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| 1 | The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting显示文摘Background Vascular smooth muscle cells (VSMCs) can express heme-oxygenase (HO), a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO). VSMC-derived CO can suppress VSMC proliferation and may serve as an antiproliferation factor. The promoter region of HO-1 shows a polymorphism with different (GT)_n repeats that has been reported to differently induce gene expression. The objective of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease. Methods Candidates who underwent coronary stent implantation were genotyped for the HO-1 promoter polymorphism using polymerase chain reaction (PCR) and automated DNA capillary sequencer. Serum levels of IL-6 and C-reactive protein (CRP) were obtained at baseline, 24 hours and 48 hours after stenting. The primary end point for the study was angiographic evidence of in-stent restenosis at 6 months. All parameters for evaluation of restenosis were analysed by quantitatve computer-assisted angiographic analysis (QCA). Results One hundred and eighty-seven patients who underwent coronary stent implantation were studied of whom 27.8% showed ≥50% restenosis after 6 months. The distribution of (GT)_n repeats of all patients in the promoter region of HO-1 genotype ranged from 22 to 42, with (GT)_ 25 and (GT)_ 32 being the two most common alleles. The allelic repeats were divided into the short class (S) with 29 (GT)_n, the middle class (M) with 30-37 (GT)_n and the long class (L) with 38 (GT)_n. There was no significant difference in the restenosis between the genotype groups or between post operation levels of inflammation markers, but carriers of the S allele (n=120) had 33.3% lower baseline IL-6 compared with non-S carriers (n=67, P=0.0008). Conclusions Although no association was observed between the HO-1 promoter polymorphism aod coronary in-stent restenosis following the stent procedure, the association with plasma IL-6 levels suggests that HO-1 S allele might protect from the atherosclerotic inflammatory process. | LI Ping Mohamed A. Elrayess Abuzeid H. Gomma Jutta Palmen Emma Hawe Kim M. Fox Steve E. Humphries | 2005 | Chinese Medical Journal2005，，18： | 6 |
| 2 | Serologic response to hepatitis B vaccine with high dose and increasing number of injections in HIV infected adult patients显示文摘 | Mario Cruciani Carlo Mengoli Giovanni Serpelloni Andrea Lanza Maurizio Gomma Stefano Nardi Claudia Rimondo Francesco Bricolo Sandro Consolaro MariaTeresa Trevisan Oliviero Bosco | 2008 | Vaccine2008，，1： | 2 |
| 3 | Extended the DARTS software design method to distributed real time applications 显示文摘 | Gomma H | 1988 | System Sciences1988，，2： | 1 |
| 4 | A software design method for real-time systems显示文摘 | | 1984 | Computer Practices1984，，： | 1 |
| 5 | Reduction in plasma concen-trations of N terminal pro B type natriuretic peptide following percu-taneous coronary intervention 显示文摘 | Kalra PR Gomma A Daly C | 2004 | Heart2004，90，11： | 1 |
| 6 | Potassium channel openers in myocardial ischaemia:therapeutic potential of nicorandil显示文摘 | Gomma AH Purcell HJ Fox KM | 2001 | Drugs2001，61，12： | 1 |
| 7 | A comparison of the radial and the femoral approaches in primary or rescue percutaneous coronary intervention for acute myocardial infarction in the elderly显示文摘 | Ziakas A Gomma A McDonald J | | 0，，02： | 1 |
| 8 | Oxidative quality and shelf life of meats 显示文摘 | GRAY J I GOMMA E A BuckleyD J | 1996 | Meat Science1996，41，： | 1 |
| 9 | Effect of azole compounds on corrosion of copper in acid medium 显示文摘 | GOMMA G K | 1998 | Materials Chemistry and Physics1998，56，1： | 1 |
| 10 | Effect of azole compounds on corrosion ofcopper in acid medium显示文摘 | Gomma G K | 1998 | Materials Chemistry and Physics1998，56，1： | 1 |
| 11 | Preprocedural inflammatory markers do not predict restenosis after successful coronary stenting显示文摘 | Gomma AH Hirschfield GM Gallimore JR Jr | 2004 | Am Heart J2004，147，6： | 1 |
| 12 | The optimum location of geotextile reinforcement in asphalt layers显示文摘 | Moussa Gomma K M | 2003 | Alexandria Engineering Journal2003，42，1： | 1 |
| 13 | Automated quantitation of peripheral blood neutrophil activation in patients with myocardial ischaemia 显示文摘 | Leckie MJ Gomma AH Purcell IF | 2004 | Int J Cardiol2004，95，23： | 1 |
| 14 | Automated quantitation of peripheral blood neutrophil activation in patients with myocardial ischaemia显示文摘 | M.J Leckie A.H Gomma I.F Purcell B Nyawo A Dewar D Okrongly J.F Burman J Hooper P.J Barnes J.R Clague Trevor T Hansel | 2003 | International Journal of Cardiology2003，，2： | 1 |
| 15 | Prepeoceduralinflammatory markers do not predict restenosis after successful coro-nary stenting显示文摘 | Gomma AH Hirschfield GM Gallimore JR Jr | 2004 | Am Heart J2004，147，6： | 1 |
| 16 | Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-llke receptor-2,-4, and-9 genes显示文摘 | Hamann L Hamprecht A Gomma A | 2004 | Journal of Immunological Methods2004，，285： | 1 |
| 17 | QoS management in service oriented architectures显示文摘 | Menasce D A Ruan H Gomma H | 2007 | Performance Evaluation Journal2007，64，78： | 1 |
| 18 | 显示文摘 | Hussein A L Moustaffa F A Gomma I | 1981 | Indian J Pure Appl Phys1981，19，： | 1 |
| 19 | Relation in plasma concentrations of N terminal pro B type natriuretic peptide following percutaneous coronary intervention 显示文摘 | Kalra PR Gomma A Daly C | 2004 | Heart2004，90，11： | 1 |
| 20 | Potassium channel openersin myocardial ischaemia:therapeutic potential of nicorandil显示文摘 | Gomma AH Purcell HJ Fox KM | 2001 | Drugs2001，61，12： | 1 |
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