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| 1 | Hygiene hypothesis in inflammatory bowel disease: A criticalreview of the literature显示文摘The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended. | Natasha A Koloski Laurel Bret Graham Radford-Smith | 2008 | World Journal of Gastroenterology2008，14，2： | 16 |
| 2 | 基于学校儿童及其家庭的减盐干预研究(School-EduSalt):一项整群随机对照试验显示文摘摘要 目标研究基于学校的小学生减盐干预能否有效减少儿童及其家庭的摄盐量。设计整群随机对照试验,学校被随机分为干预组或对照组。实施现场中国北方城市长治市区的28所小学。研究对象小学五年级的279名学生,平均年龄为10.1岁;553名成年家长,平均年龄43.8岁。 | Feng J He 武阳丰 冯向先 马军 马媛 王海俊 张京 原建慧 Ching-Ping Lin Caryl Nowson Graham A MacGregor | 2015 | 英国医学杂志中文版2015，18，6： | 6 |
| 3 | 基于智能手机应用的中国学龄儿童及其家庭成员减盐健康教育(AppSalt):平行、整群随机对照研究显示文摘目的探讨基于智能手机应用的健康教育能否降低学龄儿童及其家庭成员的盐摄入量。设计平行、整群随机对照试验,将学校随机分配到干预组或对照组(1∶1)。背景从2018年9月15日至2019年12月27日,在中国北部、中部和南部3个省份纳入54所小学。参与者592名小学3年级儿童[每所学校约11名儿童,其中308名(52.0%)男孩;平均年龄8.58岁(标准差0.41)],以及1184名成年家庭成员[其中551名(46.5%)男性;平均年龄45.80岁(12.87)]。干预在手机应用程序的支持下,对干预组中的儿童进行关于减盐的健康教育,并布置家庭作业,以带动全家参与减盐的相关活动。主要结局测量干预组和对照组在第12个月随访时盐摄入量(通过24小时尿钠排泄量测量)改变值的差值。结果基线调查后,来自27所学校的297名儿童和594名成年家庭成员被分配到干预组,另外27所学校的295名儿童和590名成年家庭成员被分配到对照组。在试验期间,由于儿童转到另一所学校或成年家庭成员无法参加随访评估,27名(4.6%)儿童和112名(9.5%)成年人失去随访。干预组其余287名儿童和546名成人,以及对照组的278名儿童和526名成人完成了12个月的随访评估。干预组儿童基线时的平均盐摄入量为5.5[标准差(SD)1.9]g/天,干预组成人10.0(SD 3.5)g/天,对照组儿童5.6(SD 2.1)g/天,成人10.0(SD 3.6)g/天。在研究期间,干预组和对照组儿童的盐摄入量均有所增加,但干预组增加的幅度较小[调整混杂偏倚变量后平均干预效果为-0.25 g/天,95%可信区间(CI):-0.61~0.12;P=0.18]。干预组和对照组成人的盐摄入量均有所下降,但干预组的盐摄入量变化更大(平均效果-0.82 g/天,-1.24~-0.40;P<0.001)。对儿童收缩压的平均效果为-0.76 mmHg(-2.37~0.86;P=0.36),成人为-1.64 mmHg(-3.01~-0.27;P=0.02)。结论采用儿童带动家长的方式,基于手机应用程序的健康教育可有效降低成人的盐摄入量和收缩压,但对儿童的效果并不显著。这种新颖的方法有可能被更大规模地推广,但在此之前方案需要进一步加强,才能减少包括学童在内的人群盐摄入量。试验注册中国临床试验注册ChiCTR1800017553。 | Feng J He 张普洪 骆蓉 李园 孙悦文 陈凤格 赵昱红 赵伟 李道西 陈航 吴田勇 周思远 刘宇 李贤 何静 Changqiong Wang Monique Tan Jing Song Graham A MacGregor | 2022 | 英国医学杂志中文版2022，25，9： | 5 |
| 4 | Robust model predictive control:reflections and opportunities显示文摘The past three decades have witnessed important developments in the theory and practice of model predictive control(MPC).In particular,considerable effort has been devoted to robust MPC theory.There have also been many successful applications.This paper will give a brief overview of existing results and summarise experience gained in two real-world applications.We also present some reflections on issues which,in the authors’opinion,deserve further attention. | Graham C.Goodwin He Kong Galina Mirzaeva María M.Seron | 2014 | Journal of Control and Decision2014，1，2： | 5 |
| 5 | From minimal to maximal surgery in the treatment of hepatocarcinoma:A review显示文摘Hepatocellular carcinoma represents one of the most challenging frontiers in liver surgery. Surgeons have to face a broad spectrum of aspects,from the underlying liver disease to the new surgical techniques. Safe liver resection can be performed in patients with portal hypertension and well-compensated liver function witha 5-year survival rate of 50%,offering good longterms results in selected patients. With the advances in laparoscopic surgery,major liver resections can be performed with minimal harm,avoiding the wound and leak complications related to the laparotomies. Studies have shown that oncological margins are the same as in open surgery. In patients submitted to liver resection(either laparoscopic or open) who experience recurrence,re-resection or salvage liver transplantation has been showing to be an alternative approach in well selected cases. The decision making approach to the cirrhotic patient is becoming more complex and should involve hepatologists,liver surgeons,radiologists and oncologists. Better understanding of the different risk factors for recurrence and survival should be aimed in these multidisciplinary discussions. We here in discuss the hot topics related to surgical risk factors regarding the surgical treatment of hepatocellular carcinoma: anatomical resection,margin status,macrovascular tumor invasion,the place of laparoscopy,salvage liver transplantation and liver transplantation. | Marcos Vinicius Perini Graham Starkey Michael A Fink Ramesh Bhandari Vijayaragavan Muralidharan Robert Jones Christopher Christophi | 2015 | World Journal of Hepatology2015，7，1： | 4 |
| 6 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 7 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 8 | Experimental intracerebral mass: time-ralated effects on local cerebral blood flow显示文摘 | Kingman T A Mendelow A D Graham D I | 1987 | J Neurosurg1987，，67： | 2 |
| 9 | 新证据表明肥胖症与多种癌症相关相关性明确,需要认真考虑如何预防显示文摘国际癌症研究机构(IARC)工作组最近在回顾了流行病学数据、动物研究结果以及机制研究数据后得出结论:过量的身体脂肪会增加结直肠、肝、胆囊、胰腺、肾脏、甲状腺、乳腺(绝经后)、子宫内膜、卵巢、食管(腺癌)、胃贲门的癌症风险,还会导致神经瘤以及多发性骨髓瘤的发生’。这可能使多余的身体脂肪成为继使用烟草之后第二个重要的可控制的癌症危险因素。 | 孙翰 Graham A Colditz 杨红 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 10 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | 2005 (9457)2005，，9457： | 2 |
| 11 | A sensing mechanism for the detection of carbon nanotubes using selective photoluminescent probes based on ionic complexes with organic dyes显示文摘The multifunctional properties of carbon nanotubes(CNTs)make them a powerful platform for unprecedented innovations in a variety of practical applications.As a result of the surging growth of nanotechnology,nanotubes present a potential problem as an environmental pollutant,and as such,an efficient method for their rapid detection must be established.Here,we propose a novel type of ionic sensor complex for detecting CNTs–an organic dye that responds sensitively and selectively to CNTs with a photoluminescent signal.The complexes are formed through Coulomb attractions between dye molecules with uncompensated charges and CNTs covered with an ionic surfactant in water.We demonstrate that the photoluminescent excitation of the dye can be transferred to the nanotubes,resulting in selective and strong amplification(up to a factor of 6)of the light emission from the excitonic levels of CNTs in the near-infrared spectral range,as experimentally observed via excitation-emission photoluminescence(PL)mapping.The chirality of the nanotubes and the type of ionic surfactant used to disperse the nanotubes both strongly affect the amplification;thus,the complexation provides sensing selectivity towards specific CNTs.Additionally,neither similar uncharged dyes nor CNTs covered with neutral surfactant form such complexes.As model organic molecules,we use a family of polymethine dyes with an easily tailorable molecular structure and,consequently,tunable absorbance and PL characteristics.This provides us with a versatile tool for the controllable photonic and electronic engineering of an efficient probe for CNT detection. | Petro Lutsyk Raz Arif Jan Hruby Anatolii Bukivskyi Olexander Vinijchuk Mykola Shandura Viktor Yakubovskyi Yuri Kovtun Graham A Rance Michael Fay Yuri Piryatinski Oleksiy Kachkovsky Anatoli Verbitsky Aleksey Rozhin | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 12 | Experimental intracerebral mass: description of model,intracranial pressure changes and neuropathology显示文摘 | Kingma T A Mendelow A D Graham D I | 1998 | J Neuropathol Exp Neurol1998，47，： | 2 |
| 13 | Time -offlight secondary ion mass spectrometry: techniques and applications for the characterization of biomaterial surfaces 显示文摘 | Belu A M Graham D J Castne D G | 2003 | Biomaterials2003，24，： | 1 |
| 14 | Significance of the cranial neural crest显示文摘 | Graham A Begbie J McGonnell I | 2004 | Developmental Dynamics2004，229，1： | 1 |
| 15 | A new technique for the assay of infectivity of human adenovirus 5 DNA显示文摘 | van der Eb A J | 1973 | Virology1973，52，2： | 1 |
| 16 | Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus显示文摘 | Anderson R A Graham J | 2000 | Circulation2000，101，15： | 1 |
| 17 | Assessing the threat to life from dam failure显示文摘 | BROWN C A GRAHAM W J | 1988 | Water Resources Bulletin1988，24，6： | 1 |
| 18 | Age at acquisition of Helicobacter pylori infection:a follow-up study from infancy to adulthood显示文摘 | Malaty HM El-Kasabany A Graham DY | 2002 | Lancet2002，359，： | 1 |
| 19 | Sedimentary record and climatic implications of recurrent deformation in the Tian Shan: Evidence from Mesozoic strata of the north Tarim,south Junggar,and Turpan basins, northwest China显示文摘 | Hendrix M S Graham S A Carroll A R | 1992 | Geological Society of America Bulletin1992，104，： | 1 |
| 20 | New PDC bit design reduces vibrational problems显示文摘 | Graham M W Will L A | 1995 | Oil and Gas Journal1995，93，22： | 1 |
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