|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6sb9v90w9bpfxu6qn0.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 2 | The Effect of CD3-Specific Monoclonal Antibody on Treating Experimental Autoimmune Myasthenia Gravis显示文摘CD3-specific monoclonal antibody was the first one used for clinical practice in field of transplantation. Recently,renewed interests have elicited in its capacity to prevent autoimmune diabetes by inducing immune tolerance. In this study, we tested whether this antibody can also be used to treat another kind of autoimmune disease myasthenia gravis (MG) and explored the possible mechanisms. MG is caused by an autoimmune damage mediated by antibody- and complement-mediated destruction of AChR at the neuromuscular junction. We found that administration of CD3-specific antibody (Fab)2 to an animal model with experimental autoimmune myasthenia gravis (EAMG) (B6 mice received 3 times of AChR/CFA immunization) could not significantly improve the clinical signs and clinical score. When the possible mechanisms were tested, we found that CD3 antibody treatment slightly down-regulated the T-cell response to AChR, modestly up-regulation the muscle strength. And no significant difference in the titers of IgG2b was found between CD3 antibody treated and control groups. These data indicated that CD3-specific antibody was not suitable for treating MG, an antibody- and complementmediated autoimmune disease, after this disease has been established. The role of CD3-specific antibody in treating this kind of disease remains to be determined. | Ruonan Xu~1 Jianan Wang~1 Guojiang Chen~1 Gencheng Han~1 Renxi Wang~1 Beifen Shen~1 Yan Li~(1,2) ~1Institute of Basic Medical Science,Academy of military Medical Science,Beijing 100850,China ~2Department of Molecular Immunology,Institute of Basic Medical Science,27 Taiping Road,Beijing 100850,China. | 2005 | Cellular & Molecular Immunology2005，2，6： | 2 |
| 3 | Adsorption of phenolic compounds from aqueous solutions by a water-compatible hypercrosslinked polymeric adsorbent 显示文摘 | Aimin Li Quanxing Zhang Gencheng Zhang | 2002 | Chemosphere2002，47，： | 1 |
| 4 | Photobleaching of metal phthalocyanine sulfonates under UV and visible light irradiation over TiO2 semiconductor显示文摘 | Sun Aihua Zhang Gencheng Xu Yiming | 2005 | Mater Lett2005，59，2930： | 1 |
| 5 | Adsorption of phenolic compounds from aqueous solutions by a water-compatible hypercrosslinked polymeric adsorbent显示文摘 | Aimin Li Quanxing Zhang Gencheng Zhang | 2002 | Chemosphere2002，47，9： | 1 |
| 6 | Adsorp- tion of phenolic compounds from aqueous solutions by a water-compatible hypercrosslinked polymeric adsorbent 显示文摘 | Li Aimin Zhang Quanxing Zhang Gencheng | 2002 | Chemosphere2002，47，： | 1 |
| 7 | The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity显示文摘 | Yurong Li Jiannan Feng Shaoxia Geng Shusheng Geng Huawei Wei Guojiang Chen Xinying Li Liyan Wang Renxi Wang Hui Peng Gencheng Han Beifen Shen Yan Li | 2010 | Molecular Immunology2010，，4： | 1 |
| 8 | Adsorption of phenolic compounds from aqueous solutions by a water-compatible hypercrosslinked polymeric adsorbent显示文摘 | Aimin Li Quanxing Zhang Gencheng Zhang Jinlong Chen Zhenghao Fei Fuqiang Liu | 2002 | Chemosphere2002，，9： | 1 |
| 9 | Interaction of the flavonoid hesperidin with bovine serum album: A fluoreseence quenching study显示文摘 | WANG Yanqing ZHANG Hongmei ZHANG Gencheng | 2007 | J Lumin2007，126，1： | 1 |
| 10 | Absorption of Phenolic Compounds from Aqueous Solution by a Water Compatioble Hypercrosslinked Polymeric Adsorbent显示文摘 | Li Aimin Zhang Quanxing Zhang Gencheng | 2002 | Chemosphere2002，47，： | 1 |
| 11 | Adsorption of phenolic compounds from aqueous solutions by a water compatible hypercrosslinked polymeric adsorbent显示文摘 | LI Aimin ZHANG Quanxing ZHANG Gencheng | 2002 | Chemosphere2002，47，9： | 1 |
| 12 | Regulation of IL-8 production by complement-activated product,C5a,in vitro and in vivo during sepsis显示文摘 | Liyan Wang Gencheng Han Renxi Wang | 2010 | Clin Immunol2010，137，： | 1 |
| 13 | Adsorption of phenolic compounds from aqueous solutions by a water-compatible hypercrosslinked polymeric adsorbent显示文摘 | Li Aimin Zhang Quanxing Zhang Gencheng | 2002 | Chemosphere2002，47，9： | 1 |
| 14 | Spectroscopic studies on the interaction between silico- tungstic acid and bovine serum albumin 显示文摘 | WANG Yanqing ZHANG Hongmei ZHANG Gencheng | 2007 | J Pharmaceut Biomed2007，43，5： | 1 |
| 15 | Non-chargedPVA-Si〇2 hybrid membranes for potential application in diffusiondialysis显示文摘 | Wu Yonghui Lin Haiyong Zhang Gencheng | 2013 | Separation and Purification Technology2013，118，： | 1 |
| 16 | γδ T细胞和αβ T细胞在体外抗原特异性免疫应答中的协同作用显示文摘γδ T细胞和αβT细胞是两种表型和功能不同的T淋巴细胞亚群。为研究两种细胞在抗原特异性免疫应答中是否具有协同作用,并进一步探讨其相互作用的方式,本文利用实验性自身免疫性葡萄膜炎小鼠模型获得脾脏和淋巴结T细胞,用γδ TCR和αβTCR单克隆抗体染色,分别用带有磁珠的抗FITC和抗PE单克隆抗体通过阳性或阴性选择获得高度纯化的γδ T细胞和αβ T细胞,观察不同比例的γδT细胞和αβT细胞在体外共孵育后IRBP1-20抗原特异性增殖和细胞因子表达,并用细胞培养薄膜将二者分开,测定细胞因子表达情况。结果表明,γδ T细胞或αβT细胞(99%纯度)都不能单独发生抗原特异性免疫应答。只有在二者比例为5%γδT细胞和95%αβT细胞时能产生最大的抗原特异性反应。当两种细胞脱离接触时,不能出现抗原特异性反应。γδ T细胞或αβ T细胞的培养上清也不能使γδT细胞或αβT细胞发生抗原特异性反应。本研究提示,小鼠γδT细胞和αβT细胞在抗原特异性免疫应答中具有协同作用,这种协同作用是通过两种细胞相互接触,γδT细胞协助αβT细胞产生免疫应答实现的。 | 蓝程 董丽伟 孙晓宁 Gencheng Han Yong Peng Deming Sun | 2009 | 现代免疫学2009，29，3： | 1 |
| 17 | Adsorption of phenolic compounds from aqueous solutions by a water-compatible hypercrosslinked polymeric adsorbent显示文摘 | Li Aimin Zhang Quanxing Zhang Gencheng | 2002 | Chemosphere2002，47，： | 1 |
| 18 | RECENT ACHIEVEMENTS IN ACUPUNCTURE ANESTHESIA IN CHINA显示文摘Acupuncture ansethesia has been practised as a developing period indepth.In clinical research,open heart surgery using extracorporeal circulation,craniocere-bral surgery have been successful.Other complex in some critical cases under acupunctureanethesia have also succeeded.The research work on the effect of combination of drug withacupuncture on analgesic efficacy has been made great progress.In the mechanism of acupuncture anesthesia,advanced scientific techniques from neuro-biology and molecularbiology have been used to promote the research.Neurophysiologicaland neurochemical mechanisms of acupuncture analgesia have been investigated in depth.Research on mechanism has been closely integrated with clinical work for further improveing the efficacy acupuncture anesthesia. | Wu Gencheng Cao Xiaoding Institute of Acupuncture Research.Shanghia Medical University,Shanghai 200032,China *Vice Secretary-General,All China Society of Acupuncture Anesthesia**chirman,All-China Society of Acupuncture Anesthesia | 1992 | World Journal of Acupuncture-Moxibustion1992，2，3： | 1 |
| 19 | THE ADSORPTION BEHAVIORS OF 2,6-DICHLOROPHENOL ONTO HYPERCROSSLINKED RESINS显示文摘 | WANG Jingping LI Zhixia ZHANG Gencheng FEI Zhenghao TANG Shuhe | 2006 | Chinese Journal of Reactive Polymers2006，15，2： | 0 |
| 20 | Functional Identification of the Stable Transfection C5aR Cell Line Molt-4显示文摘The complement C5 anaphylatoxin receptor is a member of the seven transmembrane-spanning G protein-coupled receptor superfamily that signals through Gαi and Gα16.C5aR is mostly expressed on neutrophils,macrophages and endothelial cells.C5a and C5aR interaction plays an important role in numerous biological effects such as in vivo cytokine storm which results in inflammatory damage.Considering the limitation of collection of human peripheral blood neutrophils and their short half life,the stably transfected cell line for studying the biological effects of C5aR is needed.In this study,we transfected C5aR gene into Molt-4 cell line and examined the function of ectopic C5aR.Our results showed stable expression of the C5aR in Molt-4 cell line and their interaction with human C5a induced ERK1/2 phosphorylation,Ca ++ influx.This stable transfected cell line may provide a useful tool for studying signal pathways related to C5a and C5aR interplay and antibody development specific for C5aR. | Chunmei Zhang Ruonan Xu Jianan Wang Gencheng Han Guojiang Chen Renxi Wang Huawei Wei Beifen Shen Yuanfang Ma Yan Li | 2007 | Cellular & Molecular Immunology2007，4，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员