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| 1 | OPTICAL PROPERTIES OF GeO_2 AND Ge NANOCRYSTALS显示文摘he co m pound m aterial of n m size particles Ge O2 Si O2 w as synthesied through hydrolysis of Si( O C2 H4) and Ge Cl4 . A heat treatm ent w as carried out for the sa m ples at 100 ~1200 ℃in air . Its optical property w as deter mined by U V Vis spectur m . We have found that theabsorption edge of spectru m shifted progressively to longer w avelengths . The quantu m size ef fect of nanocrystals appears because crystals gro w and energy of optical band gap reduces d ueto the influence of te m perature . By the analysis of X ray diffraction w e have observed theprocess in w hich the structure of particles changed fro m disorder into order . | Y.H.Zhou 1) ,Y.Y.Feng 2) and H.Y.Lu 2) 1)Department of Physics Nanjing Normal University, Nanjing 210097,China 2)Physics and Ch寁O P T I C A L P R O P E R T I E S O F Ge O2 A N D Ge N A N O C R Y S T A L S Y. H. Zhou1) , Y. Y. Feng2) | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 22 |
| 2 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 3 | Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/ reperfusion injury显示文摘目的: 进一步描绘膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的功能的角色在早、迟了(第二扇窗户) ischemic preconditioning (欧洲电脑生产厂商)- 并且 postconditioning (停靠港) 调停了对 ischemia/reperfusion (I/R ) 的 cardioprotection 损害。 | Sunny Yang XIANG Linda L YE Li-lu Marie DUAN Li-hui LIU Zhi-dong GE John A AUCHAMPACH Garrett J GROSS Dayue Darrel DUAN | 2011 | Acta Pharmacologica Sinica2011，32，6： | 9 |
| 4 | 冠状动脉内皮功能障碍患者胆固醇流出异常,高密度脂蛋白颗粒物浓度降低显示文摘冠状动脉内皮功能障碍(endothelial dysfunction,ED)是动脉粥样硬化早期标志,增加心血管事件发生风险。该研究假设胆固醇流出容量和高密度脂蛋白颗粒浓度(high-density lipoprotein particle concentration,HDL-PIMA)较高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)更能预测ED。 | 刘莉 叶鹏 Monette JS Hutchins PM Ronsein GE Wimberger J Irwin AD Tang C Sara JD Shao B Vaisar T Lerman A Heinecke JW | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 5 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 6 | Monocyte-derived Wnt5a regulates inflammatory ymphangiogenesis显示文摘 | Roberto Sessa Don Yuen Stephanie Wan Michael Rosner Preethi Padmanaban Shaokui Ge April Smith Russell Fletcher Ariane Baudhuin-Kessel Terry P Yamaguchi Richard A Lang LuChen | 2016 | Cell Research2016，26，2： | 2 |
| 7 | Differential expression of interleukin-15,a pro-inflammatory cytokine and T-cell growth factor, and its receptor in human prostate显示文摘 | Handisurya A Steiner GE Stix U | 2001 | Prostate2001，49，： | 1 |
| 8 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H Ge N Catron D Buchanan M E | 2001 | Nature2001，410，： | 1 |
| 9 | Pilot study of carotid surgery for acute stroke 显示文摘 | Mead GE Murray H Farrell A | 1997 | Br J Surg1997，84，7： | 1 |
| 10 | Evaluation of longitudinal ventricular function with tissue Doppler echocardiography in children treated with an- thracyclines显示文摘 | Stapleton GE Stapleton SL Martinez A Ayres NA Kovalchin JP Bezold LI | 2007 | J Am Soc Echocardiogr2007，20，5： | 1 |
| 11 | Relative weight and race influence average age at menarche: results from two nationally representative surveys of US girls studied 25 years apart显示文摘 | Anderson SE Dallal GE Must A | 2003 | Pediatrics2003，111，41： | 1 |
| 12 | Recent breakthrough development of the magnetic shape memory effect in Ni-Mn-Ga alloys显示文摘 | SODERBERG O GE Y SOZINOV A HANNULA S P LINDROOS V K | 2005 | Smart Mater Struct2005，14，： | 1 |
| 13 | Mosaicism in fragile X 'af- fected males 显示文摘 | Nolin SL Glicksman A Houck GE Jr | 1994 | Am J Med Genet1994，51，： | 1 |
| 14 | Leukocyte sequestration in pulmonary microvessles and lung injury following systemic complement activation in rabbits显示文摘 | Kuhnle GE Kiefmann R Sckell A | 1999 | J Vasc Res1999，36，： | 1 |
| 15 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 16 | Screening for Breast Canc- er 显示文摘 | Joaun GE Katrina A Constance DL | 2005 | JAMA2005，293，： | 1 |
| 17 | Orbitalspaceoccupying lesions:roleof computed tomography andmagnetic resonanceimaging:an analysis of 145 cases显示文摘 | Mafee Mf Putterman A Valvassori GE | 1987 | RadiolClin North Am1987，25，： | 1 |
| 18 | Correlation be- tween thermal fatigue and thermomechanical properties during the oxidation of multilayered TiSiN nanocomposite coatings synthesized by a hybrid physical/chemical vapour deposition process显示文摘 | A M~ge - Revil P Steyer S Cardinal | 2010 | Thin Solid Films2010，518，2010： | 1 |
| 19 | The impact of leverage on firm investment:Canadian evidence显示文摘 | Aivazian V A Ge Y Qiu J P | | 0，，11： | 1 |
| 20 | Apixaban or enoxaparin for thromboprophylaxis after knee replacement 显示文摘 | Lassen MR Raskob GE Gallus A | 2009 | New E J Med2009，361，： | 1 |
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