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| 1 | Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer therapy and diagnosis 显示文摘 | Reiter Y Pastan I | 1998 | Trends Biotech1998，16，12： | 2 |
| 2 | Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells显示文摘AIM: To present an approach for selectively killing retrovirus-infected cells that combines the toxicity of Pseudomonas exotoxin (PE) and the presence of reverse transcriptase (RT) in infected cells. METHODS: PE antisense toxin RNA has palindromic stem loops at its 5' and 3' ends enabling self-primed generation of cDNA in the presence of RT. The RT activity expressed in retrovirus-infected cells converts 'antisense-toxin-RNA' into a lethal toxin gene exclusively in these cells. RESULTS: Using cotransfection studies with PE-expressing RNAs and β-gal expressing reporter plasmids, we show that, in HepG2 and HepG2.2.15 hepatoma cells as well as in duck hepatitis B virus (DHBV) infected cells, HBV or DHBV-polymerase reverse transcribe a lethal cDNA copy of an antisense toxin RNA, which is composed of sequences complementary to a PE gene and eukaryotic transcription and translation signals. CONCLUSION: This finding may have important implications as a novel therapeutic strategy aimed at the elimination of HBV infection. | Peter Hafkemeyer Ulrich Brinkmann Elizabeth Brinkmann Ira Pastan Hubert E Blum Thomas F Baumert | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 3 | Modulation of the activity of the promoter of the human MDR1 gene by ras and p53显示文摘 | Ueda K Pastan I | 1992 | Science1992，4，： | 1 |
| 4 | Molecular cloning of mesothelin,a differentiation antigen present on mesothelim,mesotheliomas,and ovarian cancers显示文摘 | Chang K Pastan I | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 5 | P-glyeopmtein andmultidrug resistance显示文摘 | Gottesman MM Pastan L Ambudkar SV | 1996 | Curr Opin Genet Dev1996，6，5： | 1 |
| 6 | Biochemistry of muhidrug resistance mediated by the multidrug transporter显示文摘 | Gottesman MM Pastan I | 1993 | Annu Rev''Biochem1993，62，： | 1 |
| 7 | P-glycoprotein and multidrug resistance显示文摘 | Gottesman MM Pastan L Ambudkar SV | 1996 | Curr Opin Genet Dev1996，6，5： | 1 |
| 8 | Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers 显示文摘 | Chang K Pastan I | 1996 | Proc Natl Acad Sci USA1996，93，1： | 1 |
| 9 | Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers 显示文摘 | Chang K Pastan I | 1996 | ProcNatlAcadSciUSA1996，993，1： | 1 |
| 10 | Improving antibody affinity by mimicking somatic hypermutation in vitro显示文摘 | Chowdhury PS Pastan I | 1999 | Nat Biotechnol1999，17，6： | 1 |
| 11 | Modulation of activity of the promoter of the human MDR1 gene by Ras and p53显示文摘 | Chin KV Ueda K Pastan I | 1992 | Science1992，255，5043： | 1 |
| 12 | Multidrug Resistance in Human Cancer显示文摘 | Gottesman MN | 1987 | New Engl J Med1987，316，： | 1 |
| 13 | Modulation of activity of the promotor of the human mdrl gene by Ras and p53 显示文摘 | Chin K V Ueda K Pastan 1 | 1992 | Sciencel1992，255，5043： | 1 |
| 14 | Characterization of an MDR1 retroviral bicistronic vector for correction of X2 linked severe combined immunodeficiency显示文摘 | Kleiman SE Pastan I Puck JM | 1998 | Gene Ther1998，5，5： | 1 |
| 15 | The multidring transporter: a double edged sword显示文摘 | Gottesman MM Pastan 1 | 1988 | J Biol Chem1988，263，12： | 1 |
| 16 | Properties and purification of a glucose-regulatedprotein from chick embryo fibroblasts显示文摘 | Pastan I H Shiu RP | 1979 | Biochim Bopphys Acta1979，576，1： | 1 |
| 17 | TP-3 immtmotoxins improve antitumor activity in mice with osteosarcoma显示文摘 | Onda M Bruland S Pastan I | 2005 | Clin Orthop Relat Res2005，，430： | 1 |
| 18 | Vascular access and in-creased risk of death among hemodialysis patients 显示文摘 | Pastan S Soucie JM McClellan WM | 2002 | Kidney Int2002，62，2： | 1 |
| 19 | New immunotoxins targeting CD123,a stemcell antigen on acute myeloid leukemia cells 显示文摘 | Du X Ho M Pastan I | 2007 | J Immunother2007，30，6： | 1 |
| 20 | Immunotoxin therapy of cancer 显示文摘 | Pastan I Hassan R Fitzgerald D J and Kreitman R J | 2006 | Nature Reviews Cancer2006，6，7： | 1 |
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