of biofuels, such as ethanol and value-added chemicals.At present, most of the studies about sweet sorghum focus on utilization (such as ethanol production), and thestudy of suger accumulation in stem are rarely. | Liu Ruiyuan Yang Taoliwei Dong Xicun Gu Wenting Li Wenjian | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 11 | 3-39 Distribution Characteristics of Soil Nutrients and Salt Content of Northwest Arid Region in Our Country--with the Industrial Park in Gansu as an Example显示文摘According to the poor nutrient and soil salinization of Wuwei industrial park in Gansu in Northwest arid region,we collected a large number of samples in the region and measured the soil salinity and nutrient content in 020cm. By the statistical analysis and comparison the values of the water content, pH, salinity, organic matter andavailable nitrogen phosphorus and potassium (NPK) in Table 1, our results indicated that: (1) In the sample region,besides the low water content, the degree of soil salinization is predominant and the majority of soil belong to themoderate or severe saline-alkali land. (2) Due to the low nutrient content, the soil is relatively poor. There areobvious differences between the soil organic matter and the available NPK[1]. In short, the nitrogen contents ofthe soil in the region are seriously rare. The available phosphorus contents were at a moderate or deficient level,and the available potassium contents were at a sufficient level or an adequate level compared with the classificationstandard of the second general survey of soil (Table 2). | Gu Wenting Jin Wenjie Liu Ruiyuan Li Wenjian Dong Xicun | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 12 | Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts显示文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality. | Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 13 | The Halo Concentration and Mass Relation Traced by Satellite Galaxies显示文摘We study the relation between halo concentration and mass(c-M relation) using galaxy catalogs of the Seventh and Eighth Data Releases of the Sloan Digital Sky Survey(SDSS DR7 and DR8). Assuming that the satellite galaxies follow the distribution of dark matter, we derive the halo concentration by fitting the satellite radial profile with a Nararro Frank and White(NFW) format. The derived c-M relation covers a wide halo mass range from10^(11.6)to 10^(14.1)M_(⊙). We confirm the anti-correlation between the halo mass and concentration as predicted in cosmological simulations. Our results are in good agreement with those derived using galaxy dynamics and gravitational lensing for halos of 10^(11.6)– 10^(12.9)M_(⊙), while they are slightly lower for halos of 10^(12.9)– 10^(14.1)M_(⊙).This is because blue satellite galaxies are less concentrated, especially in the inner regions. Instead of using all satellite galaxies, red satellites could be better tracers of the underlying dark matter distribution in galaxy groups. | Qing Gu Qi Guo Tianchi Zhang Wenting Wang Quan Guo Liang Gao | 2022 | Research in Astronomy and Astrophysics2022，22，12： | 0 |
| 14 | Nacelle-airframe integration design method for blended-wing-body transport with podded engines显示文摘Strong shock waves and flow separation often occur during the integration of nacelle and airframe for blended-wing-bodies with podded engines. To address this problem, this paper presents an integration method with numerical simulations. The philosophy of channeling flow and avoiding the throat effect on the nacelle and airframe is established based on the analysis of flow interference in the initial configuration. A parametric integration design method is proposed from twodimensional plane to three-dimensional space with control mechanisms and selection principles of the key parameters determined by their influences. Results show that strong shock waves and flow separation can be successfully eliminated under the influence of both the reshaped channel and decelerated inflow below the nacelle. Supersonic regions around the nacelle are effectively reduced, concentrating mainly on the lip position. Thus, a significant cruise drag reduction(8.7%) is achieved though the pressure drag of the nacelle increases. | Zhenqing XIN Zhenli CHEN Wenting GU Gang WANG Zhaoguang TAN Dong LI Binqian ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，8： | 0 |
| 15 | 4-39 Identification of Flavonoids and Expression of Anthocyanin Biosynthetic Genes in Leaf Color Mutant Induced by Carbon Ion Beam in Wandering Jew(Tradescantia uminensis)显示文摘Leaf color mutants are ideal materials for studying physiological processes in plants.Here,a thermos-sensitive leaf-color mutant of Green wandering jew was isolated after carbon ions irradiation,which was designated as mt.The color of young mutant leaves was more sensitive to variations of temperature,however,the young leaves of wild type remained green under low-temperature conditions(6℃-20℃).To elucidate the characteristics of pigmentation in mutant leaves under room temperature conditions(25℃)and low-temperature conditions(7℃),the ultra-structural,pigment composition,molecular mechanisms and anthocyanin accumulation involved in this phenomenon have been investigated in four independent experiments. | Liu Ruiyuan Dong Xicun Li Wenjian Qu Ying Jin Wenjie Gu Wenting | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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