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| 1 | An unclassified tibial plateau fracture: Reverse Schatzker type Ⅳ显示文摘 | Tien Yeoh Efthymios Iliopoulos Alex Trompeter | 2018 | Chinese Journal of Traumatology2018，21，4： | 5 |
| 2 | Toward a new era of hepatitis B virus therapeutics:The pursuit of a functional cure显示文摘Hepatitis B virus(HBV)infection,although preventable by vaccination,remains a global health problem and a major cause of chronic liver disease.Although current treatment strategies suppress viral replication very efficiently,the optimal endpoint of hepatitis B surface antigen(HBsAg)clearance is rarely achieved.Moreover,the thorny problems of persistent chromatin-like covalently closed circular DNA and the presence of integrated HBV DNA in the host genome are ignored.Therefore,the scientific community has focused on developing innovative therapeutic approaches to achieve a functional cure of HBV,defined as undetectable HBV DNA and HBsAg loss over a limited treatment period.A deeper understanding of the HBV life cycle has led to the introduction of novel direct-acting antivirals that exert their function through multiple mechanisms,including inhibition of viral entry,transcriptional silencing,epigenetic manipulation,interference with capsid assembly,and disruption of HBsAg release.In parallel,another category of new drugs aims to restore dysregulated immune function in chronic hepatitis B accompanied by lethargic cellular and humoral responses.Stimulation of innate immunity by pattern-recognition receptor agonists leads to upregulation of antiviral cytokine expression and appears to contribute to HBV containment.Immune checkpoint inhibitors and adoptive transfer of genetically engineered T cells are breakthrough technologies currently being explored that may elicit potent HBV-specific T-cell responses.In addition,several clinical trials are attempting to clarify the role of therapeutic vaccination in this setting.Ultimately,it is increasingly recognized that elimination of HBV requires a treatment regimen based on a combination of multiple drugs.This review describes the rationale for progressive therapeutic interventions and discusses the latest findings in the field of HBV therapeutics. | Efthymios P Tsounis Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos | 2021 | World Journal of Gastroenterology2021，27，21： | 5 |
| 3 | Posterior shoulder fracture-dislocation:A systematic review of the literature and current aspects of management显示文摘Purpose Posterior fracture-dislocation of shoulder is an infrequent traumatic event;however,most orthopaedic surgeons may face the challenge of treating it.The aim of this study is to review and summarise systematically the current principles of the management of this complex injury,and create a treatment algorithm.Methods Both PubMed and Scopus Databases were systematically searched for the terms“posterior shoulder fracture-dislocation”or“posterior glenohumeral fracture-dislocation”or“posterior glenoid fracture-dislocation”for articles written in English and published in the last decade.Results A total of 900 articles were identified,of which 13 were retained for analysis.A total of 153 patients(161 shoulders)were identified.These patients were treated either with open reduction and internal fixation,modified McLaughlin procedure,allograft/autograft humeral head reconstruction or shoulder arthroplasty.The mean age was 40.15 years.The mean postoperative Constant score in cases treated by open reduction and internal fixation was 86.45,whereas by bone graft was 84.18.Further,the mean postoperative Constant score was between 79.6 and 67.1 in those that were managed by modified McLaughlin and arthroplasty procedure,respectively.Conclusion The management of posterior shoulder fracture-dislocation may be challenging,and the best surgical option depends on many variables such as the chronicity of the injury,the presence of a fracture at the level of the surgical neck or tuberosities and the extend of the Hill-Sachs lesion if any.A treatment algorithm is proposed,based on the current literature in an effort to create a consensus for these injuries.For the acute shoulder fracture-dislocations,an open reduction should be performed.For the chronic fracture/dislocations in the elderly low-demand patients,conservative treatment should be performed.For the rest of the patients,depending on the severity of the Hill-Sachs lesion different surgical options are available such as the McLaughlin technique,the use of an allograft,osteotomy or arthroplasty. | Georgios Paparoidamis Efthymios Iliopoulos AAli Narvani Ofer Levy Eleftherios Tsiridis loannis Polyzois | 2021 | Chinese Journal of Traumatology2021，24，1： | 3 |
| 4 | Nucleic acid vaccines: A taboo broken and prospect for a hepatitis B virus cure显示文摘Although a prophylactic vaccine is available,hepatitis B virus(HBV)remains a major cause of liver-related morbidity and mortality.Current treatment options are improving clinical outcomes in chronic hepatitis B;however,true functional cure is currently the exception rather than the rule.Nucleic acid vaccines are among the emerging immunotherapies that aim to restore weakened immune function in chronically infected hosts.DNA vaccines in particular have shown promising results in vivo by reducing viral replication,breaking immune tolerance in a sustained manner,or even decimating the intranuclear covalently closed circular DNA reservoir,the hallmark of HBV treatment.Although DNA vaccines encoding surface antigens administered by conventional injection elicit HBVspecific T cell responses in humans,initial clinical trials failed to demonstrate additional therapeutic benefit when administered with nucleos(t)ide analogs.In an attempt to improve vaccine immunogenicity,several techniques have been used,including codon/promoter optimization,coadministration of cytokine adjuvants,plasmids engineered to express multiple HBV epitopes,or combinations with other immunomodulators.DNA vaccine delivery by electroporation is among the most efficient strategies to enhance the production of plasmid-derived antigens to stimulate a potent cellular and humoral anti-HBV response.Preliminary results suggest that DNA vaccination via electroporation efficiently invigorates both arms of adaptive immunity and suppresses serum HBV DNA.In contrast,the study of mRNA-based vaccines is limited to a few in vitro experiments in this area.Further studies are needed to clarify the prospects of nucleic acid vaccines for HBV cure. | Efthymios P Tsounis Athanasia Mouzaki Christos Triantos | 2021 | World Journal of Gastroenterology2021，27，41： | 3 |
| 5 | 500 Intragastric Balloons: What Happens 5 Years Thereafter?显示文摘 | Katerina Kotzampassi Vasilis Grosomanidis Pyrros Papakostas Sofia Penna Efthymios Eleftheriadis | 2012 | Obesity Surgery2012，，6： | 2 |
| 6 | Tissue sealants in endoscopic applications for anastomotic leakage during a 25-year period显示文摘 | Kotzampassi Katerina Eleftheriadis Efthymios | 2014 | Surgery2014，，： | 2 |
| 7 | Financial development and economic growth: evidence from panel unit root and cointegration tests显示文摘 | Dimitris K Christopoulos Efthymios G Tsionas | 2003 | Journal of Development Economics2003，，1： | 2 |
| 8 | Short-run and long-run performance of international tourism:Evidence from Bayesian dynamic models显示文摘 | Efthymios G Tsionas A George Assaf | 2014 | Tourism Management2014，42，： | 1 |
| 9 | Estimation of production risk and risk preference function: a nonparametric approach 显示文摘 | Kumbhakar Subal C Tsionas Efthymios G | 2010 | Annals of Operations Research2010，176，1： | 1 |
| 10 | The Impacts of Web Experience on Virtual Buying Behavior: An Empirical Study 显示文摘 | Efthymios Constantinides Peter Geurts | 2005 | Journal of Customer Behavior2005，，4： | 1 |
| 11 | Micro-Raman and FTIR studies of synthetic- and natural apatites 显示文摘 | Anastasios Antonakos Efthymios Liarokapis Theodore Leventouri | 2007 | Biomaterials2007，28，： | 1 |
| 12 | Financial development and economic growth: evidence from panel unit root and cointegration tests显示文摘 | Dimitris K Christopoulos Efthymios G Tsionas | 2004 | Journal of Development Economics2004，，73： | 1 |
| 13 | Inflation and Productivity : Empirical Evidence from Europe 显示文摘 | Efthymios Tsionas | 2003 | Review of International Economics2003，11，1： | 1 |
| 14 | Consumer Adop- tion of Social Networking Sites: Implications for Theo ry and Practice显示文摘 | Carlota Lorenzo-Romero Efthymios Constantinides Maria-del-Carmen Alarc6n-del-Amo | 2011 | Journal of Research in Interactive Marketing2011，5，23： | 1 |
| 15 | A recursive bayesian approach for identification of network configuration changes in distribution system state estimation显示文摘 | RAVINDRA S EFTHYMIOS M BIKASH C eta/ | 2010 | IEEE Trans on Power Systems2010，25，3： | 1 |
| 16 | The effect of internal marketing on job satisfaction in health services:a pilot study in public hospitals in Northern Greece显示文摘 | Efthymios Iliopoulos Constantinos-Vasilios Priporas | | 0，，： | 1 |
| 17 | Marine isotope stage 6 canyon and spillover deposits of the bryant and eastern canyon systems, northwest gulf of Mexico: importance of fine-grained turbidites on a delta-fed prograding slope显示文摘 | Efthymios K Tripsanas William R Bryant Niall C Slowey | 2006 | Journal of Sedimentary Research2006，76，： | 1 |
| 18 | Does public sec- tor efficiency matter? Revisiting the relation between fiscal size and economic growth in a world sample 显示文摘 | KONSTANTINOS ANGELOPOULOS APOSTOLIS PHIL- IPPOPOULOS EFTHYMIOS TSIONAS | 2008 | Public Choice2008，137，： | 1 |
| 19 | The Impacts of Web Experience on Virtual Buying Behavior: An Empirical Study 显示文摘 | Efthymios Constantinides Peter Geurts | 2005 | Journal of Customer Behavior2005，，4： | 1 |
| 20 | Financial Development and Economic Growth: Evidence from Panel Unit Root and Cointegration Tests显示文摘 | Dimitris K Christopoulos Efthymios G Tsionas | 2004 | Journal of Development Economics2004，73，： | 1 |
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