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| 1 | Implementation of enteral feeding protocol in an intensive care unit: Before-and-after study显示文摘AIM To determine the effects of implementing an enteral feeding protocol on the nutritional delivery and outcomes of intensive care patients.METHODS An uncontrolled, observational before-and-after study was performed in a tertiary mixed medical-surgical intensive care unit(ICU). In 2013, a nurse-driven enteral feeding protocol was developed and implemented in the ICU. Nutrition and outcome-related data from patients who were treated in the study unit from 2011-2012(the Before group) and 2014-2015(the After group) were obtained from a local electronic database, the national Population Registry and the hospital's Infection ControlService. Data from adult patients, readmissions excluded, who were treated for at least 7 d in the study unit were analysed. RESULTS In total, 231 patients were enrolled in the Before and 249 in the After group. The groups were comparable regarding demographics, patient profile, and severity of illness. Fewer patients were mechanically ventilated on admission in the After group(86.7% vs 93.1% in the Before group, P = 0.021). The prevalence of hospitalacquired infections, length of ICU stay and ICU, 30-and 60-d mortality did not differ between the groups. Patients in the After group had a lower 90-d(P = 0.026) and 120-d(P = 0.033) mortality. In the After group, enteral nutrition was prescribed less frequently(P = 0.039) on day 1 but significantly more frequently on all days from day 3. Implementation of the feeding protocol resulted in a higher cumulative amount of enterally(P = 0.049) and a lower cumulative amount of parenterally(P < 0.001) provided calories by day 7, with an overall reduction in caloric provision(P < 0.001). The prevalence of gastrointestinal symptoms was comparable in both groups, as was the frequency of prokinetic use. Underfeeding(total calories < 80% of caloric needs, independent of route) was observed in 59.4% of the study days Before vs 76.9% After(P < 0.001). Inclusion in the Before group, previous abdominal surgery, intraabdominal hypertension and the sum of gastrointestinal symptoms were found to be independent predictors of insufficient enteral nutrition.CONCLUSION The use of a nurse-driven feeding protocol improves the delivery of enteral nutrition in ICU patients without concomitant increases in gastrointestinal symptoms or intra-abdominal hypertension. | Martin Padar Gerli Uusvel Liis Starkopf Joel Starkopf Annika Reintam Blaser | 2017 | World Journal of Critical Care Medicine2017，6，1： | 22 |
| 2 | Effect of epidural analgesia on labor and delivery: a retrospective study显示文摘 | Sandro Gerli Alessandro Favilli Marta M Acanfora Vittorio Bini Carla Giorgini Gian Carlo Di Renzo | 2011 | Journal of Maternal-Fetal and Neonatal Medicine2011，，3： | 2 |
| 3 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 4 | 关于缺血性卒中后女性妊娠以及针对不育、避孕和绝经期进行激素治疗的共识文件显示文摘已有报道妊娠与缺血性卒中风险增高相关,妊娠期间发生卒中是导致孕产妇死亡的主要原因之一。Kuklina等对1994年至1995年与2006年至2007年的住院数据进行的比较显示,孕妇在产前发生任何类型卒中的风险增高47%(从0.15次/1000次分娩~0.22次/1000次分娩),在产后发生任何卒中的风险增高83%(从0.12次/1000次分娩~0.22次/1000次分娩)。 | Valeria Caso Alberto Falomi Cheryl D. Bushnell Monica Acciarresi Jose Ronohi Nikola Sprigg Sandro Gerli 李勍 景燕 李红燕 朱沂 | 2017 | 国际脑血管病杂志2017，25，8： | 2 |
| 5 | Role of CD30 + T cells in rheumatoid arthritis:a counterregulatory paradigm for Thl-driven diseases显示文摘 | Gerli R Lunardi C Vinante F | 2001 | Trends Immunol2001，22，： | 1 |
| 6 | CD4+ CD28 T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients 显示文摘 | Gerli R Schillaci G Giordano A | 2004 | Circulation2004，109，22： | 1 |
| 7 | Specific adhesion molecules bind anchoring filaments and endothelial cells in human skin initial lymphatics显示文摘 | Gerli R Solito R Weber E | 2000 | Lymphology2000，33，4： | 1 |
| 8 | Early atherosclerosis in rheumatoid arthritis:effects of smoking on thickness of the carotid artery intima media显示文摘 | Gerli R Sherer Y Vaudo G | 2005 | Ann N Y Acad Sci2005，1051，： | 1 |
| 9 | Phytoestrogens may improve the pregnancy rate in in vitro fertilization-embryo transfer cycles: a prospective, controlled, randomized trial 显示文摘 | Unfer V Casini ML Gerli S | 2004 | Fertil Steril2004，82，6： | 1 |
| 10 | Endothelial dysfunction in young patients with rheumatoid arthritis and low disease activity显示文摘 | Vaudo G Marchesi S Gerli R | 2004 | Ann Rheum Dis2004，63，1： | 1 |
| 11 | Association of anticyclic citrullinated peptide antibodies with subclinical atherosclerosis in patients with rheumatoid arthritis显示文摘 | Gerli R Bartoloni Bocci E Sherer Y | 2008 | Ann Rheum Dis2008，67，： | 1 |
| 12 | Endothelial dysfunction in young patients with rheumatoid arthritis and low disease activity显示文摘 | Vando G Marchesi S Gerli R | 2004 | Ann Rheum Dis2004，63，1： | 1 |
| 13 | The efficacy and safety of a single dose of polyhexamethylene biguanide gynaecologic solution versus a seven-dose regimen of vaginal clindamycin cream in patients with bacterial vaginosis显示文摘 | Minozzi M Gerli S Renzo GC | 2008 | Eur Rev Med Pharmacol Sci2008，12，1： | 1 |
| 14 | Core-shell: The latest development for the paper industry显示文摘 | Gerli A | 2003 | Paper Technology2003，，3： | 1 |
| 15 | Morphology of the cardiovascular system in conjoined twins: spatial and sequential segmental arrangements in 36 cases显示文摘 | Gerlis LM Seo JW Ho SY | 1993 | Teratology1993，47，2： | 1 |
| 16 | Role of CD30^+ T cells in rheu- matoid arthritis : a couter - regulatory paradigm for Th1 - drive diseases 显示文摘 | Gerli R Lunardi C Vinante F | 2001 | Trends Immunol2001，22，2： | 1 |
| 17 | Red blood cell distribution width predicts one-year mortality following transcatheter aortic valve implantation显示文摘 | Caroline J. Magri Alaide Chieffo Azeem Latib Matteo Montorfano Francesco Maisano Michela Cioni Eustachio Agricola Remo Daniel Covello Chiara Gerli Annalisa Franco Pietro Spagnolo Ottavio Alfieri Antonio Colombo | 2014 | International Journal of Cardiology2014，，： | 1 |
| 18 | The morphology of aor-lopulmonary windm with regard lo their classifi(ation and mor- phogenesis显示文摘 | Ho SY Gerlis LM Anderson C | 1994 | Cardiol Young1994，4，2： | 1 |
| 19 | Different toxicity of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) on the nigrostriatal and mesolimbic pathways显示文摘 | Ambrosio S Gerli P Perego C | 1987 | Eur J Pharmacol1987，133，： | 1 |
| 20 | Anti-ribosomal P protein antibodies显示文摘 | Gerli R Caponi L | 2005 | Autoimmunity2005，38，1： | 1 |
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