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| 1 | Prediction of atrial fibrillation development and progression:current perspectives显示文摘Atrial fibrillation(AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression(from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF. | Konstantinos Vlachos Konstantinos P Letsas Panagiotis Korantzopoulos Tong Liu Stamatis Georgopoulos Athanasios Bakalakos Nikolaos Karamichalakis Sotirios Xydonas Michael Efremidis Antonios Sideris | 2016 | World Journal of Cardiology2016，8，3： | 16 |
| 2 | Ibutilide and novel indexes of ventricular repolarization in persistent atrial fibrillation patients显示文摘AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion. Intravenous ibutilide (1+1mg) was administered before the electrical cardioversion while close electrocardiographic (ECG) monitoring was performed. ECG indexes such as corrected QT interval (QTc), the interval from the peak until the end of T wave (Tpe), and the Tpe/QT ratio were measured before ibutilide infusion and 10 min after the end of infusion. RESULTS: The final study population consisted of 20 patients (mean age: 67.1±9.9 years, 10 men). Six patients were cardioverted pharmacologically and did not proceed to electrical cardioversion. Two patientsdeveloped short non-sustained episodes of torsades de pointes ventricular tachycardia. All but one of the aforementioned ECG indexes increased significantly after ibutilide administration. In specific, the QTc interval increased from 442 ± 29 to 471 ± 37 ms (P=0.037), the Tpe interval in precordial leads from 96 ms (range 80-108 ms) to 101 ms (range 91-119 ms) (P=0.021), the Tpe interval in lead Ⅱ from 79 ms (range 70-88 ms) to 100 ms (range 87-104 ms) (P<0.001), the Tpe/QT ratio in precordial leads from 0.23 ms (range 0.18-0.26 ms) to 0.26 ms (range 0.23-0.28 ms) (P=0.028), and the Tpe interval dispersion from 25 ms (range 23-30 ms) to 35 ms (range 27-39 ms) (P=0.012). However, the Tpe/QT ratio in lead II did not change significantly. CONCLUSION: Ibutilide increases the duration and dispersion of ventricular repolarization. The prognostic value of Tpe and Tpe/QT in the setting of drug-induced proarrhythmia needs further study. | Panagiotis Korantzopoulos Konstantinos P Letsas Anna Kotsia Giannis Baltogiannis Kallirroi Kalantzi Konstantinos Kyrlas John A Goudevenos | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 3 | Mechanisms of drug-induced proarrhythmia in clinical practice显示文摘Drug-induced proarrhythmia represents a great challenge for those involved in the development of novel pharmaceuticals and in the regulatory bodies for drug approval as well as for the prescribing clinicians.Our understanding of the mechanisms that underlie druginduced proarrhythmia has grown dramatically over the last two decades.A growing number of cardiac and non-cardiac agents have been shown to alter cardiac repolarization predisposing to fatal cardiac arrhythmias such as ventricular tachycardia or ventricular fibrillation and sudden cardiac death.These agents may induce the phenotype of long QT syndrome and less commonly of short QT syndrome and Brugada syndrome(BS).Although,genetic susceptibility underlie drug-induced proarrhythmia in certain cases,current data are limited regarding this topic.The present review surveys the current published literature on the mechanisms and the offending medical agents that predispose to drug-induced long QT syndrome,short QT syndrome and BS.Drug-induced proarrhythmia should be considered as a predictor of sudden cardiac death and should prompt critical re-evaluation of the risks and benefits of the suspicious medication.Survivors of drug-induced proarrhythmia and family members require careful examination and possibly genetic testing for the presence of a channelopathy.Treating physicians are advised to follow the lists of agents implicated in drug-induced proarrhythmia in order to minimize the risk of arrhythmia and sudden cardiac death. | Arkadia Konstantopoulou Spyros Tsikrikas Dimitrios Asvestas Panagiotis Korantzopoulos Konstantinos P Letsas | 2013 | World Journal of Cardiology2013，5，6： | 2 |
| 4 | The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation显示文摘 | KORANTZOPOULOS P KOLETYIS T M GALARIS D | 2007 | Int J Cardiol2007，115，2： | 1 |
| 5 | On the molecular mechanism of metmyoglobin-catalyzed reduction of hydrogen peroxide by ascor-bate显示文摘 | Galaris D Korantzopoulos P | 1997 | Free Radic Biol Med1997，22，： | 1 |
| 6 | Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation显示文摘 | Korantzopoulos P Kolettis TM Kountouris E | 2005 | Int J Cardiol2005，102，2： | 1 |
| 7 | Atrial fibrillation and electrical remodeling:the potential role of inflammation and oxidative stress显示文摘 | Korantzopoulos P Kolettis T Siogas K | 2003 | Med Sci Monit2003，9，9： | 1 |
| 8 | Antieoagulation and antiplatelet therapy in implantation of electrophysiological devices显示文摘 | Korantzopoulos P Letsas KP Liu T | 2011 | Europace2011，13，12： | 1 |
| 9 | The association of oxidative stress and inflammation in hemodialysis patients显示文摘 | Korantzopoulos P Siogas K Galaris D | 2004 | Am J Kidney Dis2004，43，1： | 1 |
| 10 | Electrocardiographic abnormalities and cardiac arrhythmias in structural brain lesions显示文摘 | Aristeidis H. Katsanos Panagiotis Korantzopoulos Georgios Tsivgoulis Athanassios P. Kyritsis Maria Kosmidou Sotirios Giannopoulos | 2013 | International Journal of Cardiology2013，，2： | 1 |
| 11 | Meta-Analysis of assoeialion between C-reactive protein and immediate success of electrical cardioversion in persistent atrial fibrillation显示文摘 | Liu T Li L Korantzopoulos P | 2008 | Am J Cardiol2008，101，12： | 1 |
| 12 | Electrocardiographic abnormalities and cardiac arrhythmias in structural brain lesions 显示文摘 | Katsanos AH Korantzopoulos P Tsivgoulis G | 2013 | International Journal of Cardiology2013，167，2： | 1 |
| 13 | A Randomized Con-trolled Trial to Prevent Postoperative Atrial Fibrillation by AntioxidantReinforcement显示文摘 | Rodrigo R Korantzopoulos P Cereceda M | 2013 | J Am Coll Cardiol2013，，： | 1 |
| 14 | Association Between C-Reactive Protein and Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion显示文摘 | Tong Liu Guangping Li Lijian Li Panagiotis Korantzopoulos | 2007 | Journal of the American College of Cardiology2007，，15： | 1 |
| 15 | Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation显示文摘 | KORANTZOPOULOS P KOLLETIIS TM KOUTHOURIS E | 2005 | Int J Cardiol2005，102，2： | 1 |
| 16 | Oxidative stress in hepatic ischemia-rcperfusion injury: the role of antioxidants and iron chelating compounds 显示文摘 | Galaris D Barhouti A Korantzopoulos P | 2006 | Curr Pharm Des2006，12，： | 1 |
| 17 | Uric acid levels and atrial fib- rillation in hypertensive patients 显示文摘 | Liu T Zhang X Korantzopoulos P | 2011 | Intern Med2011，50，8： | 1 |
| 18 | The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation显示文摘 | Korantzopoulos P Kolettis TM Galaris D Goudevenos JA | 2007 | Int J Cardio12007，115，2： | 1 |
| 19 | The role of oxi- dative stress in the pathogenesis and perpetuation of atrial fibrilla- tion 显示文摘 | Korantzopoulos P Kolettis TM Galaris D | 2007 | lnt J Cardio12007，115，2： | 1 |
| 20 | Atrial fibrillation and electrical remodeling:the potential role of inflammation and oxidative stress显示文摘 | Korantzopoulos P Kolettis T Siogas K | 2003 | Med Sci Monit2003，9，9： | 1 |
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