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	题名	作者	年代	出处	被引量
1	Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum.	Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu	2014	World Journal of Gastroenterology2014，20，33：	12
2	Protective effect of Bifidobacterium pseudocatenulatum CECT 7765 against induced bacterial antigen translocation in experimental cirrhosis显示文摘	Alba Moratalla Isabel Gómez‐Hurtado Arlette Santacruz ángela Moya Gloria Peiró Pedro Zapater José M. González‐Navajas Paula Giménez José Such Yolanda Sanz Rubén Francés	2014	Liver Int2014，，6：	2
3	Role of secreted glyceraldehyde-3-phosphate dehydrogenase in the infection mechanism of enterohemorrhagic and enteropathogenic Escherichia coli : Interaction of the extracellular enzyme with human plasminogen and fibrinogen显示文摘	L. Egea L. Aguilera R. Giménez M.A. Sorolla J. Aguilar J. Badía L. Baldoma	2007	International Journal of Biochemistry and Cell Biology2007，，6：	2
4	Soy isoflvonoids exhibit in vitro biological acticities of loop diuretics显示文摘	Martínez R M Giménez I Lou JM	1998	Am J Clin Nutr1998，68，1：	1
5	Beneficial effects ofgreen tea-a review 显示文摘	Cabrera C Artacho R Giménez R	2006	Journal of the American College ofNutrition2006，25，2：	1
6	Multi-criteria evaluation of hydrogen storage systems for automobiles in Korea using the fuzzy analytic hierarchy process显示文摘	Gim Bongjin Kim J W	2014	International Journal of Hydrogen Energy2014，，：	1
7	Smoking-related interstitial lung diseases:radiologic-pathologic cor-relation显示文摘	Hidalgo A Franquet T Giménez A	2006	Eur Radiol2006，16，11：	1
8	Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model 显示文摘	Gim SA Sung JH Shah FA etal	2013	Lab Anita Res2013，29，2：	1
9	Effects of substrate temperature on properties of ITO-ZnO composition spread films fabricated by combinatorial RF magnetron sputtering显示文摘	Heo G S Gim I G Park J W	2009	J Solid State Chem2009，182，10：	1
10	Contribution ofLeu and Hyp residues to antioxidant and ACE-inhibitory activi-ties of peptide sequences isolated from squid gelatin hydrolysate显示文摘	Alemán A Giménez B Pérez-Santin E	2011	Food Chem2011，125，2：	1
11	A three dimensional tire model for steady-state simulations of vehicles显示文摘	Gim G Nikravesh P E	1993	SAE1993，102，2：	1
12	Microstructure and dielectric properties of Ba1-xSrxTiO3 films grown on LaAlO3 substrates显示文摘	GIM Y HUDSON T FAN Y	2000	Appl Phys Lett2000，77，8：	1
13	American College of Rheumatology 2008 Recommendations for the Use of Nonbiologic and Biologic Disease Modifying Anti-rheumatic Drugs in Rheumatoid Arthritis显示文摘	Kenneth GS Gim GT Nivedita MP	2008	Arthritis Rheum2008，59，6：	1
14	An Analytical Model of Pneumatic Tyres for Vehicle Dynamic Simulations Part 1: Pure Slips显示文摘	Gim G Parviz E N	1990	International Journal of Vehicle Design1990，11，6：	1
15	Role of mitogen-activated protein kinase(MAPK) in the sporadic renal cell carcinoma显示文摘	Salinas-Sánchez AS Giménez-Bachs JM Serrano-Oviedo L	2012	Actas Urol Esp2012，36，：	1
16	Survival and clinicopathological characteristics of breast cancer patient according to different tumour subtypes as determined by hormone receptor and Her2 immunohistochemistry. A single institution survey spanning 1998 to 2010显示文摘	A. García Fernández N. Giménez M. Fraile S. González C. Chabrera M. Torras C. González A. Salas I. Barco L. Cirera M.J. Cambra E. Veloso A. Pessarrodona	2012	The Breast2012，，3：	1
17	A two-dimen- sional tire model on uneven roads for vehicle dynamic simulation 1 显示文摘	KIM S NIKRAVESH P E GIM G	2008	Vehicle System Dynamics2008，46，10：	1
18	An analytical model of pneumatic tyres for vehicle dynamic simulations, part 2 : comprehensive slips显示文摘	GIM G NIKRAVESH P E	1991	International Journal of Vehicle Design1991，12，1：	1
19	An Analytical Model of Pneumatic Tyres for Vehicle Dynamic Simulations Part 2: Comprehensive Slips显示文摘	Gim G Parviz E N	1991	International Journal of Vehicle Design1991，12，1：	1
20	Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo显示文摘	M. José Gómez-Lechón Pilar López Teresa Donato Angel Montoya Amparo Larrauri Patricia Giménez Ramón Trullenque Ricardo Fabra José V. Castell	1990	In Vitro Cellular & Developmental Biology1990，，1：	1

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