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| 1 | In situ observation of C_(60)(C(COOH)_(2))_(2) interacting with living cells using fluorescence microscopy显示文摘The interactions between nanoparticles and living cells were investigated by an imaging technique of fluorescence microscopy. For this pur- pose, the C60 derivative C60(C(COOH)2)2, a thera- peutic agent for degeneration diseases of central nervous system, was synthesized, purified and characterized. Its interaction with the living cell and penetration of the cellular membrane were in situ studied using the real time imaging technique, and its potential cytotoxicity was also examined by flow cy- tometry. The results indicate that C60(C(COOH)2)2 can easily enter cells, and is mainly located in cytoplasm by fluorescein labeling. Furthermore, C60(C(COOH)2)2 can carry the molecule that cannot cross cellular membranes into cells, because fluo- rescein compound itself cannot enter the cell or ad- here to membrane. At concentrations ranging from 1×10?2 to 1×102 mg/L, C60(C(COOH)2)2 does not show any detectable cytotoxicity. | YE Chang CHEN Chunying CHEN Zhen MENG Huan XING Li JIANG Yaxin YUAN Hui XING Gengmei ZHAO Feng ZHAO Yuliang CHAI Zhifang FANG Xiaohong HAN Dong CHEN Long WANG Chen WEI Taotao | 2006 | Chinese Science Bulletin2006，51，9： | 4 |
| 2 | Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents显示文摘新奇的碳 nanohybrids 成功地用作一个新磁性的回声成像 MRI 对比代理人基于未修改的 metallofullerenes 被制作了。nanohybrids 显示出更高的 R < 潜水艇 class= “ a-plus-plus ” > 1 relaxivity 和更好的使 Gd@C 明亮效果比 < 潜水艇 class= “ a-plus-plus ” > 82 哦 < 潜水艇 class= “ a-plus-plus ” > 在 T 的 X ,< 潜水艇 class= “ a-plus-plus ” > 在 vivo 的 1 幅 -weighted 先生图象。这是从原来的 gadofullerenes 的质子 relaxivity 的结果,它保留了完美的碳笼子结构可能完全那么避免 Gd 的版本 < 啜 class= “ a-plus-plus ” >3+ 个 离子。第二等的纺纱电子转移松驰机制被建议解释怎么 encaged Gd < 啜 class= “ a-plus-plus ” > 碳 nanohybrids 的 3+ 个 离子与包围的水分子交往。这条途径为开发高度有效、低的毒性 MRI 对比代理人打开新机会。 | Rongli Cui Juan Li Huan Huang Mingyi Zhang Xihong Guo Yanan Chang Min Li Jinquan Dong Baoyun Sun Gengmei Xing | 2015 | Nano Research2015，8，4： | 2 |
| 3 | Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles显示文摘 | Meng Huan Chen Zhen Xing Gengmei | 2007 | Toxicology Letters2007，，175： | 1 |
| 4 | Quantitative High-Performance Liquid Chromatographic Determination of Neurotoxin显示文摘 Grass pea (Lathyrus sativus) is leguminous crop cultivated in India,Bangladesh and Ethiopia, where it is a major protein source for people in the lowest income groups[1] .However, excessive ingestion of this pulse can lead to irreversible paralysis of the legs-a disease known as neurolathyrism or lathyrism.the causative agent was reported to be the non-protein amino acids,β-N-L-oxalyl-α,β-diaminopropionic acid (β-ODAP, sometimes, referred to as BOAA)[2]. The α-isomer of ODAP, α-N-oxaly 1-α,β-diaminopropionic acid, has been shown to be nontoxic to chicks and mice[3]. Lathyrus sativus shows good adaptation to the low rainfall conditions of northwestern China. It grows also in poor soil and is resistant to salt and flood. Our group was exploring to breed low or zero toxin varieties of Lathyrus sativus as grain crops for human consumption and as protein-rich feed for animals. So it is necessary to develop a method to detemine the toxin suitablefor differenth pu rpose.…… | XING GengMei | 2001 | Chemical Research in Chinese Universities2001，17，z1： | 1 |
| 5 | Influences of structural properties on stability of fullerenols显示文摘 | Xing Gengmei Zhang Jun Zhao Yuliang | 2004 | J Phys Chem B2004，108，11： | 1 |
| 6 | Effect of hydrogen peroxide on somatic embryogenesis of Lucium barbarum L显示文摘 | Cui Kairong Xing Gengsheng Liu Xinmin Xing Gengmei and Wang Yafu | 1999 | Plant sciene1999，1468，： | 1 |
| 7 | Acute toxicological effects of copper nanoparticles in vivo显示文摘 | Zhen Chen Huan Meng Gengmei Xing Chunying Chen Yuliang Zhao Guang Jia Tiancheng Wang Hui Yuan Chang Ye Feng Zhao Zhifang Chai Chuanfeng Zhu Xiaohong Fang Baocheng Ma Lijun Wan | 2005 | Toxicology Letters2005，，2： | 1 |
| 8 | Biologically accelerated chemical aggregation of magnetic nanoparticles in blood vessel of mice显示文摘 | Xing Gengmei Zhao Yuliang Lei Hao | 2005 | J Am Chem Soc2005，，： | 1 |
| 9 | Tuning electronic properties of metallic atom in bondage to a nanospace显示文摘 | Tang Jun Xing Gengmei Yuan Hui | 2005 | J Phys Chem B2005，109，18： | 1 |
| 10 | Influences of structural properties on stability of fullerenols显示文摘 | Xing Gengmei Zhang Jun Zhao Yuliang | 2004 | J Phys Chem B2004，108，11： | 1 |
| 11 | Influences of Structural Properties on Stability of Fullerenols显示文摘 | Xing Gengmei Zhang Jun Zhao Yuliang | 2004 | J Phys Chem B2004，1，08： | 1 |
| 12 | Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells显示文摘 | Huan Meng Gengmei Xing Elvin Blanco Yan Song Lina Zhao Baoyun Sun Xiaoda Li Paul C. Wang Alexandru Korotcov Wei Li Xing-Jie Liang Chunying Chen Hui Yuan Feng Zhao Zhen Chen Tong Sun Zhifang Chai Mauro Ferrari Yuliang Zhao | 2012 | Nanomedicine: Nanotechnology, Biology, and Medicine2012，，2： | 1 |
| 13 | Periodical variation of electronic property in polyhydroxylated metallofullerene materials显示文摘 | Tang Jun Xing Gengmei Zhao Yuliang | 2006 | Adv Mater2006，18，： | 1 |
| 14 | Assay of neurotoxin and non-protein amino acids in Lathyrus sativus by high-performance liquid chromatography with dansylation显示文摘 | Xing Gengmei Wang Fei Cui Kairong | 2001 | Analytical Letters2001，34，15： | 1 |
| 15 | Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized Au cluster probes显示文摘Increasingly serious microbial infections call for the development of new simpler methods for the precise diagnosis and specific inhibition of such pathogens. In this work, a peptide mineralized Au cluster probe was applied as a new simplified strategy to both recognize and inhibit a single bacteria species of Staphylococcus aureus(S. aureus) simultaneously. The probes are composed of peptides and Au clusters. Moreover, the peptides specifically target S. aureus cells and the Au clusters provide fluorescent imaging and have an antibacterial effect. These new probes enable the simultaneous specific detection and effective destruction S. aureus cells in situ. | Xiangchun Zhang Li Liu Ru Liu Jing Wang Xuhu Hu Qing Yuan Juanjuan Guo Gengmei Xing Yuliang Zhao Xueyun Gao | 2018 | Science China Chemistry2018，61，5： | 0 |
| 16 | Utilizing a microfluidic device to enrich and fluorescently detect circulating tumor cells显示文摘Circulating tumor cells(CTCs)are cancer cells that have propagated from primary tumor sites,spreading into the bloodstream as the cellular origin of fatal metastasis,and to secondary tumor sites.Capturing and analyzing CTCs is a kind of‘‘liquid biopsy'of the tumor that provides information about cancer changes over time and tailoring treatment[1].CTC enrichment and detection remains technologically challenging due to their extremely low concentra- | Ya-Nan Chang Mingyi Zhang Juan Li Kui Chen Weihong Gu Gengmei Xing | 2017 | Science Bulletin2017，62，7： | 0 |
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