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| 1 | Acute mechanical bowel obstruction: Clinical presentation, etiology, management and outcome显示文摘AIM: To identify and analyze the clinical presentation, management and outcome of patients with acute mechanical bowel obstruction along with the etiology of obstruction and the incidence and causes of bowel ischemia, necrosis, and perforation. METHODS: This is a prospective observational study of all adult patients admitted with acute mechanical bowel obstruction between 2001 and 2002. RESULTS: Of the 150 consecutive patients included in the study, 114 (76%) presented with small bowel and 36 (24%) with large bowel obstruction. Absence of passage of flatus (90%) and/or feces (80.6%) and abdominal distension (65.3%) were the most common symptoms and physical finding, respectively. Adhesions (64.8%), incarcerated hernias (14.8%), and large bowel cancer (13.4%) were the most frequent causes of obstruction. Eighty-eight patients (58.7%) were treated conservatively and 62 (41.3%) were operated (29 on the first day). Bowel ischemia was found in 21 cases (14%), necrosis in 14 (9.3%), and perforation in 8 (5.3%). Hernias, large bowel cancer, and adhesions were the most frequent causes of bowel ischemia (57.2%, 19.1%, 14.3%), necrosis (42.8%, 21.4%, 21.4%), and perforation (50%, 25%, 25%). A significantly higher risk of strangulation was noticed in incarcerated hernias than all the other obstruction causes. CONCLUSION: Absence of passage of flatus and/or feces and abdominal distension are the most common symptoms and physical finding of patients with acute mechanical bowel obstruction, respectively. Adhesions, hernias, and large bowel cancer are the most commoncauses of obstruction, as well as of bowel ischemia, necrosis, and perforation. Although an important proportion of these patients can be nonoperatively treated, a substantial portion requires immediate operation. Great caution should be taken for the treatment of these patients since the incidence of bowel ischemia, necrosis, and perforation is significantly high. | Haridimos Markogiannakis Evangelos Messaris Dimitrios Dardamanis Nikolaos Pararas Dimitrios Tzertzemelis Panagiotis Giannopoulos Andreas Larentzakis Emmanuel Lagoudianakis Andreas Manouras Ioannis Bramis | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 2 | Gastrointestinal stromal tumor causing small bowel intussusception in a patient with Crohn’s disease显示文摘We report a case of jejunoileal intussusception in a 42-year-old patient with Crohn's disease caused by a gastrointestinal stromal tumor. The patient complained of vague diffuse abdominal pain for a period of 4 mo. Intussusception was suspected at computer tomography and magnetic resonance imaging scans. Segmental resection of the small intestine was performed. Pathological examination of the surgical specimen revealed a gastrointestinal stromal tumor as well as aphthous ulcerations and areas of inflammation, which were characteristic of Crohn's disease. This is the f irst report of small bowel intussusception due to a gastrointestinal stromal tumor coexisting with Crohn's disease. | George E Theodoropoulos Dimitrios Linardoutsos Dimitrios Tsamis Paraskevas Stamopoulos Dimitrios Giannopoulos Flora Zagouri Nikolaos V Michalopoulos | 2009 | World Journal of Gastroenterology2009，15，41： | 7 |
| 3 | Dabigatran,rivaroxaban,and apixaban are superior to warfarin in Asian patients with non-valvular atrial fibrillation:An updated metaanalysis显示文摘BACKGROUND Most of the randomized clinical trials that led to the wide use of non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with atrial fibrillation(AF)originated from western countries.AIM To systematically review and quantitatively synthesize the real-world data regarding the efficacy and safety of dabigatran,rivaroxaban,and apixaban compared to warfarin for stroke prevention in Asian patients with non-valvular AF.METHODS Medline,Cochrane,and ClinicalTrial.gov databases were reviewed.A randomeffect model meta-analysis was used and I-square was utilized to assess the heterogeneity.The primary outcome was ischemic stroke.The secondary outcomes were all-cause mortality,major bleeding,intracranial hemorrhage,and gastrointestinal bleeding.RESULTS Twelve studies from East Asia or Southeast Asia and 441450 patients were included.Dabigatran,rivaroxaban,and apixaban were associated with a significant reduction in the incidence of ischemic stroke[hazard ratio(HR)=0.78,95%confidence interval(CI):0.65-0.94;HR=0.79,95%CI:0.74-0.85,HR=0.70,95%CI:0.62-0.78;respectively],all-cause mortality(HR=0.68,95%CI:0.56-0.83;HR=0.66,95%CI:0.52-0.84;HR=0.66,95%CI:0.49-0.90;respectively),and major bleeding(HR=0.61,95%CI:0.54-0.69;HR=0.70,95%CI:0.54-0.90;HR=0.58,95%CI:0.43-0.78;respectively)compared to warfarin.CONCLUSION Dabigatran,rivaroxaban,and apixaban appear to be superior to warfarin in both efficacy and safety in Asians with non-valvular AF. | Wei-Jia Li Paraschos Archontakis-Barakakis Leonidas Palaiodimos Dimitrios Kalaitzoglou Lazaros Tzelves Apostolos Manolopoulos Yu-Chiang Wang Stefanos Giannopoulos Robert Faillace Damianos G Kokkinidis | 2021 | World Journal of Cardiology2021，13，4： | 3 |
| 4 | A predictive score of radial artery spasm in patients undergoing transradial percutaneous coronary intervention显示文摘 | Georgios Giannopoulos Konstantinos Raisakis Andreas Synetos Periklis Davlouros George Hahalis Dimitrios Alexopoulos Dimitrios Tousoulis John Lekakis Christodoulos Stefanadis Michael W. Cleman Spyridon Deftereos | 2015 | International Journal of Cardiology2015，，： | 1 |
| 5 | Can Somatostatin Prevent Post-ERCP Pancreatitis? Results of a Randomized Controlled Trial显示文摘 | Dimitrios Arvanitidis George K Anagnostopoulos Dimitrios Giannopoulos | 2004 | J Gastroenterol Hepatol2004，19，3： | 1 |
| 6 | Rectal carcmosarcoma: A case report and review of literature显示文摘60 年的老男性为在一些星期持续时间的澄清期间加强的便秘和下腹部的不快的调查进入我们的部门。原因证明了是被腹会阴切除术和手术后的 chemo 放射疗法对待的一个直肠的癌肉瘤。病人 6 个月以后由于肝的失败死了,显示出传播疾病的证据。一般来说结肠的癌肉瘤组成其性质仍然不完全地被理解的恶意的瘤的一个稀罕范畴。没有特异疗法指南存在。外科是治疗的支柱,不管辅助治疗的增加,预后是很差的。系统的基因分析可以是为理解这些神秘肿瘤的致病的线索。 | Dimitrios Konstantinos Tsekouras Stylianos Katsaragakis Dimitrios Theodorou Georgia Kafiri Fotis Archontovasilis Panagiotis Giannopoulos Panagiotis Drimousis John Bramis | 2006 | World Journal of Gastroenterology2006，12，9： | 1 |
| 7 | Frailty in patients undergoing transcatheter aortic valve replacement:from risk scores to frailty-based management显示文摘Aortic stenosis(AS)is the most common valvular disease in the western coun-tries and is associated with aging.[1,2]Transcatheter aortic valve replacement(TAVR)now offers a therapeutic option for elderly patients who are deemed inoperable and is an excellent alternative for those who are considered high-risk for surgical valve replacement.[3,4]However,mortality after TAVR is still high with one-year and two-year mortality rates of 24.3%and 33.9%,respectively.[5]Thus,util-ization of effective risk stratification tools before TAVR cannot be overstated. | Andreas Tzoumas Damianos G.Kokkinidis Stefanos Giannopoulos George Giannakoulas Leonidas Palaiodimos Dimitrios V Avgerinos Polydoros N Kampaktsis Robert T.Faillace | 2021 | Journal of Geriatric Cardiology2021，18，6： | 0 |
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