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| 1 | In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy显示文摘瞄准:为在活体内评估一根最新发达的手持的共焦的探针在啮齿类动物的完全的胃肠道的显微镜的成像。方法:一根新奇僵硬共焦的探针(直径 7 公里) 为 fluorophore 刺激用 488 nm 单身者线激光在人为使用与类似于灵活 endomicroscopy 系统的光特征被设计。轻排放在 505 ~ 750 nm 被检测。看法的地多样地是 475 妈妈 475 妈妈。光片厚度是有 0.7 妈妈的侧面的分辨率的 7 妈妈。在不同深度(到 250 妈妈的表面) 的表面下的连续图象多样地在 1024 点在实时被产生由在轻轻的、稳定的接触把探查放到织物上的 1024 个象素(0.8 frames/s ) 。织物标本为组织病理学说的关联被取样。结果:食管,胃,小并且大肠和中央,肝,胰和胆囊是在在 n = 的高分辨率的视觉 ised 在活体内 48 个鼠标。有共焦的微型显微镜学探查的实时显微镜的成像是容易的完成。不同染色协议(荧光黄,吖啶黄,标记 FITC 的葡聚糖和 L。可食用嗯植物凝血素) 织物的每个加亮的特定的方面,和在活体内成像与常规组织学最优地相关。在活体内血流监视把功能的质量加到词法成像。结论:共焦的显微镜学是在甚至表面下的织物结构的高分辨率允许完全的官方补给的道的可视化的可行在活体内。在这研究评估的新共焦的探查设计与腹腔镜检查兼容并且显著地扩展可能的应用的地到 intra 腹的机关。它允许新在活体内染色和申请选择的立即的测试因此在病人从动物研究允许快速的转移到临床的使用。 | Martin Goetz Beena Memadathil Stefan Biesterfeld Constantin Schneider Sebastian Gregor Peter R Galle Markus F Neurath Ralf Kiesslich | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Irritable bowel syndrome and organic diseases: A comparative analysis of esophageal motility显示文摘AIM:To assess the esophageal motility in patients with irritable bowel syndrome(IBS)and to compare those with patients with autoimmune disorders.METHODS:15 patients with IBS,22 with systemic lupus erythematosus(SLE)and 19 with systemic sclerosis(SSc)were prospectively selected from a total of 115patients at a single university centre and esophageal motility was analysed using standard manometry(Mui Scientific PIP-4-8SS).All patients underwent esophagogastro-duodenoscopy before entering the study so that only patients with normal endoscopic findings were included in the current study.All patients underwent a complete physical,blood biochemistry and urinary examination.The grade of dysphagia was determined for each patient in accordance to the intensity and frequency of the presented esophageal symptoms.Furthermore,disease activity scores(SLEDAI and modified Rodnan score)were obtained for patients with autoimmune diseases.Outcome parameter:A correlation coefficient was calculated between amplitudes,velocity and duration of the peristaltic waves throughout esophagus and patients’dysphagia for all three groups.RESULTS:There was no statistical difference in the standard blood biochemistry and urinary analysis in all three groups.Patients with IBS showed similar pathologic dysphagia scores compared to patients with SLE and SSc.The mean value of dysphagia score was in IBS group 7.3,in SLE group 6.73 and in SSc group7.56 with a P-value>0.05.However,the manometric patterns were different.IBS patients showed during esophageal manometry peristaltic amplitudes at the proximal part of esophagus greater than 60 mmHg in46%of the patients,which was significant higher in comparison to the SLE(11.8%)and SSc-Group(0%,P=0.003).Furthermore,IBS patients showed lower mean resting pressure of the distal esophagus sphincter(Lower esophageal sphincter,22 mmHg)when compared with SLE(28 mmHg,P=0.037)and SSc(26 mmHg,P=0.052).23.5%of patients with SLE showed amplitudes greater as 160 mmHg in the distal esophagus(IBS and SSc:0%)whereas 29.4%amplitudes greater as 100 mmHg in the middle one(IBS:16.7%,SSc:5.9%respectively,P=0.006).Patients with SSc demonstrated,as expected,in almost half of the cases reduced peristalsis or even aperistalsis in the lower two thirds of the esophagus.SSc patients demonstrated a negative correlation coefficient between dysphagia score,amplitude and velocity of peristaltic activity at middle and lower esophagus[r=-0.6,P | Thomas Thomaidis Martin Goetz Sebastian Paul Gregor Arthur Hoffman Elias Kouroumalis Markus Moehler Peter Robert Galle Andreas Schwarting Ralf Kiesslich | 2013 | World Journal of Gastroenterology2013，19，38： | 1 |
| 3 | Iloprost to improve surfactant function in porcine pulmonary grafts stored for twenty-four hours in low-potassium dextran solution显示文摘 | Bernhard Gohrbandt Sebastian P. Sommer Stefan Fischer Jens M. Hohlfeld Gregor Warnecke Axel Haverich Martin Strueber | 2005 | The Journal of Thoracic and Cardiovascular Surgery2005，，1： | 1 |
| 4 | Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis显示文摘 | Christoph Peter Berg Gerburg Maria Stein Hildegard Keppeler Michael Gregor Sebastian Wesselborg Kirsten Lauber | 2008 | Apoptosis2008，，1： | 1 |
| 5 | The prostaglandins epoprostenol and iloprost increase left ventricular contractility in vivo显示文摘 | Hille Kisch-Wedel Gregor Kemming Franz Meisner Michael Flondor Wolfgang M. Kuebler Sebastian Bruhn Carolina Koehler Bernhard Zwissler | 2003 | Intensive Care Medicine2003，，9： | 1 |
| 6 | Impact of adaptive comfort criteria and heat waves on optimal building thermal mass control 显示文摘 | Henze Gregor P Pfafferott Jens Herkel Sebastian | 2007 | Energy and Buildings2007，39，2： | 1 |
| 7 | Antegrade versus retrograde perfusion of the donor lung: impact on the early reperfusion phase显示文摘 | Theo Kofidis Martin Strüber Gregor Warnecke Sebastian Sommer Rainer G. Leyh Leora B. Balsam Robert C. Robbins Axel Haverich | 2003 | Transplant International2003，，11： | 1 |
| 8 | Pulmonary preservation with LPD and celsior solution in porcine lung transplantation after 24h of cold ischemia显示文摘 | Sommer Gregor Warnecke | 2004 | Euro J Cardiothorac Surg2004，26，： | 1 |
| 9 | Reduced effi- ciency roll-off in phosphorescent organic light emitting di- odes by suppression of triplet-triplet annihilation显示文摘 | Reineke Sebastian Schwartz Gregor | 2007 | Ap- plied Physics Letters2007，91，12： | 1 |
| 10 | ESCRT machinery:role of membrane repair mechanisms in escaping cell death显示文摘A recent research article published in Science by Ritter et al.reported that endosomal sorting complexes required for transport(ESCRT)proteins mediate repair of lesions in the cell membrane caused by the pore-forming toxin perforin at sites of cytotoxic T cell engagement.1 Subsequent entry of granzymes and initiation of apoptosis of cancer cells is thus limited,leading to reduced sensitivity against T cell‑mediated cytotoxicity.1 Along these lines,this could constitute a new critical resistance mechanism for T cellbased treatment approaches. | Lisa Gregor Sophia Stock Sebastian Kobold | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 11 | China's Electric Vehicle Makers Target Europe显示文摘Until recently,China-based carmakers had little economic incentive to push into overseas markets as surging domestic sales buoyed them up,tripling in eight years between 2008 and 2016.Some Chinese SOEs started exporting on a bigger scale in the mid-2000s,largely in response to government pressure to signal that Chinese cars were globally competitive. | Gregor Sebastian | 2021 | China's Foreign Trade2021，，5： | 0 |
| 12 | Integrating impedance-based growth-rate monitoring into a microfluidic cell culture platform for live-cell microscopy显示文摘Growth rate is a widely studied parameter for various cell-based biological studies.Growth rates of cell populations can be monitored in chemostats and micro-chemostats,where nutrients are continuously replenished.Here,we present an integrated microfluidic platform that enables long-term culturing of non-adherent cells as well as parallel and mutually independent continuous monitoring of(i)growth rates of cells by means of impedance measurements and of(ii)specific other cellular events by means of high-resolution optical or fluorescence microscopy.Yeast colonies were grown in a monolayer under culturing pads,which enabled high-resolution microscopy,as all cells were in the same focal plane.Upon cell growth and division,cells leaving the culturing area passed over a pair of electrodes and were counted through impedance measurements.The impedance data could then be used to directly determine the growth rates of the cells in the culturing area.The integration of multiple culturing chambers with sensing electrodes enabled multiplexed long-term monitoring of growth rates of different yeast strains in parallel.As a demonstration,we modulated the growth rates of engineered yeast strains using calcium.The results indicated that impedance measurements provide a label-free readout method to continuously monitor the changes in the growth rates of the cells without compromising high-resolution optical imaging of single cells. | Ketki Chawla Sebastian C.Bürgel Gregor W.Schmidt Hans-Michael Kaltenbach Fabian Rudolf Olivier Frey Andreas Hierlemann | 2018 | Microsystems & Nanoengineering2018，4，1： | 0 |
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