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| 1 | The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORCl显示文摘 | Carsten Gram Hansen Yuen Lam Dora Ng Wai-Ling Macrina Lam Steven W Plouffe Kun-Liang Guan | 2015 | Cell Research2015，25，12： | 19 |
| 2 | Morphological and functional evaluation of chronic pancreatitis with magnetic resonance imaging显示文摘Magnetic resonance imaging(MRI)techniques for assessment of morphology and function of the pancreas have been improved dramatically the recent years and MRI is very often used in diagnosing and follow-up of chronic pancreatitis(CP)patients.Standard MRI including fat-suppressed T1-weighted and T2-weighted imaging techniques reveal decreased signal and glandular atrophy of the pancreas in CP.In contrast-enhanced MRI of the pancreas in CP the pancreatic signal is usually reduced and delayed due to decreased perfusion as a result of chronic inflammation and fibrosis.Thus,morphological changes of the ductal system can be assessed by magnetic resonance cholangiopancreatography(MRCP).Furthermore,secretin-stimulated MRCP is a valuable technique to evaluate side branch pathology and the exocrine function of the pancreas and diffusion weighted imaging can be used to quantify both parenchymal fibrotic changes and the exocrine function of the pancreas.These standard and advanced MRI techniques are supplementary techniques to reveal morphological and functional changes of the pancreas in CP.Recently,spectroscopy has been used for assessment of metabolite concentrations in-vivo in different tissues and may have the potential to offer better tissue characterization of the pancreas.Hence,the purpose of the present review is to provide an update on standard and advanced MRI techniques of the pancreas in CP. | Tine Maria Hansen Matias Nilsson Mikkel Gram Jens Brφndum Frφkjr | 2013 | World Journal of Gastroenterology2013，19，42： | 7 |
| 3 | Integrin betal mediates hepatocellular carcinoma cells chemotaxis to laminin显示文摘BACKGROUND: Chemotaxis is an important step durin the invasion of carcinoma cells. And integrins are most im portant receptors mediating interaction between cells an extracellular matrix ( ECM). This study was designed t study integrin betal mediating chemotaxis of hepatocellula carcinoma (HCC) cells to laminin (LN). METHODS: A micropipette technique was adopted to in vestigate the effect of blockade of integrin betal on pseudo pod protrusion of HCC cells in response to LN stimulation Chemotactic pseudopod protrusion of a HCC cell was eva luated using a dual-pipette set-up, in which two pipette filled with LN solution were positioned in close contact wit the same cell, and pseudopod protrusion into each pipett was viewed dynamically and recorded with a tape recorder The lengths of pseudopods were measured and plotte against time to obtain a pseudopod growth curve. The in tegrin betal subunit on the surfaces of HCC cells were ana lyzed by flow cytometry. RESULTS: In dual pipette chemotaxis experiment, whe the two pipettes were filled with LN(50 μg/ml, 200 μg/ml) pseudopods extended from the HCC cell into each of th pipettes nearly symmetrically, ie, with nearly identica maximum pseudopod length and similar pseudopod growth curves. Upon addition of anti-CD29 (20 μg/ml) to one o the pipettes, pseudopod protrusion was blocked nearly completely while protrusion into the opposite pipette be came more evidently, with a larger maximum length. Ex pression of integrin betal was up to 95.78% to cells chosen in the experiment. CONCLUSION: Integrin betal subunit was an importan constituent receptor subunit for mediating chemotactic pseudopod protrusion of HCC cell to LN. | Bian-Hong Fu, Ze-Zhi Wu and Cheng Dong Chongqing, China College of Bioengineering, Key Lab for Biomechanics and Tissue Engineering under the State Ministry of Education and College of Resources & Environmental Science , Chongqing University, Chongqing 400044, China Bioengineering Pro- gram, Pennsylvania State University, 205 Hallowell Building, University Park, Pennsylvania 16802-6804, USA | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，4： | 4 |
| 4 | Production and characterization of monoclonal antibody against recombinant fatty acid binding protein of Fasciola gigantica显示文摘 | Sirisriro A Grams R Vichasri-Grarns S | 2002 | Vet Parasitol2002，105，： | 3 |
| 5 | Microbiological spoilage of fish and fish products显示文摘 | Lone Gram Hans Henrik Huss | 1996 | International Journal of Food Microbiology1996，，1： | 3 |
| 6 | Fish spoilage bacteria – problems and solutions显示文摘 | Lone Gram Paw Dalgaard | 2002 | Current Opinion in Biotechnology2002，，3： | 2 |
| 7 | Design and synthesis of malonic acid-based inhibitors of human neutrophi collngenase(MMP-8) 显示文摘 | Grams F Brandstetter H | 1998 | J Med Chem1998，41，3： | 1 |
| 8 | Food spoilage-interactions between food spoilage bacteria显示文摘 | Ravn L Rasch M | 2002 | Int J Food Microbiol2002，78，： | 1 |
| 9 | Helicobaeter pylori infection显示文摘 | Larson JT Skjelbo E Gram LF | 1997 | Lancet1997，349，9055： | 1 |
| 10 | Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38 delta显示文摘 | Jiang Y Gram H Zhao M | 1997 | J Biol Chen1997，272，30： | 1 |
| 11 | Fish spoilage bacterial problems and solutions显示文摘 | Gram L Dalgaard P | 2012 | Current Opinion in Biotechnology2012，13，3： | 1 |
| 12 | Transient knockout of photosynthesis mediated by electrical signals显示文摘 | Koziolek C Grams TEE Schreiber U | 2003 | New Phytologist2003，161，3： | 1 |
| 13 | Food spoilage-interactions between food spoilage bacteria显示文摘 | GRAM L RAVN L RASCH M | 2002 | International Journal of Food Microbiology2002，78，1： | 1 |
| 14 | Production and characterization of a monoclonal antibody against recombinant fattyacid binding protein of fasciola gigantica显示文摘 | Sirisriro A Grams R Vichasri-Grams S | 2002 | Veterinary Parasitology2002，105，： | 1 |
| 15 | Antiepileptic drugs as a cause of worsening seizures显示文摘 | PeruccaE Gram L AvanziniG | | 0，，： | 1 |
| 16 | Magnetic: Resonance Imaging of Cranial Nerves at 7 Tesla 显示文摘 | Grams AE Kraft O Kalkmann 'i | 2013 | Clin Neuroradiol2013，23，1： | 1 |
| 17 | MAPKK-independent activation of p38 alpha mediated by TABl-dependent autophosphorylation of p38alpha 显示文摘 | GE B Gram H Di PF | 2002 | Science2002，295，5558： | 1 |
| 18 | Investigation of coagulatioin system and fibrinolysis in patients with disseminated adenocarcinomas and nonHodgdin's lymphomas显示文摘 | Zurborn KH Duscha H Gram J | 1990 | Oncology1990，47，5： | 1 |
| 19 | Fetal hemoglobin in preeclampsia: a ne causative factor, a tool for prediction/diagnosis and a potential target for therapy 显示文摘 | Hansson S R Gram M AkerstrO2m B | 2013 | Current Opinion in Obstetrics & Gynecology2013，25，6： | 1 |
| 20 | Microbiological spoilage of fish and fish product显示文摘 | Gram L Hans H H | 1996 | Int J Food Microbiol1996，33，： | 1 |
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