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| 1 | Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI显示文摘AIM:To correlate dual-energy computed tomography(DECT) pulmonary angiography derived iodine maps with parameter maps of quantitative pulmonary perfusion magnetic resonance imaging(MRI).METHODS:Eighteen patients with pulmonary perfusion defects detected on DECT derived iodine maps were included in this prospective study and additionally underwent time-resolved contrast-enhanced pulmonary MRI [dynamic contrast enhanced(DCE)-MRI].DCE-MRI data were quantitatively analyzed using a pixel-by-pixel deconvolution analysis calculating regional pulmonary blood flow(PBF),pulmonary blood volume(PBV) and mean transit time(MTT) in visually normal lung parenchyma and perfusion defects.Perfusion parameterswere correlated to mean attenuation values of normal lung and perfusion defects on DECT iodine maps.Two readers rated the concordance of perfusion defects in a visual analysis using a 5-point Likert-scale(1 = no correlation,5 = excellent correlation).RESULTS:In visually normal pulmonary tissue mean DECT and MRI values were:22.6 ± 8.3 Hounsfield units(HU);PBF:58.8 ± 36.0 mL/100 mL per minute;PBV:16.6 ± 8.5 mL;MTT:17.1 ± 10.3 s.In areas with restricted perfusion mean DECT and MRI values were:4.0 ± 3.9 HU;PBF:10.3 ± 5.5 mL/100 mL per minute,PBV:5 ± 4 mL,MTT:21.6 ± 14.0 s.The differences between visually normal parenchyma and areas of restricted perfusion were statistically significant for PBF,PBV and DECT(P < 0.0001).No linear correlation was found between MRI perfusion parameters and attenuation values of DECT iodine maps(PBF:r = 0.35,P = 0.15;PBV:r = 0.34,P = 0.16;MTT:r = 0.41,P = 0.08).Visual analysis revealed a moderate correlation between perfusion defects on DECT iodine maps and the parameter maps of DCE-MRI(mean score 3.6,k 0.45).CONCLUSION:There is a moderate visual but not statistically significant correlation between DECT iodine maps and perfusion parameter maps of DCE-MRI. | Jan Hansmann Paul Apfaltrer Frank G Zoellner Thomas Henzler Mathias Meyer Gerald Weisser Stefan O Schoenberg Ulrike I Attenberger | 2013 | World Journal of Radiology2013，5，5： | 6 |
| 2 | Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species显示文摘Objective:To evaluate the antiasthmatic and antitussive properties of the aqueous leaf extract of Bryophyilum pinnatum {B.pinnatum)(BP) Lam.Methods:Ovalbiunin-sensilized guinea pigs which were treated with BP for 21 consecutive days were exposed to 0.2%histamine aerosol in a glass chamber.Mucus viscosity,white blood cell and lymphocyte counts and tracheal wall morphometry were measured.Bouts of cough were counted pre and post acute exposure of extract-treated(X7 d) guinea pigs to 7.5%citric acid aerosol in a chamber.Phenol red expectoration was estimated in mice after 7 d of daily administration of BP.Results:Doses of 200 and 400 mg/kg/day(×21 d) BP significantly increased the time for guinea pigs to experience preconvulsive dyspnoea.BP and salbutamol(0.5 mg/kg/day×21 d) reduced mucus viscosity in the sensitized group to values comparable with controls.White blood cell,lymphocyte counts and tracheal morphometry were not significantly altered.Both doses of BP also significantly reduced the bouts of cough but only 400 mg/kg/day significantly inhibited the amount of phenol red secreted.Conclusions:BP has demonstrated antiasthmatic and antitussive properties in these rodent models.These properties may underscore its use in Nigerian ethnomedicine. | Edward O Salami Raymond I Ozolua Stephen O Okpo Gerald I Eze Dickson O Uwaya | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 2 |
| 3 | Apractical guide to ass- essment of ventricular diastolic function using Doppler echocar- diography显示文摘 | Gerald I C Joseph F P James D T | 1996 | JACC1996，27，7： | 1 |
| 4 | Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism显示文摘 | Abdelsamed Hossam Peters Jan Byrne Gerald I | 2013 | Future Microbiology2013，，9： | 1 |
| 5 | A review on the phytoeonstituents and related medicinal properties of plants in the As- teraceae family 显示文摘 | Aehika J I Arthur D E Gerald I | 2014 | Journal of Applied Chemistry2014，7，8： | 1 |
| 6 | Ieated ascorbic/citric acid solution as browning inhibitor for pre-pccled potatoes显示文摘 | Gerald M Sappers Robert I Millcr J | 1995 | J of Food Sci1995，60，4： | 1 |
| 7 | Gigas, a drosophila homolog of tuberous sclerosis gene product - 2, regulates the cell cycle 显示文摘 | Naoto I Gerald M | 1999 | Cell1999，49，5： | 1 |
| 8 | Chlamydia pneumoniae and atherosclerosis: Links to the disease process显示文摘 | Gerald I Byrne Murat V Kalayoglu | 1999 | Am Heart J1999，138，： | 1 |
| 9 | Research Issues in Knowledge Management and Virtual Collaboration in New Product Development: an Introductory Essay显示文摘 | Gerald I Susman | 2003 | Journal of Engineering and Technology Management2003，，20： | 1 |
| 10 | Characterisation of ^67 Ga^3 + complexes of triaza macrocyclic ligands: biodistribution and clearance studies 显示文摘 | PRATA M I M SANTOS A C GERALDES C F G C | 1999 | Nucl Med Biol1999，26，6： | 1 |
| 11 | Alkaloids from Cephalotaxus drupacea and Cephalotaxus fortunei显示文摘 | William W Gerald I Jerry McKay | 1963 | J Org Che1963，28，9： | 1 |
| 12 | Auditor Reputation and Earnings Management:International Evidence from the Banking Industry 显示文摘 | Kiridaran Kanagaretnam Chee Y I and Gerald J I | 2004 | Journal of Banking&Fi-nance2004，，2： | 1 |
| 13 | Shulman GI New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy显示文摘 | Petersen KF Gerald I | 2006 | Obesity2006，14，1： | 1 |
| 14 | Research Ieeues in Knowledge Management and Virtual Collaboration in New Product Development:an Introductory Essay显示文摘 | Gerald I Susman | 2003 | Journal of Engineering and Technology Management2003，，20： | 1 |
| 15 | Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies显示文摘 | Mansfield E Pastan I Fitz Gerald DJ | | 0，，05： | 1 |
| 16 | Virtual muscle:a computational approach to understanding the effects of muscle properties on motor control显示文摘 | Davoodi R Brown I E Gerald E L | 2000 | Journal of Neuroscience methods2000，101，6： | 1 |
| 17 | Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression 显示文摘 | Barbara B K Gerald I S Ralph A D | 1991 | J Clin Invest1991，87，2： | 1 |
| 18 | Cellular mechanisms of insulin resistance 显示文摘 | Gerald I Shulman R | 2000 | J Cin Invest2000，106，2： | 1 |
| 19 | Immediate implantation of a pure titanium implant into an ex-traction socket:Report of a pilot procedure显示文摘 | Barzilay I Gerald N Iranpour B | | 0，，： | 1 |
| 20 | Immunotoxin treatment of cancer显示文摘 | Pasten I Hassan R Fitz Gerald D J | 2007 | Annu Rev Med2007，58，： | 1 |
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