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| 1 | Acute mechanical bowel obstruction: Clinical presentation, etiology, management and outcome显示文摘AIM: To identify and analyze the clinical presentation, management and outcome of patients with acute mechanical bowel obstruction along with the etiology of obstruction and the incidence and causes of bowel ischemia, necrosis, and perforation. METHODS: This is a prospective observational study of all adult patients admitted with acute mechanical bowel obstruction between 2001 and 2002. RESULTS: Of the 150 consecutive patients included in the study, 114 (76%) presented with small bowel and 36 (24%) with large bowel obstruction. Absence of passage of flatus (90%) and/or feces (80.6%) and abdominal distension (65.3%) were the most common symptoms and physical finding, respectively. Adhesions (64.8%), incarcerated hernias (14.8%), and large bowel cancer (13.4%) were the most frequent causes of obstruction. Eighty-eight patients (58.7%) were treated conservatively and 62 (41.3%) were operated (29 on the first day). Bowel ischemia was found in 21 cases (14%), necrosis in 14 (9.3%), and perforation in 8 (5.3%). Hernias, large bowel cancer, and adhesions were the most frequent causes of bowel ischemia (57.2%, 19.1%, 14.3%), necrosis (42.8%, 21.4%, 21.4%), and perforation (50%, 25%, 25%). A significantly higher risk of strangulation was noticed in incarcerated hernias than all the other obstruction causes. CONCLUSION: Absence of passage of flatus and/or feces and abdominal distension are the most common symptoms and physical finding of patients with acute mechanical bowel obstruction, respectively. Adhesions, hernias, and large bowel cancer are the most commoncauses of obstruction, as well as of bowel ischemia, necrosis, and perforation. Although an important proportion of these patients can be nonoperatively treated, a substantial portion requires immediate operation. Great caution should be taken for the treatment of these patients since the incidence of bowel ischemia, necrosis, and perforation is significantly high. | Haridimos Markogiannakis Evangelos Messaris Dimitrios Dardamanis Nikolaos Pararas Dimitrios Tzertzemelis Panagiotis Giannopoulos Andreas Larentzakis Emmanuel Lagoudianakis Andreas Manouras Ioannis Bramis | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 2 | Gastrointestinal stromal tumor causing small bowel intussusception in a patient with Crohn’s disease显示文摘We report a case of jejunoileal intussusception in a 42-year-old patient with Crohn's disease caused by a gastrointestinal stromal tumor. The patient complained of vague diffuse abdominal pain for a period of 4 mo. Intussusception was suspected at computer tomography and magnetic resonance imaging scans. Segmental resection of the small intestine was performed. Pathological examination of the surgical specimen revealed a gastrointestinal stromal tumor as well as aphthous ulcerations and areas of inflammation, which were characteristic of Crohn's disease. This is the f irst report of small bowel intussusception due to a gastrointestinal stromal tumor coexisting with Crohn's disease. | George E Theodoropoulos Dimitrios Linardoutsos Dimitrios Tsamis Paraskevas Stamopoulos Dimitrios Giannopoulos Flora Zagouri Nikolaos V Michalopoulos | 2009 | World Journal of Gastroenterology2009，15，41： | 7 |
| 3 | Malignant carcinoid tumor of the cystic duct:a rare cause of bile duct obstruction显示文摘BACKGROUND:Carcinoid tumors of the extrahepatic biliary tree are extremely rare malignancies,accounting for 0.2%-2%of all gastrointestinal carcinoid tumors,while carcinoids of the cystic duct are an uncommon entity and an extremely unusual cause of bile duct obstruction.METHODS:After an extensive literature review,we retrospectively analysed 61 cases of carcinoid tumor of the biliary tree as well as one additional case of a 60-yearold female with symptoms and laboratory/imaging examination findings compatible with those of a malignant biliary tract obstruction.At laparotomy,resection of the gallbladder and common bile duct was performed.Histological study revealed a well-differentiated neuroendocrine carcinoma of the cystic duct.The patient remained disease-free at 16 months.RESULTS:Our presentation is the seventh case reported in the world literature.Compared to cholangiocarcinoma,analysis of the reviewed group indicates an increased incidence of extrahepatic carcinoid tumors in younger persons along with a slight female predominance.Statistically,the most common anatomic location is the common bile duct,followed by the perihilar region and the cystic duct.Jaundice is the most common finding.Curative surgery was realized in the majority of cases and longterm disease-free survival was achieved when surgery was curative.CONCLUSIONS:Carcinoid tumors obstructing the biliary tree are extremely difficult to diagnose preoperatively,and nearly impossible to differentiate from non-neuroendocrine tumors.As surgery offers the only potential cure for both biliary carcinoids and cholangiocarcinoma,we recommend aggressive surgical therapy as the treatment of choice in every case of potentially resectable biliary tumor. | Evangelos Felekouras Athanasios Petrou Konstantinos Bramis Evangelos Prassas Ioannis Papaconstantinou Nikoleta Dimitriou Anastasia Pazaiti Christos Tsigris Athanasios Giannopoulos | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 5 |
| 4 | Walled-off pancreatic necrosis显示文摘Walled-off pancreatic necrosis (WOPN), formerly known as pancreatic abscess is a late complication of acute pancreatitis. It can be lethal, even though it is rare. This critical review provides an overview of the continually expanding knowledge about WOPN, by review of current data from references identified in Medline and PubMed, to September 2009, using key words, such as WOPN, infected pseudocyst, severe pancreatitis, pancreatic abscess, acute necrotizing pancreatitis (ANP), pancreas, inflammation and alcoholism. WOPN comprises a later and local complication of ANP, occurring more than 4 wk after the initial attack, usually following development of pseudocysts and other pancreatic fluid collections. The mortality rate associated with WOPN is generally less than that of infected pancreatic necrosis. Surgical intervention had been the mainstay of treatment for infected peripancreatic fluid collection and abscesses for decades. Increasingly, percutaneous catheter drainage and endoscopic retrograde cholangiopancreatography have been used, and encourag-ing results have recently been reported in the medical literature, rendering these techniques invaluable in the treatment of WOPN. Applying the recommended therapeutic strategy, which comprises early treatment with antibiotics combined with restricted surgical intervention, fewer patients with ANP undergo surgery and interventions are ideally performed later in the course of the disease, when necrosis has become well demarcated. | Michael Stamatakos Charikleia Stefanaki Konstantinos Kontzoglou Spyros Stergiopoulos Georgios Giannopoulos Michael Safioleas | 2010 | World Journal of Gastroenterology2010，16，14： | 5 |
| 5 | Catheter ablation of atrial fibrillation in the elderly显示文摘BackgroundAtrial 纤维性颤动(AF ) 导管脱离为 AF 作为有希望的治疗策略出现了,但是广泛地没在老人口被采用。试图在老 population.Methods 和 ResultsThe 学习人口决定 AF 导管脱离的安全和功效的现在的学习与发作性的 AF 由 316 个病人组成了经历了左 atrial 脱离。95 个病人是 ≥65 年(48 男性,意味着年龄 68.9 ±3.0 岁) 并且 221 个病人是 <65 岁(130 男性,意味着年龄 52.5 ±10.4 岁) 。在 34.0 ± 的一个吝啬的后续时期以后;15.1 个月, 55 (57.9%) 在老组的病人与 149 相比从心律不齐复发是自由的(67.4%) 在更年轻的组的病人(P = 0.169 ) 。程序的复杂并发症在两个学习组是不平常的。在逻辑回归分析,离开了 atrial 直径( P = 0.003 ),高血压( P = 0.001 ), dyslipidemia ( P = 0.039 ),并且冠的动脉疾病( P = 0.018 )在 AF 的老 population.ConclusionsCatheter 脱离的 AF 复发的独立预言者在更老的病人安全、有效。侵略策略应该与 AF 在征兆的老病人被看作一种其他的选择。 | Louiza Lioni Konstantinos P. Letsas Michael Efremidis Konstantinos Vlachos Georgios Giannopoulos Vasileios Kareliotis Spyridon Deftereos Antonios Sideris | 2014 | Journal of Geriatric Cardiology2014，11，4： | 5 |
| 6 | Dabigatran,rivaroxaban,and apixaban are superior to warfarin in Asian patients with non-valvular atrial fibrillation:An updated metaanalysis显示文摘BACKGROUND Most of the randomized clinical trials that led to the wide use of non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with atrial fibrillation(AF)originated from western countries.AIM To systematically review and quantitatively synthesize the real-world data regarding the efficacy and safety of dabigatran,rivaroxaban,and apixaban compared to warfarin for stroke prevention in Asian patients with non-valvular AF.METHODS Medline,Cochrane,and ClinicalTrial.gov databases were reviewed.A randomeffect model meta-analysis was used and I-square was utilized to assess the heterogeneity.The primary outcome was ischemic stroke.The secondary outcomes were all-cause mortality,major bleeding,intracranial hemorrhage,and gastrointestinal bleeding.RESULTS Twelve studies from East Asia or Southeast Asia and 441450 patients were included.Dabigatran,rivaroxaban,and apixaban were associated with a significant reduction in the incidence of ischemic stroke[hazard ratio(HR)=0.78,95%confidence interval(CI):0.65-0.94;HR=0.79,95%CI:0.74-0.85,HR=0.70,95%CI:0.62-0.78;respectively],all-cause mortality(HR=0.68,95%CI:0.56-0.83;HR=0.66,95%CI:0.52-0.84;HR=0.66,95%CI:0.49-0.90;respectively),and major bleeding(HR=0.61,95%CI:0.54-0.69;HR=0.70,95%CI:0.54-0.90;HR=0.58,95%CI:0.43-0.78;respectively)compared to warfarin.CONCLUSION Dabigatran,rivaroxaban,and apixaban appear to be superior to warfarin in both efficacy and safety in Asians with non-valvular AF. | Wei-Jia Li Paraschos Archontakis-Barakakis Leonidas Palaiodimos Dimitrios Kalaitzoglou Lazaros Tzelves Apostolos Manolopoulos Yu-Chiang Wang Stefanos Giannopoulos Robert Faillace Damianos G Kokkinidis | 2021 | World Journal of Cardiology2021，13，4： | 3 |
| 7 | Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8 + T-cell responses and are lacking costimulatory molecules显示文摘 | LI L GIANNOPOULOS K | 2006 | Exp Hematol2006，34，12： | 1 |
| 8 | Adjuvant intravesical mitoxantroneversus recombinantinterferon-alpha after transurethral resection of superficial bladder cancer:a randomized prosepective study显示文摘 | Papatsoris AG Deliveliotis C Giannopoulos A | 2004 | Urol Int2004，72，： | 1 |
| 9 | Comparative evaluation of the diagnostic performance of the BTA stat test, NMP22 and urinary bladder cancer antigen for primary and recurrent bladder tumors 显示文摘 | Giannopoulos A Manousakas T Gounari A | 2001 | Urol2001，166，2： | 1 |
| 10 | Eosinophilic responses to stent implantation and the risk of Kounis hypersensitivity associated coronary syndrome显示文摘 | Nicholas G. Kounis Sotiris Giannopoulos Grigorios G. Tsigkas John Goudevenos | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 11 | Biological sources and sinks of nitrous oxide and strategies to mitigate emissions显示文摘 | Thomson A J Giannopoulos G Pretty J | 2012 | Philosophical Transactions of the Royal Society B: Biological Sci- ences2012，367，1593： | 1 |
| 12 | Transcription,translation,and immunolocalization of ODVP-6E/ODV-E56 and p74 proteins:two highly conserved ODV-associated envelope proteins of Choristoneura fumiferana Granulovirus显示文摘 | Rashidan K K Nassoury N Giannopoulos P N Guertin C | 2005 | J Biochem Mol Biol2005，38，1： | 1 |
| 13 | Hemodynamic causes of deterioration in acute ischemic stroke显示文摘 | Georgios Tsivgoulis Nicole Apostolidou Sotirios Giannopoulos Vijay K. Sharma | 2012 | Perspectives in Medicine (-)2012，，1： | 1 |
| 14 | Electrocardiographic abnormalities and cardiac arrhythmias in structural brain lesions显示文摘 | Aristeidis H. Katsanos Panagiotis Korantzopoulos Georgios Tsivgoulis Athanassios P. Kyritsis Maria Kosmidou Sotirios Giannopoulos | 2013 | International Journal of Cardiology2013，，2： | 1 |
| 15 | Early results after transatrial/transpulmonary repair of tetralogy of Fallot显示文摘 | Giannopoulos N M Chatzis AK Karros P | 2002 | Eur J Cardiothorac Surg2002，22，4： | 1 |
| 16 | Comparative evaluation of the BTA stat test, NMP22, and voided urine cytol-ogy in the detection of primary and recurrent bladder tumors显示文摘 | Giannopoulos A Manousakas T Gounari A | 2001 | J Urol2001，166，2： | 1 |
| 17 | Cerebral arterial infarc-tion in inflammatory bowel diseases 显示文摘 | Katsanos AH Kosmidou M Giannopoulos S | 2014 | Eur J Intern Med2014，25，1： | 1 |
| 18 | Renoprotective effect of remote ischemic post-conditioning by intermittent balloon inflations in patients undergoing percutaneous coronary intervention 显示文摘 | DEFTEREOS S GIANNOPOULOS G TZALAMOURAS V | 2013 | J Am Coil Cardiol2013，61，19： | 1 |
| 19 | “The Great Classicist Symphonic Movements of Beethoven... Can Be Ideally So Heard as Lasting Just a Moment:” Adorno on Musical Time显示文摘 | Ilias Giannopoulos | 2016 | Journal of Philosophy Study2016，6，4： | 1 |
| 20 | Cytokine profiles in serumand peritoneal fluid from infertile women with and without endometrio-sis显示文摘 | Kalu E Sumar N Giannopoulos T | 2007 | Obstet Gynaecol Res2007，33，4： | 1 |
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