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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Enhancement of second-migrating enatiomer peak symmetry of basic drugs by using dual-cyclodextrin system in capillary electrophoresis显示文摘 | Grard S Morin P Dreux M | 2000 | Electrophoresis2000，21，14： | 1 |
| 3 | Music decreases sedative requirements during spinal anesthesia 显示文摘 | Lepage C Drolet P Grard M | 2001 | Anesth Analg2001，93，： | 1 |
| 4 | Zika virus in Gabon (Central Africa)-2007:a new threat from Aedes albopictus? 显示文摘 | Grard G Caron M Mombo IM | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 5 | Zika virus in Gabon(Central Africa)-2007:a new threat from Aedes albopictus?显示文摘 | Grard G Mélanie C Illich Manfred M DieudonnéN Statiana MO Davy J Didier F Christophe P Eric Maurice L | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 6 | Association between a protein polymorphism in the start codon of the vitamin D receptor gene and severe diabetic retinopathy in C-peptide-negative type 1 diabetes显示文摘 | Taverna M J Jean-Louis S Grard S | 2005 | J Clin Endocrinol Metab2005，90，8： | 1 |
| 7 | The schu- mann resonance : a tool for exploring the atmospheric en- vironment and the subsurface of the planets and their satellites显示文摘 | SIMOES F GRARD R HAMELIN M | 2008 | Icarus2008，194，1： | 1 |
| 8 | Toward wide-scale all-optical transparent networking: The ACTS Optical Pan-European Network (OPEN) project 显示文摘 | Chbat M W Grard E Berthelon L | 1998 | IEEE J Sel Areas Commun1998，16，7： | 1 |
| 9 | Three-dimensional MRI of hemifacial spasm with surgical correlation 显示文摘 | Grard N Poneet M Caees F | 1997 | Neuroradiology1997，39，： | 1 |
| 10 | The Schumann reso nanee: a tool for exploring the atmospheric environment and the subsurface of the planets and their satellites显示文摘 | Simoes F Grard R Hamelin M | 2008 | Icarus2008，194，1： | 1 |
| 11 | Zika virus in Gabon (Central Africa) - 2007:a new threat from Aedes albopictus显示文摘 | GRARD G CARON M MOMBO I M | 2014 | PLoS Negl Trop Dis2014，8，： | 1 |
| 12 | Disruption of the mouse necdin gene results in early post-natal lethality显示文摘 | Hernandez L Wevrick R | 1999 | Nat Genet1999，23，2： | 1 |
| 13 | Analysis of sulfobutyl ether-beta-cyclodextrin mixtures by ion-spray mass spectrometry and liquid chromatography-ion-spray mass spectrometry显示文摘 | Grard S Elfakir C Dreux M | 2001 | J Chromatogr A2001，925，12： | 1 |
| 14 | Sulfobutyl ether-β-cyclodextrin fingerprint using ion pair reversed-phase chromatography显示文摘 | Grard S Elfakir C Dreux M | 1999 | Chromatographia1999，50，1112： | 1 |
| 15 | Characterization of sulfobutyl ether-β-cyclodextrins mixtures by anion-exchange chromatography using evaporative light scattering detection显示文摘 | Grard S Elfakir C Dreux M | 2000 | J Chromatogr A2000，897，12： | 1 |
| 16 | Zika virus in Gabon (Central Africa) --2007: a new threat from Aedes albopictus? 显示文摘 | Grard G Caron M Mombo IM | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 17 | Osmotic ad]ustment, gas ex- changes and chlorophyll fluorescence of a hexa-ploid triticale and its parental species under salt stress 显示文摘 | Annick M Elisabeth P Grard T | 2004 | Journal of Plant Physiology2004，161，1： | 1 |
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