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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 3 | Synthesis of putative intermediates in the biosynthesis of the kinamycin antibiotics: total synthesis of phenanthroviridn aglycon and related compounds显示文摘 | GORE M P GOULD S J WELLER D D | 1992 | J Org Chem1992，57，： | 2 |
| 4 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 5 | Association of hyperglycemia with increased mortality after severe bum injury 显示文摘 | Gore DC Chinkes D Heggers J | 2001 | J Trauma2001，51，3： | 1 |
| 6 | Structure and radiation properties of large-scale natural gas/air diffusion flames显示文摘 | GORE J P FAETH G M EVANS D | 1986 | Fire and Materials1986，10，34： | 1 |
| 7 | Winter-time convection in open-graded embankments显示文摘 | Goreing D J Kumar P | 1996 | Cold Regions Science and Technology1996，24，1： | 1 |
| 8 | Association of hyperglycemia with increased mortality after severe burn injury显示文摘 | Gore DC Chinkkes D Heggers J | 2001 | Trauma2001，51，： | 1 |
| 9 | Long term survival following partial vs radical ne- phrectomy among older patients with early-stage kid ney cancer显示文摘 | Tan H J Norton E C Ye Z Hafez K S Gore J L Miller D C | 2012 | JAMA2012，307，： | 1 |
| 10 | An overview of MIMO communications-a key to gigabit wireless显示文摘 | Paulraj A J Gore D A Nabar R U | 2004 | Proceedings of the IEEE2004，92，2： | 1 |
| 11 | Ursodeoxycholic acid ‘mechanisms of action and clinical use in hepatobiliary disorders’显示文摘 | Konstantinos N Lazaridis Gregory J Gores Keith D Lindor | 2001 | Journal of Hepatology2001，，1： | 1 |
| 12 | Molecular weights of lignosulphonate and carbohydrate leached from sulfite chemimechanical pulp显示文摘 | WILLIS J W YEAN W Q GORING D A L | 1987 | Journal of Wood Chemistry Technology1987，7，2： | 1 |
| 13 | Transformation of a partial nopaline synthase gene into tobaccosuppresses the expression of a resident wild-type gene显示文摘 | Goring D R Thomson L Rothstein S J | 1991 | Proc Natl Aad Sci USA1991，88，： | 1 |
| 14 | Self-rejection, A new kinase connection 显示文摘 | Goring D R and Walker J C | 2004 | Science2004，303，： | 1 |
| 15 | An experiment on the salience of country of origin in the era of global brands显示文摘 | Tse D K Gore G J | 1993 | Journal of International Marketing1993，1，1： | 1 |
| 16 | Adequate immunotoxieity testing in drug development显示文摘 | HERZYK D J GORE E R | 2004 | Toxicol Lett2004，149，13： | 1 |
| 17 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 18 | The location of guaiacyl and syringyl lignins in birch xylem tissue显示文摘 | Fergus B J Goring D A I | 1970 | Holzforschung1970，24，4： | 1 |
| 19 | Further analysis of the interactions between the Brassica S receptor kinase and three interacting proteins (ARC1, THL1 and THL2) in the yeast two-hybrid system 显示文摘 | Mazzurco M Sulaman W Elina H Cock J M and Goring D R | 2001 | Plant Molecular Biology2001，45，： | 1 |
| 20 | An Over- view of MIMO Communications-a Key to Gigabit Wireless 显示文摘 | PAULRAJ A J GORE D A NABAR R U | 2004 | Proceedings of the IEEE2004，92，2： | 1 |
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