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| 1 | Cardiac involvement in Duchenne and Becker muscular dystrophy显示文摘Duchenne and Becker muscular dystrophy(DMD/BMD) are X-linked muscular diseases responsible for over 80% of all muscular dystrophies. Cardiac disease is a common manifestation,not necessarily related to the degree of skeletal myopathy; it may be the predominant manifestation with or without any other evidence of muscular disease. Death is usually due to ventricular dysfunction,heart block or malignant arrhythmias. Not only DMD/BMD patients,but also female carriers may present cardiac involvement. Clinically overt heart failure in dystrophinopathies may be delayed or absent,due to relative physical inactivity. The commonest electrocardiographic findings include conduction defects,arrhythmias(supraventricular or ventricular),hypertrophy and evidence of myocardial necrosis. Echocardiography can assess a marked variability of left ventricular dysfunction,independently of age of onset or mutation groups. Cardiovascular magnetic resonance(CMR) has documented a pattern of epicardial fibrosis in both dystrophinopathies' patients and carriers that can be observed even if overt muscular disease is absent. Recently,new CMR techniques,such as postcontrast myocardial T1 mapping,have been used in Duchenne muscular dystrophy to detect diffuse myocardial fibrosis. A combined approach using clinical assessment and CMR evaluation may motivate early cardioprotective treatment in both patients and asymptomatic carriers and delay the development of serious cardiac complications. | Sophie Mavrogeni George Markousis-Mavrogenis Antigoni Papavasiliou Genovefa Kolovou | 2015 | World Journal of Cardiology2015，7，7： | 9 |
| 2 | Contribution of cardiovascular magnetic resonance in the evaluation of coronary arteries显示文摘Cardiovascular magnetic resonance(CMR) allows the nonradiating assessment of coronary arteries; to achieve better image quality cardiorespiratory artefacts should be corrected. Coronary MRA(CMRA) at the mo-ment is indicated only for the detection of abnormal coronary origin, coronary artery ectasia and/or aneu-rysms(class Ⅰ indication) and coronary bypass grafts(class Ⅱ indication). CMRA utilisation for coronary ar-tery disease is not yet part of clinical routine. However, the lack of radiation is of special value for the coronary artery evaluation in children and women. CMRA can assess the proximal part of coronary arteries in almost all cases. The best results have been observed in the evaluation of the left anterior descending and the right coronary artery, while the left circumflex, which is lo-cated far away from the coil elements, is frequently im-aged with reduced quality, compared to the other two. Different studies detected an increase in wall thickness of the coronaries in patients with type Ⅰ diabetes and abnormal renal function. Additionally, the non-contrast enhanced T1-weighed images detected the presence of thrombus in acute myocardial infarction. New tech-niques using delayed gadolinium enhanced imaging promise the direct visualization of inflamed plaques in the coronary arteries. The major advantage of CMRis the potential of an integrated protocol offering as-sessment of coronary artery anatomy, cardiac function, inflammation and stress perfusion-fibrosis in the same study, providing an individualized clinical profile of pa-tients with heart disease. | Sophie Mavrogeni George Markousis-Mavrogenis Genovefa Kolovou | 2014 | World Journal of Cardiology2014，6，10： | 4 |
| 3 | Cholesteryl Ester Transfer Protein Gene Polymorphisms and Longevity Syndrome 显示文摘 | Genovefa Kolovou 1* Mariarma Stamatelatou 1 Katherine Anagnostopoulou | 2010 | Open Cardiovase Med J2010，4，： | 1 |
| 4 | Cardiac Tissue Characterization and the Diagnostic Value of Cardiovascular Magnetic Resonance in Systemic Connective Tissue Diseases显示文摘 | Sophie Mavrogeni Petros P. Sfikakis Elias Gialafos Konstantinos Bratis Georgia Karabela Efthymios Stavropoulos Georgios Spiliotis Eliza Sfendouraki Stylianos Panopoulos Vasiliki Bournia Genovefa Kolovou George D. Kitas | 2014 | Arthritis Care & Research2014，，1： | 1 |
| 5 | CMR Detects Subclinical Cardiomyopathy in Mother-Carriers of Duchenne and Becker Muscular Dystrophy显示文摘 | Sophie Mavrogeni Konstantinos Bratis Antigoni Papavasiliou Eleni Skouteli Evangelos Karanasios Dimitris Georgakopoulos Genovefa Kolovou George Papadopoulos | 2013 | JACC: Cardiovascular Imaging2013，，4： | 1 |
| 6 | “How many times must a man look up before he can really see the sky?” Rheumatic cardiovascular disease in the era of multimodality imaging显示文摘Cardiovascular involvement in rheumatic diseases(RD) is the result of various pathophysiologic mechanisms including inflammation, accelerated atherosclerosis, myocardial ischemia, due to micro- or macro-vascular lesions and fibrosis. Noninvasive cardiovascular imaging, including echocardiography, nuclear techniques, cardiovascular computed tomography and cardiovascular magnetic resonance, represents the main diagnostic tool for early, non-invasive diagnosis of heart disease in RD. However, in the era of multimodality imaging and financial crisis there is an imperative need for rational use of imaging techniques in order to obtain the maximum benefit at the lowest possible cost for the health insurance system. The oligo-asymptomatic cardiovascular presentation and the high cardiovascular mortality of RD necessitate a reliable and reproducible diagnostic approach to catch early cardiovascular involvement. Echocardiography remains the routine cornerstone of cardiovascular evaluation. However, a normal echocardiogram can not always exclude cardiac involvement and/or identify heart disease acuity and pathophysiology. Therefore, cardiovascular magnetic resonance is a necessary adjunct complementary to echocardiography, especially in new onset heart failure and when there are conflicting data from clinical, electrocardiographic and echocardiographic evaluation of RD patients. | Sophie I Mavrogeni George Markousis-Mavrogenis David Hautemann Kees van Wijk Hans J Reiber Genovefa Kolovou | 2015 | World Journal of Methodology2015，5，3： | 0 |
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