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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | γ2Interferon produced by CD8 + T cells infiltrating Kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with human immunodeficiency virus-1 tat protein:an immune response to human herpesvirus28 infection显示文摘 | Fiorelli V Gendelman R Sirianni M C | 1998 | Blood1998，91，3： | 1 |
| 3 | Seasonal effects on gene expression,cleavage timing,and developmental competence of bovine preimplantation embryos显示文摘 | Gendelman M Aroyo A Yavin S | 2010 | Reproduction2010，140，1： | 1 |
| 4 | Recovery characteristics of sevoflurane and halothane in preschool aged children undergoing bilateral myringotomy and pressure equalization tube insertion显示文摘 | Davis PJ Greenberg JA Gendelman M | 1999 | Anesth Analg1999，88，1： | 1 |
| 5 | Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone显示文摘 | Adachi A Gendelman H E Koenig S | 1986 | J Virol1986，59，2： | 1 |
| 6 | Seasonal effects on gene expression, cleavage timing, and developmental competence of bovine preimplantation embryos 显示文摘 | GENDELMAN M AROYO A YAVIN S | 2010 | Reproduction2010，140，1： | 1 |
| 7 | HIV - 1 - associated dementia: a metabolic encephalopathy perpetrated by virus- infected and immune -competent mononuclear phagocytes显示文摘 | Anderson E Zink W Gendelman HE | 2002 | J Acquir Immune Defic Syndr2002，31，2： | 1 |
| 8 | Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease显示文摘 | Michael D. Boska Khader M. Hasan Danette Kibuule Rebecca Banerjee Erin McIntyre Jay A. Nelson Theresa Hahn Howard E. Gendelman R. Lee Mosley | 2007 | Neurobiology of Disease2007，，3： | 1 |
| 9 | Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy 显示文摘 | Koenig S Gendelman HE Fauci AS | 1986 | Science1986，233，4768： | 1 |
| 10 | Grain size distribution and heat conductivity of copper processed by equal channel angular pressing 显示文摘 | GENDELMAN O V SHAPIRO M ESTR1N Y HELLMIG R J LEKHTMAKHER S | 2006 | Materials Science and Engineering A2006，434，12： | 1 |
| 11 | Cell- mediated drug delivery 显示文摘 | BATRAKOVA EV GENDELMAN HE KABANOV AV | 2011 | Expert Opin Drug Deliv2011，8，4： | 1 |
| 12 | Multimodal thromboprophylaxis for total hip and knee arthroplasty based on risk assessment显示文摘 | Dorr LD Gendelman V Maheshvari AV | 2007 | J Bone Joint Surg (Am)2007，89，12： | 1 |
| 13 | Tumor lysis syndrome presenting in a patient with metastatic melanoma treated with radiation therapy显示文摘 | Dar L Gendelman O Amital H | 2014 | Case Communications2014，16，7： | 1 |
| 14 | Dynamics of linear discrete systems connected to local, essen- tiaUy nonlinear attachments 显示文摘 | VAKAKIS A F MANEVITCH L 1 GENDELMAN O | 2003 | Journal of Sound and Vibration2003，264，3： | 1 |
| 15 | Differential effects of coronary artery stenosis on myocardial function: the value of myocardial strain analysis for the detection of coronary artery disease 显示文摘 | SHIMONI S GENDELMAN G AYZENBERG O | 2011 | J Am Soc Echocardiogr2011，24，7： | 1 |
| 16 | Bifurcations of self-excitation regimes in a Van derPol oscillator with a nonlinear energy sink显示文摘 | Gendelman 0 Bar T | 2010 | Physica D:Nonlinearphenomena2010，239，34： | 1 |
| 17 | Nanomedicine in tee diagnosis and therapy of neuro degenerative disorders显示文摘 | Kabanov AV Gendelman HE | 2007 | Prog Polym Sci2007，32，89： | 1 |
| 18 | Recovery characteristics of sevoflurane and halothane in preschoolaged children undergoing bilateral myringotomy and pressureequalization tube insertion显示文摘 | Davis PJ Greenberg JA Gendelman M | 1999 | Anesth Analg1999，88，1： | 1 |
| 19 | Differential effects of coronary artery stenosis on myocardial function:The value of myocardial strain analysis for the detection of coronary artery disease显示文摘 | Shimoni S Gendelman G Ayzenberg O | | 0，，： | 1 |
| 20 | Energy pumping in coupled mechanical oscillators, part I: dynamics of the underlying Hamiltonian systems显示文摘 | Gendelman O Manevitch L Vakakis A F | 2001 | Journal of Applied Mechanics2001，68，： | 1 |
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