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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | What is the accuracy of the clinical diagnosis of multiple system atrophy? A clinicopathologic study显示文摘 | LITVAN I GOETZ C G JANKOIYZ J | 1997 | Arch Neurol1997，54，8： | 2 |
| 3 | Integratedpowertrain control of gearshifts on twin clutchtransmissions显示文摘 | Goetz M Levesley M C Crolla D A | 2004 | Transmission and DrivelineSymposium2004，，1： | 1 |
| 4 | Diagnostic procedures for Parkin- son' s disease dementia : recommendations from the Movement Disor- der Society Task Force 显示文摘 | Dubois B Burn D Goetz C | 2007 | Mov Disord2007，22，16： | 1 |
| 5 | Association with prior fluoroquinolone therapy of widespread ciprofloxacin resistance among gram-negative isolates in a veterans affairs medical center显示文摘 | MUDER R R BRENNEN C GOETZ M A | 1999 | Antimicrob Agents Chemother1999，35，： | 1 |
| 6 | Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force显示文摘 | Dubois B Burn D Goetz C | 2007 | Mov Disord2007，22，16： | 1 |
| 7 | Geological remote sensing显示文摘 | GOETZ A F H ROWAN L C | 1981 | Science1981，211，： | 1 |
| 8 | Discrimination of hydrothermally altered rocks and unaltered rocks in visible and near infrared multi- spectral images显示文摘 | ROWAN L C GOETZ A F H ASHLEY R P | 1977 | Geophysics1977，42，3： | 1 |
| 9 | Sheared lherzolites:From the point of view of rock mechanics显示文摘 | Goetze C | 1975 | Geology1975，3，： | 1 |
| 10 | Subsidence resulting from simulated postoperative neck ovements:an in vitro investigation with a new cervical fusion cage显示文摘 | Wilke HJ Kettler A Goetz C | | 0，，21： | 1 |
| 11 | Theory of Mind and Psychoses 显示文摘 | Doody G A Goetz M Johnstone E C | 1998 | Psychological Medicine1998，28，： | 1 |
| 12 | Subsidence resulting from simula- ted postoperative neck movements:an in vitro investigation with a new cervical fusion cage 显示文摘 | Wilke H J Kettler A Goetz C | 2000 | Spine2000，21，： | 1 |
| 13 | Synthesis and characterization of carbon-supported Pt-Ru-WOx catalysts by spectroscopic and diffraction methods 显示文摘 | Roth C Goetz M Fuess H | 2001 | Journal of Applied Electrochemistry2001，31，： | 1 |
| 14 | Detection of right Ventricular insufficiency and guidance of volume therapy are facilitated by simultaneous monitoring of static and functional preload parameters显示文摘 | Richter HP Petersen C Goetz AE | 2011 | J Cardiothorac Vasc Anesth2011，25，： | 1 |
| 15 | Increased cardiac BNP expression associated with myocardial ischemia显示文摘 | GOETZE J P CHRISTOFFERSEN C PERKO M | 2003 | FASEB J2003，17，： | 1 |
| 16 | ^13C-methacetin breath test :isotope-selective nondispersive infrared spectrometry in comparison to isotope ratio mass spectrometry in volunteers and patients with liver cirrhosis 显示文摘 | Adamek R J Goetze O Boedeker C | 1999 | Z Gastroenterol1999，37，12： | 1 |
| 17 | Increased cardiac BNP ex- pression associated with myocardial isehemia显示文摘 | J Goetze C Christoffersen M Perko | 2003 | Faseb J2003，17，9： | 1 |
| 18 | Possible near-IR channels for remote sensing precipitable water vapor from geostationary satellite platforms显示文摘 | Gao B C Goetz A F Westwater E R | 1993 | J Appl Meteor1993，32，12： | 1 |
| 19 | Using the SLEUTH urban growth model to simulate the impacts of future policy scenario on urban land use in the Baltimore-Washington metropolitan area 显示文摘 | Jantz C A Geog D Goetz S J | 2004 | Environment and Planning B: Planning and Design2004，31，2： | 1 |
| 20 | Interstitial iodine-125 radiosurgery alone or in combination with in icrosurgery for pediatric Patients with eloquently located low-grade gliom a:a Pilot study显示文摘 | Peraud A Goetz C Siefert A | 2007 | Child'' s Nervous System2007，23，1： | 1 |
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